PHASE III ALINA Trial data was just published in
@NEJM
. Follow the NSCLC Key Opinion Leader Discussion of the publication, editorial by
@APassaroMD
and
@peters_solange
, as well as the KOL discussion from ALINA data presented at
#ESMO23
by
@bensolomon1
and the discussant
(1/7)KOL Pulse Thread👉 📢
#ASH23
Early Buzz: Global KOL discussions on highly anticipated SYMPATICO trial in mantle cell lymphoma! 🩸 The Phase 3 Trial will be presented by Professor
@michaelwangmd
of the department of Lymphoma & Myeloma
@MDAndersonnews
Thread(1/6) Contrasting KOL Views of
#ASH23
Phase 3 PERSEUS trial, comparing Dara-VRd to VRd alone in ASCT-eligible newly-diagnosed multiple myeloma patients. 👉
@Mohty_EBMT
of
@Sorbonne_Univ_
"The findings further support the use of this regimen".
Summary of the PERSEUS trial to be presented at
#ASH23
These results further support the use of this regimen.
(LBA-1 Phase 3 Randomized Study of DARA+VRd Vs Vrd Alone in Pts with NDMM Who Are Eligible for ASCT)
@COMyCongress
@TheIACH
@Mohty_EBMT
@jryckman3
@SuyogCancer
@ASCO
Associated Research is an often overlooked data point in the OpenPayments profile. Perhaps
@ASCO
speakers should share these data as part of their COI discussions
(9/11)
@VPrasadMDMPH
claimed "No American will ever take gene therapy to lower LDL when you have drugs that do the same. This is such a fucking stupid company and everyone praising it is an idiot" ().
I am so sick of hearing about Verve. No American will ever take gene therapy to lower LDL when you have drugs that do the same. This is such a fucking stupid company and everyone praising it is an idiot.
That is all
@venkmurthy
in contrast is spot on
🧵(1/13)Did any
@fda
ODAC panel members on the recent vote re:"Minimal Residual Disease (MRD)" have potential Financial Conflicts of Interest
#COI
with Pharma and/or Biotech companies?
Let's Check OpenPayments (in order of the Vote Tally below)
FDA ODAC
ODAC approves MRD as surrogate end point for myeloma trials .
12 vs zero . Not a single vote against it . Is the corelation between MRD and OS good enough at trial level to get accelerated approvals ? Will this open gateway for MRD as end point for solid tumors? I hope not.
(8/11) However,
@venkmurthy
tweeted "Results of the heart-1 study of VERVE-101 by $VERV had serious concerning cardiac complications." "May be time to stop trials on this agent for now." He shared his thoughts in a substack post.()
Results of the heart-1 study of VERVE-101 by $VERV had serious concerning cardiac complications.
May be time to stop trials on this agent for now. Here is my thinking:
Follow the Sentiment of Top Physician Key Opinion Leaders in Myeloma regarding the FDA ODAC Vote for MRD as an endpoint for accelerated FDA Approval of Myeloma Therapies.
👉
Interesting Discussions by
@bdermanmd
@VPrasadMDMPH
@oncology_bg
@VincentRK
The FDA Grants Approval to
@ImmunityBio
drug Anktiva based on QUILT-3.032 Clinical Trial.
Follow KOL Sentiments here:
👉
The FDA approved Anktiva (nogapendekin alfa inbakicept-pmln) with (BCG) for BCG-unresponsive non-muscle invasive bladder cancer with
(7/7) Medical journalist Matthew Herper (
@matthewherper
) distilled a simple headline for STAT News "Weight loss drug Wegovy cuts risk of heart attacks in milestone trial,
@elaineywchen
reports. "().
How much did Pharma influence the recent FDA ODAC vote on MRD as an endpoint for accelerated approval for Myeloma Therapies?
#mmsm
#MedTwitter
#ASCO24
Follow the Key Opinion Leader discussion here
👉
List of top 10 plasma cell dyscrasia
#ASH23
abstracts.
List may reflect positive/negative studies, but all have influenced thinking.
I will summarize each study with teaching point.
If you are wondering if there are any practice changing myeloma studies- IMO answer is NO.
🧵
(1/12) KOL Pulse Thread 👉Follow the
@VerveTx
Drama as Biotech Reporter
@adamfeuerstein
targets Nuclear Cardiology Professor and KOL
@venkmurthy
#aha23
. This public argument is against the backdrop of $VERV drastic stock movements in November
#MedTwitter
The
@AstraZenecaUS
LAURA trial will be a plenary at
#ASCO24
. KOLs have already been discussing this trial, and some are very interested in the post-progression care of the control arm.
#lcsm
👉
#RSNA23
means meeting friends old and new!
Congratulations to the latest
@thecortexclub
members
@NeuroradLal
@sachingujarMD
and Michelle Miller-Thomas!! Welcome to the club and thank you for all your contributions to Neuroradiology education!
Physician Opinion Leaders Accuse American Board of Internal Medicine (ABIM) of Extortion, Propaganda, & Conflict of Interest in Maintaining of Certification Process (MOC). Top Influencers include:
@VincentRK
@AaronGoodman33
@doctorwes
@Dr_AmerZeidan
👇
(2/7) The results made a significant splash. As cardiologist (
@ErinMichos
) put it in a tweet that garnered over 19,000 views, the drug provided a "game changer" benefit.()
Huge news! The
#SELECT
trial presented at
#AHA23
is a game changer. Among adults with CVD and overweight/
#obesity
but without diabetes,
#semaglutide
2.4mg/wk reduced MACE by 20%, HF by 18%, and all-cause mortality by 19%! 👏👏👏
Updated Data on CHECKMATE 9ER!!! - EXTENDED FOLLOW UP... Oncology KOLs continue to address the Favourable Risk category data set.
@myESMO
#GU24
#ASCO
👉
(3/7) Heme/Onc
@jeff_sharman
Director of Research
@TheUSONetwork
generated KOL discussion about Sympatico with his commentary👉 "A lot of implications from this MCL late breaking abstract!" 👉"New SOC in eligible patients?"
A lot of implications from this MCL late breaking abstract!
1) Ibrutinib approval previously withdrawn in MCL? Time to revisit?
2) Does this combo data impact choice of BTK in r/r MCL?
3) New SOC in eligible patients?
4) Are age related toxicities the same in CLL/MCL?
(7/9) Hematopathologist/Molecular Pathologist
@sanamloghavi
, Director of ECOG-ACRIN Leukemia Bank from
@mdandersonnews
highlights her list of abstracts 👉
#ASH23
abstracts R out
I wanted to highlight a few of ours/our collaborators’, in case U’re spending 2day
#ASHing
with Ur Sunday AM ☕️ 🧵
1. WT1 mut AML
Oral, AML 613
Lead by
@HimaglobinA
J. DiGennaro, in collaboration w/
@Ramikomrokji
C. DiNardo et al
Great talk (as always) by Dr Carl Gay
@MDAndersonNews
@IASLC
#TTLC24
on Bispecifics, Trispecifics, and CARTs. These surface targeting approaches are potential game-changers in
#SCLC
(1/5)
#GU24
Real Talk from KOLs 🧵
RE: AMBASSADOR :"..Without OS we’re over treating. Adjuvant IO in all comers is on shaky ground without more data IMO" 👉
@TomPowles
Adjuvant pembro ⬆️ DFS (0.69) but ❌ OS (0.98) in UC, ~10% tox ++. Atezo also had ❌ OS. Nivo had 0.7 DFS but no OS data after ++ years-assuming it’s +ve seems unwise. Without OS we’re over treating. Adjuvant IO in all comers is on shaky ground without more data IMO
#GU24
1/ So much to see at
#ASH23
about myeloma, including a plenary!
My research focuses on ⬇️ toxicity and ⬆️ improving pt experience in
#MMsm
, and I'm excited to see so many oral presentations in this area!
As inspired by
@mtmdphd
, here are my top 10 (NDMM, then RRMM, then MGUS):
(1/14)KOL Pulse
Verve-101 AI Powered Sentiment Analysis. Top Tweets by Influencers and Academics. Which KOLs have Positive Sentiment 😀
and Which KOLs have Negative 😠
or Skeptical🫤
sentiment toward Verve-101? $verv
#aha2023
#Aha23
(2/9) From
@Yale
,
@Dr_AmerZeidan
, Associate Prof, Director
#Leukemia
Prog; A/Director Heme CTO & early therapy research, shares his top abstracts to prep you for
#ASH23
👉
🔬 Stay up to date with the latest discussions and insights from key opinion leaders in the field of Oncology & Hematology! 🌟
Don't miss out on valuable information and updates from the most recent clinical trial discussions .
#ASCO24
#LCSM
#MMSM
#BCSM
(5/6) However, Dr Vinay Prasad
@VPrasadMDMPH
, professor
@ucsf
, raises an important point: "More active drugs will always improve PFS. Whether you can get the same OS and better QoL from sequencing is forever unknown."
More active drugs will always improve PFS. Whether you can get the same OS and better QoL from sequencing is forever unknown. Myeloma has failed as a field to answer the question. Discussed here
(12/14) Negative😠:Dr. Venk Murthy,
@venkmurthy
, Cardiologist, Nuclear Cardiology Specialist, Professor
@UMich
,👉
"Results of the heart-1 study of VERVE-101 by $VERV had serious concerning cardiac complications."
Results of the heart-1 study of VERVE-101 by $VERV had serious concerning cardiac complications.
May be time to stop trials on this agent for now. Here is my thinking:
The FDA just granted an additional approval to Alecensa (Alectinib) from
@Roche
based on the ALINA clinical trial. Amid the excitement of this new treatment option, some KOLs have shared their reservations.
#lcsm
#alk
View the powerful discussion here:
@JayDShahMD
We learned that PCI can relieve symptoms in appropriately selected patient and ORBITA-2 is really the best “proof” we have to date- I’m not sure it informs practice significantly because we should still use anti-anginal medicines and practice shared decision making with patient.
What Do Key Opinion Leaders in Lung Cancer Think of the Latest Clinical Trial Data?
#lcsm
Data from
#ASCO23
#ELCC24
and
@IASLC
Meetings
👉Organized KOL Sentiment Analyses on Top Trials in Lung Cancer
ADAURA:
APPLE:
CHECKMATE 816:
6/Cardiologist and Professor
@umichmedicine
,
@venkmurthy
, reminded his colleagues to exercise caution with gene editing therapies as well, "The same sentiment should apply for gene editing in vivo for targets like PCSK9!"
The same sentiment should apply for gene editing in vivo for targets like PCSK9!
Let's see how editing performs for conditions which are more severe than HeFH and where there are fewer alternative treatments
Prepare for
#ASCO24
! Review Key Opinion Leader SoMe comments and sentiment of Top Clinical Trials of 2023-2024. Follow what the leaders in oncology have been sharing!
👉
One more note on this - some have pointed out that ORBITA2 is interesting mechanistically even if not directly clinically relevant. But was there much doubt that epicardial artery narrowing was one mechanism for chest pain?
Key Opinion Leaders react to FDA Approval of
@DayOneBio
OJEMDA (tovorafenib) for relapsed or refractory pediatric low-grade glioma with BRAF fusion,rearrangement, BRAF V600 mutation (Based on FIREFLY-1 clinical trial)
👉
#ASCO24
#MEDTwitter
(7/8)Cyrus A. Raji, MD, PhD (
@cyrus_raji
) shares a CNN summary of his team's work,
@MIRimaging
, linking belly fat to brain inflammation and dementia. He highlighted the PR collaboration with
@RSNA
and the accomplishments of lead author
@MahsaDolatshah1
.
(11/14) Negative:😠 Vinay Prasad MD MPH,
@VPrasadMDMPH
,Digital KOL and professor
@ucsf
, 👉"I am so sick of hearing about Verve. No American will ever take gene therapy to lower LDL when you have drugs that do the same."
I am so sick of hearing about Verve. No American will ever take gene therapy to lower LDL when you have drugs that do the same. This is such a fucking stupid company and everyone praising it is an idiot.
That is all
@venkmurthy
in contrast is spot on
Great post from
@OncBrothers
heading into SABCS! Was fortunate to meet up prior to the conference to discuss an exciting week ahead :) Thank you to
@OncLive
for setting this up.
(6/8)Grace G. Zhu, MD (
@totallyskates
) reflects on the importance of mentorship and explores
@SusannaLeeRad
's insights on the subject, reminiscing about the key mentors in her life.
Checking out what
@SusannaLeeRad
has to say about mentorship, an incredibly important relationship. Reflecting on the key mentors in my life…🥰
#RSNA2023