Volumetric high-resolution electron microscopy reveals thin astrocyte leaflets form gap-junction-interconnected domains that contain minuscule endoplasmic reticulum saccules and enwrap synapses in...

A pro-fibrotic, mechanosensitive CTHRC1+ fibroblast population derived from creeping fat drives intestinal fibrosis in Crohn’s disease.

Capsid-forming PICIs (cf-PICIs) produce their own capsids and exploit phage tails from unrelated species to transfer their DNA across bacterial hosts. This tail piracy enables broad dissemination and...

By solving a previously unsolved biological question, the AI co-scientist predicted a complex mechanism of gene transfer and generated hypotheses that opened new research directions, illustrating...

Minich et al. hypothesized that complete metagenome-assembled genomes, recovered through long-read DNA sequencing, would enable pangenome and microbial genome-wide association analyses to identify...

A study of 483 mammoth remains spanning over a million years reveals ancient host-associated microbes preserved in bones and teeth, offering new insights into the long-term evolution of Pleistocene...

Stereo-seq V2 facilitates single-cell-resolution spatial RNA mapping in FFPE samples through random primer capture, uncovering ncRNAs, host-pathogen transcriptome profiling, and spatial immune...

Single-cell transcriptomic analysis reveals the hepatocyte metabolic plasticity during pregnancy and lactation, highlighting a hepatic “pregnancy clock” that coordinates maternal metabolic adaptation...

This study provides an in-depth examination of the effects of BIIB078 antisense oligonucleotide therapy (ASO) in ALS patients with C9orf72 mutations. Although the drug reached the brain and spinal...

Excitation enables neuronal function; however, overexcitation and calcium overload can be deadly. This study reveals a cellular resilience program in which reduced expression of electron transport...

Microbiome and virome sequencing of non-traditional farmed and wild mammals reveal an uncharted diversity of potential pathogens and mobile antibiotic resistance genes, providing insights into the...

The postsynaptic density (PSD) condensates in neuronal synapses are soft glass-like structures due to the formation of highly percolated protein-protein interaction networks. Shank3 oligomerization...

Tomato antiSYS is a natural receptor antagonist that counterbalances agonistic systemin phytocytokines. Its deficiency triggers autoinflammatory-like symptoms affecting growth and development of...

CFAP36, a conserved cilia-specific ubiquitin reader, partners with the ARL3 GTPase to enable the selective and directional retrieval of polyubiquitinated proteins from cilia, a process essential for...

This perspective discusses how small groups of cells work together in their environment as building blocks called mesoscale modules to form tissues and organs and how understanding these modules will...

Minich et al. hypothesized that complete metagenome-assembled genomes, recovered through long-read DNA sequencing, would enable pangenome and microbial genome-wide association analyses to identify...

Stereo-seq V2 facilitates single-cell-resolution spatial RNA mapping in FFPE samples through random primer capture, uncovering ncRNAs, host-pathogen transcriptome profiling, and spatial immune...

The first-in-human study of anti-BCMA CAR-T therapy for progressive multiple sclerosis shows a favorable safety profile, depletion of plasma cells in the central nervous system, and alleviation of...