Taekjip Ha
@taekjip
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Biophysicist. Howard Hughes Medical Institute. Harvard Medical School. Boston Children’s Hospital. Father of three dragons. Occasional manuscript reviewer.
Joined December 2013
We have a web interface for predicting DNA cyclizability. Entering a PDB ID shows the preferred bending direction around a protein. Widom 601 DNA has strong and weak sides, and indeed intrinsic bending is toward the nucleosome center for the strong side (LH) only. Plz try it out!
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A whirlwind few days in Cancún for the 2nd Spatial Genome Conference 🌊 Great science, great people — and a reminder why we do this. After 20 yrs in nuclear organization, ideas once “unorthodox” (like nuclear actin) are now gaining mainstream. Science moves, and so should we.
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Imaging the time course of DNA damage response at a nonrepetitive endogenous locus: Cell Reports Methods
cell.com
Rybczynski et al. introduce a method to measure DNA repair timing at specific genomic loci using very fast CRISPR and labeling of locally denatured genomic DNA and associated repair proteins. This...
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Nuclear Localization Signals Enable the Cellular Delivery of an Anti-CRISPR Protein to Control Genome Editing
biorxiv.org
Precise regulation of Cas9 activity is essential to minimize off-target effects, mosaicism, chromosomal alterations, immunogenicity, and genotoxicity in genome editing. Although type II anti-CRISPR...
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The Plasmodium CSP repeats have elastic properties with a critical role in sporozoite motility | The EMBO Journal
embopress.org
imageimageAlthough the central repeat region of the Plasmodium circumsporozoite protein (CSP) is the main target of protective antibodies against the parasite, its structure and function are little...
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📢Deadline extended! Our 2nd Spatial Genome Organisation Conference deadline has been extended to 25 Sep, dont miss out on joining our fantastic line up of speakers, alongside Karim, Matthias and Irene in what is set to be a fantastic meeting this October! #SGO25 Final slots
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Next week! See how Prof. Taekjip Ha uses single-molecule tools to uncover how proteins search and reshape chromatin in real time. You don’t want to miss this! https://t.co/BU98cAxX9i
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DNA bendability regulates transcription factor binding to nucleosomes https://t.co/glYjQL5QKK
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N6-methyladenine modification of DNA enhances RecA-mediated homologous recombination | PNAS
pnas.org
Both DNA methylation and homologous recombination (HR) are extensively studied. In bacteria, Dam methylation is the most studied DNA modification, ...
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Structural basis for dual DNA and RNA specificity of the G-quadruplex-...
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A brief summary/perspective on my recently published PhD work: Nucleosomes constrain 1D DNA diffusion by eukaryotic transcription factors https://t.co/VnpaEu0gbc
@taekjip
nature.com
Nature Structural & Molecular Biology - The transcription factor GAGA factor (GAF) recruits chromatin remodelers to establish and maintain open chromatin for transcription in Drosophila...
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Euchromatin forms condensed domains with short active regions on the surface
biorxiv.org
Technological advances in chromatin structure characterization have continually refined our understanding of transcriptional regulation in eukaryotic systems. Despite these developments, achieving...
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Cryosectioning-enhanced super-resolution microscopy for single-protein imaging across cells and tissues | PNAS
pnas.org
DNA-points accumulation for imaging in nanoscale topography (DNA-PAINT) enables nanoscale imaging with virtually unlimited multiplexing and molecul...
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My PhD work is online! Huge thanks to my advisors Carl and TJ, and collaborators! @taekjip @maryamyamadi @FuYiben @Mejohnson81
GAGA zinc finger transcription factor searches chromatin by 1D–3D facilitated diffusion https://t.co/LbRmYoghXG
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GAGA zinc finger transcription factor searches chromatin by 1D–3D facilitated diffusion https://t.co/LbRmYoghXG
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DNA mutagenesis driven by transcription factor competition with mismatch repair: Cell
cell.com
Competition between transcription factors and mismatch repair machinery drives localized hypermutation at regulatory elements, with implications for cancer and genome evolution.
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A conserved coupling of transcriptional ON and OFF periods underlies bursting dynamics | Nature Structural & Molecular Biology https://t.co/x7YIJQduDu
nature.com
Nature Structural & Molecular Biology - Gene activity levels predict how often and how strongly genes turn on and off. Using live imaging in fruit fly embryos, the authors uncover a conserved...
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So proud of the smashing success of the International Course in Biophysics co-organized with my @berkeleyMCB colleague Carlos Bustamante @BustamanteLab and University of Salamanca @usal
https://t.co/VlCe4Pl20M Course ends with a Keynote from Nobel Laureate Richard Henderson🥇
biophysal.org
First Summer International Advanced Biophysics and Structural Biology Course. Eva Nogales - Carlos Bustamante.
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🎉 Kicking off #Nucleic25 with an inspiring talk from @taekjip on homology search in 3D genome - setting the tone for an exciting few days ahead! 🧬 🎉Our amazing poster presenters took the stage to introduce themselves and their work 🎉We wrapped up the day with a dinner full
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SEC Headlines: Texas A&M, Dabo to SEC, CFP Rankings Explained
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