Prof. Shane Crotty
@profshanecrotty
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Vaccines and immune system scientist. Professor, La Jolla Institute for Immunology (LJI), a non-profit research institute @ljiresearch. PhD not MD.
La Jolla, San Diego
Joined March 2016
Our new pre-print posted. We compare immune memory to Moderna, Pfizer, J&J, and Novavax COVID-19 vaccines head-to-head. T cells, B cells, and antibody. We think this is the most comprehensive immunological evaluation of these four different vaccines. 1/17 https://t.co/jHeQk41jHX
biorxiv.org
Multiple COVID-19 vaccines, representing diverse vaccine platforms, successfully protect against symptomatic COVID-19 cases and deaths. Head-to-head comparisons of T cell, B cell, and antibody...
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Victor is a great follow
@UCSanDiego @UCSDMedSchool I’m on twitter @victornizet if you like tweets and memes on the science of host-pathogen interactions, innate immunity, and antibiotic resistance—or the foibles of academic life
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This study on response to Omicron after #SARSCoV2 vaccination provides some optimism re “original antigenic sin” https://t.co/WJZ4debdUj TLDR: although response to Omicron dominated by preexisting B-cells, antibodies from these cells better at 6 months than 1 month. 🧵 below.
biorxiv.org
Understanding the evolution of antibody immunity following heterologous SAR-CoV-2 breakthrough infection will inform the development of next-generation vaccines. Here, we tracked SARS-CoV-2 receptor...
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All thanks to @UCSanDiego @UCSDHealth— where you are lifted by a unmatched tradition of interdisciplinary research, great patient care programs, dynamic surrounding research institutes, beaches, palm trees 🌴, fish tacos 🐟 🌮 and above all, the most amazing students and trainees
UC San Diego Distinguished Professor of Pediatrics and Pharmacy @UCSDMedSchool Dr. Victor Nizet has been elected to the National Academy of Medicine, considered among the highest honors in the fields of health and medicine.
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Seeing some discussion about this publication with a pretty catastrophic failure to understand/communicate the limitations of the work, so here's my best attempt at clarifying it 🧵 https://t.co/EdYY7dQgof
cdc.gov
This report describes three-dose monovalent COVID-19 vaccine effectiveness against COVID-19 hospitalization during Omicron predominance.
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Nice work @isaak_quast ! That’s a great graphic about the memory B cell re-recruitment 🙏🏼 @harrysutton93
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“Hopefully we shouldn’t have to keep doing boosters for very long,” Crotty says. “But the virus is in the driver’s seat.”
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On Omicron boosters and the immune system attempting to peer into the future: “All of that is really showing the brilliance of the immune system of making guesses about what variants are going to look like,” Nevertheless… https://t.co/j3dJh3Hl6y
nature.com
Nature - Worries that the immune system would get ‘stuck’ on the original SARS-CoV-2 strain are dispelled by laboratory experiments.
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Tweetorial on a very interesting paper. Crotty Lab journal club by @P1RAD
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Everybody keeps talking about antibody-escaping variants… Nice work from Andrew Godking is showing how magnitude of T cell response against SARS-CoV2 structural proteins (M,NP and Spike) correlates with protection against COVID-19 more than Ab. Go T cells
nature.com
Nature Communications - The presence of SARS-CoV-2-specific antibodies alone is not an accurate determinant of immunity. In this work, the authors investigate if whole-blood based measurement of...
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Carolyn Bertozzi – awarded the 2022 #NobelPrize in Chemistry – has taken click chemistry to a new dimension and started utilising it in living organisms. Her bioorthogonal reactions take place without disrupting the normal chemistry of the cell.
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Two Nobel prizes for Barry Sharpless! Extraordinary! And well deserved. Congrats to our neighbors down the street @scrippsresearch !
BREAKING NEWS: The Royal Swedish Academy of Sciences has decided to award the 2022 #NobelPrize in Chemistry to Carolyn R. Bertozzi, Morten Meldal and K. Barry Sharpless “for the development of click chemistry and bioorthogonal chemistry.”
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These data provide additional support that Novavax vaccine as a booster is likely to be a reasonable option. But independent clinical trials have yet to show any clear cut advantage to a protein booster compared to other boosters (e.g., Table 5 in https://t.co/5QCml4dimz
pmc.ncbi.nlm.nih.gov
Few data exist on the comparative safety and immunogenicity of different COVID-19 vaccines given as a third (booster) dose. To generate data to optimise selection of booster vaccines, we investigated...
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This complements our immune memory study comparing 4 COVID vaccines, including Novavax.
Head-to-head comparison of immune response, both antibody and cellular, for 4 vaccines: Moderna, Pfizer, Novavax and J&J https://t.co/Z0IWA9xfa7
@CellCellPress @profshanecrotty @ljiresearch @zhang_zeli @jmateust @camilahcoelho @SetteLab
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Our new paper is out showing T cell responses to the Novavax vaccine, studying Novavax vaccine clinical trial participants, led by the outstanding Dr. @CModerbacher! With a nice commentary article by @PC_immuno . 🧵 https://t.co/3OCJ9Ix5GB
https://t.co/F50tw6a1kZ
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As usual, @EricTopol beat us to tweeting about our paper. 😂
The @Novavax vaccine induces robust T-cell immunity Commentary https://t.co/QsvLraIIuN
@jclinicalinvest by @PC_immuno @RockefellerUniv Original research by @ljiresearch
https://t.co/izdImxBi6G
@profshanecrotty and colleagues
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Thanks @PC_immuno !
Thanks @jclinicalinvest for the invitation to contribute a commentary article on the T cell immune response elicited by @Novavax vaccine. Excellent work done by @profshanecrotty and team @ljiresearch . Thank you for sharing the work @EricTopol ! @RockefellerUniv
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(3) And the Discussion now spells out thoughts on clonal migration and memory B cells.
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(2) Clonal migration between LNs was visualized for several more lineages. We initially used very stringent criteria. We went back and used a reasonable less restrictive criteria. Then we found evidence that 54 out of 889 clonal lineages could be found in bilateral LNs.
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