Dirk H. Trauner
@DirkTrauner
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Penn Integrates Knowledge Professor, Natural Product Aficionado, Photopharmacologist, Fox Terrierist, and Unfulfilled Architect. #firstgen
Philadelphia, PA
Joined December 2017
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I am honored to announce that I will join the University of Pennsylvania this summer as a PIK Professor.
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How are six membered rings drawn in the chemical community? Here is my strategy. Please reply with yours!
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It should be community standard to put your name first in your CV if there is a shared co-first authorship and equal contribution, regardless of the actual order in the paper.
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On August 1, 2000, I started my independent career at UC Berkeley. Amazing what 20 years of peer review and faculty dinners can do to you. But I would not trade this job for any other.
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Check out our paper on Tetrodotoxin, a truly intoxicating molecule! Thanks to all involved in this project:
@DavidBKonrad
,
@PeterRuehmann
, Hiroyasu Ando,
@BelindaHetzler
, Nina Strassner,
@houk1000
Bryan S. Matsuura.
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Check out our course on "Synthetic Design". We will post the course notes as we go along.
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Sadly, Rolf Huisgen passed on yesterday. He almost lived for a hundred years and embodied the Golden Age of Organic Synthesis. We cannot give him a proper funeral now but there will be a time when we will gather to celebrate his life and legacy.
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I have postdoctoral positions to fill thanks to generous NIH R61 and BRAIN initiative funding. Please apply if you are interested in working at the interface of synthesis and neuroscience or spread the word/retweet!
@NYU_CNS
@nyuchemistry
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First days at UPenn. It starts on a promising note with free ice cream.
@PennSysPharmATT
@Penn
@PennChemistry
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1/2. We are looking for postdocs with a strong synthetic streak who take pride in a successful purification and structure elucidation, have independent ideas, are passionate about research, and can advise and train junior graduate students.
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Our first paper on SARS-COV2 inhibitors is online, thanks to a COVID-19 Catalyst Grant by NYU. Small molecules will be indispensable to fight coronaviruses. Chances are that they will be as successful as those developed for HIV and HCV.
@nyuchemistry
@DanNomura
@UCB_Chemistry
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LSD meets LED... Check out our first paper on the optical control of serotonin receptors. Another enjoyable collaboration with
@mo_hannes
and the Levitz lab at
@WeillCornell
.
@nyuchemistry
,
@NYULH_Neuro
@5HT_Society
@
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There is a silver lining in this crisis:
A) We are reading papers as opposed to traveling and dropping talks; B) We try to speak a common language, as opposed to talking past each other; C) We develop a common sense of purpose. Great science will emerge from this.
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Tetrodotoxin!
Thanks to NSF and an incredible team of chemists.
@nyuchemistry
@LMU_Muenchen
@NYULH_Neuro
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Sadly, Albert Eschenmoser has passed. He continues to be a huge inspiration. I will always remember a 3 h postdoc interview I had with him, in which I learned more about conformational analysis than in all the years before.
@ETH_DCHAB
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Join us at the 2024 Natural Products and Bioactive Compounds Gordon Research Conference (and retweet)! We have a fantastic lineup:
@GordonConf
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Check out our new paper on arming a cysteine-reactive electrophile with light. Thanks to a collaboration with Stefan Laufer and Stefan Knapp.
@goetheuni
@uni_tue
@nyuchemistry
@photopharma_lit
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Excited to announce an incredible lineup for Photopharmacology III. Our website is live, please sign up (it's for free) and submit a poster. Please RT and spread the news!
…
@photopharma_lit
@MolSwitches
@nyuchemistry
@chemuoft
#RealTimeChem
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Triquinacene by Woodward. There ought to be ONE molecule of dodecahedrane in this sample.
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Exciting stuff from
@Mp_Chemist
@nyuchemistry
. We need to start teaching nitro groups as (excitable) 1,3-dipoles.
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Exciting opportunity at UPenn! We are looking for a junior colleague in the broadly defined area of Organic Chemistry. Please spread the word, retweet, and apply.
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Happy birthday, America. Thank you for letting me live the American Dream. We must fight every day to make sure that dream is as true for a Black child born in Minneapolis as it was for a white chemist born in Austria and an Asian colorist born in Malaysia.
Happy birthday, America. Thank you for letting me live the American Dream. We must fight every day to make sure that dream is as true for a Black child born in Minneapolis as it was for a white bodybuilder born in Austria. via
@attn
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It's great to see so many of my science heroes on this list:
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New course material on stereoselective oxidations and reductions posted:
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For the chair I do this. Most importantly, the lines have to be pairwise parallel. It hurts otherwise."It's not a pet peeve, it's a major psychotic hatred." (George Carlin)
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Check out or latest paper merging photoswitches and natural products. Subcellular control of the
#actin
#cytoskeleton
with light.
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Thrilled to be named Honorary Skou Professor at Aarhus University, home of the Na,K-ATPase and other beautiful molecular machines.
@PennChemistry
@PennMedicine
@AarhusUni_int
@staev01
@PoulNissen
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I had a great time with the Queer in Chemistry students at Princeton and their allies. Thanks for hosting me and congratulations on the program.
@PrincetonChem
@nyuchemistry
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Check out our latest foray into natural product synthesis, working on beautiful Lycopodium alkaloids.
@nyuchemistry
@PennChemistry
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Dogs have occupied human beds since at least 500 years and there is nothing you can do about it.
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Working hard that synthesis, by the people, for the people, shall not perish from the earth.
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Excited to speak "at Scripps" tomorrow, 2-4 PM Pacific time, 5-7 PM Eastern. You are welcome to zoom in:
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Our latest paper on cell-specific Proximity Photopharmacology is out. Now targeting dopamine receptors with a photoswitchable agonist.
@nyuchemisty
@IsacoffLab
@UCBerkeleyNeuro
@photopharma_lit
@MolSwitches
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I look forward to speaking in the gorgeous new chemistry building at the University of Zurich
@UZH_Chemistry
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It was a pleasure to give a talk at the ETH in Zurich, where great chemistry meets great architecture
@morandilab
@CarreiraGroup
@ETH_DCHAB
@bode_lab
@klanglab
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Check out our paper on the optical control of translation with a puromycin switch - in neurons! A collaboration with
@tongil_ko
@KlannLab
@mo_hannes
#ribosome
#photopharmacology
#translation
#puromycin
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I am honored to serve as the 2023 Eun Lee Lecturer. Very much looking forward to exchanging ideas with my Korean colleagues an immersing myself into Korean culture!
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I am excited to serve as vice chair of the 2023 Natural Products and Bioactive Compounds Gordon Research Conference. The amazing program was put together by Philip Kym (AbbVie). Registration is now open!
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Just a reminder that this awaits you after a long, cold winter.
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Check out or review on the prevalence, synthesis, and meaning of racemic natural products:
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Woke up this morning to learn that Ben List and David MacMillan won the Chemistry Nobel Prize!!!
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Please join us for the NYU Chemical Biology Symposium via Zoom next Friday, August 7, 2020. We have a great lineup of speakers!
@aroralabnyu
@traasethlab
@nyuchemistry
@nyuniversity
@NinaHartrampf
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Introducing a selective allosteric agonist for a GPCR (mGluR2). The latest result of our ongoing collaboration with the
@IsacoffLab
, now in its 18th year.
@DavidBKonrad
@photopharma_lit
@MolSwitches
@nyuchemistry
@UCBerkeleyNeuro
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Lipopeptides, here we come! Check our our first paper on photo-lipopepetides, in a wonderful collaboration with
@tongil_ko
,
@daniel_abegg
,
@AdibekianG
,
@hanzyduzit
. Lipids love azoarenes.
@angew_chem
@PennChemistry
@PennSysPharmATT
@UPennPhysiology
Photoswitchable lipids enable optical control of lipidated natural products. Here we show this for the lipopeptide-polyketide hybrid NP cepafungin I. Great collaborative effort!
@tongil_ko
@daniel_abegg
@AdibekianG
@hanzyduzit
@DirkTrauner
@angew_chem
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Check out our new paper on A-74528, quite the Type II polyketide.
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Thanks to the organizers of the 2nd Alpine Winter Conference. Science and Skiing is a great combination!
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Happy to announce the result of a wonderful collaboration with Ken Houk and his team: the bioinspired synthesis of PF-1018.
@houk1000
@angew_chem
@Total_Synthesis
@nyuchemistry
@uclachem
@TotalSyntheses
@totalsynthesis
#biomimetic
#polyketides
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When you clean out your office you come across old friends who you are very, very familiar with. The best textbook ever written!
@Clayton5235
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Registration is now open for the GRC on Artificial Molecular Switches and Motors. Please join us for lively discussions on how to harvest energy and information with molecules and put them to work for the benefit of humanity.
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New course material on strategic applications of Diels-Alder reactions and 1,3-dipolar cycloadditions posted:
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Check out our paper on the optical control of Eg5, a motor protein crucial to mitosis:
Thanks to a wonderful collaboration with
@GennerichLab
,
@HessLabColumbia
.
Brought to you by
@nyuchemistry
,
@NYULH_Neuro
.
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!!!
BREAKING NEWS:
The Royal Swedish Academy of Sciences has decided to award the 2022
#NobelPrize
in Chemistry to Carolyn R. Bertozzi, Morten Meldal and K. Barry Sharpless “for the development of click chemistry and bioorthogonal chemistry.”
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Somebody is exhausted from a long Christmas morning walk. Happy Holidays everybody and may peace be upon you.
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As we have said before: Lipids and azobenzenes are a match made in heaven!
@nyuchemistry
@ChemBioChem
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It hurts to lose Ned Seeman, Crystallographer and DNA Wizard.
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Check out our paper on Photoactivated Protein Degraders for the Optical Control of Synaptic Function. Great collaboration with André Fenton and his team
@FentonLab
.
@NYU_CNS
,
@PennChemistry
,
@PennSysPharmATT
,
@PGGUPenn
,
@UPennPhysiology
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As we are celebrating Schatzi’s Fifth Birthday today, I want to remind everybody that Liebig isolated kynurenic acid in 1853 from dog pee.
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Optical control of the Actin cytoskeleton! Thanks to a collaboration with the Arndt Group at Jena and our former colleagues at LMU Munich.
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Congratulations to Katalin Karikó and Drew Weissman! Excited about the future of RNAs and LNPs at UPenn.
@PennMedicine
@PennChemistry
@BMBGGUPENN
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One, Two, Three:.....Biomimetic Synthesis Elucidates the Origin of Preuisolactone A | Journal of the American Chemical Society
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Guangbin Dong visited us at NYU as our Organic Syntheses Lecturer and delivered an amazing seminar.
@GBD_Lab
@UChiChemistry
@OrgSynth
@nyuchemistry
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Nature doesn't use azobenzene photoswitches, as far as we know. But Nature has evolved humans who can feed azobenzene photolipids to cells. The consequences are remarkable:
@NoemiJRojo
@HowardRiezman
,
@mo_hannes
,
@NCCR_ChemBio
@nyuchemistry
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Greetings from the Trauner Group retreat in Atlantic City.
@tongil_ko
treated us to a fabulous Brazilian barbecue. Historically marginalized chemists were discussed.
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As we are entering day 2 of the Artificial Switches and Motors GRC, I want to share with everyone that Doritos contain 3 types of azobenzenes. Not sure if this is a good thing…
#GRC_switches_motors
,
#photoswitches
,
#tartrazine
,
#Red40
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Photolipids continue to deliver. And two azobenzene photoswitches are better than one. Optical control of mTOR and Hippo signaling through a wonderful collaboration with
@basktastic
,
@mo_hannes
.
@MolSwitches
@photopharma_lit
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Working on dopamine receptors keeps me happy. Check out our latest paper on Proximity Photopharmacology, again with
@IsacoffLab
and Prashant Donthamsetti.
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Congrats to Paramjit Arora for getting the Ralph Hirschmann Award! Way to go, Bobby!
@nyuchemistry
,
@aroralabnyu
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New course material on strategic applications of olefinations, olefin-metatheses, and cross couplings posted:
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Here is the 2007 "Survey of Sam's Syntheses", compiled with input from the entire Danishefsky research family. It needs to be updated and corrected. Any volunteers?
@Pitt_Chemistry
,
@YaleChem
,
@sloan_kettering
,
@Total_Syntheses
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Thinking of the Chemistry behind these gorgeous colors. The leash must be an azobenzene. Did I mention that there’s a photopharmacology conference at the end of this month?
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Our “Need Motivation “ button is back, upon popular request. Feel a little down? Press it, press it NOW!!
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Greetings from the 2023 Trauner Group Retreat!
@fernhallinn
@PennSysPharmATT
@PennChemistry
@PGGUPenn
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Things that fall out of books when you clean up your office. Wieland Award 2012.
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2019 ends on a Synthetic Biology note. Check out our paper on the conversion of a human insulin receptor into a glutamate receptor, and then a photoreceptor. Thanks to our wonderful French collaborators!
@nyuchemistry
@photo_pharma
@Syn_Biology
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Two weeks to go until Photopharmacology III:
Registration is free, we already have > 300 attendees and an amazing lineup.
@chromism
@CarreiraGroup
@GCREllisDavies
@jF_lab_
@tayyaba_hasan
@IsacoffLab
@haraldjanovjak
@ThornSesholdLab
@Weiping_HKU
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I look forward to speaking at Scripps Research (Florida) today. The Webinar starts at 2PM EST. The topic is Proximity Photopharmacology, but I will be able to sneak in a short total synthesis.
@scrippsresearch
@nyuchemistry
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