Alessandro Sette
@SetteLab
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These findings suggest potential therapeutic strategies aimed at enhancing regulatory T cells, and identify a target for antigen-specific T cells that may enable precision therapeutics in ALS.
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We identify the C9orf72 protein as a target for a T cell inflammatory autoimmune response with IL-5/ IL-10 releasing CD4+ T cells that might have an anti-inflammatory role. IL-10-mediated T cell responses were significantly higher in donors with a longer predicted survival time
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The HUVE Perform hydrogen water bottle uses advanced electrolysis to infuse your water with molecular hydrogen - a powerful antioxidant, shown to help neutralize free radicals, reduce inflammation, and support recovery at the cellular level. Independently tested and verified by
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It was suspected that autoimmune responses may play a role in ALS pathology, and that T cells contribute to the rapid loss of neurons during progression of this devastating disease, with little recourse for the involved patients.
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I am excited to share that our new study on Amyotrophic lateral sclerosis (ALS) is out in Nature today. Awesome collaboration with Dave Sulzer at Columbia and several clinical groups; and a big thank to all blood donors.
nature.com
Nature - An analysis of T cell responses in people with amyotrophic lateral sclerosis shows that the C9orf72 antigen is a key target of autoimmune responses in the disease, and identifies C9orf72...
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The emphasis on communication is most important, and we all as Scientists have the crucial task to communicate scientific results to scientists in their disciplines, but also to non-scientists and the general population.
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The future of science is open — and we’re building it together. Introducing Open Science, our new X community where researchers, founders & curious minds collide to explore DeSci, biotech & innovation. Join us ⬇️
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The Prize was instituted in 1950 to honor contributions to Science , with emphasis on communicating research to scientists in other disciplines. It is humbling to see that previous recipients involved four Nobel Prize winners, and Jane Goodall, Margaret Mead and Stephen Jay Gould
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Honored to receive the 2025 Procter Prize for Scientific Achievement "for understanding basic mechanisms of antigen recognition and immunity, predicting immune activity, and developing interventions against cancer, infection, autoimmunity, and allergies. "
lnkd.in
This link will take you to a page that’s not on LinkedIn
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I am honored to have received the 2025 William Procter Prize for Scientific Achievement "for understanding basic mechanisms of antigen recognition and immunity, predicting immune activity, and developing interventions against cancer, infection, autoimmunity, and allergies. "
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Prestigious prize recognizes Sette's accomplishments as a researcher and scientific communicator
lji.org
Prestigious prize recognizes Sette's accomplishments as a researcher and scientific communicator
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💫 The Edge Nobody Talks About is Looking Beyond The Line Everyone’s chasing data. We’re chasing energy. Numbers can tell you what should happen — but not what a player feels. They can’t measure birthdays, redemption games, heartbreaks, first starts after loss, or nights when
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Encouraging all qualified candidates to apply for the ISSNAF prizes. A wonderful opportunity to get recognition and network with your peers.If not directly eligible, please circulate to your peers.
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Particularly significant to be awarded on the 2025 Italian Research day. I am proud to follow my passion for Research. Scientific research has a profound impact on technological breakthroughs, human health, economic growth and education, and should not be taken for granted.
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I am honored and humbled to have been knighted by the Republic of Italy as Cavaliere al Merito della Repubblica. Heartfelt thanks to the Italian Government, Italian Embassy, the Consul Raffaella Valentini, ISSNAF , my family, friends and colleagues.
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Have you registered for the 2024 IEDB Virtual User Workshop yet? It will be held from November 5 to 7 on Zoom, so it's totally free. Sign up now! https://t.co/Szr5gz0WDY More information can be found here - https://t.co/N07ZjKCUKN We look forward to seeing you on Zoom, soon!
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The procurement process can be a city hall-sized headache. 🤕 We’ve got the cure. @ErinGRock is the procurement expert. Before joining The Southern Group, Erin executed some of Florida’s largest projects and procurements in the state’s history. Let her be your guide to
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We conclude that should a widespread human HPAI H5N1 outbreak occur, cross-reactive T cells might limit disease severity.
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We found most previously identified CD4 and CD8 T cell epitopes are identical or highly conserved. Our experimental data shows a nearly complete preservation of pre-existing T cell responses in HPAI H5N1 recognition
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Is there some degree of H5N1 preexisting immunity in humans? Cross-reactive H5 antibodies are low or not detected. However, the N1 component is shared between seasonal H1N1 and H5N1 What about T cells? Our study fills in this gap-of-knowledge
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dear algorithm: please show this post to everyone who’s been looking for the axiom of @zora thank you
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Recent cases of H5N1 2.3.4.4b flu from poultry and mammals into humans raised potential pandemic concerns. And a Recent report on H5 human case in Missouri increased the concern on potential human to human transmission: https://t.co/yKjxeL06oo.
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Our new study is out: https://t.co/VbhIVEN6jO Collaboration of my lab @Alba_Grifoni and @BjoernPeters2 @ljiresearch @IEDB with flu experts @florian_krammer and @rorydevries.
biorxiv.org
Frequent recent spillovers of subtype H5N1 clade 2.3.4.4b highly pathogenic avian influenza (HPAI) virus into poultry and mammals, especially dairy cattle, including several human cases, increased...
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