Clair Crewe
@CreweLab
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Joined September 2022
Final version of our new paper "Mapping Organism-wide Single Cell mRNA Expression Linked to Extracellular Vesicle Biogenesis, Secretion, and Cargo" is now available Open Access. https://t.co/lNX3RsaZzS
academic.oup.com
Abstract. Extracellular vesicles (EVs) are functional lipid-bound nanoparticles trafficked between cells and found in every biofluid. It is widely claimed
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Gemma Conroy @Nature wrote a fantastic news feature on #mitochondria transfer. It’s exciting to see so much interest! Many good friends and colleagues highlighted here! Check it out. https://t.co/XTWCu9Sf2N
nature.com
Nature - Researchers are studying why the energy factories are moving between cells and whether the process can be harnessed to treat cancer and other diseases.
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Speaker Spotlight: Dr. Rana Gupta (@DukeU) Join us @ #AdiposeBiology Conference in Montreal🇨🇦, Aug 19-20, 2025, to hear from Rana about #adiposedevelopment. Don’t miss his talk! 🔗 Register now – https://t.co/kbll9EWR9r
#ABC2025 #Metabolism #Adipogenesis #ObesityResearch
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Scientists are now organizing events, called Stand Up for Science, on 7 March in Washington, D.C., and state capitals. https://t.co/fhMS1HI3YW
@NewsfromScience
science.org
New group hopes to turn out researchers for 7 March demonstrations against Trump administration policies
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Strong article from Tom Maniatis, head of the NY Genome Center, on the history of the NIH and its role in maintaining U.S. scientific leadership. Safeguarding the future of biomedical science in the United States: Cell
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I’m excited to share that my thesis work on brown adipocyte-secreted proteins and their role in regulating Type 1 Diabetes is now published! Huge thanks to @ThePistonLab and collaborators!
diabetesjournals.org
Current treatments for type 1 diabetes (T1D) focus on insulin replacement. We demonstrated the therapeutic potential of a secreted protein fraction from em
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Transforming traditional views laid by “CNS immune privilege,” our research uncovers the brain’s purposeful presentation of self – that is the brain engages with the immune system through “guardian” peptides to ensure immune tolerance. @jonykipnis
https://t.co/XRr11LC82M
nature.com
Nature - Central nervous system (CNS)-derived regulatory self-peptides are essential for maintaining a continuous dialogue between the CNS and the immune system while balancing overt autoreactivity.
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Very excited to share our latest paper out today @NatMetabolism showing that #mitochondria transfer and transplantation may reduce the morbidity and mortality of #LeighSyndrome, a fatal mitochondrial disease with no effective therapies.
nature.com
Nature Metabolism - Administration of exogenous mitochondria from mice or humans, or stimulation of mitochondria transfer from haematopoietic cells through bone marrow transplant from wild-type...
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If you are new to extracellular vesicle research and want some guidance on how to study them in metabolic regulation check out our comment in @NatMetabolism. Thank you Dan Lark @ERM_Lab, Kerstin Stemmer, and Wei Ying for these insights! https://t.co/D3YG8So726
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Really excited to share our latest paper describing the MitoLuc assay for quantitative mitochondrial protein import, which we wrote in collaboration with @IanofBristol!
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“For centuries, scholars from around the world have called Boston home or traveled here for research and immersion.” — Mayor Michelle Wu | Register for #ENDO2024 ( https://t.co/FzZiTcaalC) and join us in beautiful Boston, MA. Read the mayor’s letter welcoming the conference to the
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Want to learn more about circular RNAs and immunity? Come join our CB&P Seminar tomorrow (April 1st) at 1:00 PM!
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We are looking for a postdoc! If you are interested in obesity/type 2 diabetes and extracellular vesicles apply below! https://t.co/aInZylwCgH
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As Black scientists, we usually face unique challenges in academia. Often feeling isolated. Come learn how Doctors Rita Brookheart and Bettina Blake navigated their journeys!!! There will be food!!! 🍰 Edited · 12s
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The 2024 conference is being chaired by Jonathan Brestoff, MD, PhD (@BrestoffLab) and Nada Abumrad, PhD from WashU and Gregory Steinberg, PhD (@DrGregSteinberg ) from McMaster University.
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https://t.co/ZnpWkoeS89 I am thrilled to see our pre-print out and available to the scientific community. Co-led by @AbbyBartlett_, we identify two mammalian enzymes that drive the catabolism of 4-hydroxy acids through FAO via 4-phosphoacyl-CoA intermediates. #lipids #metabolism
biorxiv.org
Fatty acid β-oxidation (FAO) is a central catabolic pathway with broad implications for organismal health. However, various fatty acids are largely incompatible with standard FAO machinery until they...
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The new and improved manuscript! (aka, peer reviewed, revised, and published). The zebrafish hypochord contributes to Tagln+ cells on the aorta, and early ISV perivascular cells express Tagln... before Pdgfrb. Now with movies! 📽️🦓🐟 @StratmanLab
https://t.co/VvocfFf6av
anatomypubs.onlinelibrary.wiley.com
Detailed analysis of pdgfrb/tagln vascular expression patterns in embryonic zebrafish Identified novel regions of tagln-positive populations such as the hypochord and a mural cell progenitor popula...
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