Dan Lark
@ERM_Lab
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Studying extracellular vesicle biology in the context of metabolic disease. Assoc. Prof. in Health & Exercise Science at @CSU
Fort Collins, CO
Joined January 2016
I'm very happy to have our #endogenous #SkM #EV paper out in @AJPCellPhys. https://t.co/VMPHd2xH2P A beautiful piece of art inspired by our paper (by Andrew Crowe) was selected for the cover. A 🧵 about the science (and our growing pains as a new lab in a new (to us) field)...
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I am extremely pleased to announce that our paper is now published in Nature Communications. Here, we show for the first time that the GLP-1R signals from endosomes by forming contacts with the ER via the ER membrane contact site tethers VAPA and VAPB🧵 https://t.co/OXuZR7qazb
nature.com
Nature Communications - Following its internalisation, active endosomal GLP-1R engages with VAPB and SPHKAP at ER membrane contact sites to assemble a local cAMP/PKA condensate for the control of...
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Today, we report a cellular cross-species RNA-seq atlas of myogenesis: Using mouse & human cell culture models combined with in vivo snRNA-seq from muscle we provide a comprehensive resource for investigating skeletal muscle differentiation. https://t.co/8xLNwIP2Dd
biorxiv.org
Skeletal muscle formation and regeneration is a tightly regulated process involving extensive transcriptional reprogramming as proliferating myoblasts fuse into mature myotubes. However, a comparat...
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🤯🤯 A Paper from David Baker labs is here!!👇 Can we control immune cell behavior by precisely tuning how cytokine receptors are positioned in space relative to each other?@UWproteindesign @biorxivpreprint "Geometric Tuning of Cytokine Receptor Association Modulates Synthetic
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Computational design of insulin proteins that bind to the insulin receptor and "induce different downstream responses." "We identified designs more potent than insulin, causing longer-lasting glucose lowering in vivo and retaining activity on disease-causing IR mutants..." in
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Spatial Multiomics (Metabolome➡️ Lipidome➡️ Glycome) on a single 10 µm brain section👹 +Sami Spatial Augmented Multiomics Interface with Small Molecule Pathway Database Direct pixel-to-pixel matching across modalities😎 @RCSunlab @NatureComms 2025 https://t.co/66INVGwfar
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Today in @ScienceMagazine, we report a new DNA editing technology to seamlessly write massive changes into the right place in the human genome. The reason gene editing hasn't transformed human health is that current gene editing technologies like CRISPR are very limited. The
What if we could universally recombine, insert, delete, or invert any two pieces of DNA? In back-to-back @Nature papers, we report the discovery of bridge RNAs and 3 atomic structures of the first natural RNA-guided recombinase - a new mechanism for programmable genome design
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Towards establishing consensus standards to unify indirect calorimetry experiments and their analysis for more consistent, meaningful and reproducible results-the latest proposals
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Happy to share our new paper in @Nature led by staff scientist Xuejing Liu @Jessielxj2. We report identification of a UCP1-independent pathway of brown fat thermogenesis involving ATP-consuming metabolism of BCFA in peroxisomes. #Obesity #T2D
https://t.co/9NBWQxrRYc
@WashUDeptMed
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Wonderful to see our paper on the #organelle signatures of #neurons and #astrocytes out in final form - congratulations @ShanRhoads and team! 🎉 https://t.co/BPxKlbU6Ou
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Congratulations to the Arizona Democrats for getting the ball rolling on this enormously important issue. Billionaires must not be allowed to buy Democratic primary elections. Other states should follow suit.
We did it! AZ Dems made history today. We are the first state party in our nation to commit to ban billionaires and corporations from buying our primary elections! Thank you to everyone who helped make it happen from our amazing @stopbigmoneyaz organizing team to @BernieSanders!
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The remarkable benefit of exercise was just extended to improved survival after cancer in a randomized trial @NEJM #ASCO25
https://t.co/rJXBq11wmC
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We are recruiting! We have an open position for a Postdoctoral Fellow with the Aging, Exercise and Bioenergetics group at the Translational Research Institute in Orlando, Florida. If you know of an any trainees who might be interested, please let them know!
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1/10 Excited to write this thread summarizing our new paper in @NatMetabolism, which identifies a potentially critical part of the signaling pathway that drives skeletal muscle growth in response to resistance exercise! Free link https://t.co/JWca6dVU2a
#Myotwitter @NIH_NIAMS
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GDF8 and activin A blockade protects against GLP-1–induced muscle loss while enhancing fat loss in obese male mice and non-human primates https://t.co/nw8xQW8Fcl
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🚨in 3 days!🚨 Join us on May 13th for the next talk in our SNEV Translational EV Series! Dr. Nicole Noren Hooten will discuss innovations & challenges in using EVs as non-invasive biomarkers. 🕒TimeZone: https://t.co/bdJbGnIpds 🎯Join the SNEV network: https://t.co/IRpFeatZMk
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Present your research at APS New Trends in Sex Differences and Women’s Health Research (#APSSexDiff2025) 10/23–25 in New Orleans. Abstracts due 6/12: https://t.co/C4ILfbbl2I. Don’t miss the chance to be part of this inspiring program. #WomensHealthResearch #APSWomensHealth #SABV
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Chairing "New Discoveries and Best Practices for Studying the Physiological Functions of Extracellular Vesicles In Vivo" with @CreweLab @AhmedIsmaeelPhD @AlyssaTipler!
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Final version of our new paper "Mapping Organism-wide Single Cell mRNA Expression Linked to Extracellular Vesicle Biogenesis, Secretion, and Cargo" is now available Open Access. https://t.co/lNX3RsaZzS
academic.oup.com
Abstract. Extracellular vesicles (EVs) are functional lipid-bound nanoparticles trafficked between cells and found in every biofluid. It is widely claimed
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New! Online now: Protein O-GlcNAcylation and hexokinase mitochondrial dissociation drive heart failure with preserved ejection fraction https://t.co/nyWG12edzY
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