Nature Metabolism
@NatMetabolism
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Nature Metabolism publishes studies that advance our understanding of metabolic and homeostatic processes in physiology and disease.
Berlin, Germany
Joined December 2017
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Last Seen Profiles
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NEW ISSUE 🙌
Enjoy a weekend reading on the human
#fasting
proteome (our cool cover😎), an editorial on our NEW brief article type, as well as the latest on
#metabolism
research across the board.
0
8
26
Online now! Multifaceted mitochondria: moving mitochondrial science beyond function and dysfunction
14
181
562
Online now! Mice as experimental models for human physiology: when several degrees in housing temperature matter
3
170
504
Online now! Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo
2
136
357
Online now! Lactate helps in tissue repair by promoting efferocytosis-induced macrophage proliferation
0
93
351
Online now! Adipocytes reprogram cancer cell metabolism by diverting glucose towards glycerol-3-phosphate thereby promoting metastasis
0
110
324
Online now! Futile lipid cycling: from biochemistry to physiology
1
98
312
Online now! A practical guide for the analysis, standardization and interpretation of oxygen consumption measurements
2
87
309
Nature Metabolism is now officially open for submissions!
#metabolism
#cellularmetabolism
#diabetes
#obesity
#nafld
#physiology
#mitochondria
#aging
#senescence
#microbiome
#atherosclerosis
#exercise
4
210
296
REVIEW
Measurements of oxygen consumption rates are central to study metabolism. Divakaruni &
@MartinJastroch
(
@UCLA
,
@Stockholms_univ
) provide a guide advising on the selection of experimental models, instrumentation, analysis & interpretation of data.
2
87
294
REVIEW |
#NAD
metabolism from A-Z: The
@Auwerx_Lab
presents comprehensive coverage of basic NAD+ biochemistry, role in physiology, disease, & therapeutic potential.
#tbt
🔙
2
57
270
Online now! Iron accumulation drives fibrosis, senescence and the senescence-associated secretory phenotype
2
60
263
Online now! Hot news about temperature and lifespan
4
57
265
Online now! AMPK as a direct sensor of long-chain fatty acyl–CoA esters
2
90
253
Online now! The pentose phosphate pathway in health and disease
2
80
250
COMMENT | If you have not read it yet,
@LagzielShoval
, Eyal Gottlieb & Tomer Shlomi provide arguments & quantitative examples of why choosing an appropriate cell culture medium matters, particularly in metabolic studies.
Mind your media! 🧫
#tbt
🔙
4
72
248
Online now! Lipolysis: cellular mechanisms for lipid mobilization from fat stores
2
61
233
Online now! Non-alcoholic fatty liver disease: the interplay between metabolism, microbes and immunity
1
68
224
Online now! Mitophagy in human health, ageing and disease
0
84
221
PERSPECTIVE | Once thought simply a waste product of glycolysis, an appreciation for
#lactate
as a universal circulating fuel for mammalian cells is garnering new attention, discuss Josh Rabinowitz (
@princeton
) & Sven Enerbäck (
@uniofgothenburg
).
#Tbt
🔙
0
69
222
Online now! Iron at the intersection of macrophage–adipocyte interactions
0
48
210
Online now! Systemic induction of senescence in young mice after single heterochronic blood exchange
4
43
202
Online now! Exercise and cardiac health: physiological and molecular insights
0
72
199
Review | mTORC1 integrates nutrients, hormones, growth factor & energy signals into metabolic decisions for cell growth & survival.
@AlexValvezan
(
@RWJMS
)
@Manning_BD
(
@HarvardChanSPH
) review the physiology, pathology, & therapeutic potential of mTORC1
1
53
200
Online now! Single-cell multi-omics analysis of human pancreatic islets reveals novel cellular states in type 1 diabetes
0
43
194
Online now! Fasting drives the metabolic, molecular and geroprotective effects of a calorie-restricted diet in mice
1
41
195
Online now! Sex differences in the intergenerational inheritance of metabolic traits
2
61
188
Breaking news: our first batch of three papers will be published online on 19 November! We are thrilled to share them with the rest of the world 😀 Two more papers likely to follow in December. The rest of Nature Metabolism Issue 1 will then go live on 7 January!
0
42
189
Online now! The gut microbial metabolite formate exacerbates colorectal cancer progression
1
43
189
Online now! Optimizing metabolism is a complex issue
1
45
186
Online now! Serine catabolism generates liver NADPH and supports hepatic lipogenesis
1
46
186
First content online! Read the first three Nature Metabolism papers, ahead of Issue 1, at
#metabolism
1
69
185
CONSENSUS STATEMENT
Reactive oxygen species are complex & difficult to measure.
A group led by Murphy & Halliwell (
@Cambridge_Uni
,
@NUSingapore
) proposes guidelines on ROS nomenclature & assessment in cells, tissues & in vivo.
2
65
186
REVIEW | Zoom in on
#exercise
&
#health
:
Jones & Koelwyn (
@sloan_kettering
,
@WeillCornell
) discuss how exercise induces changes in the tumor microenvironment through immunometabolism & how this may blunt cancer pathogenesis.
#TBT
🔙
2
63
184
Online now! The aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK
1
45
179
💫 FREE to read! Led by
@MitoPsychoBio
(
@ColumbiaMed
) on Multifaceted
#mitochondria
, where authors call for more specific
#terminology
.
Have a look 👀
1
60
176
Online now! Revisiting energy expenditure: how to correct mouse metabolic rate for body mass
1
47
179
REVEIW | Normal
#cells
eventually lose their ability to divide.
@TheDrWiley
& Judith Campisi (
@BuckInstitute
) discuss metabolic inducers of
#senescence
& its cellular alterations, while highlighting interventions to mitigate senescence.
#TBT
🔙
0
54
173
NEWS & VIEWS | From the
@BarteltLab
(
@LMU_Muenchen
,
@HelmholtzMunich
):
An elegant quantitative analysis of brown fat & skeletal muscle metabolite flux reveals unpredicted fuel usage during
#thermogenesis
.
2
39
174
Online now! Mitochondrial RNA stimulates heat production in young adipocytes to reduce obesity
0
52
175
Online now! Adipose tissue macrophages exert systemic metabolic control by manipulating local iron concentrations
1
39
175
Online now! The weight-loss-independent benefits of fasting
4
51
176
Online now! Obesity causes mitochondrial fragmentation and dysfunction in white adipocytes due to RalA activation
1
48
173
PERSPECTIVE
Joshua Rabinowitz, Caroline Bartman &
@tarateslaa
(
@PrincetonChem
) provide a review of techniques for measuring, analyzing & interpreting metabolic flux in intact mammals, & how they can be applied to investigate
#metabolism
in vivo.
#TBT
🔙
0
49
175
Online now! GLUT2, glucose and oxygen sensing in CD8+ T cells
0
40
171
Online now! Exercise hormone irisin is a critical regulator of cognitive function
0
48
170
Online now! Sun exposure stimulates appetite in males
4
56
167
Online now! A homoeostatic switch causing glycerol-3-phosphate and phosphoethanolamine accumulation triggers senescence by rewiring lipid metabolism
1
55
171
Online now! Lysosomal control of senescence and inflammation through cholesterol partitioning
0
39
171
Online now! Brown fat resolves hepatic inflammation in obesity
0
48
168
Online now! Cholesterol drives inflammatory senescence
2
48
168
Online now! NAD+ homeostasis in health and disease
2
67
159
REVIEW
A team of researchers from
@UniGraz
discuss mechanisms facilitating the mobilization of intracellular fatty acids & how they affect lipid-mediated signaling, metabolic regulation & energy
#homeostasis
in health & disease.
#TBT
🔙
0
53
160
🏆 Best of
#NatMetab2022
| CITATIONS
#1
✨
Reactive oxygen species are complex & difficult to measure. A group led by Murphy & Halliwell (
@Cambridge_Uni
,
@NUSingapore
) proposes guidelines on ROS nomenclature & assessment in cells, tissues & in vivo.
1
57
163
Online now! Non-oxidative pentose phosphate pathway controls regulatory T cell function by integrating metabolism and epigenetics
1
47
163
REVIEW
The tumor microenvironment (TME) is a unique cellular landscape.
@HaigisLab
&
@ilaria_elia
(
@Harvard
) examine how
#metabolism
influences complex cell interactions within the TME, highlighting therapeutic opportunities.
#CancerResearch
#tbt
🔙
0
54
164
Review | Exercise requires coordination of nutrient sensing, delivery, uptake & utilization.
@markfebbraio
(
@MonashUni
),
@robyn_murphy1
(
@latrobe
)
&
@MattWattUnimelb
(
@unimelb
) explore factors governing intertissue communication during exercise.
1
48
163
Online now! A spatiotemporal proteomic map of human adipogenesis
0
47
161
REVIEW | Exercise coordinates nutrient sensing, delivery, uptake & use.
@markfebbraio
,
@robyn_murphy1
&
@MattWattUnimelb
(
@MonashUni
,
@latrobe
, (
@unimelb
) explore factors governing inter-tissue communication during
#exercise
. 🏋️♀️🤸♂️⛹️♀️
#tbt
🔙
0
44
162
Online now! Identifying strategies to target the metabolic flexibility of tumours
0
56
161
PERSPECTIVE | Led by
@MitoPsychoBio
(
@ColumbiaMed
):
The terms
#mitochondrial
‘function’ & ‘dysfunction’ do not do justice to the diverse mitochondrial features, activities, functions & behaviors within cells, thus calling for more specific
#terminology
.
3
45
157
⚠️ Attention
#Mito23
attendees:
FREE to read! Led by
@MitoPsychoBio
(
@ColumbiaMed
) on Multifaceted
#mitochondria
, where authors call for more specific
#terminology
.
Have a look 👀
1
51
152
NEWS & VIEWS | Angelim & Moraes-Vieira (
@unicampoficial
):
A transient burst of glycolysis is crucial for continual efferocytosis, in a mechanism that differs from the metabolic adaptation observed in pro-inflammatory macrophages.
2
26
152
COMMENT | The
#Warburg
effect describes a propensity for tumors to metabolize glucose anaerobically, even when oxygen is available.
@RJDLab
&
#notwitternav
discuss misconceptions around this phenomenon.
#cancermetabolism
#CancerResearch
#tbt
🔙
0
34
154
NEW ISSUE
✅Reviews on 1) Mitophagy and 2) Ketone Bodies
✅Original research on
#metabolism
in animal models & the clinic
Our cool cover highlights work on
#stress
& mitochondria, which provides a link between metabolism &
#emotional
disorders.
0
35
149
Online now! Glycolysis modulates efferocytosis in a noncanonical manner
0
41
149
COMMENT | The
#Warburg
effect describes a propensity for tumors to metabolize glucose anaerobically, even when oxygen is available.
@RJDLab
&
#notwitternav
discuss misconceptions around this phenomenon.
#cancermetabolism
#CancerResearch
#Tbt
🔙
0
40
149
Online now! A high-protein diet prevents weight regain
0
53
147
Online now! A leucine–macrophage mTORC1 connection drives increased risk of atherosclerosis with high-protein diets
1
62
148
REVIEW
@michael_krashes
,
@ivancedric_a
et al. (
@NIDDKgov
,
@NIH
) discuss the central mechanisms that dictate
#eating
behavior, by dissecting the neural circuits involved in food procurement, consumption, & meal termination 🧠🍽️
0
40
148
REVIEW
From
@Palmer_IMet_lab
(
@Tulane
,
@TulaneNPRC
):
Metabolic processes of immune & non-immune cells following virus recognition modulate the natural course of viral infections. Such alterations could influence longer-term manifestations of infection.
0
37
143
Online now! Illuminating the ‘healthy obese’ phenotype
3
67
145
Online now! Astrocytic OxPhos: more than just energy production
0
38
146
Online now! Short-chain fatty acids as potential regulators of skeletal muscle metabolism and function
0
51
144
Review | Discovered in 1994, leptin has revolutionized our understanding of adipose tissue & systemic metabolic homeostasis.
Jeffery Friedman (
@RockefellerUniv
) revisits the adipokine discovered with Doug Coleman & presents a new framework for obesity
0
24
142
Online now! Synthetic metabolism without the TCA cycle
1
54
142
REVIEW
Vincent Prevot,
@sreekalasn
,
@RubenNogueiras
et al. present glial cells as key mediators of energy balance through integrating peripheral signals in discrete
#brain
regions, highlighting their relevance in metabolic diseases.
1
42
141
Online now! Time-restricted feeding makes the mouse run like a pro
1
45
140
Online now! Metabolites and the tumour microenvironment: from cellular mechanisms to systemic metabolism
1
45
141
Review | In addition to supplying energy & substrate, TCA intermediates & derivatives have signalling functions in cancer & immunity, as reviewed by
@evanna_mills
,
@laoneill111
,
@echouchani
,
@FrezzaLab
Mike Murphy,
@FrezzaLab
&
@hiranprag
1
44
142
Review | Rudolf Zechner & cols. (
@UniGraz
) discuss mechanisms facilitating intracellular fatty acid mobilization & how they affect
#lipids
signaling, metabolic regulation & energy
#homeostasis
in health & disease. Check it out!
#lipolysis
#metabolism
0
37
140
Online now! Physiological and pathological roles of lipogenesis
1
41
139
Online now! Switching to the cyclic pentose phosphate pathway powers the oxidative burst in activated neutrophils
2
34
136
Online now! mTORC1 directly inhibits AMPK to promote cell proliferation under nutrient stress
1
60
133
Online now! Pre-operative exercise therapy triggers anti-inflammatory trained immunity of Kupffer cells through metabolic reprogramming
0
41
134
PERSPECTIVE | Once thought simply a waste product of glycolysis, an appreciation for
#lactate
as a universal circulating fuel for mammalian cells is garnering new attention, discuss Josh Rabinowitz (
@princeton
) & Sven Enerbäck (
@uniofgothenburg
).
#Tbt
🔙
0
40
137
Online now! Hypermetabolism and energetic constraints in mitochondrial disorders
1
43
134
Online now! Human metabolome variation along the upper intestinal tract
1
50
133
Online now! The major cap-binding protein eIF4E regulates lipid homeostasis and diet-induced obesity
1
26
134
Online now! SREBP1-induced fatty acid synthesis depletes macrophages antioxidant defences to promote their alternative activation
2
30
132
Online now! Fructose stimulated de novo lipogenesis is promoted by inflammation
2
60
128
Online now! Nuclear metabolism and the regulation of the epigenome
0
38
133
RESEARCH | From Kyeonghwan Roh et al. (
@SNUnow
):
Senescent cells accumulate cholesterol in lysosomes, which upregulates mTORC1 signaling, supporting the
#senescence
-associated secretory phenotype & promoting senescence-associated
#inflammation
.
1
35
127
#NatMetabPicks
| Published in
@NatureCellBio
, led by Anne Brunet (
@Stanford
), authors show that mono-unsaturated fatty acids extend
#lifespan
of C. elegans through induction of peroxisomes & lipid droplets in fat tissues.
1
44
131
Online now! The liver-clock coordinates rhythmicity of peripheral tissues in response to feeding
0
35
130