Cell Metabolism
@Cell_Metabolism
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Cell Press journal publishing cutting-edge research in metabolism biology, from molecular/cellular biology to translational and clinical studies.
Joined May 2015
Dietary sugar lowers immunity and microbiota that protect against metabolic disease
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😻 Shoutout to @Trends_Endo_Met for their purrfect cover to complement an illuminating December issue! #Meowyoudoin’? .
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#NewIssue Ft cover art by Kehuitang Art Studio. He et al. reveal a protective effect of acetate against metabolic and cognitive impairments caused by sleep disruption. Inspired by Monet’s famous Water Lilies paintings, a “mitochondrion” boat drifts in a lotus pond full of water
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On this #WorldObesityDay, we bring you this Special Issue on Obesity, highlighting the complexities of this disease and systemic challenges we must overcome to combat it.
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⚡️TWO seminal reviews out today in @CellCellPress and @Cell_Metabolism by Guido Kroemer & co."Hallmarks of aging: An expanding universe".🔗"Meta-hallmarks of aging and cancer".🔗
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#NewIssue On the cover: In this issue of Cell Metabolism, Li et al. reveal that sick neurons release lipids to the glia, causing lipid droplet accumulation and neuroinflammation. The artwork, inspired by Van Gogh's Starry Night, depicts a brain with lipid droplets. Artwork by
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“Sweet death”: Fructose as a metabolic toxin that targets the gut-liver axis
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New! Online now: Metabolic reprogramming in liver fibrosis
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#WATsGoingOn? Adipocytes transfer their mitochondria to macrophages but this is disrupted in Obesity. @BrestoffLab et al. explains more in this article from #CellMet1YearAgo! #OpenAccess
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Insulin action in adipocytes, adipose remodeling, and systemic effects
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Cardiovascular disease in diabetes, beyond glucose
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Mitochondrial membrane lipids in the regulation of bioenergetic flux
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“Sweet death”: Fructose as a metabolic toxin that targets the gut-liver axis
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Mitochondrial fatty acid synthesis is an emergent central regulator of mammalian oxidative metabolism
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Lactate controls cancer stemness and plasticity through epigenetic regulation
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How & when should we eat & exercise to achieve a healthier metabolic state? Our latest issue presents several clinical & mechanistic studies focusing on the feasibility & timing of healthy eating & physical activity. #chrononutrition #exercise .
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New! Online now: NAD depletion in skeletal muscle does not compromise muscle function or accelerate aging
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New! Online now: IgG is an aging factor that drives adipose tissue fibrosis and metabolic decline
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New! Online now: Lactate homeostasis is maintained through regulation of glycolysis and lipolysis
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New! Online now: Mitochondrial fatty acid synthesis is an emergent central regulator of mammalian oxidative metabolism
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New! Online now: Lactate controls cancer stemness and plasticity through epigenetic regulation
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Extracellular vesicles mediate the communication of adipose tissue with brain and promote cognitive impairment associated with insulin resistance
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Circadian modulation by time-restricted feeding rescues brain pathology and improves memory in mouse models of Alzheimer’s disease
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Gang of 3: How the Krebs cycle-linked metabolites itaconate, succinate, and fumarate regulate macrophages and inflammation
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NEW ISSUE: Featuring work by Gómez-Valadés et al. on mitochondrial cristae in POMC neurons that adapt to nutritional conditions. The hotdog artwork by Pau Serra symbolizes the link between these structures and obesity.
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New! Online now: Hepatic malonyl-CoA synthesis restrains gluconeogenesis by suppressing fat oxidation, pyruvate carboxylation, and amino acid availability
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Maternal circadian rhythms during pregnancy dictate metabolic plasticity in offspring
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Dietary restriction of isoleucine increases healthspan and lifespan of genetically heterogeneous mice
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Microbiota-gut-brain axis drives overeating disorders
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Mitochondrial-derived vesicles in metabolism, disease, and aging
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High dietary fructose promotes hepatocellular carcinoma progression by enhancing O-GlcNAcylation via microbiota-derived acetate
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Early immune pressure makes tumors metabolically stronger
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New! Online now: Amino acid is a major carbon source for hepatic lipogenesis
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Excessive exercise training causes mitochondrial functional impairment and decreases glucose tolerance in healthy volunteers
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Comprehensive quantification of metabolic flux during acute cold stress in mice
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Endothelial metabolic control of insulin sensitivity through resident macrophages
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Nutrient inputs and social metabolic control of T cell fate
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Cholesterol-induced toxicity: An integrated view of the role of cholesterol in multiple diseases
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New! Online now: Adipo-glial signaling mediates metabolic adaptation in peripheral nerve regeneration
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Lactate homeostasis is maintained through regulation of glycolysis and lipolysis
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Age-associated remodeling of T cell immunity and metabolism
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New! Online now: Separate gut-brain circuits for fat and sugar reinforcement combine to promote overeating
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Diabetes-induced skeletal muscle fibrosis: Fibro-adipogenic precursors at work
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New! Online now: Circadian modulation by time-restricted feeding rescues brain pathology and improves memory in mouse models of Alzheimer’s disease
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Alternate Day Fasting Improves Physiological and Molecular Markers of Aging in Healthy, Non-obese Humans
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New! Online now: Psychological stress-induced microbial metabolite indole-3-acetate disrupts intestinal cell lineage commitment
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Extracellular vesicle-based interorgan transport of mitochondria from energetically stressed adipocytes
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New! Online now: Central glucagon-like peptide 1 receptor activation inhibits Toll-like receptor agonist-induced inflammation
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When a calorie is not just a calorie: Diet quality and timing as mediators of metabolism and healthy aging
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New! Online now: Microbiota-gut-brain axis drives overeating disorders
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New! Online now: Acetate enables metabolic fitness and cognitive performance during sleep disruption
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Title: Elevated glucose levels favor SARS-CoV-2 infection and monocyte response through a HIF-1α/glycolysis dependent axis
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New! Online now: Electron transport chain inhibition increases cellular dependence on purine transport and salvage
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Regenerating the heart by metabolically reprogramming the cardiomyocyte epigenome
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Mitochondria ensure immune surveillance by retro-communication with the nucleus
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New! The mitochondrial pyruvate carrier regulates memory T cell differentiation and antitumor function
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New! Online now: SLC25A48 controls mitochondrial choline import and metabolism
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New Review! Emerging therapies in cancer metabolism
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New! Online now: Ketogenic diet promotes tumor ferroptosis but induces relative corticosterone deficiency that accelerates cachexia
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“Shunt-ing” down obesity with novel endogenous metabolites
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Alpha-Ketoglutarate, the Metabolite that Regulates Aging in Mice
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New! Online now: Regulatory T cells require IL6 receptor alpha signaling to control skeletal muscle function and regeneration
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Cholesterol-induced toxicity: An integrated view of the role of cholesterol in multiple diseases
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New! Online now: Nutrient inputs and social metabolic control of T cell fate
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New! Online now: Microglial lipid droplet accumulation in tauopathy brain is regulated by neuronal AMPK
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New! Online now: Mitochondrial membrane lipids in the regulation of bioenergetic flux
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Intercellular Mitochondria Transfer to Macrophages Regulates White Adipose Tissue Homeostasis and Is Impaired in Obesity
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New! Online now: Augmentation of scleral glycolysis promotes myopia through histone lactylation
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This Resource presents the quantification of metabolic fluxes in mice on either high-carbohydrate or ketogenic diet. Rabinowitz lab @realTonyHui #openaccess #1YearAgo
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New! Online now: Physical exercise mediates cortical synaptic protein lactylation to improve stress resilience
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New! Online now: Gang of 3: How the Krebs cycle-linked metabolites itaconate, succinate, and fumarate regulate macrophages and inflammation
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New! Online now: Quantification of nutrient fluxes during acute exercise in mice
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Circadian rhythms and the gut microbiome synchronize the host’s metabolic response to diet
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New! Online now: Endothelial metabolic control of insulin sensitivity through resident macrophages
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mTOR takes charge: Relaying uncharged tRNA levels by mTOR ubiquitination
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New! Online now: Comprehensive quantification of metabolic flux during acute cold stress in mice
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GDF15 is a major determinant of ketogenic diet-induced weight loss
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New! Online now: Oncogenic fatty acid oxidation senses circadian disruption in sleep-deficiency-enhanced tumorigenesis
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New! Online now: Overnutrition causes insulin resistance and metabolic disorder through increased sympathetic nervous system activity
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Famsin and fasting adaptation: A glucagon connection
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Lactylation: Linking the Warburg effect to DNA damage repair
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Acetate enables metabolic fitness and cognitive performance during sleep disruption
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Hepatic malonyl-CoA synthesis restrains gluconeogenesis by suppressing fat oxidation, pyruvate carboxylation, and amino acid availability
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Intercellular Mitochondria Transfer to Macrophages Regulates White Adipose Tissue Homeostasis and Is Impaired in Obesity
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Work by Hall et al. on ultra-processed foods has gained wide attention from both nutrition scientists and the general public. The article & two related Letters: now free to the public. #nutrition #openaccess.
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New! Online now: Extracellular vesicles in fatty liver promote a metastatic tumor microenvironment
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New! Online now: Hyperinsulinemia acts via acinar insulin receptors to initiate pancreatic cancer by increasing digestive enzyme production and inflammation
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New! Online now: Two independent respiratory chains adapt OXPHOS performance to glycolytic switch
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Mitochondrial (but not glycolytic) ATP regulates endothelial fatty acid uptake and transport.#openaccess #1YearAgo @AranyLab.
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