A new cover for SUPER AGERS after making the NYT bestseller list. Thanks to you for making it the #1 ranked new non-fiction book on Amazon.

First real-time human embryo implantation recorded (in 2D and 3D). Time lapse video of 2 embryos (200 μm apart) implanting in the 3D platform @ScienceAdvances

Discovery of a mechanism for the increased risk of arterial blood clots in people with diabetes: platelet hyperactivity mediated by SEC61B, calcium balance inside these cells.@jclinicalinvest .

We've seen how human genome editing is working for disease- causing mutations in the blood, liver and eye. The brain was considered to be an exceptionally difficult target. That's changing @Nature by @heidiledford .

And here's the cover of the @NatureAging

I don't think there are any "new rules of aging" or "revolutionary understanding of how to be healthy," as asserted here. But the newfound opportunity to prevent the major age-related diseases is something I'm excited about (not covered in the piece) .

FRAUD ALERT: I have nothing to do with these phony books using my name on the cover. I have not written a memoir or partnered with/inspired any cookbooks!.Attempts to get @amazon to take these down have gone nowhere.

The challenges of eliminating (the bad) senescent cells with multiple shots on goal.

Platelets sequester and harbor cell-free tumor DNA, which could enhance our ability to make early, microscopic diagnosis of cancer .@ScienceMagazine .

Loss of integrity of our adaptive immune system with aging (becoming a "saboteur").

The potential consequences of too youthful immune system in an older person —> autoimmunity.

Inflammaging: with aging comes untoward inflammation, a summary graphic .

As I wrote in SUPER AGERS, the immune system is the key to modulating our aging process and the opportunity to extend healthspan. Today @NatureAging 7 new articles, summarized here, that reinforce its central role.

An important application of generative A.I. is facilitating discovery to override antimicrobial resistance with newly designed antibiotics, as demonstrated here for in vivo effectiveness vs S. aureus and N. gonorrhoeae.@MIT @broadinstitute @wyssinstitute @MITdeptofBE

The potential for LLM virtual personal health coaching for fitness and sleep with performance similar to humans experts for over 850 case studies (not a prospective, real world assessment) @NatureMedicine

And this regarding privacy and GenAI browser help.

How malicious A.I. chatbots could extract personal information from users, plus recommendations to address this vulnerability.

A first-rate review of MASH (fatty liver disease) @NEJM

A natural experiment provides evidence for promoting moderate-vigorous physical activity: the importance of walkable cities .

Summary of this important study @Nature by @maxdkozlov