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As large-scale neurodevelopmental MRI studies gain prominence, the authors identify trade-offs between sample size and quality control that can dramatically affect results, and evaluate a range of approaches to mitigate risk for error.

Human-like expression of the CLOCK gene in mouse neocortex enhances cognitive flexibility and neural connectivity, suggesting an evolutionary gain of function. @Brain_EvoDevo @KonopkaLab @CircadianClocks .

A review on changing genes, cells and networks to reprogram the brain after stroke.

Fine-mapping genomic loci refines bipolar disorder risk genes. @MKoromina, @NiamhAMullins.

RT @NatureConf: New conference alert 🚨.Brain Energy Metabolism in Health and Disease, with @KAUST_News, will explore how energy metabolism….

RT @NatureConf: New conference alert 🚨.Towards Healthy Brain Aging will explore the latest advances in brain aging research in animal model….

Cortical closed-loop electrical stimulation can prevent pathological hippocampal-cortical communication and preserve long-term memory in focal epilepsy. @dk2955 @AhnafRHassan @UCIEngineering @NeuroE_C @UCIrvine @UCI_EpiCenter .

@ericmtrautmann, @HesseJanis, @gabrielmstine, Ruobing Xia, @shudezhu, @djoshea, Bill Karsh, Jennifer Colonell, @FrankLanfranchi, @SaurabhsNeurons, @AndrewZimnik, @AmematsroElom, @NatSteinemann, @danielwagenaar, @marius10p, Alexandru Andrei, Carolina Mora Lopez, John O’Callaghan,.

Neuropixels 1.0 NHP: a 45 mm, high-density silicon probe capable of recording large numbers of neurons with single-neuron resolution from most areas in a macaque’s brain.

Heat shock proteins function as signaling molecules to mediate neuron–glia communication via extracellular vesicles during aging in C. elegans. @Dong_Yan.

Protective exercise responses in the dentate gyrus of Alzheimer’s disease mouse model revealed with single-nucleus RNA-sequencing. @WrannLab, @MGBResearchNews, @NR_Tucker, @UpstateResearch.

Hippocampal neural activity in mice encodes both environmental location and experience relative to rewards, spanning distances far from reward, through parallel and flexible population-level codes. @lisa_giocomo.

A discrete GABAergic neuronal ensemble in the mouse medial orbitofrontal cortex (mOFC) that is selectively recruited in response to binge alcohol drinking and limits further drinking behavior.

A route for cerebrospinal fluid flow through leptomeningeal arterial–venous overlaps enables macromolecule and fluid shunting. @jonykipnis @Drieu_Antoine @WashU .

Autism is associated with inflexibility of brain dynamics. Watanabe and Yamasue show that TMS over the right superior parietal lobule while the brain is ‘stuck’ in a certain state reduces this rigidity and relieves various autistic traits. @takamitsu_w .

Mouse retrosplenial cortex encodes spatial hypotheses with well-behaved recurrent dynamics, which can combine these hypotheses with incoming information to resolve ambiguities. @jvoigts .

How homeostatic mechanisms protect the representational map of sounds after neuron loss in mouse auditory cortex.

Multiday imaging of CA1 neurons during learning reveals that the representation stabilizes as the number of readily retrievable, information-rich and stable place cells increases, and suggests novel mechanisms of hippocampal memory formation.