Patrick Hsu
@pdhsu
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@ArcInstitute co-founder, @BerkeleyBioE professor, @ThriveCapital investor | biology and ML research | ๐จ๐ฆ prev @harvard @broadinstitute, Fast Grants
Palo Alto and Berkeley, CA
Joined March 2009
Today in @ScienceMagazine, we report a new DNA editing technology to seamlessly write massive changes into the right place in the human genome. The reason gene editing hasn't transformed human health is that current gene editing technologies like CRISPR are very limited. The
What if we could universally recombine, insert, delete, or invert any two pieces of DNA? In back-to-back @Nature papers, we report the discovery of bridge RNAs and 3 atomic structures of the first natural RNA-guided recombinase - a new mechanism for programmable genome design
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intelligence is overrated. thereโs a saying about that but i canโt remember it
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BREAKING: Inside Thrive Capital w/ Partner Philip Clark Investing in OpenAI, Wiz, Cursor, Nudge, Physical Intelligence โJosh always had a line to me when I joined Thrive, which is that the people who win deals are the ones who want to win them most.โ In this conversation,
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In my view, researchers also need to stoke two warring urges: (1) an opinionated sense of taste in a relentless search for beauty and (2) a yeomanโs grindset for the unglamorous dirty work required to get things done. In patent language, we call this conception and reduction to
I do not think you can pursue meaningful research without (1) some grandiose delusion about your abilities (2) a sense of esthetics and harmony to judge ideas still free of experimental confirmation (3) an unreasonable taste for the required tangible work (e.g. programming)
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๐จ Actress Diane Keatonโs Cause of Death Revealed Read more
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CRISPR-All by powerhouse Theo Roth and team!
Excited to present the first major work after starting our lab at Stanford and the Arc this year: CRISPR-All, a unified genetic perturbation language for programming any major type of genetic perturbation simultaneously, in any combination, at genome scale, in human cells.
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when will a major fashion house drop the first line of robot couture?
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i am of course aware of image trace in illustrator but imo it barely works
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Use our Player Prop Cheat Sheet to quickly find favorable bets! Supports NFL player props on Underdog, DraftKings, FanDuel, and PrizePicks.
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I would do anything for a high quality image to editable vector graphic model to add on top of this. Would save scientists an insane number of hours
Until a few hours ago, creating this kind of scientific image would have required at least an hour of professional work. Now, with NanoBanana Pro, it only takes a simple prompt & less than 30 seconds! Prompt: โDescribe in an illustration the events for a cytotoxic T cell
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after months of antibody design papers that only work on single chains, we are seeing much-needed progress on full IgG congrats to the chai team!
Today, weโre releasing new data showing that Chai-2 can design antibodies against challenging targets with atomic precision. >86% of our designs possess industry-standard drug-quality properties without any optimization. Thread๐
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Spatial thinking in a reasoning trace
Thinking (test-time compute) in pixel space... ๐ Pro tip: always peek at the thoughts if you use AI Studio. Watching the model think in pictures is really fun!
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Today in @Nature, in work led by @aditimerch, we report the ability to prompt Evo to generate functional de novo genes. You shall know a gene by the company it keeps! 1/n
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FFLS invests in companies positioned to lead global megatrends* while shorting those at risk of disruption, creating a balanced strategy that combines growth potential with risk management.
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Very exciting work demonstrating the emergence of in-context learning in Evo 2 on purely synthetic tasks.
For years since the GPT-2 paper, emergent in-context learning (ICL) from 'next-token' training has been treated as something deeply tied to ๐ก๐ฎ๐ฆ๐๐ง ๐ฅ๐๐ง๐ ๐ฎ๐๐ ๐. But โฆ is it? Thrilled to share our latest result: ๐๐ฒ๐ป๐ผ๐บ๐ถ๐ฐ๐งฌ ๐บ๐ผ๐ฑ๐ฒ๐น๐ ๐๐ฟ๐ฎ๐ถ๐ป๐ฒ๐ฑ ๐ค๐ฃ๐ก๐ฎ ๐ผ๐ป
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Ok this is amazing
As an example of how we are building on top of Gemini 3, AI Mode in Search now uses Gemini 3 to enable new generative UI experiences, all generated completely on the fly based on your query. Hereโs how you might use this to learn a complex topic like how RNA polymerase works.
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the best phages (and hair) at @arcinstitute
@samuelhking
Closing the AI-to-lab loop is hard, especially if you want to test your WHOLE GENOME generator.. Viruses are the only genomes cheap enough to print en mass, but raise biosafety flags So @ArcInstitute chose phages! We went deep w/ @samuelhking & @driscoll_cl on how they did it:
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Congratulations to Arc Science Fellow, @UcheMedoh, on being named a winner of the 2025 @ScienceMagazine & @SciLifeLab Prize for Young Scientists! His work solves a decades-old mystery in cell biology, revealing the enzyme responsible for BMP synthesis: https://t.co/e84WTyIKnE
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gene editing to save the iconic American chestnut tree!
I'm a simple man. If I see a field trial of genetically-engineered trees, I read it. A recent preprint reports the largest field trial to-date of American Chestnut trees engineered to resist a blight. And the results look promising. For context: The U.S. was once filled with
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Since the late 1990s, small businesses like my brother's have accounted for between 43.5% and 50.7% of the United Statesโ gross domestic output (GDP). Congrats @adhsu and @connorzwick!
AI language learning app Speak has crossed $100 million in annualized revenue. Founded by former Thiel fellows @connorzwick and @adhsu in 2016, the company is up against better-known rival Duolingo as it enters the U.S. market. https://t.co/EzAq1eaapC
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