KB: So today we are pleased to introduce the Chromium Single Cell ATAC + Gene Expression solution. 2 modalities in one simple workflow, both at high sensitivity.
#AGBT20
We are excited to announce the release of our large-scale
#immunology
dataset. The dataset, using over 150k CD8+ T cells from 4 human donors, analyzed 44 specific antigens. We hope it enables a new way of exploring adaptive immunity.
Observe tumor biology in its native tissue with high-resolution, high-target in situ analysis. Get your first look at the upcoming Xenium In Situ platform at Booth 3340
@AACR
#AACR22
Spatially resolved transcriptomics publications are on the rise! With so many papers and not enough time to read them all, where should you start? We’ve got a list of exciting recent publications featuring spatial transcriptomics. Learn more on our blog.
Excited to celebrate our
#10xGenomicsIPO
on
@NASDAQ
today. The Century of Biology is here and we are thrilled to be a part of it. Thank you once again to our customers, investors and our team!
A new public company, yet another milestone on our path to mastering biology to advance human health. This is the Century of Biology.
#10xGenomicsIPO
#CenturyofBiology
$TXG
@NASDAQ
We’re excited to announce that
#VisiumHD
is now available for pre-orders, offering:
✅ Whole transcriptome spatial analysis at single cell scale
✅ Continuous tissue coverage (really, no gaps!)
✅ Best-in-class data
Enter the HD era to see for yourself:
Breaking 🗞: The first Xeniums are heading out into the world! We can’t wait to see what insights they uncover. Want to level up your research? See how Xenium lets you map 100s of RNA targets with subcellular resolution & reserve yours today:
Combined
#singlecell
&
#spatialtranscriptomics
analysis of 300,000 single cell transcriptomes & 400 patient samples produced the most detailed picture of heterogeneous T cells in the tumor microenvironment to date. Explore the published resource ➡️
Thank you to our customers, employees and investors for getting us to today. With over 500 scientific papers published using 10x, we can’t wait to achieve even more in the coming decades.
#CenturyOfBiology
$TXG
#10xGenomicsIPO
Recently, the
@JD_Buenrostro
Lab identified a new artifact called Barcode Multiplets in data generated with our Single Cell ATAC Solution . Please see our note here .
Visit us in Union at
#AGBT22
to get your first glimpse inside the Xenium Analyzer & learn about the latest in single cell, spatial and in situ biology.
We are excited to announce the acquisition of
@STomics
, a pioneer in the emerging field of
#spatialtranscriptomics
. The new field allows researchers to not only see what is in a cell, but how the cells are organized in relation to one another.
#SingleCell
and
#SpatialGeneExpression
tools were transformational. Xenium
#InSitu
technology is revolutionary. Explore the cellular localization of 100s of targets and fully immerse yourself in your tissue. See for yourself in our new preprint:
We are excited to announce the launch of the Chromium Single Cell ATAC Solution! The new solution enables researchers to reveal chromatin accessibility cell by cell with
#singlecell
#epigenomics
#ATACseq
. Learn more here:
Our team has been hard at work getting the Single Cell Multiome ATAC + Gene Expression kits ready to ship. The first kits shipped today. Leverage two modalities at once to enhance characterization of cell types & states, & reveal gene regulatory programs.
We know it’s tough to work from home, homeschool, and entertain children. To help inspire your budding scientist we put together a coloring sheet. Share your artwork as a Reply! (click on image & download)
#ColoringSheet
Gain deeper insights into cell types and states with integrative multi-modal
#singlecell
analysis. Join
@satijalab
as he demonstrates the power of Seurat v4 for integrative analysis of gene expression alongside additional modalities.
We’re excited to see this recent Nature article showcasing how a longitudinal single cell atlas using Chromium
#SingleCell
Immune Profiling v2 identifies a complex temporal relationship between type I interferon response and COVID-19 severity. Read more:
There have been recent reports on the litigation by Bio-Rad against 10x. Our CEO, Serge Saxonov’s, letter gives context. You can rest assured that we have been extensively planning to ensure our customers' important research continues without disruption.
Experience the revolutionary resolution of our Xenium
#InSitu
technology first hand by taking a subcellular tour of our
#BioRxiv
preprint breast cancer gene expression dataset using our new interactive visualization tool:
We're excited to announce that the Visium Spatial Gene Expression Solution is now shipping. Our CSO Ben Hindson tells
@FierceBiotech
how Visium works and which questions it can help scientists answer.
#spatial
Tumor clonal evolution is crucial to understanding the heterogeneity that drives cancer progression and therapeutic response, but difficult to trace. Learn how
@CalebLareau
, PhD, developed mitochondrial single cell ATAC-seq to track clonal lineages.
We believe the future is bright for spatial biology & are thrilled
@naturemethods
agrees! They named spatially resolved transcriptomics their Method of the Year 2020 & included 10x Genomics Visium Spatial images on the issue’s cover. Learn more on our blog.
Hot off the press!
#singlecell
learning on the go. Watch this nine-part miniseries to learn:
🔑 Key considerations for single cell experimental design
📕 Best practice guidance for successful sample preparation
🔎 Single cell analysis workflow
Good things are worth waiting for. We might have made you wait a little longer than you wanted…😅 but the wait is over! We’re shipping
#VisiumHD
today, putting
#wholetranscriptome
spatial discovery power at single cell–scale resolution in your hands.
While most 10x Genomics employees are safely sheltering in place at home, some essential employees are at the office keeping our operations going. THANK YOU to our manufacturing and operations teams, and the teams that support them!
#InThisTogether
Excited to share this video on Spatial Transcriptomics, which allows scientists to measure gene activity w/i a tissue & map where activity occurs. Spatial technology has led to advancements in understanding of diseases including Alzheimer's, Parkinson's, cancer & more.
#Spatial
Important new cancer research using 10x technology - Researchers have developed a new method, RAGE-seq, to spot rare immune cells that are reactive against cancer cells, from within a patient's own immune system.
#Cancer
#Immunotherapy
Based on overwhelming demand for in situ technology, we’re kicking off an In Situ access program. A select number of researchers will have access to the current Cartana technology, while we build out an end-to-end solution. Applications open mid-2021!
#Xperience10x
Loupe—our desktop visualization & analysis tool—can guide your
#singlecell
data exploration & maximize biological insights. And it just got an upgrade. Attend our Jan 25th webinar to see the latest features in action with a live demo. Register now ➡️
Excited to be getting closer to the launch of Visium Spatial Gene Expression Solution, our new product that allows scientists to measure all gene activity within a tissue sample & map where activity occurs. Learn the types of discoveries possible.
#Spatial
We would like to welcome
@STomics
to the 10x family! We are joining forces to provide researchers with innovative tools to help drive new discoveries within disease areas, such as oncology, neurology and immunology.
#spatialtranscriptomics
Visium Spatial Gene Expression for FFPE v2 is here! Larger capture areas, CytAssist compatibility, and protein + GEX from a single section. Learn more in Union at
#AGBT22
This morning, NanoString received a court-ordered injunction to stop selling CosMx instruments and reagents for RNA detection in Germany. We’re dedicated to ensuring your research continues. Learn more: (1/5)
Scientists at
@sloan_kettering
are believed to have made a fundamental discovery about how dendritic cells in immune system are organized into distinct types, which could inform immunotherapy for cancer & other diseases. The team used 10x
#scRNAseq
.
18K. It’s the number of genes you can spatially map in human and mouse FFPE tissues, while maintaining morphological context and insights, using
#VisiumHD
. That’s whole transcriptome discovery power at the resolution you need—
#singlecell
scale! Learn more:
NR: FFPE is the most commonly used preservation method, and today we are introducing FFPE enablement. Using a modified Visium protocol we are able to recover data that correlates between FFPE and Fresh Frozen
#AGBT20
Great collaboration w/
@UCSF
,
@Princeton
& 10x, resulting in a recent
@NatureBiotech
publication, describing an enhanced method for functional genomics using
#singlecell
#CRISPR
screens that simultaneously detects the guide RNAs & resulting transcriptomes.
The
@naturemethods
2019 Method of the Year is.... single cell multimodal omics. 10x is proud to be a part of this shift toward multidimensional analysis and the larger scientific effort to develop a complete and vivid picture of complex biology.
1/2 - Today we are launching the Chromium Single Cell CNV Solution, the first scalable and easy-to-use technology for rapid and massively parallel profiling of
#singlecell
genomes.
#GoExponential
#AACR18
10x Co-founder and CSO Ben Hindson, was invited to speak at the
#ozSingleCell19
Conference Dinner yesterday evening. A native of Australia, Ben's inspirational story of how he co-founded 10x Genomics resonated powerfully with the attendees back home.
Our new building in Pleasanton is coming along, and we will need more people to fill the space. Browse our job openings or learn about a career at 10x:
What’s possible when FFPE is no longer a barrier to spatial gene expression analysis? See the exciting future that researchers like
@DrLizJaffee
and
@FertigLab
are envisioning with spatially resolved transcriptomics for FFPE samples. Learn more:
The next generation of multiomics is here. Find out how researchers created TEA-seq and DOGMA-seq, new techniques to help you discover more from the same single cell. Read the blog for more.
We have launched two new Master Course episodes on
#spatial
technology. Learn how you can map the whole transcriptome while maintaining morphological context, which provides new insights into your research in this Master Course series.
Access a transformative view of cells and complex biology with Chromium Single Cell Multiome ATAC + Gene Expression from 10x Genomics. Watch this video to explore the power of measuring two modalities in one cell.
#multiome
Excited this paper by Stanford & 10x researchers is on BioRxiv! Researchers integrated single cell transcriptomic & epigenomic profiles from leukemia to help track the developmental origins of the cancer & uncover pathogenic gene regulatory signatures.
As 2020 comes to a close, we want to look back on and honor the significant strides that have been made to understand
#COVID19
and the host immune response. Explore this summary of innovative COVID-19 research enabled by
#singlecell
technology.
8 months since Xenium launched. Over 100 Xenium instruments shipped. And so many happy customers! 🤩 See what our early customers are saying about this milestone, then stay tuned—because we’re just getting started!
FFPE has been a blessing to life science research but a challenge to genomic analyses, including spatial biology. That’s about to change with the arrival of Visium for FFPE. Read our latest blog post to learn more.
B cells are an undisputed juggernaut in adaptive immunity, but their role in anti-tumor immunity is a mystery. A
#singlecell
study suggests that a B-cell surface protein may be a major clue. Learn how this finding could inform future immunotherapies!
Chromium X is on the move! Our latest single cell instrument has made its way to
@Bruskolab
and is looking good in its new home. Excited to see where it will end up next. Is Chromium X headed to your lab? Share your photos with
#MyChromiumX
Important new research - Scientists from
@sangerinstitute
,
@UniofNewcastle
& Univ. of Cambridge, and colleagues have created the human developmental liver cell atlas that provides crucial insights into how the blood and immune systems develop in the fetus.
To make groundbreaking discoveries, you need innovative tools that let you reach new insights into complex biology. Join our Next Generation Multiomics Symposium to explore the latest technology and discoveries in multiomic profiling. Register today:
#Singlecellspatial
imaging technologies empower new insights—but how do the different platforms stack up? Find out in a webinar where leading spatial researchers compared Xenium In Situ and NanoString CosMx and see which came out on top in their hands:
Scientists from the
@lieberinstitute
recently leveraged the Visium Spatial Gene Expression Solution to study layer-specific gene markers and cell-type enrichment in the six layers of the human prefrontal cortex. Read more in our blog:
We recently launched the Visium Spatial Gene Expression Solution & are excited to announce the accompanying software is now available. Space Ranger enables automated data & image processing, while Loupe Browser allows you to visualize data. See a tutorial.
Excited to be at Single Cell Genomics Day hosted by
@satijalab
! 10x Scientist Grace Zheng is up talking about Dissecting Complex Systems with Multidimensional Data to a full room at NYU Center for Genomic and Systems Biology.
#SingleCell
Register and join
@LGMartelotto
in this webinar where he introduces single nuclei pathology sequencing
#snPATHOSeq
with FFPE samples, and how he uses CytAssist enabled Visium for deconvolution to understand cell type composition.
#singlecell
#RNASeq
We highly recommend this fantastic review from
@sophia_longo
@MargaretGuo3
and
@andrewlji
on the latest methods for integrating scRNA-seq & spatial transcriptomics data, a powerful approach to elucidate intercellular tissue dynamics.
B cells are an undisputed juggernaut in adaptive immunity, but their role in anti-tumor immunity is a mystery. A
#singlecell
study suggests that a B-cell surface protein may be a major clue. Learn how this finding could inform future immunotherapies!
New pub in
@CellCellPress
uses the
#SingleCell
Immune Profiling Solution to pair gene expression with TCR typing from 27,000 T cells, revealing the combinatorial impact of TCR utilization on phenotypic diversity in the tumor microenvironment.
It's been a great week for
#immunology
papers using 10x
#single
cell. Here are three papers with important research.
-Innate immune response to infections & immunity
-Immunity to chronic infections
-Asthma
Ever wish you could run single cell experiments with fixed samples? Now you can. With our new Single Cell Fixed RNA profiling kit, you can access a greater breadth of clinical samples collected at all hours, from all over the world, or containing fragile cell types.
#Xperience10x
Our R&D team used BEAM-Ab to screen 100 million PBMCs from a donor who recovered from COVID-19, identifying 222 antibodies with high binding affinity to SARS-CoV-2 spike protein. Don’t miss
@mjtstubbington
presenting May 7 at 9:42 AM PDT, Room A105-106.
#AAI2022
@ImmunologyAAI
New
@nature
cover - Researchers use
#singlecell
#RNAseq
to create a single-cell atlas of the interface that forms between mother & the developing fetus. The atlas should help identify the causes of problems in pregnancy such as pre-eclampsia & stillbirth.
We are excited to announce the launch of Targeted Gene Expression. The addition of targeted panels to our whole transcriptome capabilities enables the flexibility, scalability and efficiency to maximize your
#singlecell
&
#spatial
gene expression studies.
We sat down with three leading scientists of
@GarvanInstitute
,
@WEHI_research
and
@UQ_News
to uncover how they are using our single cell and spatial technologies to see biology in new ways. Watch the first of our four-part Australia Thought Leader Series:
The Gene: An Intimate History, airs TOMORROW. The program brings to life the story of today's revolution in medical science at the forefront of the search for genetic treatments. We're proud to be the local sponsor on KQED 9.
#TheGenePBS
Mapping spatial organization of cells in complex tissues like the brain is challenging. Join Dr. Omer Bayraktar for a discussion on successfully integrating
#singlecell
& spatial transcriptomics data to create high-resolution atlases of complex tissues:
This very popular webinar is now available on-demand. Hear guest speaker
@satijalab
of
@nygenome
discuss Seurat v3, a software that addresses challenges of integrating different data types (
#scRNAseq
,
#scATACseq
,
#spatial
).
Happy Anniversary to us! 🎉 We kicked off our celebration of
#10yearsof10x
with a fun-filled family day last Saturday. We’re excited to continue celebrating our growth and community with each other. Here’s to an amazing 10 years and many more after that!
Dr. Diether Lambrechts of KU Leuven is sharing his insights about using
#singlecell
immune profiling technology to uncover the cellular, molecular, and inflammatory features of mild and severe
#COVID19
. Find out more in this upcoming webinar:
Want to know what motivates the work we do at 10x Genomics? It’s your amazing research! We're celebrating a milestone of 1,000 publications leveraging 10x Genomics technology. That’s 1,000 steps closer to mastering complex biology. Read more on our blog.
We’ve been running demos of our new Connect product this week at
#ASHG19
. Here’s
@DarishaJhutty
showing how Connect automates
#SingleCell
library prep.
Don’t miss our double feature today at the
#SFN22
poster hall! Check out our first poster, “Spatial Transcriptomic Profiling of Brain FFPE Tissues Sectioned on Glass Histology Slides by Automated Transfer of Analytes” (Presentation # 161.09)...
We value our talented team of women scientists and appreciate the passion that they bring to their work. Meet scientist Jill Herschleb, Director, Sample Prep, who knew from an early age that she wanted to pursue science and decided nothing would stop her.
Interesting
#scRNAseq
research on the development of congenital heart defects. "Single-cell analysis of cardiogenesis reveals basis for organ-level developmental defects" in
@nature
.
Some say that the peaks present in scATAC-Seq libraries from
@10xgenomics
are indicative of the periodicity of the chromatin structure
Personally, I would like to believe they are from a ghost that haunts me in the lab: