Carolyn Bertozzi
@CarolynBertozzi
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Prof. @StanfordUChem ; Baker Family Director, @Stanford_ChEMH ; @HHMINews Investigator; EIC of @ACSCentSci ; She/Her 🏳️🌈
Stanford University
Joined March 2012
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Pinned Tweet
People are asking me about the origins of and key milestones in the timeline of
#bioorthogonal
chemistry, so here is a quick summary. 1/n
BREAKING NEWS:
The Royal Swedish Academy of Sciences has decided to award the 2022
#NobelPrize
in Chemistry to Carolyn R. Bertozzi, Morten Meldal and K. Barry Sharpless “for the development of click chemistry and bioorthogonal chemistry.”
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Thanks Tom! Maybe we can get the band back together someday 😉 “Ve-Ri-Loud”
@Harvard
Congrats to my former
@Harvard
bandmate
@CarolynBertozzi
on her
@NobelPrize
in chemistry! We won the Ivy League Battle of the Bands in 1986 with our rockin’ group ‘Bored Of Education’, with her on keyboards & me in spandex.
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By tradition,
@Stanford
@NobelPrize
Laureates are invited to join a football game as celebratory guest 🏈. That was a fantastic experience two weeks ago, but what about women’s athletics, I asked? 1/4
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Turns out, no one had ever considered the idea, perhaps because I am the first woman Nobel Laureate
@Stanford
. They responded by making me honorary coach of our championship women’s volleyball team
@StanfordWVB
for the day 🏐! 2/4
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@BerkeleyLab
@tmorello
@Harvard
@NobelPrize
Here are a few I found of the incomparable
@tmorello
circa 1986
@Harvard
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Next month I will have the equally incredible honor of joining our amazing women’s basketball team for a game
@StanfordWBB
🏀. So honored to support Stanford Athletics in this way. 4/4
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Garbage alert: this “big authorship data” analysis stumbles on what we already know about gender bias in academia, then stupidly advises that the key to women’s success is to avoid female mentors and instead align with privileged males. Who reviewed this?
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Iranian women are showing the world what courage looks like, standing up for their very basic human rights in an historic movement 💪, freedom of thought, freedom of speech, and autonomy as human beings are cornerstones of a just society and essential for advancement of science.
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Incredibly disrespectful to legions of biopharma (and academic) scientists and physicians who dropped everything to deploy their skills for
#COVID19
, on no sleep, progressing toward diagnostics, therapeutics and vaccines at unprecedented pace. Finest people in their finest hour.
Sanders: “In the midst of this epidemic, you’ve got people in the pharmaceutical industry saying, ‘Wow,’ <rubs hands together> ‘what an opportunity to make a fortune.’”
#COVID19
#DemDebate
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It would be great if
@ChemicalScience
could help me share this message 😃
Impactful words by
@CarolynBertozzi
today on how diversity in her trainees enabled creativity, not playing by the rules, and ultimately the work that built the field of bioorthogonal chemistry. Diverse science leads to better science!
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Legendary chemist and educator
@drdre4000
profiled
@Nature
TikTok’s dancing chemist catalyses joy in students
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Important article about the extra burden minoritized academics often bear in the form committees and service, important work that is rarely valued in promotions, problem that needs to change while greater care is taken to avoid overburdening.
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Deeply honored and grateful to join this list of spectacular scientists
The Wolf Prize in Chemistry 2022 is awarded to Professors Bonnie L. Bassler, Carolyn R. Bertozzi, and Benjamin F. Cravatt III 3/6
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One thing we all agree on is that science is of great benefit to humanity
@amyklobuchar
@RandPaul
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People are asking me to share an old photo of me and my younger sister Diana with Larry Bird (~1986). Our mother insisted we stand in line for hrs to get his signature on that poster, which hung in our house like a shrine. She was an avid
@celtics
fan, d. Oct 16, 2021 ❤️🩹
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Thank you
@POTUS
for taking the time to meet with us, and for your enduring support of science and education 🙏
Yesterday I met the 2022 U.S. Nobel Prize Winners in Chemistry, Physics, and Economic Sciences. They've created some of the most exciting breakthroughs in human understanding and have expanded our sense of possibility.
Congratulations, Dr. Clauser, Dr. Bertozzi, and Dr. Diamond.
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My sister Diana is a health care worker in NJ, she had and recovered from COVID-19, now back at work in the COVID ward working double shifts. There is no break for these warriors.
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Small RNAs are modified with N-glycans and displayed on the surface of living cells - ScienceDirect
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Mind racing with emotions after the shock of this news, Sabatini fired from MIT/HHMI for sexual harassment/toxic behavior. Reactions suggest his behavior was an open secret for >decade. My line is open for survivors and trainee refugees whose careers are (temporarily) derailed.
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🤦♀️
A Nobel laureate claimed antimale discrimination. An early-career researcher called it out | Science | AAAS
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Twitter at its best: I retweeted a posting about an open postdoc position, an academic follower saw it and pointed it out to his student who was looking for postdoc, she applied and it turned out to be a great match, the deal is done! Love it.
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Thank you
@AmerChemSociety
for this tremendous honor, and for all you do for the "central science" 🙏
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And so many applications of bioorthogonal chemistry beyond glycan labeling, too many to recount. It has been an amazing ride of mechanistic and synthetic chemistry, cell biology and most recently clinical translation. 27/fin
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Outsider no more!
An outsider parachuted into the US system in 2014, I quickly learnt that there was no one to speak for me. Thank you for de-orphanizing me,
@CarolynBertozzi
@taekjip
@KirchhausenLab
2/6
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When we recruited
@doudna_lab
to
@berkeleyMCB
and
@UCB_Chemistry
in 2002 we already saw her as high potential for
@NobelPrize
for her groundbreaking work in RNA structural biology and enzymology. I still contend she is worthy of a second! Nice to see Wikipedia keeping pace:
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Wonderful recognition of what it took to develop a revolutionary new class of vaccines and medicines based on mRNA, congratulations!
BREAKING NEWS
The 2023
#NobelPrize
in Physiology or Medicine has been awarded to Katalin Karikó and Drew Weissman for their discoveries concerning nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19.
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“In my training and career across seven institutions…I have only been taught by three Black professors. It would have made such a difference to have seen more faculty who looked like me. I hope I can make that difference for future students.”
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Thank you
@UCB_Chemistry
for this incredible honor, made even deeper by decades of memories working in Latimer Hall and gazing at the legends on that wall. Extra special that I share the space with the other two American women who have won the prize, all in the great state of CA
🎉🎉🎉We were delighted to host a reception to unveil the
@CarolynBertozzi
plaque in Latimer Hall last week celebrating her Nobel Prize. Prof. Bertozzi is an alumna & former professor at the College. She is the 3rd woman associated with our College to win the prize.
@NobelPrize
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PERFECTION!
BREAKING NEWS:
The 2020
#NobelPrize
in Chemistry has been awarded to Emmanuelle Charpentier and Jennifer A. Doudna “for the development of a method for genome editing.”
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A special day in Washington DC with physics
@NobelPrize
Laureate John Clauser and 2-time chemistry Nobel winner Barry Sharpless, all from the great state of CA!
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Whoa, just noticed that
@verified
came through! Thank you all the supporters who joined my little chorus!
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Fun fact: The grad student who did this work, Eliana Saxon, was the third person I pitched the project to. The first two thought it wouldn't work and took a pass. Eliana got her first big results during the summer before grad school even started! 16/n
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Glycans are the most diverse and structurally complex of all biopolymers. They are found attached to proteins, lipids and, yes, RNA on cell surfaces and are sometime free on their own, and they are “read” by glycan binding proteins that orchestrate cell-cell interactions and more
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Look who showed up in Stockholm!! Great celebrating with the
@UCB_Chemistry
grad student team that built the house of
#bioorthogonal
chemistry 🙏 . Can you name the now-famous scientists in this photo?
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Exciting announcement - JHU to name new building after Henrietta Lacks who gave us the HeLa cell line
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Let me acknowledge the brilliant work of Prof. Dr. Rolf Huisgen, who passed in 2020 just a few months shy of his 100th birthday (). I had the great privilege of meeting him at Univ. Munich in 2012, where he sat in the front row for my lecture😅. 1/n
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One might consider this as a prize for use of the C-glycoside pseudouridine to reduce RNA immunogenicity, another win for
#glycotime
!
BREAKING NEWS
The 2023
#NobelPrize
in Physiology or Medicine has been awarded to Katalin Karikó and Drew Weissman for their discoveries concerning nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19.
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My superstar lab manager made this cool graphic of our group members, Halloween style 🎃
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Thanks for the birthday note
@UCBerkeley
@UCB_Chemistry
and
@BerkeleyLab
, best wishes from that “other school” 😂
Happy Birthday to Carolyn Bertozzi,
@Cal
Ph.D. 1993 & Professor of Chemistry 1996-2015. She won the 2022 Nobel Prize in Chemistry "for the development of click chemistry and bioorthogonal chemistry," for work done primarily at
@BerkeleyLab
, though she is now at some other school.
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My scientific hero
@francesarnold
@Caltech
just won the
@NobelPrize
. What a fabulous day this has turned out to be. 🌈🍾🎉
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What an incredible honor to share a selfie with the talented
#GilliamFellows
@HHMINEWS
! Looking forward to seeing them many more times as their careers skyrocket 🎉
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The
@WolfPrize_
ceremony is extra special when shared with good friends like Ben Cravatt!
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Overheard a conversation about trainees preferring career paths that differed by gender. So I analyzed permanent jobs of my own former trainees to see how it breaks down, data as follows. Some observations...
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As a postdoc
@UCSF
in Steve Rosen's lab, I was struck by how powerful live cell and in vivo imaging tools for proteins and nucleic acids had become, while cell-surface glycans remained in accessible. 2/n
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I am excited to announce that Nathanael Gray and Priscilla Yang are moving to
@Stanford
!!Nathanael will join us
@Stanford_ChEMH
and Dept of Chem & Sys Biol and Priscilla will join Dept of Micro & Immunol, supercharging chem bio on The Farm🔥
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This is kindest, most meaningful and humbling thing a person could ever say about a coworker. I am so touched by this blog
@Koopgirl
, we miss you too!!
A good win – View From an Irish Back Yard
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What I love most about the mRNA vaccines is their reliance on 1-methyl-pseudouridine, a synthetic C-glycoside, to avoid innate immunity while enhancing translation.
#glycotime
to the rescue once again!
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Congratulations David Macmillan
@MacMillan_Lab
and Ben List! A cause to celebrate pure organic chemistry and two extraordinary chemists 🎉🥂
BREAKING NEWS:
The 2021
#NobelPrize
in Chemistry has been awarded to Benjamin List and David W.C. MacMillan “for the development of asymmetric organocatalysis.”
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Honored to be among the incredible people associated with this award, and deeply grateful to my coworkers/trainees
@UCB_Chemistry
,
@Stanford_ChEMH
and
@StanfordUChem
, whose work is being recognized by the
@hein_prizes
.
#breaking
Biochemist Carolyn Bertozzi is receiving the Dr H.P. Heineken Prize for Biochemistry and Biophysics 2022 for her ground-breaking research into communication between cells and methods of influencing this communication. Read the press release:
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Poignant 🧵 by
@glycocode
, my first grad student
@UCB_Chemistry
who took a chance on a new prof and launched us on the path we walk today. We shared experiences of prejudice and obstacles, and, ultimately, triumphs. And of course a love of
#glycotime
!
This thread is on how diversity in science can lead, via direct and indirect ways, to amazing things and a reminder that scientists like
@CarolynBertozzi
#NobelPrize2022
also faced adversity and roads that were not always smooth.
#CRBStories
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@grubreport
This 👆entire thing happened to us today as well! But it was my kid who changed his name to “this video sucks” and got an unpleasant email from teacher. All while I zoom lecture and meet with Deans etc.
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Amazingly, the Staudinger ligation could be performed in live animals, a feat accomplished by
@jenn_prescher
@UCIrvine
and Danielle Dube
@BowdoinCollege
. A first-in-class achievement by these intrepid young chemists, published
@Nature
in 2004: 17/n
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Another brilliant
@LEGO_Group
avatar by the great
@20tauri
! 🙏 Can I get one for my office collection?
Happiest birthday,
@CarolynBertozzi
! In light of last week's Nobel news, I gave your minifig an update ;-)
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Please consider
@ACSCentSci
for more chemical/biochemical work, we are open access with no fees for authors or readers! $0
After a tweet from yesterday, I was curious so I graphed open access fees vs impact factor for a handful of journals my lab would potentially publish in
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Excited to speak at the Chinese Bioscience Association today, what a thoughtful gift from CBA sponsorship director Charlie Ao!
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We figured out how to do just that with the "Staudinger Ligation" as we called it (and others added my name later on, "Bertozzi-Staudinger Ligation", 🥳). This was the next big story from our lab, published
@ScienceMagazine
in 2000: 15/n
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@michelleoyen
Actually I have always appreciated how I can just be myself as an academic scientist, dress as I want, look as I want, with a lot less pressure to conform to feminine appearance pressures that women in other sectors are subjected to. Frees up tons of time as well!
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Wow, I am so happy to see this work, single molecule imaging of glycoproteins and glycolipids showing attachment sites of glycans. Breathtaking to see these
#glycotime
images!
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Questions like, what kinds of sugars are expressed on different cell types and how do they change upon perturbation, could not be answered without destroying cells and much labor. The first project I worked on illustrates the point. 3/n
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Grateful for this recognition of the hard work of my many trainees over >25 years 🙏
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Lara Mahal
@glycocode
@UAlberta
and Kevin Yarema
@JohnsHopkins
pulled it off with this amazing study, the first big paper from my fledgling lab. 9/n
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A tremendous honor to join the list of Carty Award recipients, looking forward to celebrating with all the scientists at the NAS meeting.
We’re honoring
#NASmember
@CarolynBertozzi
of
@Stanford
@HHMINEWS
with the 2020 John J. Carty Award for the Advancement of Science for her invention of bioorthogonal
#chemistry
!
#NASaward
#PhysicalSciences
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I was teaching first semester organic chem as I often do, and in the course of writing my annual lecture on ring strain a thought came to mind. Perhaps a strained alkyne in a ring system would react faster. 21/n
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This is devastating news, we lost a superstar. Sammy's work
@BlackInChem
will have a lasting positive effects in our field, we must be diligent in honoring her legacy by carrying on the work.
It is with utmost sorrow and heavy hearts to announce the passing of our President and Co-Founder of BlackinChem, Samantha “Sammy” Mensah. She was a phenomenal activist, leader, inventor, science communicator. and a doctoral candidate in chemistry at UCLA. (1/3)
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Congratulations to
@StevenMBanik
and the team on their publication of
#LYTACs
@nature
. Steve joins our faculty
@Stanford_ChEMH
and
@StanfordUChem
in Jan 2021, great opportunity for new students and postdocs.
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Kudos to
@nature
for calling attention to this issue of STEM conferences held in hostile locations: “A decision to host in an LGBT+ hostile country should never be taken lightly”.
Nature is proud to support Pride in STEM
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Thank you again
@NagoyaUniv
and host
@Itamilab
for this beautiful medal and the honor of sharing the work of my students and postdocs with such a distinguished audience.
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This is an incredible honor and I look forward to the chance to celebrating with the amazing faculty, students and postdoc
@TAMUChemistry
once we are all back in action!
.
@Stanford
chemist,
@theNASciences
member & bioorthogonal chemistry founder
@CarolynBertozzi
has been selected to receive the 2020 F.A. Cotton Medal for Excellence in Chemical Research, presented by
@TAMUChemistry
& the
@TAMU
Section of
@AmerChemSociety
:
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Look who I (finally) got to meet in person! It’s about time I got a selfie with the great
@jenheemstra
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I wonder if they stopped for a moment to think it through one more step: once those male-enabled women finish their training and become a mentor themselves, who will be advised to work for them? This paper is a joke, not a funny one unfortunately.
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As a postdoc I had a serendipitous encounter with the great Prof. Dr. Werner Reutter at a boutique conference in Southampton, England, where he talked about sialic acid biosynthetic enzymes tolerating unnatural substrates: 5/n
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Woo hoo!
Based on our exhaustive research, scientists will be more successful by choosing mentors and/or mentees whose last name starts with 'B'. Wondering where I could submit this...
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Congratulations to this trio, quantum dots for the win!
BREAKING NEWS
The Royal Swedish Academy of Sciences has decided to award the 2023
#NobelPrize
in Chemistry to Moungi G. Bawendi, Louis E. Brus and Alexei I. Ekimov “for the discovery and synthesis of quantum dots.”
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This one was a long time coming and wonderfully deserved, a discovery that has impacted the world in such a tangible way. I say this as someone who sleeps with her phone under the pillow!
The 2019
#NobelPrize
in Chemistry has been awarded to John B. Goodenough, M. Stanley Whittingham and Akira Yoshino “for the development of lithium-ion batteries.”
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Postdoc
@raflynn5
and I are keen for feedback on preprint posted
@biorxivpreprint
. He made the shocking discovery that Y RNAs + other small RNAs are modified in the secretory pathway with N-glycans. Thus begins the new world of “glycoRNA”.
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Methods for imaging and profiling sugars on live cells/animals were lacking, a clear unmet need that I thought might be tackled with chemical approaches. But how to do it? 4/n
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In celebration of today’s chemistry
@NobelPrize
here is a look back to a wonderful contribution
@ACSCentSci
🎉
Quantum Dots with Highly Efficient, Stable, and Multicolor Electrochemiluminescence | ACS Central Science
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It’s official, I am an honorary member of the
@francesarnold
lab! Thanks for the T-shirt, what a great way to celebrate chemistry
@NobelPrize
.
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😮 🤯
Replace an aromatic carbon with nitrogen, leave the rest of the skeleton the same. A huge first step towards the problem I started my lab to tackle, thanks to
@tyler_j_pearson
,
@ryoma_ous
,
@DriscollJuliaL
,
@balu_dherange
, and Dong-Il.
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Interesting study by
@DirkTrauner
and coworkers
@J_A_C_S
, attachment of medium chain lipids to small molecule drugs enhances their cell permeability.
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Thalidomide is a molecular glue degrader that acts via cereblon binding.
@drcmwoo
and collaborator
@MattRPratt
discovered that cereblon mediates degradation of endogenous protein cyclic imides, a form of protein damage. Art imitates life!
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Prof. Huisgen's foundational 1950's work set the stage for the most important reaction in chemical biology, a development he could not have foreseen in the moment. As well, we don't know today what the impact of our work will ultimately be. Support curiosity-driven basic science.
We are sad to hear that Rolf Huisgen, best known for research on 1,3-dipolar cycloadditions, has passed away. Sharpless included and extended this work in his Click Chemistry.
#chemheroes
Huisgen's
#Classicsinchem
:
Click Chemistry:
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Look I am sitting next to at
#ACSSpring2023
!!
@LewisLabMSKCC
, pioneer of in vivo human (!) bioorthogonal chemistry
@MSKCancerCenter
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Congratulations collaborative team lead equally by
@GabbyTender
@KayvonPedram
and
@ShonJs
, w/coworkers from
@LImmunotherapy
and Weaver labs. Mucins drive cancer progression; we drugged them with targeted mucin proteases.
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Whoa, covalent RNAylation as a newly discovered protein modification!
#glycoRNA
has some good company.
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Awesome news! Polly Fordyce
@fordycelab
@Stanford_ChEMH
is the recipient of the 2023 Eli Lilly Award in Biological Chemistry! Her revolutionary work on high throughput quantitative methods to study proteins and enzymes will be showcased in a special award Symposium
#FallACS2023
!
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So happy to have our lab holiday party in person, complete with white elephant gift game. What a privilege to work with this talented team!
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Powerful story by
@Shenvi_Lab
on his experience as nearly solo caregiver to 4 young children during his partner’s residency while running his lab as young prof, testimony to the challenges faced by working parents and importance of mental health.
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We lost a lion of organic synthesis. I took first semester organic chem from Dave in Fall 1985 when I was a bio major premed. Thanks to his amazing teaching, I fell in love with the subject and switched my major to chem. He forever altered the course of my life. Thank you Dave!!
Breaking news courtesy of Kevin Campos and Dave MacMillan, from Sally Evans.
Dave passed away last night. This pic that they included is how Dave looked during my days in his group. Circa 1985-87
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The tolerance of that pathway for nonnative acyl groups got me thinking about whether metabolism could allow delivery of chemical handles to cell surface sialic acids for covalent labeling with imaging probes. But what type of chemistry would allow this in living systems? 6/n
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Take a first look at direct image of single glycan molecules, wow! Historic accomplishment for
#glycotime
Imaging single glycans | Nature
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This form of "copper-free click chemistry" had all the right stuff for in vivo imaging. Scott Laughlin
@stonybrooku
and
@basktasktic
performed an elegant study of dynamic changes in cell-surface glycans during zebrafish development
@ScienceMagazine
: 25/n
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There is 6th factor they do not mention that might contribute to the disparity: many covid papers were obviously rushed and are of low quality. Perhaps women researchers are less willing to submit low quality papers.
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