🚨 New in @NatureComms: We present a spatial multi-omics platform that maps the metabolome, lipidome, and glycome from a single brain section. Combining MALDI imaging with our computational tool Sami, we reveal metabolic diversity in health and Alzheimer's disease. 🔗

RT @tangming2005: Yes, that's it.

RT @UFBreathe: Today's #NeuroNines session featured presentations by Delaney Kelemen, Cameron Shedlock, & Todd Williams. We will be taking….

Thanks for the highlight ! @NatMetabolism.

RT @UFBreathe: The next session of #NeuroNines is happening this Thurs, June 12 (9am) featuring Delaney Kelemen, Cameron Shedlock, & Todd W….

RT @Fusion_Conf: 📣Don't forget to register and submit your abstract for short talk consideration at #RedoxBio25.The chairs would love to ha….

RT @ScholarshipfPhd: Academic ironies

RT @apoptosislab: Many cool articles in the Metabolist this month.

RT @DeryaTR_: The biomedical field has been flooded with low-quality or crappy work for a long time, especially following the rise of preda….

RT @NatMetabolism: 🚨Job Alert!🚨.@NatMetabolism seeks an Associate or Senior #Editor to join our team. If being a #Metabolism Editor is for….

For everyone who wish to try and utilize the tripleomics workflow (), our center @UFCASBR will gladly help. Please DM or email or visit our website!

6/ This work opens new frontiers in spatial systems biology—we can now map metabolism across regions, conditions, and diseases using a unified platform. Adaptable to other tissues and disease models. We believe this approach will accelerate hypothesis generation in spatial

5/We applied the method to WT and Ps19 tauopathy model brains. → Found regional metabolic rewiring in the isocortex and cerebellum. → Ps19 cortex shows elevated glycogen and altered TCA, glycolysis, and carnitine metabolism.

4/Sami enables dimensionality reduction and anatomical clustering, helping everyone make sense of the hundreds of millions of pixels examined by spatial metabolomics, aligning omics signals with brain regions like cortex, CA3, and corpus callosum. → We show that metabolism alone

3/This triple-omics approach is powered by our custom software Sami (Spatial Augmented Multiomics Interface), which co-registers datasets, integrates features across modalities, and performs clustering + spatial pathway analysis.

2/ what is the barrier currently? There is a lack of spatial and unified multi-omics workflows—metabolomics, lipidomics, and glycomics are typically performed separately, often in pooled samples across facilities. We designed a sequential workflow that enables spatial

🧵1/ Due to popular demand, we’re doing an X-tutorial on the new Nature Communications paper: Spatial mapping of the brain metabolome, lipidome, and glycome. Here we developed a triple-omics MALDI imaging and computational pipeline to change the game on how to study metabolism in

Another exciting discovery from the DiNcola Lab:.Dissecting redox control in lung cancer, this study demonstrates the roles of glutathione and thioredoxin in supporting Nrf2-driven progression. 📄 Redox Biology:

Thx for the highlight ! This is a real multidisciplinary team effort ! @lichenbiostat @XinMa13.

sharing our new story "Hyper-Glycosylation as a Central Metabolic Driver of Alzheimers Disease" here on biorxiv.