Paradox of high TPS PD-L1 in oncogene-related NSCLC yet insensitive to IO: One explanation relates to historically only scoring TC & not IC in NSCLC, in contrast to CPS in other cancers. In EGFR mutated, TC may be 90% but IC often 0%. Few CD8+ TILs to do the work. Plus low TMB

On this last day of #LCAM, may we recommit ourselves to a world where no one dies of #lungcancer, through earlier detection, accelerated innovation, reduced stigma, equitable access and improved outcomes. #LCSM

In 48 hours we’ve raised over $100k to feed those in need through #HCWvsHunger, an annual competition to raise money for the food banks YOU CHOOSE. Donate today and log your donation for your favorite team at https://t.co/OHoD0whC0U And if you can’t donate, please repost!

Yes, #MedTwitter! Together we’ve raised almost $77K in the first 24 hrs of #HCWvsHunger 2025. I love our community of #generosity. Best week of the year every year on Twitter. 🥹 Donate to any foodbank/hunger org & log it on https://t.co/X2LGOTu2Vq for your fave team.

Why guess when you can know?

From EGFR to Global Impact: Nathan Pennell on Scaling Care, Keeping Patients First @n8pennell @Dr_Harutyunyan @bmsnews @ClevelandClinic https://t.co/B01igwi8Ox #OncoDaily #Oncology #Cancer #Health #Medicine #MedTwitter #MedEd #MedOnc #MedNews #EGFR #LungCancer

Don’t forget to take advantage of matching to make your #HCWvsHunger dollars go further. 5x match @unicefusa.org 5x match @careorg.bsky.social 3x match @nokidhungry.org And then log your donation under your favorite team at

My next #HCWvsHunger donation is to @familyreach. They support families facing cancer who have young children in the home. With assistance to meet basic needs, they can focus on what REALLY matters: cancer treatment & recovery. Team #DiagnoseAndTreats fights cancer AND hunger 🍎

Donated to @CleFoodBank for #HCWvsHunger for team #DiagnoseAndTreats, and don’t forget to check if your company matches donations!

I’m glad to see JAMA is giving light to data and editorials that highlight how UNACCEPTABLE the rates of screening continues to be, while mountains of dead people keep piling up as intellectuals keep debating the “barriers” of lung screening. Please stand up and DO SOMETHING

Um, people have seen Snowpiercer, right? The Strange and Totally Real Plan to Blot Out the Sun and Reverse Global Warming - POLITICO

Let’s Talk About Lung Cancer Differently - @tania_small @n8pennell https://t.co/ikY5W2PJid #Cancer #Medicine #Health #Oncology #OncoDaily #LungCancer #LCSM #MedX #MedNews #MedEd

❗️ Median OS was 1.7 months ❗️24% of patients died in a later hospitalization for a non-hospice related admission ❗️27% of patients died in a nursing facility 😱 33% of post-SNF therapy was given in the last 30 days of life

Of the 131 who received further treatment 🤔39% died/enrolled in hospice before further disease assessment 🤔36% had stable disease or a PR to further tx (11% of the total cohort)

In 427 hospitalized patients (40% tx naive) with mNSCLC discharged to SNF based on functional status 🎯54% returned for an outpatient oncology appointment 🎯30% received further systemic therapy, ranging from 74% in those planned for TKI down to 20% in those planned for chemo

🗣️See you in clinic after you get stronger at rehab, to restart chemo 🤔How often does this actually happen? 🚨 My fellowship passion project was just published in @JCOOP_ASCO looking at this question Tl;dr it depends. A 🧵

@n8pennell @JCOOP_ASCO Of patients who did restart treatment, 39% died or transitioned to hospice before next scan. More from the publication here: https://t.co/97J3EzYedM

When patients with metastatic cancer are admitted to the hospital, many people optimistically say "you'll go to rehab and get stronger and we'll see you back!" IMO this data suggests we need 1) better care coord with SNF & 2) more honest discussion of what outcomes may be after.

Wow. Data from @n8pennell & team @JCOOP_ASCO confirming the care fragmentation many of us see in real life. Patients with metastatic NSCLC whose docs felt it was reasonable for them to restart treatment after rehabbing at a SNF: - Only 54% saw outpt onc again - 31% restarted tx

For #LCAM let’s move beyond awareness and take action to reduce deaths from lung cancer! #LCSM with @tania_small @bmsnews #OneBMS

Meta-analysis of surrogate endpoints in #SCLC @ESMO_Open. In first-line, PFS correlates with OS but RR does not. In later lines, neither PFS nor RR correlated with OS. Exercise caution when using RR for go / no-go decisions in early phase SCLC studies! https://t.co/ZxSj5SiuLu