Original Article: Safety and Efficacy of Obicetrapib in Patients at High Cardiovascular Risk (BROADWAY trial) . #Cardiology

Tirzepatide and semaglutide are both highly effective for the management of obesity. How the two drugs compare in patients with obesity but without diabetes has been unknown. Research findings from the SURMOUNT-5 phase 3b trial are summarized in a short video.

Original Article: Neoadjuvant and Adjuvant Pembrolizumab in Locally Advanced Head and Neck Cancer (KEYNOTE-689 phase 3 trial) . Editorial: Harnessing Immunotherapy in Curative-Intent Treatment of Head and Neck Cancer . #Oncology

Erin C. Fuse Brown, JD, MPH (@efusebrown), discusses the manifestations and effects of corporatization in health care. Listen to the full interview with NEJM Executive Managing Editor Stephen Morrissey (@srm128):

𝐏𝐡𝐚𝐠𝐨𝐜𝐲𝐭𝐨𝐬𝐢𝐬 is the process by which a phagocyte (a type of white cell such as macrophage, monocyte, or neutrophil) engulfs large particles, usually pathogens or debris from dead or dying cells, and removes them from the bloodstream. To learn more about this NEJM

Original Article: Early Tirofiban Infusion after Intravenous Thrombolysis for Stroke (ASSET-IT phase 3 trial) . #Neurology

A Double Take video reviews the risk factors for acute heat-related illnesses, along with clinical features, complications, and management, and discusses preventive guidelines and measures. Watch now:

Original Article: Structured Exercise after Adjuvant Chemotherapy for Colon Cancer (CHALLENGE phase 3 trial) . Editorial: Extending Cancer Survival with Exercise — Time for Oncology to Act . #Oncology

Grieving her father after his sudden death, a resident finds herself paralyzed by fear that her lack of knowledge will cause harm to patients. Read the Perspective by Kristina Klara, MD:

A 23-year-old man presented with a 2-day history of painful swallowing and hoarseness. The symptoms had started immediately after he had inhaled nitrous oxide through his mouth from a hand-held canister for recreation. Read the full case details in the Images in Clinical

Prenatal genomic sequencing revealed congenital thrombotic thrombocytopenic purpura, enabling immediate plasma therapy. The case highlights the value and ethical complexity of reporting incidental findings. Read the full case details:

Presented at the 11th Annual Conference of the Chinese Stroke Association: . In patients with acute ischemic stroke treated with intravenous thrombolysis, early tirofiban improved functional outcomes at 90 days. Intracranial hemorrhage was uncommon but more frequent with

A report from the National Academy of Medicine (@theNAMedicine) proposes a research agenda to address climate-related health risks and data gaps, emphasizing equity, innovation, and interdisciplinary collaboration. Read the full report:

A 77-year-old woman presented to the emergency department with a 2-day history of abdominal pain, nausea, and vomiting. On physical examination, there was abdominal distension with tenderness in the left lower quadrant. Computed tomography of the abdomen showed herniation of a

Navigating cases of potential self-neglect is complicated for older adults and for the family members, clinicians, and social and legal services professionals involved in ensuring their well-being, write Kristin Lees Haggerty, PhD, and David B. Reuben, MD, in a new Perspective.

A 64-year-old man presented with a 5-month history of a painful ulcer of the lateral left ankle. Recently, he had noticed malodorous secretions, increased erythema and edema, and worsening pain. Read the full case details in the Clinical Problem-Solving article “Caving In to

New in the July 3, 2025, issue of NEJM: . Exercise after Chemotherapy for Colon Cancer (CHALLENGE phase 3 trial) . Tirzepatide vs. Semaglutide for Obesity (SURMOUNT-5 phase 3b trial) . Pembrolizumab in Head and Neck Cancer

A 57-year-old man presented with a 2-week history of worsening shortness of breath. Radiography and CT showed perihilar airspace opacities in both lungs, and bloody aliquots of fluid were obtained by bronchoalveolar lavage. Read the full case details in the Images in Clinical

In the first Perspective of a new series, Erin C. Fuse Brown, JD, MPH (@efusebrown), writes that “corporatization” of health care, a process predicted decades ago, now refers to the general trend throughout the industry toward higher levels of integrated control by consolidated

As health systems confront the social, economic, and political drivers underlying worsening U.S. population health, a new Perspective series examines the extent to which the business of health care may promote or impede progress. Learn more: