Cell Stem Cell
@CellStemCell
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A monthly journal at the forefront of stem cell science and policy. Posts & opinions from Editor-in-Chief, Dr. Sheila Chari
Cambridge, MA
Joined June 2009
Interested in sharing your research at our Cell Symposium in LA?.We're keeping the abstract submission system open for poster and short talk submissions until August 1, 2025. Submit here: @CellSymposia #CSStemCells25
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Online Now! Non-canonical functions of DNMT3A in hematopoietic stem cells regulate telomerase activity and genome integrity #stemcells.
cell.com
Challen and colleagues show that the clonal expansion of Dnmt3a-null HSCs in serial bone marrow transplantation assays is not dependent on the loss of DNA methylation functions of Dnmt3a. They...
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Final call: Abstracts for Gene and cell-based therapies are due tomorrow Friday, July 18. Submit now for a chance to present your work at this symposium in LA! @CellSymposia #CSStemCells2025.
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Explore cutting-edge @CellStemCell research: Cell Stem Cell papers are available for full download 12 months after publication
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Looking forward to hearing from @Thomas_Rando @UCLAstemcell, Gordana-Vunjak-Novakovic @GVNlab @Columbia & Juan Carlos Izpisua Belmonte @altos_labs in our session “Aging and rejuvenation” @CellSymposia #CSStemCells2025. Abstracts due: July 18! .
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Explore a collection of articles highlighting recent advancements in gene editing, viral vector delivery, and bioengineering techniques that are accelerating the development of gene and cell-based therapies.
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Online Now! Bacterial ADP-heptose triggers stem cell regeneration in the intestinal epithelium following injury #stemcells.
cell.com
Here, Goyal et al. identify that the ALPK1-TIFA innate immune signaling pathway regulates regeneration in the intestinal epithelium. Importantly, detection of ADP-heptose by ALPK1 triggers intestinal...
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Toward building kidney organoids with plumbing: Fusion of nephron with ureteric bud
cell.com
The fusion of distal nephron and ureteric bud represents a critical developmental milestone required for establishing a functional kidney plumbing system. In this issue of Cell Stem Cell, Shi et al....
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The future belongs to those who believe in multiplex CAR T engineering
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We’ve extended the abstract deadline for @CellSymposia #CSStemCells2025 unitl July 18 to allow participants more time to complete their submissions. Submit your abstract for a chance to present your research at this exciting event in LA! .
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Beyond transplantation: Gene-edited pig liver supports function in a human host
cell.com
A recent study in Nature demonstrates that a gene-edited pig liver can function in a brain-dead human for short-term support. This highlights the potential of xenogeneic liver transplantation as...
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From symbiote to bad neighbor: The intestinal microbiome as a driver of CHIP
cell.com
Hematopoietic stem cells (HSCs) with mutations that can cause clonal hematopoiesis of indeterminate potential (CHIP) accumulate during aging. Agarwal et al. demonstrate in Nature that intestinal...
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An organ-chip model of sporadic ALS using iPSC-derived spinal cord motor neurons and an integrated blood-brain-like barrier
cell.com
Lall et al. differentiate iPSCs from young-onset, sporadic ALS patients into spinal cord motor neurons and co-culture them with brain microvascular endothelial-like cells in a microfluidic organ-chip...
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To play Paneth or goblet: Shapeshifting secretory cells read the room
cell.com
(Cell Stem Cell 32, 861–863; June 5, 2025)
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Multiomic profiling reveals that prostaglandin E2 reverses aged muscle stem cell dysfunction, leading to increased regeneration and strength
cell.com
Wang et al. uncover that aged muscle stem cells have blunted PGE2-EP4 signaling that is critical for their regenerative function. Treatment with exogenous PGE2 reverses age-related defects in muscle...
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Human airway submucosal gland organoids to study respiratory inflammation and infection
cell.com
Lin and Pou Casellas et al. established human airway submucosal gland (SMG) organoid cultures that capture region-specific mucous cells and viral infection responses. These SMG organoids provide a...
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Preferential tumor targeting of HER2 by iPSC-derived CAR T cells engineered to overcome multiple barriers to solid tumor efficacy
cell.com
Hosking and colleagues have generated and preclinically characterized an off-the-shelf, allogeneic CAR T cell, derived from an induced pluripotent stem cell, that is intended to target HER2 on cancer...
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IGF2BP1 restricts the induction of human primordial germ cell fate in an m6A-dependent manner
cell.com
Zhang, Gu, Tong, et al. use human primordial germ cell-like cells induced from ESCs to show that germline entry is restricted via epitranscriptomic regulation of OTX2 by the m6A reader IGF2BP1. They...
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Deconvoluting clonal and cellular architecture in IDH-mutant acute myeloid leukemia
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