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Tom Powles Profile
Tom Powles

@tompowles1

Followers
13K
Following
359
Media
639
Statuses
2K

Interested in Urology Cancers, biomarkers and drug development.

Joined December 2019
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@Kenrickng1
Kenrick Ng
16 hours
One of the best overviews of emerging mCRPC treatments to date by @PBarataMD . Bispecifics and ADCs are the future, alongside advances in radioligands. Despite all we have achieved in past 10 years, still a clear unmet need for mCRPC post docetaxel and ARPI, where rwOS ~12 mths
@Uromigos
Uromigos
2 days
ADC & cellular therapies may transform prostate cancer. Phase 2s exist but there are 3 RIII trials as @PBarataMD states in this video. I-DXD vs docetaxel is the ADC R3. While 2 bispecifics RII (pasritamig targeting KLK-2 & Xaluritamig targeting STEAP-1) are ongoing @OncoAlert
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@PGrivasMDPhD
Petros Grivas
1 day
@tompowles1
Tom Powles
1 day
Randomized trials testing ctDNA and HER-2 biomarkers in bladder cancer both delivered positive results with OS #ESMO25 . Here @scocmem described how these and other biomarkers are changing bladder cancer. @PGrivasMDPhD @OncoAlert #uromigosLive
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@tompowles1
Tom Powles
1 day
Randomized trials testing ctDNA and HER-2 biomarkers in bladder cancer both delivered positive results with OS #ESMO25 . Here @scocmem described how these and other biomarkers are changing bladder cancer. @PGrivasMDPhD @OncoAlert #uromigosLive
@Uromigos
Uromigos
1 day
How useful are the 4 utilised biomarkers in urothelial ca (FGFR3, ctDNA, PD-L1, HER-2). Here @scocmem addresses these issues & discussed key informing trials (IM011, DV/Toripalimab, THOR, NORSE). Will PD-L1 remain ultilzed, is HER2 IHC sufficient, is ctDNA predictive? @OncoAlert
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@uromigosjapan
ウロミーゴズ
1 day
#UromigosLive 2025がいよいよ11月7日、8日で開催されます。今年も #UromigosCup 参加に向けてΤシャツを作りました🤭 3人で頑張ってきます‼️ @YujiMiura5 @hiroshi_dko @Uromigos
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@tompowles1
Tom Powles
1 day
I suspect an ADC, alone or in combination with a T cell engager, will beat docetaxel chemo in prostate cancer in thr not too distant future #uromigosLive . Here @PBarataMD tells us how and when that might happen. @Silke_Gillessen @OncoAlert @Annals_Oncology @APCCC_Lugano
@Uromigos
Uromigos
2 days
ADC & cellular therapies may transform prostate cancer. Phase 2s exist but there are 3 RIII trials as @PBarataMD states in this video. I-DXD vs docetaxel is the ADC R3. While 2 bispecifics RII (pasritamig targeting KLK-2 & Xaluritamig targeting STEAP-1) are ongoing @OncoAlert
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@DochasForever
Robert Kilfane
2 years
Some things just work, even if you feel as though they should not.
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@BethN01
Beth Nally
2 days
First ph3 RCT showing PFS benefit with adjuvant combination therapy in RCC! Growing evidence to support periop therapy following host of negative studies. Work to be done in identifying those most likely to benefit from therapy
@OncoAlert
OncoAlert
2 days
LITESPARK-022 Update NEWS FROM INDUSTRY Source: MERCK Merck announced positive topline results from the Phase 3 LITESPARK-022 trial, showing that pembrolizumab combined with belzutifan significantly improved disease-free survival 📈 compared with pembrolizumab alone in patients
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@tompowles1
Tom Powles
3 days
Treatment after EVP in bladder cancer is undefined. Izalontamab brenitecan (HER2/3 TROP2 ADC) has good activity in bladder+lung cancer. A global randomised phase III has started enrolment 👉 Iza Bren alone vs platinum chemo in previously treated pts (including EVP). @OncoAlert
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@AmandaNizamMD
Amanda Nizam, MD
3 days
We are excited to open this much needed trial with a dual-targeted ADC led by @shilpaonc at @ClevelandClinic soon! @ChrisWeeMD @MosheOrnsteinMD @DemitriDedousis @LauraBukavinaMD @BladderCancerUS
@tompowles1
Tom Powles
3 days
Treatment after EVP in bladder cancer is undefined. Izalontamab brenitecan (HER2/3 TROP2 ADC) has good activity in bladder+lung cancer. A global randomised phase III has started enrolment 👉 Iza Bren alone vs platinum chemo in previously treated pts (including EVP). @OncoAlert
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@Uromigos
Uromigos
2 days
The Eurasia team 🇯🇵 🇨🇳 🇦🇺 🇳🇱 🇪🇸 🇮🇳 are now 7-0 ahead for the Uromigos cup 🏆 @MichvdHeijden getting a record 98 ♥️. The final round for Eurasia is @crisuarez08 🇪🇸 🇪🇸 🇪🇸 🇪🇸 with a little help from Gaudi. It feels hard to beat. The #UromigosLive!meeting is next week @OncoAlert
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@eidon_ai
EIDON AI
5 months
Full arm + hand tracking in Eidon SYM, our full stack robotics system. We are building a complete stack connecting the triangle of our - cost effective + accurate robotics data collection hardwares - simulation environment - robot hardware. The flow must be completed.
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@Uromigos
Uromigos
2 days
Team America 🇺🇸 🇨🇦 have their final entry for Uromigos cup 🏆. Eurasia is winning. Here @TDorffOnc goes for a 🇺🇸 🇦🇺 fusion photo with kangaroos. ♥️ =points. Surely it’s time for a win for the Americas. #UromigosLive meeting is next week btw 7th/8th @OncoAlert @montypal
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@scocmem
Sara Coca Membribes
2 days
🚨Big day for RCC: 2 positive belzutifan combo studies‼️ - Belzutifan + pembro (adjuvant): DFS ✅ - Belzutifan + lenvatinib (pretreated mx): PFS ✅ Well tolerated & promising partner but is combining better than sequencing? Will EMA need OS? @OncoAlert @OncoReporte @DrChoueiri
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@MichvdHeijden
Michiel van der Heijden
2 days
@Uromigos @crisuarez08 @OncoAlert Wow, this is for sure the best picture in the series! Captain @crisuarez08 saved the best for last!! Vote ❤️for team Eurasia uromigos 🏆 @LAUrology_NL @KoenvdMijn @Brouwer_MD_PhD @MyriamChalabi @y_loriot @AlbigesL So looking fwd to #UromigosLive! meeting
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@tompowles1
Tom Powles
2 days
2️⃣ positive trials for belzutifan on the same day! LITESPARK-022 tests adjuvant belzutifan+pembro vs pembro alone post surgery in ccRCC. It is +ve for DFS. It’s the 1st +ve combination trial in adjuvant RCC & moves pateint care forward.@DrChoueiri https://t.co/8s5MvBU2NQ
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@scottdclary
Scott D. Clary
56 minutes
The hardest part about getting in shape: It's not the workout. It's the 23 hours when you're not working out. The decisions at restaurants. The snacks at midnight. The excuses at 5am. The gym is easy. Life is hard. Fitness isn't about what you do for an hour. It's about what you
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@tompowles1
Tom Powles
2 days
LITESPARK-011 (lenvatinib + belzutifan vs cabozantinib in pretreated clear cell RCC) is positive for PFS. Belzutifan is well tolerated making it a good partner. It’s the 1st positive targeted therapy combo RIII trial in RCC @OncoAlert #UromigosLive https://t.co/E3i1VH6hvy
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@TresUramigas
Tres Uramigas
2 days
🎥 #UromigosShorts vídeos sobre distintos temas de Oncología GU. Los vídeos con ➕visualizaciones recibirán un premio durante #UromigosLive 👇🏼En este vídeo, la Dra. Sara Coca Membribes comenta sobre "Biomarcadores en cáncer urotelial". @OncoAlert @Uromigos @uromigosjapan
@Uromigos
Uromigos
5 days
The UromigosLive 2025 meeting presents #UromigosShorts videos on GU Oncology topics. The videos with the most views win a prize at #UromigosLive November 7-8th in Nashville, TN. Below, Dr. Sara Coca Membribes discusses: Biomarkers in Urothelial Cancer.
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@Uromigos
Uromigos
2 days
Radioisotopes in prostate cancer are expanding quickly. @anis_a_hamid describes novel targets such as potential (STEAP2, hK2) as well as novel combination (IO, chemo, PARPi). Optimal dosing is uncertain & also addressed as well as new isotopes such as actinium or lead @OncoAlert
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@tompowles1
Tom Powles
2 days
This is one of my favourite Uromigos short videos. @anis_a_hamid describes the next steps for radioisotopes in prostate cancer. A number of new studies with novel agents and alternative approaches are starting.
@Uromigos
Uromigos
2 days
Radioisotopes in prostate cancer are expanding quickly. @anis_a_hamid describes novel targets such as potential (STEAP2, hK2) as well as novel combination (IO, chemo, PARPi). Optimal dosing is uncertain & also addressed as well as new isotopes such as actinium or lead @OncoAlert
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@Dr_Aggen
David H Aggen, MD PhD
3 days
Excited for Izabright for patients s/p EV+P. The first of many 2nd gen ADCs with dual antigen targets.
@tompowles1
Tom Powles
3 days
Treatment after EVP in bladder cancer is undefined. Izalontamab brenitecan (HER2/3 TROP2 ADC) has good activity in bladder+lung cancer. A global randomised phase III has started enrolment 👉 Iza Bren alone vs platinum chemo in previously treated pts (including EVP). @OncoAlert
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@DrOmarMian
Omar Mian
3 days
Are you incorporating MDT for oligometastatic prostate cancer❓ ✅Here's a brief recap of key trials for #UromigosLive, including ongoing RCT's: METANOVA, TERPS, PROMETHEAN, and KNIGHTS. Please share and comment! #ProstateCancer
@Uromigos
Uromigos
5 days
The UromigosLive 2025 meeting presents #UromigosShorts videos on GU Oncology topics. The videos with the most views win a prize at #UromigosLive November 7-8th in Nashville, TN. Below, Dr. Omar Mian discusses: Metastasis-directed Therapy in Prostate Cancer.
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@Dr_Aggen
David H Aggen, MD PhD
5 days
🎶 Wondering how to tackle variant histologies in bladder cancer? Think of them as music genres—same stage, different openers (neoadj.) and headliners (1st line tx). 🎤 From micropapillary to plasmacytoid—each has a style & strategy. 🎧 Watch here ⬇️ @Uromigos @Dr_Aggen
@Uromigos
Uromigos
6 days
The UromigosLive 2025 meeting presents #UromigosShorts videos on GU Oncology topics. The videos with the most views win a prize at #UromigosLive November 7-8th in Nashville, TN. Below, Dr. David Aggen discusses : Variant Histology Bladder Cancer.
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