Anshul Kundaje
@anshulkundaje
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Federally funded academic research is the innovation engine of the US economy. Reform is welcome. Destruction will have long term consequences.
Stanford, CA
Joined July 2006
@amanpatel100 is a fantastic CS grad student graduating ~March 2026, interested in AIxBio industry positions. Has deep expertise in DNA/bio language models, sequence-to-function models, popgen/evolution. Please touch base with him (link in next message) if u have positions 1/
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Guy who spent years scolding everyone about “gold standard science” How did Prasad make such a mistake? —> Apparently, rather than waiting for the finalized report that he had ordered, he sent staff the Nov. 28 memo before the scientists had completed their assigned work.
medpagetoday.com
Vinay Prasad's conclusions overshot what the agency's analysts ultimately found
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Let what happened at MiMedx serve as the poster child for what can happen to public companies and their management under today's new legal system. Learn the strategies you need to protect your company, shareholders and your professional legacy. Knowledge is everything!
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Our latest preprint revisits the classic model of mutation-selection balance. Do human recessive genes fit Haldane's 100-year old model? This work is by the wonderful Jon Judd, and co-mentored by Jeff Spence.
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Note the radio silence on the rising measles outbreaks from HHS, NIH, CDC ,CDER, CBER, FDA "leaders".
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This is such a critical and overlooked problem and why we need a better infrastructure/system for reporting annotations and experimental data.
"Notably, curators struggled to locate consistent sequence annotations and performance values because the data were scattered across the main text, figures, and supplementary files."
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Analysis of alternative splicing uncovers a vastly expanded transcriptomic response to hypoxia in human vascular endothelial cells https://t.co/SsU8r0Gdv8
#biorxiv_genomic
biorxiv.org
Hypoxia is a fundamental pathophysiological stimulus that plays important roles in multiple cardiopulmonary diseases. During hypoxic stress, cells adapt by undergoing widespread transcriptional...
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@JTLonsdale Ahhh, good to see you care about political decorum all of a sudden Joe, but I understand you can't bite the hand that feeds you, so you can only call out certain politicians.
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@jura_bio We can run a billion distinct experiments, physically constructed and functionally measured. This changes the logic of discovery in ways that are easy to underestimate. I wrote a little about what that means: https://t.co/UHQt5h9CrQ
jura.bio
For decades, drug discovery has been constrained by a simple fact: experiments are expensive, so you have to guess well. We built a system where you don't have to guess — testing a billion distinct...
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Review I wrote with Marianne and Liz on epigenetic editing.
Epigenetic editing: from concept to clinic https://t.co/dy0bt4Ui4O
https://t.co/O7Ps5IKXjk Epigenetic editing aims to reprogramme gene expression by rewriting epigenetic signatures, without editing of the genome. Find out about progress in the field in this new Review
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Two top programs. One unforgettable night. Arkansas & Houston bring big time college basketball to the Garden State at Prudential Center on Saturday, December 20 for the 2025 Never Forget Tribute Classic! Buy your tickets today.
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"Notably, curators struggled to locate consistent sequence annotations and performance values because the data were scattered across the main text, figures, and supplementary files."
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It would be nice if America took teaching kids to read books one tenth as seriously as it takes youth sports.
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Fascinating. FDA is weakening the rules around dietary supplement labels making it less clear to consumers that the claims the products make haven’t been reviewed by FDA.
fda.gov
Letter to the Dietary Supplement Industry on the DSHEA Disclaimer
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This travel ban has quietly reshaped the personal and scientific futures of many Iranian scholars, including my own. After a full year of planning for a U.S. postdoc, tens of hours of interview preparation, fellowship applications, constant monitoring of whether Harvard’s legal
The new travel ban is far more expansive than the one in 2017, yet the political response this time around has been muted to the point of silence. A Republican congresswoman seems to be the loudest voice raising concerns. The cynic in me can't help wondering whether this is
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Prasad's memo suggesting 10 pediatric reported VAERs deaths were "likely, probably or possibly" caused by the vaccine was inaccurate and jumping the gun, based on a December 5th safety memo by FDA scientists who looked into the issue. The FDA needs to publicly share the cases
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@USMortality Ben writes another thread filled with cherry-picked distortions & deceptions! Let's break it down & DESTROY each of his claims, shall we? 1) Africa: Vaccination coverage rose from 50% to 71%. Cases in 2019? HIGHER than in 2000. How does more MMR vaccination = more cases?
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@USMortality Thanks for engaging, but you're wrong. First off you completely didn't adjust for population. Africa's population grew substantially from 2000 to 2019. The population-adjusted equivalent reaches approximately 839,000 cases (520,000 × 1.613) by 2019. So technically case RATES
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I & @JackScannell13 wrote a manifesto on reviving pharma productivity for @IFP. Public debates focus on improving science or loosening approval. We argue there's real leverage in optimizing the middle part of the drug discovery funnel: Clinical Trials. https://t.co/yZwzDVyWDy
macroscience.org
We're optimizing the wrong steps in drug discovery.
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Anyway, let's hope (1) these initiatives end up being very successful, (2) synergizing with trad academia which also really needs support, (3) triggers reforms in trad academia especially wrt incentives to make it competitive and further justify support for it. 11/11
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📣 PostgreSQL developers: Meet Azure HorizonDB the new AI-ready database service with native AI capabilities built in. For enterprise scale, security, and performance without compromise.
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Again, all this depends on how this is implemented. It could end up being revolutionary & greatly augmenting the value of trad academia. Or it could further cripple basic science & training initiatives that are already in deep trouble. 10/
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While this is and can be a useful funding model, IMO it is heavily biased towards selecting for specific types of personalities. I'm not sure this is necessarily going to favor selecting for the most impactful science vs. the best sales pitch. 9/
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