Cell Stem Cell
@CellStemCell
Followers
59K
Following
2K
Media
2K
Statuses
10K
A monthly journal at the forefront of stem cell science and policy. Posts & opinions from Editor-in-Chief, Dr. Sheila Chari
Cambridge, MA
Joined June 2009
Bioprinted platform for parallelized screening of engineered microtissues in vivo https://t.co/CIuMiizEzk Article highlight from Cell Stem Cell
0
5
32
Read a joint collection from @CellStemCell and @stemcellreports (@ISSCR) on organs-on-a-chip systems which as research advances promise to transform biomedical science and improve therapeutic outcomes. https://t.co/MAOBXcIW3y
@GairdnerAwards @SickKidsNews
0
0
8
Online Now! Injury-induced Clusterin+ cardiomyocytes suppress inflammation and promote regeneration in neonatal and adult hearts by reprogramming macrophages https://t.co/WBxhjJZM7v
#stemcells
cell.com
Zeng and colleagues identify Clu+ cardiomyocytes as key regenerative drivers that orchestrate a cardio-immune circuit to resolve inflammation and promote CM proliferation, highlighting CLU as a...
0
5
31
Boosting dopamine: Following the lineage toward Parkinson’s repair
cell.com
Low yields of dopamine neurons in human stem cell-derived neural grafts limit their potential for treating Parkinson’s disease. Zhang et al. develop a new three-dimensional differentiation method,...
0
1
8
RPE replacement therapy for dry AMD—early success in a phase 1/2 clinical trial
0
0
5
Tissue regeneration: Unraveling strategies for resolving pathological fibrosis
cell.com
Tang and colleagues dissect cellular contributions and interplay among fibroblasts, epithelial progenitors, immune components, and vasculature in both regenerative and fibrotic responses to tissue...
0
11
45
N6-methyladenosine on L1PA governs the trans-silencing of LTRs and restrains totipotency in naive human embryonic stem cells
3
4
22
Human heart-macrophage assembloids mimic immune-cardiac interactions and enable arrhythmia disease modeling
cell.com
O’Hern et al. present a novel human heart-macrophage assembloid platform generated by integrating hPSC-derived embryonic monocytes into heart organoids. These tissue-resident macrophages regulate...
0
5
12
3D-generation of high-purity midbrain dopaminergic progenitors and lineage-guided refinement of grafts supports Parkinson’s disease cell therapy
0
1
5
EZHIP restricts noncanonical PRC2 binding and regulates H3K27me3 intergenerational inheritance and reprogramming
6
10
30
Vitamin C conveys geroprotection on primate ovaries
cell.com
Jing et al. demonstrate that oral vitamin C supplementation delays ovarian aging in non-human primates, attenuating key aging hallmarks and rejuvenating the ovarian cellular and molecular profiles....
0
4
5
Crosstalk between tissue mechanics and BMP4 signaling regulates symmetry breaking in human gastrula models
cell.com
Brivanlou and colleagues used optogenetics to spatially control BMP4 expression in human stem cell models across different mechanical regimes. By combining these experiments with mathematical...
1
7
32
Hypoxia promotes airway differentiation in the human lung epithelium
cell.com
Dong and colleagues uncover low oxygen-directed differentiation of human lung progenitors to airway rather than alveolar fate and show how the process is controlled by hypoxia-inducible factors....
1
7
25
A mineralizing pool of Gli1-expressing progenitors builds the tendon enthesis and demonstrates therapeutic potential
cell.com
(Cell Stem Cell 29, 1669–1684.e1–e6; December 1, 2022)
0
1
4
Safety and tolerability of RPESC-RPE transplantation in patients with dry age-related macular degeneration: Low-dose clinical outcomes
cell.com
Retinal pigment epithelium (RPE) cell loss in dry age-related macular degeneration leads to progressive vision decline. Stern and others implanted adult RPE stem cell-derived RPE progeny at a 4-week...
0
2
5
Check out our new resource paper @CellStemCell, where we present a brain organoid atlas of human neurodevelopmental disorders. Surprising was that nearly all patients had abnormal organoids. The challenge was aligning defects to clinical. https://t.co/0YtGTd4Dwb
3
51
190
Thrilled to share our new paper in @CellStemCell! We present a brain organoid atlas for NDDs, integrating hBO phenotypes, transcriptomics, WES, and brain imaging. We hope this resource inspires new studies and therapies for NDDs!
Check out our new resource paper @CellStemCell, where we present a brain organoid atlas of human neurodevelopmental disorders. Surprising was that nearly all patients had abnormal organoids. The challenge was aligning defects to clinical. https://t.co/0YtGTd4Dwb
2
2
8
Online Now! A phenotypic brain organoid atlas and biobank for neurodevelopmental disorders https://t.co/36hWuHDZM0
#stemcells
cell.com
Wang and colleagues present a phenotypic brain organoid atlas for neurodevelopmental disorders, revealing disease-specific cellular and molecular alterations that illuminate NDD pathogenesis....
0
3
12
Online Now! Senolytic-sensitive p16Ink4a+ fibroblasts in the tumor stroma rewire lung cancer metabolism and plasticity https://t.co/8FwA7UbG6B
#stemcells
cell.com
The tumor stroma contains heterogenous cell types with senescent phenotypes. Lee et al. characterize a cancer-associated fibroblast (CAF) subtype characterized by p16INK4a expression and myofibrobl...
2
7
16
Online Now! Generation of human nucleus basalis organoids with functional nbM-cortical cholinergic projections in transplanted assembloids https://t.co/jyeju9DNxv
#stemcells
cell.com
The nucleus basalis of Meynert (nbM) regulates cortical function and cognition. Liu and colleagues report a method for creating human nbM organoids (hnbMOs) containing cholinergic projection neurons...
1
4
18