Cell Host & Microbe
@cellhostmicrobe
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The scientific editors of Cell Host & Microbe, a Cell Press journal, bring you the latest information and insights from the forefront of host-microbe research.
Cambridge, MA
Joined November 2014
Our July issue is out today!.Cover art depicts precision antibacterial strategies that allow non-toxigenic V. cholerae to dominate toxigenic rivals.
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We’re honored to welcome Yasmine Belkaid (@BelkaidLab, @institutpasteur) as a keynote at @CellSymposia #CSMicrobiome2026! May 10–12, 2026 | Bruges, Belgium .Abstract deadline: January 16. Join the program.
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Amino acid competition shapes A. baumannii carriage. A. baumannii uses ornithine to compete w/ microbiota & persist in gut. Amino acid supplementation & differences in diet promote A. baumannii gut colonization in mice and humans.@laurenpalmerphd.
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RT @Hatzios_Lab: Congrats to postdoc @ZheZhou_ICA on her paper out today in @cellhostmicrobe showing that gut bacteria cross-feed a common….
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RT @YaleWestCampus: The Stavroula Hatzios lab has revealed how different gut bacteria feed on a dietary antioxidant found in mushrooms – an….
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Diverse antiphage defenses:.Functional metagenomics reveals hundreds of sequences from soil & human microbiomes that block phage--including modification-dependent nucleases, outer membrane proteins that inhibit phage adsorption & genes of unknown function.
cell.com
Rodríguez-Rodríguez et al. use functional metagenomics to identify hundreds of sequences from diverse environmental bacteria that block phage infection when expressed in E. coli. Their discoveries...
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RT @RonceroJoan: Honored to see our work on how embryos defend themselves against bacteria featured in @ScienceMagazine, under the title “G….
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RT @ADiaz_PhD: Congratulations, @luis840alberto and @kvnforsberg, on your recent publication in @cellhostmicrobe. “Metagenomic selections….
cell.com
Rodríguez-Rodríguez et al. use functional metagenomics to identify hundreds of sequences from diverse environmental bacteria that block phage infection when expressed in E. coli. Their discoveries...
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Restoration of skin microbiome post HSCT. Patients w/DOCK8 deficiency have disrupted skin microbial balance, w/eukaryotic viral predominance & bacterial shifts. HSCT restores immunity, reducing pathogenic viruses, clearing HPV & decreasing S. aureus.
cell.com
Che et al. show that immune deficiency in DOCK8 patients disrupts skin microbial balance, driving eukaryotic viral predominance and bacterial shifts. Hematopoietic stem cell transplantation restores...
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The prototypic crAssphage is a linear phage-plasmid:. New work demonstrates that C. communis, a ubiquitous human gut phage that evades conventional plaque-based isolation, predominately replicates as a low-copy linear phage-plasmid w/ broad host range.
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Characterizing phage gene essentiality with PhageMaP:.• High-throughput approach to generate genome-wide loss-of-function phage libraries. • Interrogates gene essentiality w/insights into phage genome organization, host antiviral defense & gene function.
cell.com
Chen et al. report PhageMaP, a high-throughput approach to generate and characterize genome-wide loss-of-function phage libraries. PhageMaP systematically interrogates conditional gene essentiality,...
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Collection: Plants!!!.Browse our collection of recent reviews and articles on how microbes influence plant health, acting positively through beneficial interactions or negatively by causing disease.
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Collection: Bugs as Drugs. Enjoy our collection of recent reviews and articles exploring the impact of microbes on therapeutic efficacy as well as advancing capabilities to utilize microbes as therapeutics or in microbiome modulation.
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Fungal cues, fibrotic consequences:. Highlight of @ImmunityCP work uncovering role for commensal fungi in lung fibrosis, showing that their interaction w/alveolar macrophages triggers profibrotic transcriptional program through Dectin-1-Raf1 signaling axis.
cell.com
In a recent issue of Immunity, Qiu et al. uncover a pivotal role for commensal fungi in promoting lung fibrosis, showing that their interaction with alveolar macrophages triggers a profibrotic...
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How hosts accurately command bacteria for gut health:. Highlight of @Nature work revealing how hosts distinguish & respond to specific symbionts. Host APOL proteins engage Bacteroidales to trigger OMV release, which sustains gut immune homeostasis.
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Phage counter-defense repertoires:.New work IDs broad & specific anti-defense genes in variable regions of Pseudomonas phage genomes. Inhibitors neutralize diverse bacterial immune systems, highlighting how phages evolve broad & specific strategies.
cell.com
Costa, van den Berg, Esser, et al. identify two broad and three specific anti-defense genes by examining variable regions of Pseudomonas phage genomes. These inhibitors neutralize diverse bacterial...
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Waste as an antibacterial weapon:. Elgrail & Glickman highlight work showing methylglyoxal, a metabolic byproduct of glycolysis, is part of macrophage arsenal limiting L. monocytogenes & MTb but is countered by pathogen methylglyoxal detoxification enzymes.
cell.com
Intracellular pathogens neutralize and evade macrophage-intrinsic host defenses. In this issue of Cell Host & Microbe, Anaya-Sanchez et al. show that methylglyoxal, a metabolic byproduct of glycoly...
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Methylglyoxal: antibacterial effector. Methylglyoxal produced by infected macrophages upon transition to aerobic glycolysis acts as an innate immune antimicrobial effector that bacteria must detoxify for virulence and to prevent mutations.
cell.com
Infected macrophages that transition to aerobic glycolysis produce the reactive aldehyde methylglyoxal. In this study, Anaya-Sanchez et al. use both host and bacterial genetics to show that methylg...
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Innate defense at onset of development:.Embryos eliminate bacteria via phagocytosis by epithelial cells. Zebrafish embryos engulf bacteria via zippering protrusions, inducing program crucial for development. Phagocytosis conserved in mouse & human embryos.
cell.com
Roncero-Carol et al. show that early embryos eliminate bacteria via phagocytosis by epithelial cells. Quantitative live imaging across scales in zebrafish embryos reveals an epithelial immune program...
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Staphylococcus promotes metastasis:.· Staphylococcus enriched in metastatic lung tumor lesions.· S. nepalensis & S. capitisl-secreted lactate promotes metastatic potential via MCT1-mediated pseudohypoxia signaling.· MCT1 inhibition abolishes metastasis .
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Upper vs lower airways: Microbes shape the local milieu.Highlight of work on microbiome contribution to metabolism in upper vs lower airways. Oral commensals contribute to metabolic milieu w/P. melaninogenica synthesizing inosine&glutamate in lower airways.
cell.com
In this issue of Cell Host & Microbe, Wong et al. investigate the contribution of the microbiome to airway metabolism, revealing differential microbial pathways and metabolites between the upper and...
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