Meg Tirrell
@megtirrell
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Dr Fauci: "There is a fact that permeates virology, and that is: Viruses cannot mutate if they don't replicate."
Put it on a👕
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Pfizer puts out statement in response to numerous states saying they’ve been told their allotments of
#covid19
vaccine have been reduced, & as FL cited Pfizer production issues as reason - noting no issues and millions of doses in warehouse they haven’t received instructions for.
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Dr Fauci is *not* on board with administering just 1 dose of mRNA vaccines. At WH Covid briefing, he says:
-neutralizing antibody titers go up 10x with 2nd dose
-suboptimal response to 1 dose could inadvertently select for mutant strains
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AMA president says he’ll continue masking indoors regardless of CDC’s updated guidance and recommends others do the same to protect those at higher risk:
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Pfizer CFO on timeline for
#covid19
vaccine for kids, today at Morgan Stanley conf:
-results in kids 5-11 by end of Sept, filing for EUA early Oct
-filing for EUA for kids 6 months - 5 years about a month later, early Nov
(clarity on timeline for younger kids is new) (1/2)
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Regeneron notes of report President Trump has antibodies: “Given the volume of IgG antibodies delivered in our therapy, and the timing of these tests, it is likely that the second test is detecting REGN-COV2 antibodies.”
The patient had a whopping (8g) dose of a
#SARSCoV2
neutralizing IgG antibody cocktail. Then they detected antibodies. You must be kidding me, Dr. Conley?
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CVS says its 10,000 pharmacies alone can do 1M
#covid19
shots per day once fully activated:
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WHY DO THINGS THAT USED TO BE PHONE CALLS NOW HAVE TO BE ZOOM CALLS
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Covering the drug industry, you usually hope you never have to try the products you report on. This one was different. Got my 1st shot of
#covid19
vaccine today. Making spike proteins! Super grateful.
#PlanYourVaccine
#vaxxie
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What vaccine makers are saying about B.1.1.529:
-Moderna notes it's shown it can get into clinic (human trials) within 60 days; question is regulatory process from there. Manufacturing new doses could take a few months.
-BioNTech expects lab data within 2 weeks (1/2)
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"We are terrible at assessing risk," vaccines expert
@DrPaulOffit
tells reporters in briefing. "People ask me what's the most dangerous aspect of getting vaccines - the most dangerous aspect is driving to the location to get the vaccine."
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Starting today, all three major insulin manufacturers are offering $35/mo caps on out-of-pocket costs.
Also today, they’re cutting list prices by 70% or more - a move that’s expected to *save* them hundreds of millions of dollars a year.
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Fauci: I’m not entirely sure what president was referring to, but believe it was a report of hydroxychloroquine and azythromicin. Many of the things you hear out there are anecdotal reports. They may be true - but the only way to know is randomized trials
#COVID19
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Weill Cornell’s Dr Matt McCarthy: “At one of the busiest hospitals in the country, I don’t have (a test) at my fingertips. I still have to call the Dept of Health, make my case, plead to test people.”
#COVID19
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Pfizer says its
#covid19
vaccine trial in kids ages 12-15 is fully enrolled w 2,259 participants as of yesterday
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Moderna says its two-dose
#covid19
vaccine series for kids 6mo-under 6yrs met study goals, will file with regulators in coming weeks
Primary goal was immune response, found to be similar in these ages w 1/4 dose (25mcg) as full dose in adults 18-25
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Quest Diagnostics:"We will not be in a position to reduce our turnaround times as long as cases of COVID-19 continue to increase dramatically across much of the United States. This is not just a Quest issue. The surge in COVID-19 cases affects the laboratory industry as a whole."
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So excited to join
@CNN
’s amazing health team as a medical correspondent. I start next week!
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.
@KatyTurNBC
nicely sums up the Q so many women reporters have asked themselves at times about this medium
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Vaccine scientist Dr. Stanley Plotkin among those giving public comments in CDC's advisory committee mtg. His turn came after several anti-vax comments.
He begins: "After hearing some of the prior comments, I would move to remind you that there is no vaccine against stupidity."
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FDA then asked expert panel whether healthcare workers or others at high risk for occupational exposure be included in Pfizer/BioNTech booster EUA
Yes: 18
No: 0
Abstain: 0
So recommendation is for 65+, those at high-risk of severe disease, and those with job exposure risk
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Pfizer on masks: "We are maintaining our existing guidance of requiring mask/PPE and social distancing in our workplaces regardless of vaccination status, as to protect those who are not vaccinated or are immunocompromised. Our priority is to keep our workplace safe for all."
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Biden signing 10 executive orders and other directives today on
#covid19
. Here they are per
@WhiteHouse
fact-sheet: 🧵
1. EO directing agencies to fix supply of PPE, materials for testing & vaccines, including through Defense Production Act
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Moderna says its vaccine shows durable 93% efficacy through 6 months, says it expects to complete FDA submission for full approval this month:
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How to make a reporter cry on live national television.
(Thank you
@KellyCNBC
@CNBCTheExchange
& that kind viewer for the very nice words ❤️)
Yes, we CAN recognize
@megtirrell
for her extraordinary reporting, dedication and hard work all year 👏👏👏 thank you so much for being our go-to person throughout 2020, Meg!
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Muted the guy constantly trying to undermine me for lack of credentials, and it feels good! (I didn't block though, so this person who thinks I am unqualified to cover this beat can... keep following what I share about this beat. 👋)
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WHEN WILL THIS END??
I asked
@CDCDirector
yesterday - when, and how.
She said it depends on human behavior, and "human behavior in this pandemic hasn’t served us very well.”
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Regeneron reports new results on
#covid19
antibody drug, from 500 additional patients. Finds in recently diagnosed patients:
The drug reduced COVID-19 related medical visits by 57% overall, 72% in patients with one or more risk factor.
The problem: only 50k doses available.
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Quest Diagnostics says its average turnaround time for
#COVID19
tests is now 7 or more days for non priority 1 patients
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Fauci to Paul: "I totally resent the lie you are now propagating, Senator... Those viruses are molecularly impossible to result in SARS-CoV-2... You are implying what we did was responsible for the deaths of individuals. If anybody is lying here, Senator, it is you."
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Moderna CEO Stephane Bancel, in company’s R&D day this AM, says the co expects first clinical trial data on its quadrivalent seasonal flu vaccine candidate very soon; expects Moderna to be first to market w Covid-flu-RSV combo shot
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Based on Johns Hopkins data on China:
80,735 confirmed cases
58,728 recovered (73%)
3,120 died (3.9%)
The rest presumably still in the course of their disease.
#COVID19
Only 70% have recovered. 30% is pretty high not recovered? What happened to the other 30%?
@megtirrell
@SaraEisen
@WilfredFrost
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What vaccine makers are saying about B.1.1.529 (cont):
-lab data will tell BioNTech whether B.1.1.529 could be an escape variant
-Pfizer/BioNTech can adapt mRNA vaccine within 6 weeks, ship initial batches within 100 days in event of escape variant (2/2)
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LabCorp says starting tomorrow, it will be able to perform more than 20,000
#COVID19
tests per day
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.
@Jaketapper
notes in intvw w Moncef Slaoui that immigrants like him (Morocco,Belgium), Pfizer CEO
@AlbertBourla
(Greece),
@moderna_tx
CEO Stephane Bancel (France) & chairman
@NoubarAfeyan
(Lebanon) have led the vaccine race. “This is what we all love about America,” Slaoui says.
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Moderna says it plans to submit EUA application for
#covid19
vaccine for kids 6mo-5yr by the end of the month
To summarize: FDA needs Moderna and Pfizer to submit applications for EUA before it can begin review process for kids under 5
And suggests it requires more manufacturing data from Novavax to complete review
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Hi David, welcome to 2021, where women speak how they speak and you don’t have to like it or approve 👋
@megtirrell
to Meg. Giggling and upspeak about a disease that is killing is not cute. Get your shit together and speak like a professional and not a sorority rush chairman...
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Today was my last day at
@CNBC
. Thank you to all my wonderful colleagues for an incredible 9 years. I’m so proud of the work we got to do together, and even more grateful for the friendships I’ll carry with me.
Goodbye
@megtirrell
and good luck in your next adventure. You will be missed here at
@CNBC
!!
@MorganLBrennan
@jonfortt
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WASHINGTON (AP) — AP Exclusive: US to begin sharing up to 60M AstraZeneca COVID-19 vaccine doses with world after federal safety review. (h/t
@SteveKopack
)
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Trump: We have other things we're looking at too, vaccines, but that will take longer - this (chloroquine) would be a gift from heaven if it works.
#COVID19
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FDA authorizes new home
#covid19
rapid antigen test that it says will double home testing capacity in the US over the next several weeks
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WH Covid Response team's Jeff Zients says Yelp today is announcing new feature allowing consumers to search for businesses with fully vaccinated workers or businesses that require proof of vaccination to enter
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BREAKING: Pfizer/BioNTech say their vaccine is more than 90% effective in preventing
#covid19
at first interim look at phase 3 trial. No serious safety issues. CEO
@AlbertBourla
: “Today is a great day for science and humanity.” He joins us next on
@SquawkCNBC
.
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In new letter just posted, Gilead CEO says the company has ramped up remdesivir supply to 1.5 million individual doses (depending on optimal duration of treatment, which is being studied, could equate to 140K+ courses) which it’s providing to treat severe
#COVID19
at no cost (1)
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Dr Fauci’s estimate for reaching herd immunity has been steadily inching up,
@nytimes
’ Donald McNeil Jr reports. Fauci told us at last week’s
@CNBC
#HealthyReturns
that it may be 75-85%.
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McCarthy: The message today we’re hearing from the administration is the risk is low. “That’s simply not true. There are going to be thousands of cases here. We’ve already moved from containment to mitigation. There’s going to be widespread disruption to daily life.”
#COVID19
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Pfizer has enough follow-up data on its
#covid19
vaccine to file for full FDA approval.
Also, an update from a trial of 800 people in South Africa. There were 9 cases of
#covid19
, all among people who received placebo. 6 of those cases were B.1.351. Strong (but early) results.
BREAKING: Pfizer vaccine study shows 91% efficacy after 6 months
-Enough data to file for full approval with FDA
-No serious safety concerns
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Normally this time ahead of JPM I am huddled up somewhere prepping for two days of live interviews. This year, I am doing something even more nerve-wracking: attempting to trim my newborn’s tiny, razor sharp fingernails for the first time. 😱
#JPM19
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Whenever I turn on
@CNBC
w my toddler in the room he watches the ticker and shouts “green triangle! Red triangle!” (Future financial genius.)
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Moderna reports 83.7% efficacy for RSV vaccine in phase 3 trial in adults 60+:
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J&J issues statement on
#covid19
vaccine supply after NYT report that mistake at Emergent BioSolutions plant ruined 15M doses & has halted future shipments in the US while the FDA investigates: https:/www.jnj.com/johnson-johnson-statement-on-u-s-covid-19-vaccine-supply
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Pfizer
#covid19
vaccine for kids 5-11 shows 90.7% efficacy in clinical trial - per FDA briefing docs just posted ahead of Oct 26 advisory committee meeting
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Moderna says lab studies show a booster w half the dose of its
#covid19
vaccine increases antibody levels against delta by 42-fold
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First outdoor pool swim since the pandemic. Jumped in w my mask on 🤷🏻♀️
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Operation Warp Speed chief adviser Dr Moncef Slaoui has submitted his resignation at the request of the Biden team, per two sources. He’ll stay 30 days, through the transition, though his role will be significantly diminished come Jan. 20.
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Every day, when my 2.5-year-old returns from a morning walk outside, he declares: "What a nice, beautiful day!" Doesn't matter what it's doing outside. 🥰
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My first
@CNN
story!
Lilly’s experimental Alzheimer’s drug donanemab meets goals of phase 3 trial & Lilly will seek FDA approval this quarter.
Coming up on
@CNNThisMorning
!
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Just now on
@FaceTheNation
Pfizer board member
@ScottGottliebMD
lays out more specific potential timeline for Pfizer
#covid19
vaccine for kids:
-clinical trial results in Sept for ages 5-11, potential FDA clearance late Nov, early Dec
-results for ages 2-5 in Nov
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Pfizer & BioNTech final results on
#covid19
vaccine phase 3: *95% effective*
170 cases in trial
-162 among placebo group
-8 on vaccine
10 severe cases
-9 on placebo
-1 on vaccine
94% efficacy for those 65+
Fatigue, headache after 2nd shot
Plan to submit to FDA within days
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For everybody getting mad at me for quoting the president in tweets: I’m... quoting the president. It’s important to have a record of what this nation’s leaders say, and when, in response to a global pandemic. I’m doing it in real time during briefings; analysis comes later.
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Pfizer CEO concludes media call:
“Science will win.”
(Then, thinking the call had hung up, he said, “That went well. Everybody happy?”)
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And in the 9th month of covering the pandemic from home,
@CNBC
installed a tv studio in my house.
See you soon on
@thenewsoncnbc
!
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Pfizer/BioNTech
#COVID19
phase 1/2 vaccine trial results preprint is up: all 24 participants on 2 lower doses generated neutralizing antibodies at levels 1.8-2.8x those seen in patients who recovered from the disease
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In interview this AM, Moderna CEO says they expect omicron + original virus bivalent booster to be approved in late summer for fall rollout.
Though FDA meets late June to discuss strain selection, he says that wouldn't be enough time for any manufacturer to pivot by early fall
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Trump: We don't have much time. We have a lot of very sick people right now. We're going to deliver a lot of samples to NY and other places and we're going to find out very shortly whether it's going to work.
#COVID19
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Some personal news: I recently left CNBC for NameofNewsPublication
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White House extends plan to slow
#COVID19
to April 30. Notes coming Tuesday announcement. Trump: “By June 1 we’ll be well on our way to recovery. We think by June 1 a lot of great things will be happening.”
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What vaccine makers are saying about B.1.1.529 - now Omicron (cont):
-Novavax "has already initiated development of a new recombinant spike protein based on the known genetic sequence ... and will have it ready to begin testing and manufacturing within the next few weeks." (4/2)
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Moderna
#covid19
vaccine FDA briefing documents are out. One key detail included not in FDA’s briefing book but in addendum from Moderna: some potential protection from *infection* (not just symptomatic disease) after one dose:
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This is a fascinating decision from FDA. Accelerated approval means FDA cleared aducanumab conditionally, on the basis that it clears amyloid plaques from the brain. Biogen must run confirmatory trial showing clinical benefit. If that trial doesn’t confirm, FDA can pull approval.
Biogen Alzheimer’s drug APPROVED through accelerated approval pathway:
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In congressional hearing, Dr Fauci cites a “disturbing surge of infections” in some areas of the country that reflect an “increase in community spread, and that’s something I’m really quite concerned about.”
#COVID19
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7. EO calling on OSHA to immediately release guidance for employers to keep workers safe from
#covid19
exposure, enforce worker health & safety requirements, "targeting the worst violators"
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Bc everything can seem very dark right now (except for good vaccine data), wanted to share a moment of levity from my day:
My little boy is almost 2 and he's starting to string words together. His latest: "silly Mama!" 🥰
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“The goal is to sanitize all of the MTA's 6,400 subway cars and 5,700 buses every three days — and every station on a nightly basis — until the virus is contained.”
How... how frequently were they sanitized before? 😳
#COVID19
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8. EO requiring mask-wearing in airports & on many trains, planes, ships & intercity buses; proof of negative
#covid19
test for intl travelers before departing for US & compliance w CDC isolation/quarantine guidelines; consideration of addtl domestic travel public health measures
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2. Presidential Memo directing FEMA to increase federal reimbursement to 100% (from 75%) of cost of National Guard personnel & emergency supplies; restoring full reimbursement for eligible costs to support safe school reopening through FEMA Disaster Relief Fund
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“By the end of next week we should have the the capacity to test 10,000 Americans a day,”
@ScottGottliebMD
says on
@CNBC
special report just now. “Once we have that capacity in place and doctors are ordering more tests we’re going to find more positives.”
#COVID19
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The price of Covid-19 antiviral drug Paxlovid is expected to rise by as much as 5x, to $2500/course, as US transitions to a commercial market. While it will still be free through an access program for govt-insured and uninsured, others will have a copay:
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Mainly just gratified I tied
@ScottGottliebMD
. (It’s no pergola but I tried.) Thanks
@ratemyskyperoom
!
New look. Art. Chair. Love the lighting. Perspective. Flowers. Succulents. 9/10
@megtirrell
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Pfizer offered its 2nd quarter allotment of
#covid19
vaccine to the US govt multiple times,
@ScottGottliebMD
tells
@SquawkCNBC
. US declined to strike additional agreement on option to purchase, relying instead on multiple other vaccine agreements. (1)
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5. EO to improve data collection, production, sharing & analysis; create publicly available dashboards w national & state level info on cases, testing, vaccinations & hospital admissions "to make real-time information available to policymakers and the public"
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Important re: Pfizer timeline for kids:
-availability of vaccine also based on length of FDA review;
@ScottGottliebMD
has suggested 4-6 wks; Reuters reported health officials said could be 3 wks
-everything is dependent on data showing it’s safe, produces immune response (2/2)
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First patient to receive dose of
#COVID19
vaccine from NIH & Moderna tomorrow in phase 1 trial, AP reports
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CDC director overrules advisory committee, recommending
#covid19
booster dose for all categorizes FDA authorized:
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6. EO directing Depts of Education & Health to provide guidance on safe reopening & operating for schools, child care providers & higher ed; collect data around reopening and school closures; encourages FCC to increase connectivity for students w/o reliable home broadband
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Alaska’s opening
#covid19
vaccines to everyone over age 16
Effective immediately, Alaska will become the 1st state in the nation to allow anyone over the age of 16 to get the COVID-19 vaccine. This marks a significant step forward in our efforts to put the virus behind us.
#akgov
#CovidVaccine
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3. EO to establish Pandemic Testing Board; increase testing capacity by directing use of Defense Production Act; promote surge capacity of testing in the US; onshore test manufacturing, expand public health workforce, support
#covid19
screening for schools;ensure equitable access
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What vaccine makers are saying about B.1.1.529 (cont):
-J&J says it's closely monitoring new strains and is "already testing the effectiveness of our vaccine against the new and rapidly spreading variant first detected in southern Africa." (3/2)
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What vaccine makers are saying about Omicron (cont):
-Moderna announces 3-pronged strategy:
-evaluating full booster dose of original vaccine
-studying two multi-valent boosters
-advancing Omicron-specific booster
(5/2)
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