Physician-Scientist. Chief Research Officer
@EngIPM
. Gellert-John P. Leonard Scholar, Associate Professor
@WeillCornell
. Husband & father. RTs ≠ endorsements
I am excited to share we have received the NoA of an R01, converted to the prestigious MERIT R37. Grateful for the
@NIH
@theNCI
's funding for the next 7 years! This will support our work on targeting APOBEC3 cytidine deaminases as drivers of resistance in
#bladdercancer
Excited to share our new
@biorxivpreprint
: The evolution of genomic, transcriptomic, and immune features of metastatic upper tract urothelial carcinoma . A
#Teamscience
project spearheaded by K. Ohara and co-led by
@FaltasLab
and J.M. Mosquera
Pre-print alert 🚨Excited to share our new preprint “The interplay between mutagenesis and extrachromosomal DNA shapes urothelial cancer evolution” 🧬🔬
#bladdercancer
@OncoAlert
Pre-print alert 🚨 New story from my lab "The cytidine deaminase APOBEC3G drives cancer mutagenesis and clonal evolution in bladder cancer" This is one of the first projects in my lab, so I am thrilled to see it come to fruition 🐁🧪 🔬
#bladdercancer
#biology
@OncoAlert
Excited to share our new
@biorxivpreprint
: The evolution of genomic, transcriptomic, and immune features of metastatic upper tract urothelial carcinoma . A
#Teamscience
project spearheaded by K. Ohara and co-led by
@FaltasLab
and J.M. Mosquera
Honored and delighted to receive the 2023
@UrologySBUR
Young Investigator Award given to SBUR members under the age of 45 who "have made significant contributions to Urologic Research."
#SBUR23
in San Antonio.
Very proud dad today! Got to accompany my 13 year old son
@NasdaqExchange
opening bell 🔔 ceremony. He was invited as a silver key awardee of
@artandwriting
Scholastic Awards as part of their 100th year celebration
Dinner with oncology legend Dr. Lawrence Einhorn. Hundreds of thousands of men are alive today because of his pioneering work that led to curing testicular cancer. Humility, impact and wisdom!
Great news! 🎉 Very grateful 🙏to the
@CDMRP
for funding our work on APOBECs as drivers of metastasis in
#bladdercancer
. Thanks to the reviewers for a perfect score! My lab is hiring postdocs to work on these exciting projects! Please spread the word 📢
A MERIT grant was awarded to Dr. Bishoy Faltas (
@FaltasLab
) from
@theNCI
at
@NIH
to study mutations that drive bladder cancer.
"This prestigious award will allow us to pursue more high-risk, high-reward angles," says Dr. Faltas of
@WCMEnglanderIPM
.
Three
#WCM
faculty members have received Young Physician-Scientist Awards from the American Society for Clinical Investigation (
@the_asci
).
Congratulations to Drs. Bishoy M. Faltas (
@FaltasLab
), Gunisha Kaur (
@GunishaKaur
) and Hasina Outtz Reed.
🚀 Exciting opportunity alert! My Lab at Weill Cornell 🏥 is seeking postdoctoral candidates in cancer biology 🔬 and bioinformatics 💻! Full ad here:
#PhD
#postdoc
#phdstudent
#phdchat
spread the word 📣 by retweeting and sharing!
A great day hosting the legend
@DrChoueiri
who is visiting us at
@WeillCornell
from
@DanaFarber
@harvardmed
Amazing to see all the progress for patients with kidney cancers led by Toni and his team and to collaborate on more advances for patients!
Very grateful for new funding from the Starr Cancer Consortium. Exciting project led by postdoc
@Rahul_RaSingh
in my lab 👏Looking forward to collaborating with
@Samuel_Bakhoum
and
@mittallab
to define the role of the APOBEC3 enzymes in metastasis
@WeillCornell
Congrats to Dr. Bishoy Faltas (
@FaltasLab
), Dir. of Bladder Cancer Research
@WCMEnglanderIPM
, on his new Starr Cancer Consortium award to study "Targeting cytidine deaminase-induced chromosomal instability as a driver of metastasis in
#bladdercancer
"!
Had a lot of fun presenting our work
@ASCO
#GU24
featuring a deep learning model 🔗fusing outputs of 3 neural networks trained on pathology images 🔬+ gene expression 🧬+ spatial cell data from patients with bladder cancer to predict clinical trial responses to chemotherapy.
Excited to present our work
@ASCO
#GU24
A collaboration b/w
@FaltasLab
@ElementoLab
@feiwang03
& S1314 team. We built a deep learning model to 🔗fuse 3 neural networks trained on pathology images 🔬+ gene expression 🧬+ spatial cell data to predict clinical trial outcomes
Historic advance in the treatment of patients with metastatic bladder cancer. The first time a treatment improves outcomes compared to first-line chemotherapy- took more than 30 years! Congratulations to
@tompowles1
and the team
Applause mid-presentation marking the moment the standard of care changed in
#bladdercancer
The data speaks for itself, but
@tompowles1
spoke for all of us thanking patients, not just those on EV 302, but the many who came before allowing us to celebrate this milestone
#EVPembro
Honored to be in the
@WeillCornell
magazine. The real story is that of my brave patient featured in this article. She had urothelial cancer in both kidneys, had surgery, and adjuvant chemo. Finally, she got a kidney transplant. We have a lot of work to do for UC patients
Excited to present our work
@ASCO
#GU24
A collaboration b/w
@FaltasLab
@ElementoLab
@feiwang03
& S1314 team. We built a deep learning model to 🔗fuse 3 neural networks trained on pathology images 🔬+ gene expression 🧬+ spatial cell data to predict clinical trial outcomes
The Faltas Lab has two open postdoctoral positions. If you are excited about genomics, the mechanisms that generate mutational signatures and germline mutations in
#bladdercancer
, come to join us
#RETWEEET
I know that this May is different that any other but, it is still
#Bladdercancerawareness
month. We need to continue to spread awareness about this disease. We are making huge advances but there is a lot more to be done.
Look who just dropped into my office! Thrilled to welcome the amazing
@montypal
to WCM, straight from sunny California! ☀️Always learn a lot from his insights and wisdom. Plus, I even got the chance to capture a 'Thinking Monty' moment right beside the legendary Dr. Papanicolaou!
Great to catch up with friends, share our latest work, discuss the advances being made by the
#bladdercancer
research community and learn from patients at
#BCANTT22
@BladderCancerUS
See you next year in DC!
As an oncologist, nothing is more satisfying than realizing that your patient has now turned one year older and hit an important milestone with no evidence of cancer
#defeatbladdercancer
Congratulations
@JoshMeeks
great work ! Immune activation is essential for the antitumor activity of EZH2 inhibition in urothelial carcinoma | Science Advances
Thrilled to kick-off the 18th annual
@BladderCancerUS
#BCANTT23
in just 4 days! 🗓️Honored to chair the premier bladder cancer meeting with
@eugene_pietzak
in Washington DC. Excited to see friends, exchange ideas and discuss the latest in
#bladdercancer
research!
My comments in the
@NYT
on the importance of understanding the effects of genetic diversity on treatment responses in
#bladdercancer
patients
@WeillCornell
Decades of genetic studies have focused mainly on white patient populations. Now, new research grants have been awarded to projects examining the role of race and ethnicity in major types of cancer.
Our
@ASCO
#GU22
abstract presented by
#FaltasLab
mentee and
@ConquerCancerFd
merit award recipient
@Kyrillus2
: Serial ctDNA analysis predicts clinical progression in patients with advanced urothelial carcinoma . Now published @
Congrats to Dr. Bishoy Faltas (
@FaltasLab
),
@WCMEnglanderIPM
's Dir. of Bladder Cancer Research and
@MSKCancerCenter
's Dr. Jonathan Rosenberg on their new
@WCMC_CTSC
Pilot Award for their proposal: "Reinterpreting the pathogenicity of VUS in UC patients from diverse ancestries."
"Cancer immunotherapy is generating huge excitement, but the future may lie elsewhere, in antibody–drug conjugates, proteolysis-targeting chimeras, and liquid biopsy for early detection"
Today
@weisi_liu
and I gathered extra glove boxes from
@FaltasLab
and donated to
@WeillCornell
oncology clinic. Please consider donating extra PPE to healthcare workers at your medical center 🏥 to protect them against
#COVID19
Excited to give the state-of-the-art lecture at
#EAU21
on Germline mutations and urothelial cancer management. Looking forward to discussion with
@GNiegisch
and
@pcvblack
1-Patients with urothelial cancer whose disease progresses after chemotherapy and immunotherapy have no approved treatments at this point. We have been working hard to develop new treatments for these patients.
@ASCO
#GU19
in a multi-center study
@DrScottTagawa
@cornellGUcancer
Few things are better than getting a visit from your mentor. Seems like it was yesterday when I was a postdoc in
@MarkARubin1
‘s lab. It was great to catch up!
The husband of my late patient stopped by. He was thankful that she had 18 more months to live because of a clinical trial I enrolled her in. He quit his job, they spent time together and traveled a lot. We need more
#bladdercancerresearch
because life is short
@cornellGUcancer
Progress in the treatment of genitourinary cancers has been nothing short of extraordinary in 2021...the fruits of translational advances are built on foundations of basic science that require serious investments and take years in the making
@ASCOPost
🚀 Exciting opportunity alert! My Lab at Weill Cornell 🏥 is seeking postdoctoral candidates in cancer biology 🔬 and bioinformatics 💻! Full ad here:
#PhD
#postdoc
#phdstudent
#phdchat
spread the word 📣 by retweeting and sharing!
Today
@GoogleDoodles
honors Dr. Papanikolaou, the Greek cytopathologist who worked with his wife to develop the life-saving test known as the Pap smear. Here is a picture of his statue which can be seen today at the entrance of
@WeillCornell
Photo credit
@jameshorowitzmd
Really enjoyed my time at
@kochinstitute
@MIT
Great scientific discussions and collaboration opportunities Thanks to my wonderful and generous host
@fjsanchezrivera
!
Thank you
@US_FDA
for issuing draft guidelines for use of ctDNA in drug development for solid tumors in the early stage, non-metastatic setting. Will likely become standard for rapid patient selection and treatment response assessment
Need transcriptomic profiling of FFPE tissues, but not sure about the best approach? check out our latest pre-print . We compared 3 RNA exome capture methods with RNAseq from fresh frozen samples
@Kyrillus2
@iRonB25
@ElementoLab
@asbonerw
A. Alonso
Enjoyed serving as a judge for medical student research day
@WeillCornell
. Very proud of medical student Lilly Gu who did a great job presenting her work in the Faltas lab over the summer. Thanks for
@WCMC_CTSC
for funding her summer fellowship.
The program schedule and registration for the SUO Summer Virtual Webcast on July 18 are now available: . The webcast will feature lectures from the popular SUO Afternoon Session at the AUA. Registration is free!