Nature Neuroscience
@NatureNeuro
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News, commentary and research coverage from the international monthly journal publishing the highest quality of work in all areas of neuroscience.
New York City
Joined January 2013
Our Chief Editor Shari Wiseman @sharilwiseman will be at the Chinese Neuroscience Society meeting in Xi'an next week. Send her an email if you'd like to meet to talk about your work! #CNS2025
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Grid cells do not operate as a global positioning system but rather estimate position within multiple local reference frames @KevinAllenLab
https://t.co/N67uggXomn
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Nature Neuroscience - Grid cells do not maintain a stable pattern during a self-motion-based task, but track animal movement in multiple local reference frames and reanchor to task-relevant...
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The activations of a canonical set of large-scale cortical functional networks are organized in an inherently cyclical manner, ensuring periodic activation of essential cognitive functions https://t.co/g7jyY7eASv
nature.com
Nature Neuroscience - The human brain cycles through a repertoire of brain networks on a 1-second timescale during rest and tasks. This cycling appears to allow periodic engagement of essential...
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Allothetic and idiothetic spatial cues control the multiplexed theta phase coding of place cells @yotaro_ramen
https://t.co/R0zLLkQRST
nature.com
Nature Neuroscience - Using a virtual reality apparatus in rats that dissociates external landmarks from self-motion cues, the authors describe how the two modes of theta phase coding in the...
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CRISPR screening by AAV episome-sequencing (CrAAVe-seq): a scalable cell-type-specific in vivo platform uncovers neuronal essential genes @MartinUCSF
https://t.co/9Da8KJDKCJ
nature.com
Nature Neuroscience - The authors developed an adeno-associated virus-based high-throughput in vivo CRISPR screening platform for endogenous mouse brain cell types. Using this platform, they define...
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Toxoplasma gondii infection and chronic IL-1 elevation drive hippocampal DNA double-strand break signaling, leading to cognitive deficits https://t.co/uRUD6emce1
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Nature Neuroscience - Chronic brain infection and IL-1 exposure impair spatial memory by triggering DNA double-strand break signaling in hippocampal neurons. Blocking this pathway prevents memory...
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Longitudinal neuroimaging in three adults, followed before and up to 5 years after arm amputation, reveals that amputation does not trigger large-scale cortical reorganization @HunterSchone
@Chris_I_Baker
@plasticity_lab
https://t.co/CiPn8e6fuO
nature.com
Nature Neuroscience - Longitudinal neuroimaging of participants with planned arm amputations shows that the cortical body map remains stable after amputation, with no evidence of hand or face...
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FOXP genes regulate Purkinje cell diversity and cerebellar morphogenesis @NaghamFarah_PhD
https://t.co/s3QddM57av
nature.com
Nature Neuroscience - The Li lab mapped molecularly distinct Purkinje cell (PC) subtypes in 3D and linked them to adult cerebellar architecture. They found that Foxp1/Foxp2 are essential for PC...
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Impaired capillary–venous drainage contributes to gliosis and demyelination in mouse white matter during aging @AndyShih_Lab
https://t.co/BHBNOZ07JG
nature.com
Nature Neuroscience - How reduced blood flow plays a role in progressive white matter loss during aging and associated cognitive decline is unclear. Here the authors show that selective...
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Viral reexpression of embryonic transcription factors (ISL1 and LHX3) in postnatal spinal motor neurons partially reactivates a youthful gene expression program and alleviates disease-relevant phenotypes in the SOD1G93A mouse model of ALS https://t.co/tKlxJUlanP
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Nature Neuroscience - Lowry et al. use embryonic motor neuron selector transcription factors to partially rejuvenate the gene expression profile of mature neurons, making them more resistant to an...
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Differential kinematic coding in sensorimotor striatum across behavioral domains reflects different contributions to movement https://t.co/001BLjMPx1
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Nature Neuroscience - Hardcastle and Marshall et al. show that striatal function is domain specific, required for task-related but not spontaneously expressed movements. This functional distinction...
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A pancreas–hippocampus feedback mechanism regulates circadian changes in depression-related behaviors https://t.co/D2L3UUo3at
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Nature Neuroscience - The mechanisms linking neuropsychiatric and metabolic disorders remain unclear. The authors show a pancreas–hippocampus feedback loop whereby metabolic and circadian...
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Aberrant splicing exonizes C9orf72 repeat expansion in ALS/FTD @suzhou_yang @guo_lab @Yale_INP @YaleNeuro @YaleMed
https://t.co/8ZGV5YzvSF
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Nature Neuroscience - By selectively isolating and sequencing the rare RNA transcripts containing C9orf72 repeat expansion from ALS–FTD neurons, the authors uncover an alternative splicing...
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Layer-specific changes in sensory cortex across the lifespan in mice and humans https://t.co/mCniiDKIuf
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Nature Neuroscience - The principal layer architecture of the sensory cortex is altered with aging. The authors show that overall thinning of the primary somatosensory cortex is driven by deep...
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Cross-species analysis of adult hippocampal neurogenesis reveals human-specific gene expression but convergent biological processes @UPenn_SongMing @zhoujoeyyi
https://t.co/ncFYJLqzc0
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Nature Neuroscience - Machine-learning-augmented single-nucleus transcriptomic analysis compared molecular landscapes of immature neurons in the mammalian hippocampus across species, highlighting...
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Potentiation of mitochondrial function by mitoDREADD-Gs reverses pharmacological and neurodegenerative cognitive impairment in mice https://t.co/j8GJXVrkDT
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Nature Neuroscience - Activation of Gs signaling at mitochondria by mitoDREADD-Gs increases mitochondrial metabolism, leading to better memory in mouse models of dementia, directly linking brain...
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Hypoxia ameliorates neurodegeneration and movement disorder in a mouse model of Parkinson’s disease @FumitoIchinose @VamsiMootha @MGH_RI @HarvardMed @BroadInstitute @HHMINEWS @MGBResearchNews @MGHanesthesia
https://t.co/Wan89lHJ4b
nature.com
Nature Neuroscience - Parkinson’s disease (PD) involves toxic protein buildup and energy failure in neurons. Continuously breathing low-oxygen air protected mice from PD-like neuronal loss...
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