The Hornberger Lab
@HornbergerLab
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Our lab uses a variety of molecular techniques to define how mechanical signals regulate skeletal muscle mass
Madison WI
Joined December 2018
1/10 Excited to write this thread summarizing our new paper in @NatMetabolism, which identifies a potentially critical part of the signaling pathway that drives skeletal muscle growth in response to resistance exercise! .Free link .#Myotwitter @NIH_NIAMS
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RT @Matt_Muscle_Guy: Interesting new @NatureComms paper: Early-life exercise extends healthspan but not lifespan in mice. .
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Time-of-day effect of high-intensity muscle contraction on mTOR signaling and protein synthesis in mice | Scientific Reports
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RT @JYUBiolPA: Conference: Inter-individual variation in exercise. Please join! The speakers include e.g. @mackinprof @AbigailMackey1 @Marc….
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RT @JustinHardeePhD: 📢The Integrative Muscle Plasticity Lab @UF_HHP is seeking graduate students (MS/PhD) & staff for Fall 2025 / Spring 20….
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RT @AhmedIsmaeelPhD: Soo pumped to see this paper online! Much of my work over the past 3 years. Fitting to be ending my time at @UKYCMB….
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RT @Dev_Cell: Online now: AKT-mediated phosphorylation of TSC2 controls stimulus- and tissue-specific mTORC1 signaling and organ growth htt….
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If you're interested in knowing more details about the proposed FY2026 budget for each of the proposed NIH institutes, then go to the link below. Warning. It's bad. really really bad. here https://officeofbudget.od.nih.gov/insti_center_subs.html
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Here is where your institute/center at NIH would go under the proposed restructuring plan. For the NIAMS folks, you would now go to the National Institute of Body Systems and the collective institutes in there would experience at 30% budget reduction (better than the 40% average)
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Great points are raised in this 5 min read. Plan to restructure NIH would stall science, not streamline it
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RT @KevinMurachPhD: Post doc opportunity with Karyn Esser @UF working on the SOMMA project! Reach out to her if you are interested. https:/….
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The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan
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This looks awesome. Can’t wait to give it a careful read.
Amazing to see this collaboration paper in @CellPress @CellReports . Molecular landscape of sex- and modality-specific exercise adaptation in human skeletal muscle through large-scale multi-omics integration!. Led by @nir_eynon & @MacsueJ .
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2/2 For instance, in 2018 the president requested a 21.5% reduction in the NIH budget. However, when all was said and done, NIH walked away with an 8.7% increase. This gives me at least a little bit of hope. .
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1/2 _ If you're at all like me then you've been frantically worried about what will happen with NIH funding in 2026. Today I found the following link to see what history tells us and I walked away feeling a bit better.
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RT @CraigAGoodman1: It was a pleasure & a privilege to work with @scbodine on this 'News and Views' piece for @NatMetabolism highlighting n….
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10/10 Finally, we also determined that genetically activating MKK3b could prevent the loss of muscle fiber size that occurs during disuse! #muscleatrophy
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9/10 Then, by genetically activating MKK3b in mouse muscle, we determined that prolonged activation of the pathway is sufficient to induce an increase protein synthesis, and muscle fiber size 💪
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8/10 We also developed a new BONCAT-based method for measuring rates of protein synthesis in mice and the outcomes of our mouse studies mirrored the human data, showing again that prolonged activation of the pathway occurs specifically in response to resistance exercise.
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