Jason McLellan
@McLellan_Lab
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Professor of Molecular Biosciences The University of Texas at Austin Opinions are my own and not the views of my employer
Austin, TX
Joined July 2014
A potently #neutralizing and protective human #antibody with a unique antigenic footprint on #RSV and #hMPV fusion glycoproteins. Collaborative work with @McLellan_Lab @jjmousa @BonamiRachel @croweje @RHCarnahan, and others. https://t.co/T3IcpUfqmH
biorxiv.org
Human respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) are frequent drivers of morbidity and mortality in susceptible populations, most often infantile, older adults, and immunoco...
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Applications are open for PhD students via our ILS graduate programs. Come have fun and do great science in Austin! https://t.co/Cv8viZoVY6
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I'm honored to receive this award and I'm looking forward to the event in September! Thank you!
Grateful to the @SAmedfound for supporting the #2024InnovationAward. Looking forward to celebrating the groundbreaking work of @McLellan_Lab in September.
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Great work Cory!
Very excited to share this story about two substitutions in a sarbecovirus spike that enhance infectivity by increasing RBD availability. My first cryoEM structure was of the RsSHC014-CoV spike protein and is included in this manuscript!
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Very excited to share this story about two substitutions in a sarbecovirus spike that enhance infectivity by increasing RBD availability. My first cryoEM structure was of the RsSHC014-CoV spike protein and is included in this manuscript!
biorxiv.org
Understanding the zoonotic risks posed by bat coronaviruses (CoVs) is critical for pandemic preparedness. Herein, we generated recombinant vesicular stomatitis viruses (rVSVs) bearing spikes from...
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It was an honor to receive this award with Dr. Holmgren and Dr. Graham. Many thanks to IVI and SK bioscience for supporting this award. I had a wonderful week and enjoyed my interactions with all the scientists. I look forward to new collaborations. Thank you Jerome!
Privileged to honor 3 prominent vaccinologists with 2024 IVI - SK bioscience Park MahnHoon Award. Thank you Profs. Holmgren, Graham and McLellan for your contributions to vaccines for global health.
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Privileged to honor 3 prominent vaccinologists with 2024 IVI - SK bioscience Park MahnHoon Award. Thank you Profs. Holmgren, Graham and McLellan for your contributions to vaccines for global health.
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Check out our pre-print describing a CCHFV glycoprotein complex in the pre-fusion conformation! We used several engineering tricks to design our final construct, GP38-GnH-DS-Gc. Great collaborative effort, led by graduate student @Eliza4Science!
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Thank you, I am honored to receive this award! I want to thank all the terrific scientists, collaborators, and colleagues who helped contribute to the development of the RSV and COVID-19 vaccines, particularly @BarneyGrahamMD. Exciting times for structure-based vaccine design!
Congrats to Dr. Jason McLellan, @McLellan_Lab, recipient of the 2024 "Building the Foundation Award," supported by @JNJNews! Dr. McLellan and his lab developed technologies leading to the 1st FDA-approved vaccine for #RSV. https://t.co/9d0UIRfZZM
#RAAwards
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former postdoc Pat Byrne @PatByrne0 as well as Alison Lee from the @maynard_lab.
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gB-C7 and related stabilized ectodomains should be helpful for isolating antibodies that bind exclusively to the prefusion conformation of gB proteins. Overall, this was a fantastic group effort led by graduate student Madeline Sponholtz with major contributions from ...
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Interestingly, and in contrast to what has been observed for many class I fusogens, immunization (of mice) with gB-C7 did not result in higher neutralizing antibody titers than postfusion gB. We offer some explanations for this in the discussion.
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which revealed some additional secondary structure elements at the membrane-distal apex. Because we omitted the membrane-proximal region from our soluble construct, the tips of domain I, including the fusion loops, are disordered (that’s why we called it prefusion-like).
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We found that inter-protomer disulfide bonds were key, and this approach should be generally applicable to related class III fusogens. We obtained a high-resolution cryo-EM structure of our most-stabilized variant, gB-C7, ...
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Excited to share the pre-print describing our efforts to stabilize the HCMV gB ectodomain in a prefusion-like conformation. We and others have now routinely stabilized class I viral fusion proteins, but class III viral fusogens have been more difficult.
Structure-based design of a soluble human cytomegalovirus glycoprotein B antigen stabilized in a prefusion-like conformation https://t.co/gko1JISVVi
#bioRxiv
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