
Daniel J Drucker
@DanielJDrucker
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A clinician scientist at LTRI @sinaihealth studying GLP-1, diabetes, obesity and the gut endocrine system Proud 🇨🇦Not going anywhere Am 🇮🇱Chai
Toronto
Joined May 2011
Some new information about the anti-inflammatory actions of GIP from @RolaHammoud1 Gain and loss of GIPR signaling modifies gut inflammation in mice with 5FU-induced enteritis, with data on Tirzepatide & Semaglutide @JCI_insight @BBDC_UofT @SinaiHealth @CIHR_IRSC
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RT @BevTchangMD: For patient safety, clinicians in the U.S. should have the option to prescribe multi dose injectors for tirzepatide and se….
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The proteomic blueprint of #aging across 13 human tissues
cell.com
A 50-year multi-tissue proteomic atlas reveals transcriptome-proteome decoupling, proteostasis decline with amyloid accumulation, and asynchronous aging clocks, identifying circulating senoproteins...
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PVH and SON Oxytocin neurons differentially modulate food intake by either reducing or increasing caloric consumption, respectively.@MolMetab .
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In the SUMMIT trial greater weight loss on treatment with tirzepatide was associated with greater improvements in 6MWD and KCCQ in HFpEF #obesity
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Preclinical data reveal that dietary fat sources differentially regulate natural killer and CD8 T cell infiltration and function within the tumour microenvironment, governed by distinct effects on the plasma metabolome and intracellular metabolism.
nature.com
Nature Metabolism - This study shows that animal-based high-fat diets accelerate tumour growth and impair anti-tumour response to melanoma in obese mice, whereas plant-based high-fat diets do not.
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Understanding disulphide bond shuffling is crucial for developing strategies to mitigate #insulin aggregation, thereby improving the therapeutic management of #diabetes
nature.com
Nature Communications - Researchers find that the shuffling of insulin’s disulfide bonds, while initially slowing protein aggregation, ultimately forms distinct and more toxic fibrils,...
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A multi-tissue atlas of #exercise induced endocrine interactions in rats, serving as a resource for novel exerkine discovery and mechanistic investigation.
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A flagellin Toll-like receptor 5 (TLR5) peptide YY (PYY)-labelled colonic neuropod cell axis leads to PYY release onto NPY2R vagal nodose neurons to regulate feeding .
nature.com
Nature - A study reveals a gut–brain sensory pathway through which the microbial component flagellin activates neuropod cells in the colon to signal the brain and reduce feeding in mice.
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Adipose tissue-derived mesenchymal stromal/stem cells (ADMSCs) represent a novel therapeutic intervention for Type 1 #Diabetes (T1D). An update @commsbio
nature.com
Communications Biology - ADMSCs offer promise for Type 1 Diabetes therapy due to their immunomodulatory and regenerative properties. This review highlights current findings, clinical relevance, and...
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Exciting preclinical studies demonstrate that the Glia-derived peptide Octadecaneuropeptide may be valuable for targeting weight and glycemic control via the hindbrain without eliciting the common treatment side effects seen with GLP-1 receptor agonists
science.org
Dorsal vagal complex action of the glucose-responsive gliotransmitter octadecaneuropeptide improves body weight and systemic glucoregulation.
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A new online resource of GPCR drugs, clinical trial agents, targets and disease indications
nature.com
npj Drug Discovery - An online GPCR drug discovery resource
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WAT-derived N-acetylaspartate (NAA) is an endocrine regulator of postprandial body temperature with broader roles for metabolic homeostasis.
nature.com
Nature Metabolism - Aspartoacylase expression in white adipose tissue regulates circulating levels of N-acetylaspartate, which in turn modulates plasma pyrimidine levels and regulates postprandial...
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Here Tony Lam and colleagues @UHN identify that lipid sensing in HFD-fed rats is enhanced by metformin to trigger an endocrine GIP to NTS GIPR axis to reduce food intake unveiling potential targets to enhance GIP action and reduce weight in #obesity
diabetesjournals.org
An acute increase of lipids in the upper small intestine (USI) of rodents and humans triggers lipid-sensing pathways to reduce food intake. However, USI li
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A REV-ERBα mechanism by which the liver contributes to peripheral tissue wasting in #cancer cachexia, offering perspectives for future therapeutic interventions .
cell.com
Cancer-induced liver changes promote body wasting through secreted factors, with circadian regulators and hepatokines being important contributors to cancer cachexia.
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RT @NatMetabolism: RESEARCH | @clarissamliu, @DanielJDrucker, M Véniant et al (@Amgen, @SinaiHealth). Part 1: This study and a co-pub delve….
nature.com
Nature Metabolism - This study, together with a companion manuscript, shows that in mice, weight loss as a result of GIP receptor antagonism requires and potentiates functional GLP-1 receptor...
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Analysis of human pancreas indicates that the molecular mechanisms driving #pregnancy induced #islet adaptations in humans differ from those in mice, highlighting the need for human-based studies @NatureComms
nature.com
Nature Communications - Here the authors show that human pancreatic islets adapt during pregnancy with increased α-cell area and GLP-1 abundance, while key differences from islet adaptations...
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A mechanistic framework linking gut microbial metabolites to discrete stages of T cell fate and function
nature.com
Nature Immunology - Tran et al. discuss the role of the gut microbiome and gut microbiome-derived metabolites in T cell biology.
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Studies from mice and humans reveal that semaglutide may revert the circulating proteome associated with #MASH to the proteomic pattern observed in healthy individuals reducing #inflammation #fibrosis .
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