MacMillan Group
@MacMillan_Lab
Followers
22K
Following
389
Media
726
Statuses
1K
Shining light on organic chemistry
Princeton, NJ
Joined June 2015
Old tissue, new tricks??.We introduce μMap-FFPE—a high-resolution protein photoproximity labeling platform for archived FFPE tissue. Check out this paper for your spatial proteomics needs and to learn more about CD20 in clinical tissue samples. 📃:
pubs.acs.org
Many disease states can be understood by elucidating small-scale biomolecular protein interaction networks, or microenvironments. Photoproximity labeling methods, like μMap, have recently emerged as...
1
7
55
RT @PrincetonChem: With thanks to these esteemed early-career researchers Steve, Sijbren, Alex, Kristina, and Erik who presented at yesterd….
0
2
0
RT @PrincetonChem: ‘Tis the season! Here, Noah Bissonnette of the @MacMillan_Lab during his dissertation defense, and being introduced by a….
0
1
0
Alcohols + aryl acids = C(sp3)–C(sp2) bonds! In collaboration with @LongLabCal & Merck Boston, we combine NHC-deoxygenation & Ni-catalyzed decarbonylation to link overlooked building blocks. Congrats Eva, Johnny, Edna, Stephanie, Kurtis, Cesar & Ryan!.
pubs.acs.org
Alcohols and aryl carboxylic acids are among the most commercially abundant, synthetically versatile, and operationally convenient building blocks in organic chemistry. Despite their widespread...
2
13
207
RT @PrincetonChem: Thrilled to announce that Brandon Bloomer of the @MacMillan_Lab has been named a 2025 @BeckmanFnd Postdoctoral Fellow in….
0
3
0
Check out our newest work in Chem to achieve 3-functionalization of BCPs to access diverse aryl bioisosteres. Congrats Kat!. Give it a read here:
cell.com
Growing interest in C(sp3)-rich bioisosteres has driven efforts to synthetically manipulate bicyclo[1.1.1]pentane (BCP) scaffolds. The strained geometry of BCPs imparts high C(sp3)–H bond-dissociat...
1
10
169
Want to selectively couple two radicals?. You're in luck! . Check out our newest work in Nature where we use dynamic orbital selection to unlock alkylation of native aryl C–H bonds. Congrats to @GrosskopfJo, Charlene, Robert, and Alex!. Read more at:
6
51
345
RT @ckellzchem: Spring into some great seminars from @POCC_Chem ! Next week's installment is @PrincetonChem very own @dmac68 for our Allan….
0
6
0
Check out our latest work in JACS, where we sort nitrogen-centered radicals and alkyl radicals across alkenes in a regioselective aminoalkylation reaction. Congrats to Will, Johnny, and our collaborator Jesús from Janssen Spain!.
pubs.acs.org
The direct synthesis of C(sp3)-rich architectures is a driving force for innovation in synthetic organic chemistry. Such scaffolds impart beneficial properties onto drug molecules that correlate with...
1
24
207
RT @J_A_C_S: Parallel Proteomic & Transcriptomic Microenvironment Mapping (μMap) of Nuclear Condensates in Living Cells Journal of the Amer….
pubs.acs.org
Cellular activity is spatially organized across different organelles. While several structures are well-characterized, many organelles have unknown roles. Profiling biomolecular composition is key to...
0
22
0
Check out this latest work in JACS from Steve, Roderick, Niels, Brandon, Philip, and Iakovos! 🎄
pubs.acs.org
Cellular activity is spatially organized across different organelles. While several structures are well-characterized, many organelles have unknown roles. Profiling biomolecular composition is key to...
🎄A new festive µMap photocatalyst and an RNA-seq workflow for profiling the proteomic & transcriptomic magic of nuclear condensates. 🎁🎁🧬🔬Big congrats to Roderick, Niels, Brandon, Philip, Iakovos and @MacMillan_Lab for this Christmas miracle! ✨✨✨
0
3
30
Nothing like a little holiday cheer in the lab! Our chemistry department got a surprise visit from therapy dogs today—bringing smiles, tail wags, and a much-needed break from the bench. 🐾✨ #LabLife #HolidayCheer #TherapyDogs #ScienceAndSmiles
0
2
57
Check out our latest work in JACS— Access to a nucleophilic Fe(I) complex allows for activation of 1° electrophiles via an SN2-type mechanism. Subsequent SH2 bond formation enables all-carbon quaternary centers. Congrats Andria, Felix, Wei, and Marissa!.
pubs.acs.org
Quaternary carbon centers are desirable targets for drug discovery and complex molecule synthesis, yet the synthesis of these motifs within traditional cross-coupling paradigms remains a significant...
1
41
349
Our latest chemical biology paper is out now in JACS! We developed a platform to profile the phagocytic surface proteome in a temporally resolved manner. Congrats to Sean, Jacob and James! @HuthSean @JacobGeri1 @JamesO760.
μMap-Interface: Temporal Photoproximity Labeling Identifies F11R as a Functional Member of the Transient Phagocytic Surfaceome | JACS @Princeton @PrincetonChem #muMap #Photoproximity #Labelling #F11R #Functional #Transient #Phagocytic #Surafeceome
1
9
54
RT @PrincetonChem: It was a pleasure for the @MacMillan_Lab to host high school organic chemistry students from the @TrevorDaySchool in NYC….
0
1
0
Check out our latest article in Nature Chemical Biology where an intracellular micromap proximity labeling platform is established to investigate stress granule disassembly mechanisms. Congrats to Roderick, Steve and Sean!.
nature.com
Nature Chemical Biology - Pan et al. establish a general photoproximity labeling approach in living cells, applying microenvironment mapping with a HaloTag-based platform (HaloMap) to profile the...
1
18
140
Farewell, Vittorio and Ryan! It's been a pleasure having you both in the lab, sharing your knowledge and passion for chemistry. Wishing you all the best in your next adventure. You'll be missed! #SafeTravels
1
4
83
Congratulations to our German postdoc Johannes Grosskopf (@GrosskopfJo) who has been awarded the 2024 Albert-Weller award by the German Chemical Society @PhotochemGDCh for his outstanding contributions to photochemistry as a young academic. Well done, Johannes!
5
4
61
For any cyclopropane fans – ICYMI, see our latest report in @Nature. Using one-electron logic, iron carbenes can be made from simple reagents like lactic acid, trifluoroethanol or alanine. Congrats to Ben, Nate and our awesome collaborators at Janssen!.
nature.com
Nature - Metal carbenes are accessed using a metallaphotoredox platform that exploits iron carbene reactivity using readily available chemical feedstocks and α-elimination.
1
17
162
RT @PrincetonChem: Congratulations to the @MacMillan_Lab for their latest, just out in @Nature: “Unlocking carbene reactivity by metallapho….
0
40
0