mBio
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The American Society for Microbiology’s first broad-scope, online-only, open-access journal. Contact us at mBio @asmusa .org.
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Applying CRISPRi technology to Acinetobacter baumannii uncovers essential genes in this antibiotic-resistant bacteria, revealing new drug targets and promising avenues for improved treatment strategies.
@Warren_E_Rose
#mBio
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29
97
Analyzing scientists' decisions in situations such as avoiding being scooped, sharing reagents, and choosing journals through the lens of the prisoner's dilemma suggests cooperation is always the best strategy.
@ACasadevall1
#mBio
1
36
89
Many bacterial populations produce toxic reactive oxygen species to antagonize neighboring microbes. How do they avoid 'friendly fire' from these molecules? Check out this new
#mBio
paper from
@MicroMische
,
@tera_levin
and colleagues!
0
24
72
The symmetrical wave pattern of base-pair substitution rates across the E. coli chromosome has multiple causes:
- timing & progression of replication
- 3D structure of the DNA
- biases in error correction
@ASMicrobiology
0
33
71
Repurposing estrogen receptor antagonists for the treatment of infectious disease: new mBio minireview
@ASMicrobiology
2
42
69
A Grad-seq View of RNA and Protein Complexes in Pseudomonas aeruginosa under Standard and Bacteriophage Predation Conditions
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Check out this update on our understanding of the Gram-negative cell envelope permeability barrier.
#mBio
0
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Did you know that toxins and antitoxins are often located in genomic toxin islands? Did you know that bacteria that live in extreme temps are depleted of toxins? Check out our new Toxinome DB describing ~2 million toxins and antitoxins.
@AsafLevyHUJI
#mBio
0
25
54
New
#mBio
paper led by
@geoffseverin
shows the CBASS anti-phage defense system of V. cholerae is activated by both quorum sensing and folate depletion.
@VictorDiRita
@WatersLabMSU
@katiford_micro
1
13
51
The pathogens S. aureus and P. aeruginosa often co-occur in infections. A new
#mBio
study using experimental evolution reveals that S. aureus can quickly adapt to inhibitory compounds secreted by P. aeruginosa, thereby favoring coexistence.
@RolfsMicrobes
0
22
51
Commentary: Cooperative evolutionary strategy between the bacteriome and mycobiome
0
57
48
A Streptococcus Quorum Sensing System Enables Suppression of Innate Immunity
0
15
48
Infections caused by Klebsiella pneumoniae continue to be a global public health threat, and the treatment of these infections is complicated by the high frequency of multidrug resistance. Check out this new
#mBio
article on this important topic:
1
17
46
Host-pathogen interactions: What the EHEC are we learning from host genome-wide screens?
@ASMicrobiology
1
20
46
Researchers found that Pseudomonas aeruginosa persists and continues to evolve throughout the upper and lower airways of people with CF despite the use of highly effective modulator therapy.
@catarmbruster
@vscooper
@jbombscientist
0
29
47
A multi-species study from the lab of
@harry_mobley
demonstrates how the response regulator ArcA contributes to fitness during Gram-negative bacteremia.
#mBio
1
18
45
A genome-wide knockout screen in human macrophages identified host factors modulating Salmonella infection
@ASMicrobiology
0
21
46
Combined quorum sensing and siderophore activity of the virulence-associated yersiniabactin system of uropathogenic Escherichia coli.
@DrJPHenderson
@glkatumba
@McCoyIVLab
#mBio
0
11
44
Fallacy of the unique genome: Sequence diversity within single H. pylori strains
2
45
43
A New Sugar for an Old Phage: a c-di-GMP-Dependent Polysaccharide Pathway Sensitizes Escherichia coli for Bacteriophage Infection
0
14
43
Hypervirulent Klebsiella pneumoniae acquired a virulence plasmid encoded regulator that suppresses type 3 fimbriae in response to iron. Bacteria switches between high fimbraie and low capsule mucoidy or vice versa in response to iron.
@YongMelvin
@yunnhwen
0
21
43
Quorum Sensing Promotes Phage Infection in Pseudomonas aeruginosa PAO1
0
6
43
Hidden Viral Sequences in Public Sequencing Data and Warning for Future Emerging Diseases
0
16
42
A specialized peptidoglycan synthase promotes Salmonella cell division inside host cells
0
41
41
A bacteriophage T4 nanoparticle-based dual vaccine against anthrax and plague
1
31
40
0
16
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Major errors found in the data and methods of a 2020 paper reporting on a cancer microbiome, including millions of reads misidentified as bacteria.
@stevensalzberg1
#mBio
0
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41
Introducing THOR, a model microbiome for genetic dissection of community behavior
2
20
41
Hypothesis: a plastically produced phenotype predicts host specialization and can precede subsequent mutations in bacteriophage
@ASMicrobiology
0
27
40
Klebsiella pneumoniae strains use different strategies to colonize the mouse GI tract: One size does not fit all!
@egonozer
@kelly_bachta
@tkochanphd
#mBio
0
7
39
Cryptococcus neoformans invades the murine brain by escaping from airways and breaching the blood-brain barrier, followed by engulfment by microglia.
@Ness_Francis88
@fungalhyphae
@ACasadevall1
@Emma_BCC
@caipcoelho
#mBio
0
11
36
Lighting up mutation: a new unbiased system for the measurement of microbial mutation rates. New mBio commentary.
@ASMicrobiology
0
15
39
Shigella sonnei O-antigen inhibits internalization, vacuole escape, and inflammasome activation
@ASMicrobiology
0
13
39
Filamentous phage-bacterial host interactions prompted rapid evolution and epidemic spread of Pacific-Native Vibrio parahaemolyticus.
@CAWhistler
@vscooper
#mBio
0
17
39
Using a small molecule to dissect the physiology and antibiotic susceptibility of Mycobacterium tuberculosis, work from the
@StallingsLab
reveals new mechanisms to sensitize this dangerous pathogen to existing antibiotics.
#mBio
0
13
36
Drivers of microbiome diversity: a review of general rules, feces, and ignorance
0
23
37
Fungal Extracellular Vesicles Are Involved in Intraspecies Intracellular Communication
1
10
37
HssS activation by membrane heme defines a new paradigm for 2-component system signaling in Staphylococcus aureus.
@DelphineLechar1
#mBio
0
9
37
#mBio
Editorial: Evidence suggests that editors are having to invite more and more reviewers to identify those willing to perform peer review.
@gilbertjacka
0
23
37
Bacterial Type II Secretion System and Its Mitochondrial Counterpart
0
8
36
Novel insights into selection for antibiotic resistance in complex microbial communities
@ASMicrobiology
0
22
35
Bacteriophage T4 Escapes CRISPR Attack by Minihomology Recombination and Repair
0
6
36
1 plaque = 1 infectious virus? Not necessarily, especially for mutagenized viruses
0
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33
New work exploring the diversity and genetic coding strategies of phages that infect CPR bacteria.
@JettLiu_
@alexander_jaffe
@BanfieldLab
#mBio
0
10
35
The Yersinia High-Pathogenicity Island Encodes a Siderophore-Dependent Copper Response System in Uropathogenic Escherichia coli
2
15
35
Polyphosphate Functions In Vivo as an Iron Chelator and Fenton Reaction Inhibitor
1
18
35
Evolution in Long-Term Stationary-Phase Batch Culture: Emergence of Divergent Escherichia coli Lineages over 1,200 Days
0
6
34
#mBio
and
@ASMicrobiology
welcome early-career researchers to apply for the Junior Editorial Board by 10/31. Check out what inaugural member
@ceeadinortey
thought about the program below, and find details and apply here: .
1
15
33
Multiplex CRISPRi System Enables the Study of Stage-Specific
Biofilm Genetic Requirements in Enterococcus faecalis
0
6
34
Bacterial transcription factors often bind sites within genes, but we know little about how these sites function. By mapping the regulon of E. coli PhoB, Fitzgerald et al. provide evidence that most binding sites within genes are nonfunctional.
@wadelab
0
13
32
Emergence of an extensively drug-resistance S. enterica serovar Typhi clone harboring a promiscuous plasmid encoding resistance to fluorquinolones and third-generation cephalosporins
0
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Discovery of a Diverse Set of Bacteria That Build Their Cell Walls without the Canonical Peptidoglycan Polymerase aPBP
0
10
32
Salmonella enterica Serovar Typhimurium SPI-1 and SPI-2 Shape the Global Transcriptional Landscape in a Human Intestinal Organoid Model System
0
11
33
Acinetobacter baumannii Can Survive with an Outer Membrane Lacking Lipooligosaccharide Due to Structural Support from Elongasome Peptidoglycan Synthesis
0
9
32
The CRISPR spacer space is dominated by sequences from species-specific mobilomes
1
29
31
See how prey bacteria can defend themselves against the type 6 secretion system by forming microcolonies.
@jpcotelab
@MargotDessarti4
@CascalesLab
#mBio
0
11
30
Alginate overproduction may be an important factor driving P. aeruginosa coinfection with S. aureus
0
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Very little is known regarding the anaerobic gut fungi diversity and community structure in marsupial mammals. To fill this knowledge gap, the authors conducted an amplicon-based diversity survey targeting AGF in 61 fecal samples from 10 marsupial species.
0
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32
Increased use of antiseptics is associated with reduced susceptibility in clinical isolates of S. aureus
#ASMClinMicro
0
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30
Bacterial aggregates allow P. aeruginosa to avoid phage killing but planktonic dispersal cells are susceptible
1
23
30
Translational fidelity may trade off against exponential growth by mutations in essential tRNA-modifying enzymes.
@vscooper
#mBio
@ASMicrobiology
0
11
31
Toward a Phage Cocktail for Tuberculosis: Susceptibility and Tuberculocidal Action of Mycobacteriophages against Diverse Mycobacterium tuberculosis Strains
0
8
31
Impact of homologous recombination on the evolution of prokaryotic core genomes
1
20
31
Copper Resistance Promotes Fitness of Methicillin-Resistant Staphylococcus aureus during Urinary Tract Infection
0
8
30
Quorum Sensing in Streptococcus mutans Regulates Production of Tryglysin, a Novel RaS-RiPP Antimicrobial Compound
0
11
30
Bacteria with low levels of intrinsic resistance often evolve to become even more susceptible to antibiotics in the absence of corresponding selection
1
19
30
Bacteroidetocins Target the Essential Outer Membrane Protein BamA of Bacteroidales Symbionts and Pathogens
1
13
30
Synergy between Cell Surface Glycosidases and Glycan-Binding Proteins Dictates the Utilization of Specific Beta(1,3)-Glucans by Human Gut Bacteroides
0
12
30
Fluorescently labeled DNA interacts with competence and recombination proteins and is integrated and expressed following natural transformation of B. subtilis
0
7
30
Two point mutations in Old World hantavirus glycoproteins afford the generation of highly infectious recombinant vesicular stomatitis virus vectors
0
11
28
Klebsiella pneumoniae Reduces SUMOylation To Limit Host Defense Responses
0
12
30
Have you heard about
#mBio
's Early-Career Editorial Board program? We're training early-career researchers in peer review. Check out the details, read Editorials by program graduates, and sign up for updates here:
0
13
29
The Dynamic Transition of Persistence toward the Viable but Nonculturable State during Stationary Phase Is Driven by Protein Aggregation
0
8
29
Klebsiella phage KP34p57 capsular depolymerase structure serendipitous show that this enzyme can work as a smaller monomeric protein. This finding is key to the design of active mini-enzymes against K. pneumoniae.
#mBio
0
9
29
#mBio
minireview: Behrens and
@natesherer
describe recent advances in our understanding of retroviral RNA nuclear export, focused predominantly on HIV-1 Rev's subcellular trafficking and role in forming multi-subunit ribonucleoprotein export complexes.
0
10
27
The expanding number of microbial genes of unknown function require multiprong investigation strategies
0
28
28
Deep subsurface coal seams are highly anoxic, oligotrophic environments, where most carbon is locked away in aromatic rings. This is the first description of organisms with the genetic potential to unlock this carbon from the coal geopolymer.
@bronwyncc
0
7
28
Staphylococcus aureus ATP Synthase Promotes Biofilm Persistence by Influencing Innate Immunity
0
15
27
Introduction of large sequence inserts by CRISPR-Cas9 to create pathogenicity mutants in the multinucleate filamentous pathogen S. sclerotiorum
0
24
28
TnCentral: a Prokaryotic Transposable Element Database and Web Portal for Transposon Analysis
0
8
28
Bacteriophage Treatment Rescues Mice Infected with Multidrug-Resistant Klebsiella pneumoniae ST258
0
8
28
New
#mBio
minireview focuses on single-stranded RNA viruses (excluding retroviridae) and summarizes the current knowledge of DVG generation, the functions and diversity of DVG species, and the roles DVGs play in influencing disease progression.
0
9
27
#mBio
Editor's Pick: New paper by
@MouldDMicrobe
in
@thehoganlab
highlights the importance of cross-feeding between closely related Pseudomonas aerguinosa genotypes and when in co-culture with S. aureus.
0
7
28
Spraying beneficial bacteria on leaves? Studying phyllosphere ecology? Leaf side matters! Check out this recent
#mBio
work by
@_Wenke_
,
@bkoskella
,
@NoahFierer
, and
@CorinneMWalsh
.
@ASMicrobiology
0
10
27
Microwave-Generated Steam Decontamination of N95 Respirators Utilizing Universally Accessible Materials
0
9
27
Evolutionary Stabilization of Cooperative Toxin Production through a Bacterium-Plasmid-Phage Interplay
0
10
27
Development of next-generation vaccines should leverage non-neutralizing functions of antibodies.
#mBio
0
9
27
The Penicillin-Binding Protein PbpP Is a Sensor of β-Lactams and Is Required for Activation of the Extracytoplasmic Function σ Factor σP in Bacillus thuringiensis
0
7
26
Cyanobacteria use the same complex for the assembly of the motility appendages, type 4 pili, and protein secretion.
@mBioJournal
0
6
27
Evolution of Antibiotic Tolerance Shapes Resistance Development in Chronic Pseudomonas aeruginosa Infections
0
12
27