David R. Martinez
@David_RMartinez
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Scientist. Assistant Professor of Immunobiology @YaleIBIO @YaleCII @YaleMed . Hanna H. Gray Fellow of the @HHMINEWS . Husband/Dad. 🇸🇻 🇺🇸
Connecticut, USA
Joined October 2012
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Happy to share one of my main postdoc projects just out in
@ScienceMagazine
“Chimeric spike mRNA vaccines protect against Sarbecovirus challenge in mice”. (Thread)
@Baric_Lab
@UNCpublichealth
@HHMINEWS
#COVID19
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“Drugmakers are planning a public pledge to not send any Covid-19 vaccine to the FDA for review without extensive safety and efficacy data.”
👏🏻👏🏻.
What crazy times we live in when vaccine makers are the ones keeping the regulators in check. Who would have thought.
BREAKING: Vaccine makers are planning a public statement to push back on pressure on the FDA:
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Elated to share that my
#COVID19
paper was just REJECTED at
@cellhostmicrobe
! If you’re a young grad student or trainee, don’t take rejection too hard. This is part of the process. Dust yourself off, pick yourself up, and try again. Stay the course!
#AcademicTwitter
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Some of this already announced by companies. Looks like
#Omicron
fully evades the REGN mAbs. Same with Lilly. And only one of the two AZ mAbs (just given EUA yesterday) neutralize it. Sotrovimab from Vir going strong against Omicron. Preprint linked 👇🏼
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Humbled to announce that I have been selected as a Hanna H. Gray Fellow of the HHMI
@HHMINEWS
. Many people to thank for their mentorship including my postdoc advisor Ralph Baric
@Baric_Lab
, Sallie Permar
@SalliePermar
(thread)
@UNCpublichealth
@DukeMGM
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Elated to be a part of these two monkey studies studies just published in Science in collaboration with Dan Barouch. In the first study, we answered a key unanswered question: does SARS-CoV-2 immunity protect against reinfection? The answer is yes.(Thread below).
@ScienceMagazine
Two new studies in macaques offer hope that humans could develop protective immunity against
#SARSCOV2
, either as the result of a natural infection or by way of a vaccine.
@BIDMChealth
Read the research:
👉
👉
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We are happy to share our discovery of the broadest human neutralizing monoclonal antibody reported to date against the greater Sarbecovirus subgenus just out in
@ScienceTM
! This study was led by
@Dapeng_LI
@sophie_gobeil
@aschaefe29
and I.
@HHMINEWS
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Parents take note 👇🏼 below is Cornell’s head pediatrician getting her son vaccinated against
#COVID19
. Safe and effective
#COVID19
vaccines reduce risk of potential life-threatening
#COVID19
and long-term
#COVID
symptoms.
#VaccinesWork
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Our paper characterizing a MERS-related 🦇
#CoV
is out in
@ScienceTM
! In this study we evaluated the ability of Bt-CoV 422 to replicate in primary human airway cells partially evade countermeasures. TLDR: merbecoviruses are poised for emergence (1/2)
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Happy to share my pre-print describing chimeric mRNA spikes that elicit broadly neutralizing antibodies against SARS-CoV, SARS-CoV-2, and high-risk pre-emergent bat CoVs and protect against challenge in mice (thread)
@Baric_Lab
@UNCpublichealth
#COVID19
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Our latest universal
#coronavirus
vaccine work is out in
@NatureComms
. We used nanoparticle vaccines that elicited broadly neutralizing antibodies in monkeys against
#SARS2
variants and protected mice against 🦇 SARS-related CoVs (Brief thread 👇🏼)
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Huge congrats to our fearless leader, Ralph S. Baric, who just got elected into the National Academy of Sciences!
@theNASciences
@UNCpublichealth
@UNC
@UNC_SOM
@Baric_Lab
Richly deserved accolade.
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Y’all being a dad is so great. Our baby boy came on 11/11/22 and is doing great. Momma is doing great too. Excited about this new chapter!
#newdad
#academicpoppa
Guys I have the best lab mates! Check out these onesies. We have a super creative and crafty member (Rachel Graham) who made these, and this super cool card. At week 39, my partner and I are anxiously waiting for our baby’s arrival!
@UNCpublichealth
@Baric_Lab
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I’m 0/3 with grants I submitted as PI since I started my lab 😄🙌🏼🤣
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Humbled to be selected for the “Premio Joven Investigador” Award. Thanks to
@VanderbiltU
and Drs. Hinton, Jenkins, Spencer, and Marnett!
@phdgprotein86
@VUBasicSciences
#HispanicHeritageMonth
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Unsurprising yet reassuring. T cell immunity remains stable against more divergent variants like
#OmicronVirus
. While there’s a small decrease in T cell recognition of
#Omicron
, this is really great news.
Our T cells appear to be ready, willing and able to defend vs Omicron CD4+ and CD8+ cells hold up well in people vaccinated or prior Covid
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Beyond thrilled to share that my main dissertation project, which took me 4.5 years to finish, was just published in Cell! (Thread - 1/5)
@dukeMGM
@DukeMedSchool
@cellcellpress
@uncpublichealth
@bwf
@amays_bwfund
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Yes we are. “Scientists relieved as Joe Biden wins tight US presidential election”
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Our paper describing a ferritin nanoparticle RBD vaccine that protects mice against
#SARSCoV
and
#MERSCoV
and neutralizes highly mutated
#SARSCoV2
#VOCs
is out in
@CellReports
Team effort with
@TheDHVI
@aschaefe29
thread👇🏼
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Check out our
#preprint
describing a broadly neutralizing RBD antibody, which protects against SARS-CoV, bat pre-emergent CoVs, and SARS-CoV-2 B.1.351 challenge in mice. This work was led by me,
@aschaefe29
@sophie_gobeil
@Dapeng_LI
(thread)
@Baric_Lab
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Seeding cells at BSL2 today for a full
#SARS2
neutralization assay day in the
#BSL3
tomorrow testing one of the leading vaccine candidates!
#dailygrind
#StopCovid19
#weneverstop
@Baric_Lab
@UNCpublichealth
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Our
#pangolin
#CoV
characterization paper is finally out in Nature Microbiology. In this study, we characterized the tropism, immunogenicity, and pathogenesis of a SARS2-related CoV sequenced from a pangolin. Glad
@aschaefe29
and I contributed.
@Baric_Lab
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Elated to share that I received my
@NIAIDFunding
#F32
notice of award. Thanks to my mentors, mentees, and
#virology
@UNC
colleagues for your support.
@Baric_Lab
@UNCpublichealth
#dengue
#lovevirology
#vaccines
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Happy to share our
@timothysheahan
lab study just out in
@ScienceTM
of an orally bioavailable drug that strongly dampens
#SARSCoV2
disease in mice. Let’s stop pandemics before they occur!
@aschaefe29
@UNCpublichealth
#antivirals
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New data alert 🚨 Worried about the
#SARSCoV2
variants like the South African B.1.351 ? Good news is that the
#CoV
vaccine like the one from
#Moderna
and
#Pfizer
can protect against the B.1.351 variant in aged (highly vulnerable) mice. And so can our universal
#mRNA
vaccines!
We have added more LIVE VIRUS UK B117 and mink neutralization variant data, in addition to SA B1.351 VOC, comparing our universal CoV mRNA vaccine strategy to the SARS-CoV-2 mRNA vax. All three variants are efficiently neutralized despite a small reduction against the SA B1.351.
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We conclude that the epitope bound by DH1047 is an Achilles Heel of sarbecoviruses and could be a template for a universal vaccine. Our antibody, DH1047, could not only be deployed in the current
#COVID19
pandemic but could also be stockpiled to prevent a SARS-CoV-3 epidemic.
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Extremely humbled to have made it onto this list with other
#Latinx
scientists that are my own role models. Thank you to my peers for this totally unexpected surprise. I look forward to inspire the next generation of scientists from diverse backgrounds.
#LatinxHeritageMonth
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Elated to share our
#COVID19
vaccine paper just published in
@nature
: a single shot Ad26 protects against
#SARSCoV2
infection in rhesus macaques. This vaccine is going into human Phase 3 clinical trials (Thread)
@Baric_Lab
@BWFUND
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Very important study from
@SetteLab
@Alba_Grifoni
@profshanecrotty
@Dani6020
and colleagues. 👇🏼 high degree of T cell preservation against
#COVID19
#variants
in vaccinated individuals. So even though people freak out about a drop in antibody levels, don’t forget we have T cells!
A 2nd report today from
@ljiresearch
also demonstrates vaccination induced T-cells vs Omicron (B.1.1,519) well preserved compared with all variants and with 3 different vaccines
@aetarke
@SetteLab
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This is alarming. Dr. Fauci thinks the US is failing at this. Unlike other countries where anyone who suspects a
#COVID19
infection can be quickly tested, in the US only your physician can order a test for you. Ccing
@SalliePermar
@Jmsteinbrink
@CarlosdelRio7
@AJMarkm
Dr. Fauci on availability of coronavirus tests in the US:
“The system is not really geared to what we need right now, what you are asking for. That is a failing … Let’s admit it.”
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Great to finally meet the incomparable
@HarmitMalik
in person! Thanks so much for the great mentorship and key advice as the
#Martinezlab
launches next year.
#MedezSymposium
@fredhutch
@HHMINEWS
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I’m excited to share my first-author paper just published in
@CellReports
. In this study, we identify a unique role for the genetic variation observed in
#Dengue
#virus
serotype 2 among the various circulating genotypes. (1/3)
@UNCpublichealth
@BWFUND
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Scientists, physicians, nurses, and first responders are working hard 💪🏼 to defeat the number 1 enemy:
#SARS2
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Easily the most important pipetting I’ve ever done in my life. Humbled and honored to be in this group featured in the
#Smithsonian
and led by
@KizzyPhD
and
@BarneyGrahamMD
with the support of
@DenisonLab
@Baric_Lab
@McLellan_Lab
and countless others!
#COVID19
#vaccineswork
Our
@NIH
Moderna vaccine research team is featured in the
#FUTURES
exhibit at the
#Smithsonian
. It opens today; go see it if you can!
@BarneyGrahamMD
@McLellan_Lab
@Baric_Lab
@David_RMartinez
@Ardinajp
@KizzyPhD
and many others, some pictured on a Zoom call.
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Happy to be a part of this study just out in
#Immunity
@ImmunityCP
led by
@andrabi_raiees
in which we characterize broadly neutralizing anti-S2 antibodies that protect against
#SARSCoV
#SARSCoV2
and
#MERSCoV
@Baric_Lab
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Humbled to be a part of this group of postdocs. I look forward to presenting my work at the
#EddieMendez
Symposium in Seattle
@fredhutch
Congratulations to the recipients of the
@fredhutch
2022 Dr. Eddie Méndez award! 👏
The recipients are postdoctoral researchers from across the US with research expertise in
#cancer
,
#InfectiousDisease
, and basic sciences.
Learn more:
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Awesome to meet the great
@CterminiPhD
in person! Bonus: had coffee in her awesome office
@fredhutch
while soaking in the
#NewPI
advice!
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I am hiring a lab manager. Come join the Laboratory of Viral Pathobiology and Immunity!
@YaleIBIO
We are a fun, supportive, and friendly group.
We welcome all and actively work to foster a lab environment where everyone feels welcome.
Please RT
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Glad to see this pre-print out with Bart Haynes and Kevin Saunders. Here,
@Dapeng_LI
,
@aschaefe29
, others, and I, show that in vitro antibody dependent enhancement (ADE) of SARS-CoV-2 antibodies do not mediate ADE in in vivo both in mice and in monkeys.
@TheDHVI
@Baric_Lab
New preprint on study led by Haynes & Saunders lab
@TheDHVI
. Excited to contribute to structural analyses of these new antibodies.
@Dapeng_LI
,
@David_RMartinez
- so well done!
@KarthikManne
,
@sophie_gobeil
- nice structures!
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Elated to share that our paper was selected as the cover of
@ScienceTM
! Thanks to
@aschaefe29
@sophie_gobeil
and
@Dapeng_LI
@priyam2021
for the collaboration.
But the MVP to thank is the artist beneath the cover:
@FalconieriV
!
@UNCpublichealth
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Despite all of the stressful
#COVID19
work in the lab, I recently received great news. My NIAID
#F32
scored in the 1 percentile. Now praying to the “grant gods” for a payline above a 14 😂. Thanks to my mentors for your continued support - you know who you are.
#AcademicChatter
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Guys I have the best lab mates! Check out these onesies. We have a super creative and crafty member (Rachel Graham) who made these, and this super cool card. At week 39, my partner and I are anxiously waiting for our baby’s arrival!
@UNCpublichealth
@Baric_Lab
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Got my
#BA4
#BA5
#COVIDBooster
, seasonal
#flu
shot, and
#Tdap
booster all today because my wife and I are due in 10 weeks. My wife already received her
#Tdap
booster. Pharmacist
@Walgreens
curiously asked why I was getting all 3 shots? My response: “Why not?”
#vaccineswork
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I’m humbled to be featured in
@ForbesScience
. Thanks
@ligaze
for highlighting my work on
#Dengue
and
#SARSCoV2
.
@UNCpublichealth
@Baric_Lab
#lovevirology
#LatinoinSTEM
Salvadoran scientist
@David_RMartinez
is exploring how to block Covid-19 from infecting human cells, after his Dengue project shut down. My latest
#globalsouthscience
@forbesscience
#covid19
ATTN:
@Onwill
@wfsj
@red_mpc
@caminosciencia
@acpccolombia
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Ecstatic to share my
#COVID19
co-first author paper just out in Cell! This study was co-led by
@Y_Jacob_Hou
, Kenichi,
@caitelizedwards
, and I. This paper would not have been possible without many others from the
@Baric_Lab
and from
@UNC
(Thread below)
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Guys this is my bay mate Jacob. He’s a postdoc in the
@Baric_Lab
. He’s one of our in-house molecular virology extraordinaries and a prime mover of the all of the reagents being generated to study
#SARS2
in the BSL3. Welcome to Twitter Jacob.
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Congrats to my beautiful and brilliant wife Kelsey on a phenomenal PhD dissertation defense! She killed it! Meet the # toxicologist Dr. Kelsey A. Behrens, Ph.D.
#luckyguy
#proudhusband
#Phdone
#phdchat
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When the undergrad tries to help the postdoc with an experiment:
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@TamayoLab
The same was said to me during grad school at Duke. How did I deal with the situation? I outperformed every single one of these voices from so-called “friends” by all measures (i.e., # of first author papers etc). And I recently received a perfect score on a non-diversity F32.
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Animals that received the full length
#SARS_CoV_2
Spike had >3 logs reduction in respiratory tissues. Vaccine-elicited neutralizing antibodies correlated with protective efficacy. These findings are encouraging for the development of
#Covid_19
vaccine.
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The
#COVID19
vaccines are working the way they were intended.
I and others spoke with the brilliant
@KatherineJWu
about sterilizing immunity or lack thereof.
COVID-19 Vaccines: The Myth of 'Sterilizing Immunity'
@TheAtlantic
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Hopefully soon, once the
#COVID19
pandemic comes to an end, our politicians will not get amnesia about this viral threat and will work with scientists and industry to try to develop a universal coronavirus vaccine!
@florian_krammer
@Baric_Lab
#AcademicTwitter
#scicomm
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Stay in your lane,
@elonmusk
. We’ll leave the electric cars and rockets to you. Leave the virology/Immunology/epidemiology to us experts, meaning biomedical scientists and medical doctors. Thank you. Tweets like these are irresponsible.
@FxzzOnTheBeat
Virality of C19 is overstated due to conflating diagnosis date with contraction date & over-extrapolating exponential growth, which is never what happens in reality. Keep extrapolating & virus will exceed mass of known universe!
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Any others out there who worked non-stop on
#COVID19
for the last 1.5 years still feel exhausted/burned out despite taking time off?
#askingforme
burnout is real. It’s probably worse for the physicians who have worked arduous shifts and no end in sight now with the
#Delta
surge.
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The
#lab
’s first lunch outing to welcome new members. We had New Haven style
#apizza
from Sallie’s. Stay tuned for upcoming science updates from this highly talented set of
#womeninscience
trainees!
@YaleIBIO
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Happy to have contributed to this
#SARSCoV2
vaccine study just out in
@NEJM
! I’m feeling optimistic about the
#COVID19
vaccines moving forward in clinical trials!
@Baric_Lab
@UNCpublichealth
@UNC
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Office set up is coming along well. Got a fresh coat of paint, put up some decorations, and a big white board to remind me of my to-do list.
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I received the packages containing the NHP
#SARS2
vaccinated samples tweeps.
#BSL3
fun? ... yeah maybe in retrospect it will seem fun. 😅 wish me luck!
@Baric_Lab
@UNCpublichealth
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Our first
#COVID
-19 antibody pre-print in collaboration with
@VUMC_Vaccines
. We identify a large panel of
#SARSCoV2
neutralizing antibodies. Huge team effort!
@Baric_Lab
@UNCpublichealth
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Out of office email notifications turned on ✅ . Going on vacation to Key West, FL. Will be enjoying the sun, the pool, and the beach. Will not, for the first time in a long time, be thinking about lab or pending work ✌🏻
#WorkLifeBalance
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Our
#COVID19
therapy paper, in which
@aschaefe29
@SarahRLeist
@timothysheahan
and I combined highly potent mAbs from
@NussenzweigL
with Remdesivir, is out
@CellReports
(Thread below) "Prevention and therapy of SARS-CoV-2 and the B.1.351 variant in mice"
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A landmark
#COVID19
study published by
@VirusesImmunity
and team. Congrats!
Just published
@nature
: The maladaptive, misfiring of the immune response differentiates moderate vs severe
#COVID19
, by serial pan-assessment in 113 patients
by
@carolilucas
@VirusesImmunity
@YaleMedicine
@YaleIBIO
@HHMINEWS
and team
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Nice article with key Q and A by DNA virus expert
@DamaniaLab
!
#monkeypox
@UNC
@UNCpublichealth
Monkeypox: Info on the virus, symptoms, possible NC spread | Raleigh News & Observer
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Highlight of my week: sending our industry partner the live-virus neutralization data of their potent neutralizing monoclonal antibodies. And I sent them my protocol for their FDA application that’s going in! 🙌🏼
#antibodies
#therapeutics
now back to the
#BSL3
today!
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Science can be hard. Peer review can be a demoralizing process when the work that you pour your heart and soul into is criticized and torn apart.
I like to remember small and big victories. This one is the result of a fun collaboration and teamwork.
#AcademicTwitter
@ScienceTM
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Enjoying the first couple of days off since the
#COVID19
pandemic began. I’m feeling a bit guilty not being in lab, but we have been pushing hard for key data required to advance the two leading vaccines for Phase III trials. I’ll try not to feel guilty and enjoy the beach😎
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Happy to be a part of this study just out in
@NatImmunol
!
Targeted isolation of diverse human protective broadly neutralizing antibodies against SARS-like viruses
@Baric_Lab
@UNCpublichealth
@andrabi_raiees
2
10
62
Beaming with pride to finally be a target for trolls and anti-vaxx phony
@Twitter
accounts. I guess that must mean my advocacy for
#COVID19
vaccines is working. I’ll wear this one as a badge of honor.
#VaccinesWork
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Our latest universal vaccine study with
@BarouchLab
is out in
@Nature_NPJ
Vaccines.
We targeted the most conserved sarbecovirus proteins: the RNA-dependent RNA polymerase and the Helicase.
@aschaefe29
@Baric_Lab
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Apply!
The
#HannaGray
#Fellowship
from
@HHMINEWS
is game changing!
Bonus: you also get cute baby onesies!
📢 Please RT - incredible opportunity for 8 years of funding from postdoc>TT faculty position in the biomedical sciences
@HHMINEWS
#HannaGrayFellows
program
#DEI
Deadline is 12/7/2022
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Thanks for the swag
@HHMINEWS
! I’m thankful for the opportunity to present my work at the HG symposium. Best of luck to all! I look forward to meeting the rest of the participants via Zoom.
6
1
59
Thrilled to share my final first-author publication in
@mbiojournal
from my PhD in
@SalliePermar
lab. In this study, we isolated 225 HIV-specific monoclonal
#antibodies
from HIV-infected nontransmitting and transmitting women.(Thread - 1/n)
4
17
55
Thanks
@NIAIDNews
for the commemorative coins! Glad to be a part of the
@moderna_tx
#COVID19vax
team along with
@KizzyPhD
,
@DenisonLab
at
#VUMC
,
@McLellan_Lab
@UTAustin
,
@Baric_Lab
at
@UNCpublichealth
#vaccineswork
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Our
#AViDD
has a new paper out. We characterized an oral drug 💊 with broad in vivo efficacy against all tested coronaviruses🦠 “Efficacy of the oral nucleoside prodrug GS-5245 (Obeldesivir) against SARS-CoV-2 and coronaviruses with pandemic potential”
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Structure of the RNA-dependent RNA polymerase from COVID-19 virus | Science
0
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Finally I’m thrilled to join the center for infection and immunity
@YaleCII
led by the brilliant
@VirusesImmunity
. I’m also excited to interact with new colleagues
@WilenLab
@OConnorLabYale
@EllenFoxman
, David Schatz,
@SaadOmer3
and many other new colleagues.
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I am highly enthusiastic about continuing to explore broadly acting countermeasures against large groups of viruses to prevent pandemics before they happen! Stay tuned for more coming from our group on the antivirals front in this area!
@UNCpublichealth
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Looking forward giving a talk on Immunologic Approached to Emerging Coronaviruses and Flaviviruses at the
@GlobalVirusNews
hosted today by
@JohnsHopkinsSPH
.
Bonus: listening to my “scientific grandmother” Diane Griffin present her expert view on measles virus pathogenesis.
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Excellent analogy
@KizzyPhD
👌🏻. I’m going to start using this analogy and giving you credit.
#SciComm
at its finest.
@UNC
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The hypocrisy of this tweet is beyond me. Here’s someone who trained in a “majoritarian” PI’s lab at an elite institution. Yet when URMs do the same then something is wrong? And suddenly their accomplishments are solely because of the clout of their postdoc PI? I don’t think so.
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Congrats to our fearless
@Baric_Lab
leader, Ralph Baric, on getting elected into the American Academy of Arts and Sciences!
And in the same week as getting inducted into the National Academy of Sciences!
@UNCpublichealth
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