Dipesh Uprety MD FACP
@DipeshUpretyMD
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Associate Prof | Thoracic Oncology 🫁 & Phase-I @karmanoscancer | EIC @BTFCancerNews |Previously @MayoCancerCare @gundersenhealth @JeffHealthAb | Tweets my own
Detroit, MI
Joined June 2018
Pleased to share our study -"Trends in Incidence & Survival Outcomes in Small Cell Lung Cancer Patients" ➡️SCLC cases have gradually declined, now comprising 11.2% of all lung cancers @OncoAlert #LCSM @BTFCancerNews @aniroulaMD
@kaushalpar @thadid1
https://t.co/rC5Vy1A578
onlinelibrary.wiley.com
Background There has been a lack of updated epidemiological data on the incidence and survival outcomes for patients with small cell lung cancer (SCLC) in the United States over the last two decade...
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Trainees & junior faculty: the #TexasLung26 Poster Competition is open - winners will receive registration, travel, and accommodation to the 2026 Texas Lung Cancer Conference at Austin City Limits, April 9-11, 2026. Submit today! Details at https://t.co/23wG464LxK
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Hey ID Fellows, what are your favorite ID consults? Asked that question during a recent visit to the ID division at Johns Hopkins, and here's what their fellows said.
blogs.jwatch.org
Just back from a visit to the Infectious Diseases Division at Johns Hopkins, thanks to the kind invitation of current ID chief Dr. Amita Gupta and her predecessor, Dr. David Thomas. On a personal...
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🔥🚨#November is 🫁 #LungCancerAwareness Month. Lung Cancer Awareness #SavesLives. Together, WITH #Patients, we keep the #Fight against #LungCancer. We have made a great #Progress but still have a long way to go. #LCAM25 👇🏼Sharing, like every year, my #AWARENESS #Mnemonic
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🔥🚨@OncoAlert Hot Off The Press. Just published @NEJM in conjunction with presentation @myESMO #ESMO25 Results of: 🎯#OptiTROP-Lung04 phase 3 trial of: ⭐️#Sacituzumab tirumotecan (#TROP2 #ADC) VS #Chemotherapy in advanced #EGFR mutant non-small cell #LungCancer after
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🔥🚨@OncoAlert Hot Off The Press. Just published @TheLancet in conjunction with presentation @myESMO #ESMO25 Results of: 🎯#HARMONi-6 phase 3 trial of: ⭐️#Ivonescimab + #Chemotherapy VS #Tislelizumab + #Chemotherapy as 1st line Tx for advanced #Squamous non-small-cell
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Dr. Pedro Simoes da Rocha at #ESMO25 presents intracranial efficacy of ifinatamab deruxtecan (I-DXd, B7-H3 ADC) in #SCLC. Intracranial RR 46.2% (among pts with no prior radiation, icRR 57.7% and in pts with no brain mets, only 12.5% had CNS progression. #ESMOAmbassadors
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🆙#ESMO25🇩🇪 🔥#LCSM Mini Oral, non-mets, SCLC ☑️DeLLphi-304: Safety analysis of phase III study to evaluate tarlatamab versus chemotherapy for previously treated SCLC ☑️All G AEs: Anemia 19.8%, Neutropenia 7.5% 🎙️ Dr. Martin H. Schuler @OncoAlert @myESMO @Larvol
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Dr. @NReguart discusses tarlatamab in #SCLC at #ESMO25. Outlines rationale and very reassuring to see consistency from other efforts. Will use of T Cell engagers be the future for all eligible patients with SCLC? #ESMOAmbassadors
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🔥 #ESMO25 🇩🇪 🔥 #LCSM Proffered paper, mets ☑️SOHO-01: Sevabertinib (BAY 2927088) in advanced HER2-mutant non-small cell lung cancer ☑️mPFS (PreTx w/o HER2, Pre HER2-ADC, Tx-naive): 8.3m, 5.5m, and not reached 🎙️ @LeXiuning
@OncoAlert @myESMO @Larvol
🆙#ESMO25 PREVIEW🇩🇪 🔥#LCSM Proffered paper, mets ✅SOHO-01: Sevabertinib (BAY 2927088) 🎙️ @LeXiuning
@OncoAlert @myESMO @Larvol
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BEAMION-Lung01; 1st line dataset from cohort 2; zongo 120mg od; stable and or asymptomatic bm; n=74; 66% YVMA; ORR 77%; DCR 96%; responses early; no new toxicity signals; 3% ILD (mild) #ESMO25
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🔥 #ESMO25 🇩🇪 🔥 #LCSM Proffered paper, mets ☑️Beamion LUNG 1: Zongertinib as first-line treatment in patients with advanced HER2-mutant NSCLC ☑️ORR 77%, 6m DoR 80%, 6m PFS 79% 🎙️ @DrSanjayPopat
@OncoAlert @myESMO @Larvol
🆙#ESMO25 PREVIEW🇩🇪 🔥#LCSM Proffered paper, mets ✅Beamion LUNG 1: Zongertinib 🎙️ @DrSanjayPopat
@OncoAlert @myESMO @Larvol
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ALEX trial 1st L alectinib (vs crizo) not ⬆️OS but trial not powered for OS. The best drug first? living w/o disease PD and good control of risk of brain PD count most!!Today lorlatinib is one SoC, futute SoC in 1st line Neladalkib (NVL655), ALKZAR trial vs alectinib?. #ESMO25
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PACIFIC-2 @JCO_ASCO ➡️Pts with unresectable stage III NSCLC randomized (2:1) to durvalumab or placebo from the start of concurrent chemo-RT ➡️No difference in PFS and OS #LCSM @OncoAlert @BTFCancerNews
https://t.co/7PzFLbgGBp
ascopubs.org
PURPOSEImmunotherapy targeting PD-L1 improves outcomes in patients with unresectable stage III non–small cell lung cancer (NSCLC) and no progression after definitive, concurrent chemoradiotherapy...
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HER2 TKI for HER2m NSCLC are real again Zongeritinib (the 2nd xombie 🧟♂️) outstanding activity in 1st Line (n=74, 30% Brain mets) with most G1-2 AEs (better safety than sebavertinib) Ready to replace 1st line CTIO? Awaiting for the ph3 trial BeamionLung02 zonge vs SoC #ESMO25
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FLAURA-2 @NEJM ➡️Pts w/ advanced NSCLC randomized to osimertinib versus chemo plus Osi ➡️↑ OS with chemo plus osi (Md OS: 47.5 mo vs. 37.6 mo; HR: 0.77) @OncoAlert @BTFCancerNews #LCSM
https://t.co/IDiTEh1aBL
nejm.org
The primary analysis of this trial showed that first-line treatment with osimertinib plus chemotherapy with a platinum-based agent and pemetrexed led to significantly longer progression-free surviv...
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Sevabertinib in Advanced HER2-Mutant Non–Small-Cell Lung Cancer @NEJM ➡️ORR 38%-71% Md DoR 8.3-11 mo #LCSM @OncoAlert @BTFCancerNews
https://t.co/yGP54wRC6K
nejm.org
HER2 gene mutations occur in 2 to 4% of patients with non–small-cell lung cancer (NSCLC). Sevabertinib is an oral, reversible tyrosine kinase inhibitor that has shown anti-HER2 activity in preclini...
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🚨🔥@OncoAlert Hot Off The Press Just published @NEJM
#OverallSurvival data from: ⭐️#FLAURA2 trial of #Osimertinib + #Chemotherapy vs #Osimertinib in 1st line Tx for patients with #EGFR+ advanced #LungCancer (#NSCLC). ✅Impressive Statistically Significant & Clinically
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