The complete #defensome of #Acinetobacter baumannii shows that ST2 clinical strains replace R-M systems with an Ssp system that drives their #phage and #antibiotic resistance profiles. @agarvil @ajperezpulido #CRISPR

The first in vivo (C. elegans) model of temperate #phage-#antibiotic synergy shows temperate phages can reduce the therapeutic dose of an otherwise ineffective antibiotic, but also that this is likely already driving success of many antibiotic treatments.

Taking images of microbes without light. Incandela et al. demonstrate the use of electrical capacitance measurements as a non-optical method for imaging live microbial samples.

Human and ecosystem health problems arise from exposure to fluorinated compounds. This high-throughput screening method for microbiological degradation of #PFAS can help society destroy "forever chemicals" in the environment. #defluorination

Synthetic C1 metabolism meets evolution: @PabloINik's team engineered #Pseudomonas putida to grow exclusively on formate and methanol, two CO₂-derived, renewable feedstocks. A leap toward sustainable bioproduction with fully synthetic C1 assimilation.

A comparison of catalytic and stable-binding anti-#CRISPR systems reveals situations where enzymatic activity is beneficial. @fraser_lab @joeBondyDenomy

Using advanced microscopy to examine how #Toxoplasma parasites build their specialized cytoskeleton, Engelberg et al. find that #microtubule organization determines the assembly of membrane structures critical for parasite division. @MJGubbels

The (digestive) path less traveled: influenza A virus and the gastrointestinal tract. This new #mBio minireview discusses how gastric exposure is a potential non-respiratory route for A(H5N1) IAVs in mammals that can lead to infection. #influenza #H5N1

New #mBio study reports that a single #biotherapeutic molecule from gut bacteria repairs both liver damage and detoxification functions and restores gut barrier lining. This offers a powerful new strategy for treating chronic liver diseases.

Genomic epidemiology of Histoplasma in Africa: this population #genomics study of African #Histoplasma isolates reveals three distinct genetic lineages and helps fill gaps in our understanding of African fungal diversity.

Paired scRNA-seq and spatial #transcriptomics from human #tuberculosis granulomas uncovers a central role for osteopontin-expressing macrophages in TB. @denniskoHiHOST

The newest Story behind the Science paper tells the history of the discovery of CagA, the protein that causes gastric cancer, where teams in the U.S. & Italy made independent observations that ultimately merged, and also honors the late Antonello Covacci.

Oxidative protein folding is a crucial process for #mycobacteria. Disulfide bonds are critical for stabilizing cell division, cell envelope biogenesis, and antibiotic resistance proteins in mycobacteria.

Conjugation-based genetic manipulation of #Fusobacterium animalis, an #oncobacterium associated with colorectal cancer, to expand our understanding of its virulence traits.

Molecular mechanism revealed for bacterial sugar overload. @MRKmicrobes @DoerrLab

New #mBio minireview by Oscar Romero and @JGMProteomics of @UofG_MCB - Breaking down #biofilms across critical priority fungal pathogens: #proteomics and computational innovation for mechanistic insights and new target discovery.

Deciphering a novel network where epigenetic control of the Fur and FNR master regulators contributes to bacterial survival in diseased environments where damage to the airways reduces the amount of oxygen in the lungs, as is encountered in #COPD patients.

New #mBio minireview - Breaking down #biofilms across critical priority fungal pathogens: #proteomics and computational innovation for mechanistic insights and new target discovery. #mycology

HIV-1 is a #retrovirus that has adapted to human cells by acquiring some proteins whose sole purpose appears to be antagonizing host restriction factors. Understanding the interplay between restriction factors & HIV may be critical to finding a cure. #mBio

COVID-19 convalescents have antibodies that act like ACE2, the #SARS-CoV-2 receptor. Enzyme correlates with BP changes after mild exercise. Antibodies against SARS-CoV-2 may help mediate problems experienced by #COVID-19 convalescents. @SteveZeichner #mBio