Immunity
@ImmunityCP
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Cutting-edge research in immunology from around the world. This account is no longer monitored, and content is automated. Join us on BlueSky!
Cambridge, MA, USA
Joined May 2011
We are turning this account into a fully automated page. To learn more about what’s going on at Immunity, please follow us on Bluesky! https://t.co/2BFKPbcSGQ
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Online now: A chemical agonist and the Golgi-resident lipid PI4P activate STING by inducing transmembrane helix rearrangement
cell.com
While the phospholipid PI4P is implicated in STING activation, its molecular mechanism has remained elusive. Han et al. reveal that PI4P cooperates with the transmembrane agonist GNE-6468 to activate...
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Excited to hear from #CSImmuneHomeostasis26 keynote Diane Mathis @harvardmed! She’ll be sharing her groundbreaking talk on how meningeal Tregs regulate brain health and influence neurodegeneration. Don’t miss it! @CellSymposia
https://t.co/yrIneit3Xs
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Online now: A host-centric view of the microbiota metabolome
cell.com
Our current understanding of microbial-host communication is largely based on context-dependent examples and anecdotes. Yamada and Palm present a teleological framework that organizes microbial...
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Clonal persistence dominates homeostatic intestinal IgA responses @ImmunityCP
https://t.co/pcFBzeWSg1 🇩🇪
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Online now: Clonal persistence dominates homeostatic intestinal IgA responses
cell.com
Gut plasma cells secrete IgA, which prevents infections, neutralizes toxins, and regulates the gut microbiota. Simons et al. demonstrate that stable IgA production results not from the persistence of...
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Theory @ImmunityCP @Ananya94Saha
@EmoryPBEE Quantifying the waning of humoral immunity https://t.co/ml76XVmHay
cell.com
Memory is a central feature of the adaptive immunity. Saha et al. quantitatively model humoral memory and find that the pattern of waning of antibodies is better described by a power-law model rather...
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#WeekendRead! #FroendsOrFoes?! Benamar, Chatila &co identify @ImmunityCP a #GutBrain axis driving microbiota- & TLR-dependent Notch3+ Tregs in the gut that during multiple sclerosis go to the CNS & interacting with microglia become pathogenic Th17 cells
cell.com
Benamar et al. demonstrate that Notch3+ Treg cells are increased in multiple sclerosis and in EAE. They are induced in the gut by microbiota and translocate to the CNS to degenerate into pathogenic...
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Online now: Quantifying the waning of humoral immunity
cell.com
Memory is a central feature of the adaptive immunity. Saha et al. quantitatively model humoral memory and find that the pattern of waning of antibodies is better described by a power-law model rather...
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Online now: Human lung CD8+ tissue-resident memory T cell-derived interferon-γ orchestrates subset-specific antiviral programming in airway epithelial cells
cell.com
Mattingly et al. use human lung cells to show that virus-specific CD8+ tissue-resident memory T cells trigger epithelial antiviral defenses via IFNγ. This early protective response varies by epithe...
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Online now: Deep profiling of human T cells defines compartmentalized clones and phenotypic trajectories across blood and tonsils
cell.com
Human T cell responses are often studied using blood, yet most T cells reside in tissues. By comparing T cell receptor repertoires from millions of T cells from autologous tonsils and blood, Suresh...
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Topography of the HLA-A protein enforces shared and convergent immunodominant B cell and antibody alloresponses in transplant recipients https://t.co/qKt4pJsY2L
@John_Killian @ImmunityCP @UABNews
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Iliyan Iliev (@WeillCornell) shares insights on mucosal immunity and host–microbiome dialogue at @CellSymposia #CSMicrobiome2026. May 10–12, 2026 | Bruges Abstracts due Jan 16 https://t.co/BecuqvwWPz
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Online now: Topography of the HLA-A protein enforces shared and convergent immunodominant B cell and antibody alloresponses in transplant recipients
cell.com
Donor-specific antibodies against mismatched HLA proteins cause allograft failure, but the structural epitopes recognized by these antibodies are not well defined. Killian et al. identify immunodom...
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Online now: IL-9 as a naturally orthogonal cytokine with optimal JAK/STAT signaling for engineered T cell therapy
cell.com
Cytokines optimize and fine-tune effector T cell responses. Here, Jiang et al. utilize IL-9, with scarce receptor expression in normal tissues, to boost IL-9R engineered T cells for cancer therapy....
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Online now: IL-9 signaling redirects CAR T cell fate toward CD8+ memory and CD4+ cycling states, enhancing antitumor efficacy
cell.com
Castelli et al. show that incorporating interleukin-9 (IL-9) signaling reprograms chimeric antigen receptor (CAR) T cells to expand, persist, and resist dysfunction in solid tumors. This strategy...
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Immunity is now on LinkedIn! Follow us if you love #immunology! And if you don't already love immunology, maybe we'll change your mind😀 https://t.co/cFweadDWEQ
linkedin.com
Immunity by Cell Press | 509 followers on LinkedIn. Immunity publishes the most important advances in immunology research. We welcome studies that provide fundamental new immunological insights at...
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Engineering T cells (CAR T) for treatment of solid cancers has had mixed success to date. Two reports today raise the promise of using interleukin-9 as a way to raise efficacy @ImmunityCP
https://t.co/brwOZIgZOU
https://t.co/QfMQRIYWo6
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Online now: Membrane integrity changes upon viral infection activate sphingomyelinase SMPDL3B to restrict cGAS-STING signaling via cGAMP degradation
cell.com
(Immunity 58, 2670–2684.e1–e10; November 11, 2025)
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FOXP3 expression depends on cell-type-specific cis-regulatory elements and transcription factor circuitry https://t.co/LiUhQrdWOt
@ImmunityCP @GladstoneInst
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Online now: Sequential class switching generates antigen-specific gut IgA from IgG1 B cells
cell.com
IgA antibodies protect mucosal surfaces from foreign antigens. Siniscalco et al. identify germinal center (GC)-independent and GC-derived pathways of gut IgA generation following immunization....
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