Some new information about the anti-inflammatory actions of GIP from @RolaHammoud1 Gain and loss of GIPR signaling modifies gut inflammation in mice with 5FU-induced enteritis, with data on Tirzepatide & Semaglutide @JCI_insight @BBDC_UofT @SinaiHealth @CIHR_IRSC

RT @BevTchangMD: For patient safety, clinicians in the U.S. should have the option to prescribe multi dose injectors for tirzepatide and se….

The proteomic blueprint of #aging across 13 human tissues

Fasting, metabolism #longevity and health. Benefits, risks and unknowns

PVH and SON Oxytocin neurons differentially modulate food intake by either reducing or increasing caloric consumption, respectively.@MolMetab .

In the SUMMIT trial greater weight loss on treatment with tirzepatide was associated with greater improvements in 6MWD and KCCQ in HFpEF #obesity

Preclinical data reveal that dietary fat sources differentially regulate natural killer and CD8 T cell infiltration and function within the tumour microenvironment, governed by distinct effects on the plasma metabolome and intracellular metabolism.

Understanding disulphide bond shuffling is crucial for developing strategies to mitigate #insulin aggregation, thereby improving the therapeutic management of #diabetes

A multi-tissue atlas of #exercise induced endocrine interactions in rats, serving as a resource for novel exerkine discovery and mechanistic investigation.

A flagellin Toll-like receptor 5 (TLR5) peptide YY (PYY)-labelled colonic neuropod cell axis leads to PYY release onto NPY2R vagal nodose neurons to regulate feeding .

Adipose tissue-derived mesenchymal stromal/stem cells (ADMSCs) represent a novel therapeutic intervention for Type 1 #Diabetes (T1D). An update @commsbio

Exciting preclinical studies demonstrate that the Glia-derived peptide Octadecaneuropeptide may be valuable for targeting weight and glycemic control via the hindbrain without eliciting the common treatment side effects seen with GLP-1 receptor agonists

A new online resource of GPCR drugs, clinical trial agents, targets and disease indications

WAT-derived N-acetylaspartate (NAA) is an endocrine regulator of postprandial body temperature with broader roles for metabolic homeostasis.

Here Tony Lam and colleagues @UHN identify that lipid sensing in HFD-fed rats is enhanced by metformin to trigger an endocrine GIP to NTS GIPR axis to reduce food intake unveiling potential targets to enhance GIP action and reduce weight in #obesity

Does Tirzepatide improve #insulin sensitivity independent of #weightloss ? @DiabetologiaJnl

A REV-ERBα mechanism by which the liver contributes to peripheral tissue wasting in #cancer cachexia, offering perspectives for future therapeutic interventions .

RT @NatMetabolism: RESEARCH | @clarissamliu, @DanielJDrucker, M Véniant et al (@Amgen, @SinaiHealth). Part 1: This study and a co-pub delve….

Analysis of human pancreas indicates that the molecular mechanisms driving #pregnancy induced #islet adaptations in humans differ from those in mice, highlighting the need for human-based studies @NatureComms

A mechanistic framework linking gut microbial metabolites to discrete stages of T cell fate and function

Studies from mice and humans reveal that semaglutide may revert the circulating proteome associated with #MASH to the proteomic pattern observed in healthy individuals reducing #inflammation #fibrosis .