Cell Host & Microbe
@cellhostmicrobe
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The scientific editors of Cell Host & Microbe, a Cell Press journal, bring you the latest information and insights from the forefront of host-microbe research.
Cambridge, MA
Joined November 2014
Our November issue examines Global Steps Forward as we mark 5 years of COVID-19. The issue includes discussion pieces from authors across the globe, examining insights gained on SARS-CoV-2, lessons learned, and next steps forward. https://t.co/ibKjXf8HC6
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Lantibiotic-producing bacteria impact microbiome resilience & resistance Gut colonization w/ lantibiotic-producing Blautia pseudococcoides SCSK prevents recovery of antibiotic-induced dysbiosis & increases susceptibility to K. pneumoniae & C. difficile https://t.co/wej3xoM6lr
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Insights into microbiome via structural proteome: Structure database of human gut microbial proteins & structure-aware AI model for remote homolog detection. Reveals diversification of phage endolysins & bacterial enzymes for melatonin biosynthesis https://t.co/QJ6X8fgYxJ
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Infant gut metabolic development: Maternal & environmental factors shape developing infant gut microbiome & metabolome in Bangladesh. Key signaling molecules, including microbially derived bile acids & N-acyl lipids, increase during infant development https://t.co/HOtFeCCb9g
cell.com
Kvitne et al. show that maternal and environmental factors shape the developing infant gut microbiome and metabolome in Bangladesh, a low- and middle-income country. They report a rapid increase in...
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Microbe-mediated stress? Microbial metabolite Imidazole propionate reaches brain, dampens hypothalamic activity & promotes stress-related behaviors. In humans, higher ImP is associated w/reduced hypothalamic responses & emotional eating @pipethero
https://t.co/xZTxrkWdVc
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Iliyan Iliev (@WeillCornell) shares insights on mucosal immunity and host–microbiome dialogue at @CellSymposia #CSMicrobiome2026. May 10–12, 2026 | Bruges Abstracts due Jan 16 https://t.co/V7VtNPMWDh
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"Keystone Pseudomonas species in the wheat phyllosphere microbiome mitigate Fusarium head blight by altering host pH" https://t.co/Mm5eyEFQbD
#NanjingAgriculturalUniversity Wu Xiong, Xuewen Gao, Qin Gu & colleagues @cellhostmicrobe
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Symbiont-coral partnerships Hologenome of B. pseudoalternata reveals a division of labor between deep-sea coral & symbionts. Host provides habitat & manages immunity, while symbionts recycle waste, supply nutrients, resist viruses & produce antioxidants https://t.co/vGwHXuvuwN
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Pseudomonas mitigate Fusarium head blight via pH Host-acidifying Pseudomonas, selectively enriched in wheat phyllosphere during F. graminearum invasion, counteract pathogen-induced alkalinization through organic acid production, thereby suppressing FHB https://t.co/JRYGr0tiOh
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Mapping the oral microbiome opens links to periodontitis: @MattagenOlmics highlights work establishing improved genome database of the human oral microbiome, which is then used to discover a connection between periodontitis & an enigmatic bacterial phylum https://t.co/miRiZoGvIu
cell.com
Many microbiome analysis techniques can only detect the microbes present in the reference genome database used. In this issue of Cell Host & Microbe, Cha et al. establish an improved genome database...
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Catalog of human oral microbiome: Human reference oral microbiome (HROM) comprises 72,641 genomes from 3,426 species, including 2,019 novel species. HROM reveals disease-assoc. species & ectopic oral species in the gut predictive of systemic diseases https://t.co/c7YXg3hnhz
cell.com
Oral microbiome shows rising importance in human health. Cha et al. present the human reference oral microbiome (HROM), comprising 72,641 high-quality genomes from 3,426 species, including 2,019...
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Evolution of Ab cross-reactivity to influenza H5N1 NA: Isolation & characterization of protective antibody against influenza neuraminidase that acquires cross-reactivity to avian H5N1 as a byproduct of affinity maturation against human H3N2 @wchnicholas
https://t.co/RGeirbNuPj
cell.com
Lv et al. isolated a protective antibody against influenza neuraminidase that acquires cross-reactivity to avian H5N1 as a byproduct of affinity maturation against human H3N2. Along with structural...
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Triggering infection: When microbial pathogens are in cahoots Highlight of @Nature paper revealing that Candida albicans, a fungus frequently found in the gut, facilitates the intestinal colonization and infection of Salmonella. https://t.co/6Ju9f7QF6H
cell.com
Due to the presence of gut microbiota, enteric pathogens such as Salmonella are rarely alone in their battleground with the host. In a recent study published in Nature, Jaswal et al. revealed that...
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Gut bacterial metabolism of steroid hormones Gut bacterial pathway involving OsrABC reduces natural & synthetic steroid hormones, including prednisolone. This microbial activity is enriched in Crohn’s disease patients & diminishes drug bioavailability https://t.co/Z7VVa7PkMH
cell.com
Jacoby et al. identify a gut bacterial pathway that reduces natural and synthetic steroid hormones, including the anti-inflammatory drug prednisolone. This microbial activity is enriched in Crohn’s...
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Bacteria block host cell death by protein cut-&-paste Preview of work reporting Shigella OspB catalyzes recombination between pro-death members of BCL-2 family, creating inactive chimeras that block apoptosis of cells, promoting bacterial virulence https://t.co/V4aM9WOa6z
cell.com
Bacterial pathogens interfere with host cell signaling by inducing post-translational modifications. In this issue, Xu and colleagues report that the Shigella flexneri effector OspB catalyzes an...
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Bacterial effector hijacks apoptosis via remodeling BCL-2 family proteins: Shigella OspB enzymatically recombines BH3-only activators & BAX/BAK via peptide-bond exchange. Chimeric proteins fail to mediate mitochondrial membrane permeabilization & apoptosis https://t.co/S2LaHd3xD2
cell.com
Shao et al. show that the Shigella effector OspB blocks apoptosis by enzymatically remodeling host BCL-2 proteins through peptide-bond recombination. This reveals a unique pathogen strategy to rewire...
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Cadaverine rewires macrophages: Gut-microbiota-derived cadaverine reprograms macrophage energy metabolism, altering inflammatory immunophenotypes. In IBD, cadaverine is associated w/increased flare risk & regulated by Enterobacteriaceae https://t.co/i6diJexPda
cell.com
de Oliveira Formiga et al. present that gut-microbiota-derived cadaverine reprograms macrophage energy metabolism in a concentration-dependent fashion, promoting either anti- or pro-inflammatory...
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Sarah Leeber (@UAntwerpen) joins @CellSymposia #CSMicrobiome2026 to discuss microbial ecology and host physiology. May 10–12 | Bruges Abstract deadline: Jan 16 https://t.co/q8ujxEDk7u
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A duet of T6SS effectors Preview of new work reporting a BtapC-orchestrated co-secretion mechanism for T6SS effectors BtpeA and BtaeB in gut Bacteroidota, revealing a conserved strategy for interbacterial competition and gut microbiota modulation https://t.co/tLRJ4bT2KF
cell.com
How do gut bacteria outcompete rivals in dense microbial ecosystems? In this issue of Cell Host & Microbe, Li et al. report a BtapC-orchestrated co-secretion mechanism of T6SS effectors BtpeA and...
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Co-secretion of T6SS effectors: Bacteroidota T6SS effectors BtpeA & BtaeB have distinct cell-wall destructive activities yet are co-delivered via coordinated binding to adaptor BtapC. This conserved synergistic system enhances fitness of encoding strains https://t.co/w566OiLi0a
cell.com
Type VI secretion systems (T6SSs) mediate bacterial competition. Li et al. reveal that Bacteroidota T6SS effectors BtpeA and BtaeB induce distinct cell-wall destructive activities yet are co-delive...
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Brain hacks: Engineering a microbial factory for Parkinson’s disease Preview of work that engineers a microbiota-based therapeutic for sustained, non-fluctuating L-DOPA production, demonstrating therapeutic promise for PD via stable dopamine signaling https://t.co/1nM46W3xOV
cell.com
Motor complications in Parkinson’s disease (PD) are exacerbated by the pulsatile delivery of levodopa (L-DOPA). In this issue of Cell Host & Microbe, Padhi et al. engineer a microbiota-based therap...
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