Matt Pratt
@MattRPratt
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Professor at USC in chemistry
Chemistry @ USC
Joined August 2011
My lab @USCChemistry has a postdoc position open for an enthusiastic individual interested in protein posttranslational modifications. Background in carbohydrate or peptide/protein chemistry is a plus but not a requirement.
theprattlab.com
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So excited to share this story with the world! A mimic of the mammalian ‘don’t eat me’ signal CD47 encoded by a pathogen!
How thrilling to see this online after 8 years in the works!!! We showed that #Lyme bacteria mimic our own“don’t eat me” signal with their P66 protein to hide in plain sight!!! This tricks our SIRPa protein to trigger the breaks on immune clearance! https://t.co/jxdc0xJVjr
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At last... we're thrilled to send our story on macrocyclic mini-tau seeds out into the world. Organic chem, protein mimicry, cryo-EM, cell function; something for everyone! Congrats to Isaac & Xueyong, and collabs from Purdue and IUSM! https://t.co/uDXgGZet1l
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it induces almost no pathology in neurons or mice (PFF injection model). Mechanically, the O-GlcNAc amyloid does not seed aggregation of endogenous aSyn in neurons. Yet another mechanism where O-GlcNAc can promote the solubility of aSyn and inhibit aggregation.
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New paper on aSyn O-GlcNAc modification with @Hlashuel and amazing collabs. @SaelicesL, Kelvin Luk & Virginia Lee. Briefly, we find that a certain O-GlcNAc forces aSyn to make a distinct amyloid structure which can seed aggregation in vitro but…
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The 12th Austrian Peptide Symposium has taken off with a great dinner and excellent company on Monday evening. Now the second session is already in full swing...@peptide_drugs @mitchell_chem @AnneConibear
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Repost:📢The Weiss Lab is hiring a Postdoctoral Research Associate to join us at the CCRC @universityofga! This position is supported by a new NIGMS/NIH R35 award focused on investigating the regulation of GAG biosynthesis. Come join us! https://t.co/39ut3Cq7Sn
#glycotime
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🔬 Exciting News in Cellular Health! 🌐 In collaboration with @48HourDiscovery, GlycoNet Investigator Dr. David Vocadlo's team achieved a breakthrough in understanding protein modification. 🚀 Discover more here:[ https://t.co/tOMxI8VP61]
#GlycoNet #Glycotime #Research #Innovation
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Very excited and happy to share this news. The addition of Michelle and Chris Chang to Princeton Chemistry is a dream come true....As scientists, friends and colleagues, you couldn't ask for more. Giddy Up!
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David Vocadlo and I wrote a review for @jbiolchem on O-GlcNAc’s potential in neurodegenerative diseases. Thanks to Bob Haltiwanger and Jerry Hart for including us in this special edition.
jbc.org
O-GlcNAc is a common modification found on nuclear and cytoplasmic proteins. Determining the catalytic mechanism of the enzyme O-GlcNAcase (OGA), which removes O-GlcNAc from proteins, enabled the...
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Interesting review about the roles of O-GlcNAc in neurodegenerative diseases: Tau and alpha-Syn proteins, methods for modulating O-GlcNAc in cells and in vivo, O-GlcNAcase inhibitors @jbiolchem
https://t.co/P50Kv6pQkD
#glycotime
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Congratulations to Sarah Slavoff of @YaleWestCampus on Receiving the ACS Chemical Biology Young Investigator Award! The @SlavoffL studies #genomic dark matter and its interactions with RNA in human cells. @ACSBioMed
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Fantastic fun and excellent talks at this meeting. Awesome seeing old friends and making new ones.
Almost the end of #AusPeptide2023 sadly! Thank you all for coming and having a great time, giving amazing presentations and presenting fantastic posters. Hope to see everyone again soon! 🇦🇺👀🧪
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