Tyler Pearson
@tyler_j_pearson
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Currently Postdoc with @levinchem, @group_levin at @UChiChemistry; PhD with @Freedman_Lab, 2021; Yale 2015 @tylerpearson.bsky.social
Chicago, IL
Joined July 2019
Today it's my pleasure to present my magnum opus from my time in the Levin group: a site-selective benzene-to-pyridine "transmutation" Now, you can perform C-to-N replacements in arenes with intuitive and predictable site selectivity! Read all it here:
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Things are getting tense over on the chemistry faculty search status tracker. Stay kind to yourselves!
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A chemistry breakthrough could make medication discovery easier. UChicago scientists have created a way to easily replace carbon with nitrogen atoms. Learn more about the studies published in @ScienceMagazine and @Nature:
news.uchicago.edu
Method to replace carbon with nitrogen atom has been ‘top of wish list’
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See a lovely writeup of our recent C-N exchange reactions in the Levin lab! @group_levin
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Our democratically elected #paperofthemonth is @group_levin's impressive study on aromatic nitrogen scanning by nitrene internalization! https://t.co/pwRhADMbPS
science.org
The proper oxidant enables conversion of aryl azides to pyridines with the nitrogen atom selectively replacing the azide-bound carbon.
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What an honor! Thanks!
#ProcterPOW: Out in @ScienceMagazine the @group_levin from @UChiChemistry report a skeletal editing strategy for nitrogen-scanning; selectively 🔄 an aromatic C - bound to an azide - for N by ipso-selective nitrene internalisation. 🔗👇
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Putting a nitrogen in place of carbon in these molecules’ aromatic rings can result in dramatic improvements in key pharmacological parameters—so much so that medicinal chemists have dubbed it the “necessary nitrogen atom.” Read more:
cen.acs.org
New reaction replaces carbon with nitrogen
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The Levin Group has created a new reaction by swapping a carbon atom with a nitrogen atom in an aromatic ring, which "could make nitrogen scanning much easier." @LevinChem @UChicagoPSD @UChicagoNews @cenmag @UChiChemistry
Chemists have developed a reaction that replaces a carbon atom in an aromatic ring with a nitrogen atom. The new reaction gives medicinal chemists another skeletal editing transformation they can use to modify drug candidates. Read more:
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Don't want to jinx it but... our group submitted our first paper today and I'm super excited about it!! 🎉 Also my first time trying @ChemRxiv
https://t.co/qQuIPZ8hwm
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It was delightful to chat with @LevinChem and @tyler_j_pearson about their aromatic atom swap for my latest in @cenmag. https://t.co/oiRsTZugZ6
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https://t.co/yQfNGDTe55 Check out this awesome write-up by @beth_halford @cenmag about our benzene-to-pyridine transformation! #chemtwitter
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Thanks for the excellent write up!
Amerikaanse chemici (@LevinChem) vonden een manier om in een benzeenring een van de C-atomen regioselectief te vervangen door een N-atoom, @ScienceMagazine: https://t.co/RKdkZqE5dI Also in English: https://t.co/gwuk9saEl4 Met dank aan Jeroen Codée (@LeidenScience @UniLeiden)
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@LevinChem @tyler_j_pearson @ryoma_ous @DriscollJuliaL @balu_dherange no offense but this is the coolest thing I’ve ever seen
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She's here! 🥳 So proud to share this work. This was such a magical reaction to work on and an amazing team to be a part of 🥹
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I owe a lot to my amazing coworkers, coauthors, and advisor @LevinChem I came to the Levin group with no practical experience in developing organic reactions. They took a chance on me and gave me the ideal environment to grow into the chemist I am now.
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It was such a huge pleasure to take this project on! Even when I was doing this reaction every day it still made me excited to draw it at the top of my notebook pages.
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