Moritz Mall
@MoritzMall
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Cell fate engineer @DKFZ reconstructing human development and disease
Joined October 2013
What keeps cancer cells in check—and can we tame hem? In 2 collaborative preprints, we trace glioblastoma cell transitions in space and decode what regulates their plasticity 🧠👇 📍 Spatial & multi-omic atlas: https://t.co/GNGoASIYCc 📍 Regulatory logic: https://t.co/j3D1N24HpW
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I happened to read @manusaraswat10 's EPIC supplement from his scDORI preprint. It is probably the best & most comprehensive methods section I have ever read & written with a goal to help readers of all background understand it. Fabulous! https://t.co/7Z3rZVETXt
biorxiv.org
Glioblastoma (GB) is one of the most lethal human cancers, marked by profound intratumoral heterogeneity and near-universal treatment resistance. Cellular plasticity, the capacity of cancer cells to...
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New in Nature Reviews Genetics: my Review on how advanced genomic technologies are redefining cellular reprogramming: mapping trajectories, dissecting chromatin dynamics, + lineage tracing & synthetic circuits to push the boundaries of cell identity. https://t.co/8NBM5ohxkJ
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Since their discovery in 2004, the grid cells in the brain have been regarded as a kind of "GPS in the head." However, scientists at DKFZ and @uniklinik_hd have now shown that grid cells work much more flexibly than previously assumed. @NatureNeuro
https://t.co/7AndI5Ezno
dkfz.de
Since their discovery in 2004, the grid cells in the brain, which are important for our orientation, have been regarded as a kind of “GPS in the head.” However, scientists at the German Cancer...
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Dr. Biao Huang, Pedro Medina (@Pmed27), and a team in the @LiLab_Kidney developed kidney progenitor assembloids to study autosomal dominant #PolycysticKidneyDisease! Read the @CellStemCell paper: https://t.co/a5LaPZIwNM Listen to the discussion: https://t.co/liKm4tpZqZ
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🔬 Don't miss out on NO-COST virtual tickets to the UC San Diego Sanford Stem Cell Institute symposium Oct. 16-17. 👩🏽🔬 Keynote speakers include PhDs @TannishthaReya, Fred Gage, Andreas Trumpp & retired astronaut/microbiologist Kate Rubins. RSVP: https://t.co/a7519jEW4r
#MedTwitter
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It’s a wrap! #SCC2025HD concluded after three days of wonderful talks, discussions and presentations. Heartful thanks to all speakers, participants and chairs. See you next time in Heidelberg! 👋👋👋
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Join us next week for a conversation with Dr. Lars Velten from @CRGenomica! 🩸 Check out his team's @Nature paper on the dynamics of blood aging: https://t.co/NiKg6M2ZWN
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Like primary brain cancers, neuronal activity drives the growth of SCLC #BrainMets via functional synapses. Excited to share this #LungCancer🫁 #CancerNeuroscience story led by the now independent @humsav @BWHNeurology and @StanfordMed grad/@MGBNeurosurgery resident @SavchukSol.
1/ Excited to share our new study, product of a 6-year collaborative effort by @michelle_monje lab and @VenkteshLab illustrating that neuronal activity regulates the progression of small cell lung cancer #SCLC in the lung and brain #CancerNeuroscience 🧵… https://t.co/t0SN44MTBf
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We are excited to share that our paper (D. Lindenhofer et al.) on SDR-seq, a combined single-cell DNA-RNA sequencing method, has been published in @naturemethods! 🎉 Watch co-author Julia Bauman’s video on how SDR-seq links coding & non-coding variants to gene expression.
What good is a science communication channel if you don't get to talk about your own papers on it occasionally, right?😊 We developed a method to simultaneously sequence single-cell DNA and RNA targets, enabling association of genomic variants (including non-coding!) with gene
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So, we (Dylan Liabeuf and Anastasiia Maksiuk) are organising the first Berlin symposium on organoids. The objective is to bring together the Berlin organoid community and to develop further interactions. Info: https://t.co/HdXz2uH7Kk Free registration: https://t.co/df5w4Qd8Gq
bihealth.org
Registration: Berlin Organoid Symposium - Berliner Institut für Gesundheitsforschung - Charité und Max-Delbrück-Centrum
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Den GSCN 2025 Publication of the Year Award erhält Moritz Mall zusammen mit Bryce Lim und weiteren Co-Autoren für ihre Veröffentlichung "Active repression of cell fate plasticity by PROX1 safeguards hepatocyte identity and prevents liver tumorigenesis". @NatureGenet
@gscn_office
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🚨 @DKFZ Postdoctoral Fellowships 2025 — Postdoc opening (Mall Lab) Work at the interface of neurodevelopment, epigenetic repression & cancer neuroscience. Apply: https://t.co/NZTUn2cMLy
#Postdoc #Plasticity #Neurodegeneration #CancerNeuroscience
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Join @LenPennacchio, @ZhipingWeng, @xielablife, me and all speakers in beautiful Suzhou, China for this year's CSH Asia Systems Biology of Gene Regulation & Genome Editing meeting, Oct 20-24. Let's bring the international communities together! Abstract deadline Sept 5! More infos
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We are happy to share our latest paper @natBME spearheaded by @BreinigMarco. Together with @MoritzGerstung we hack commercial #spatialtranscriptomics @10xGenomics to decode #phenotypes from #genotypes in #cancer: https://t.co/JTXzMkDiCW
@DKFZ @uniklinik_hd
nature.com
Nature Biomedical Engineering - A method integrates perturbation mapping with 10X Visium spatial transcriptomics to map tumour genetic complexity and heterogeneity.
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Diet/microbes place the gut epithelium as a nexus for evolutionary change. With @TheSpenceLab @genomeCraig, we use #organoids to explore how evolution prepared the developing human intestine for exposure to the environment. @ScienceMagazine #evodevo 🧵1/11 https://t.co/VKQtZ3LMaW
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Great line of speakers in 12th International Heidelberg Symposium on Stem Cells and Cancer. #SCC2025 Register to meet the top experts in stem cells and cancer fields. More Info: https://t.co/r2FhKIBtST Abstract Deadline: 15 July 2025 Registration Deadline: 1 August 2025
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Don't miss the Keynote Lecture by Prof. Andrew Wei from the Peter MacCallum Cancer Center at the 12th International Heidelberg Symposium on Stem Cells and Cancer. #SCC2025 Abstract Deadline: 15 July 2025 Registration Deadline: 1 August 2025 More Info: https://t.co/JXqNxHtVsr
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Registration still open! 🚨 Come and join us in the 12th International Heidelberg Symposium on Stem Cells and Cancer. Abstract Deadline: 15 July 2025 Registration Deadline: 1 August 2025 More Info: https://t.co/r2FhKIBtST
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Don't miss the Keynote Lecture by Prof. Elaine Fuchs from the Rockefeller University at the 12th International Heidelberg Symposium on Stem Cells and Cancer. #SCC2025 Abstract Deadline: 15 July 2025 Registration Deadline: 1 August 2025 More Info: https://t.co/r2FhKIC1Ir
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