Jason Spence
@TheSpenceLab
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Studying stem cells, development and disease. Opinions are my own.
Ann Arbor, Michigan
Joined August 2013
@ChanZuckerberg We identified two transcriptional states for alveolar AT2 cells. Using spatial transcriptomics, we found that AT2 cell states reside in specific niches (neighborhoods), interact with distinct alveolar fibroblast subtypes and are driven by inflammatory/anit-inflammatory signals.
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Excited to share our newest preprint, "Clinical Interventions and Inflammatory Signaling Shape the Transcriptional and Cellular Architecture of the Early Postnatal Lung". Led by Tristan Frum with funding from the @ChanZuckerberg Pediatric Network. https://t.co/i0fucaxWg4
biorxiv.org
The early postnatal period in human development is characterized by extensive remodeling of the distal lung to support gas exchange, but this critical period remains poorly understood. Here, we...
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@biorxivpreprint Clinical Interventions and Inflammatory Signaling Shape the Transcriptional and Cellular Architecture of the Early Postnatal Lung https://t.co/QHR2V8I6bp
@TheSpenceLab @UMichMedSchool
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New #organoid preprint from the Spence Lab, the Translational Tissue Modeling Laboratory ( https://t.co/BGl1rw3CZB) in collab with @jonnysexton @SextonLabUM A scalable long-term in vitro model of human colonic epithelium with continuous barrier function https://t.co/pJgI7YRs8g
biorxiv.org
Background & Aims Human in vitro models of differentiated intestinal epithelium are valuable research tools for discovery and translational medicine. Primary adult colonic epithelium barrier function...
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Human-mouse cross-species comparison identifies common and unique aspects of intestinal mesenchyme development https://t.co/6EC6M7MVkP A companion piece to our recent work from my colleague Kate Walton, led by Kelli Johnson and Xiangning Dong!
Excited to share our latest preprint led by Kelli Johnson- Mapping mesenchymal diversity in the developing human intestine and organoids! We defined 5 mesenchymal populations occupying discrete anatomical locations within the human intestine. https://t.co/rzSfsdGhjO
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Impaired stromal-epithelial cross-talk in Hirschsprung disease highlights the risk of epithelial damage, suggesting a therapeutic option https://t.co/ZLdlmeOrIW
@ScienceTM
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Excited to share our latest preprint led by Kelli Johnson- Mapping mesenchymal diversity in the developing human intestine and organoids! We defined 5 mesenchymal populations occupying discrete anatomical locations within the human intestine. https://t.co/rzSfsdGhjO
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🔬Advances in Precision Medicine underscore the importance of 🧬biomarker-informed care in NSCLC. Learn how upfront NGS testing can provide the most comprehensive biomarker information, while also reducing overall cost and time to results:
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Diet/microbes place the gut epithelium as a nexus for evolutionary change. With @TheSpenceLab @genomeCraig, we use #organoids to explore how evolution prepared the developing human intestine for exposure to the environment. @ScienceMagazine #evodevo 🧵1/11 https://t.co/VKQtZ3LMaW
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Recent evolution of the developing human intestine affects metabolic and barrier functions @ScienceMagazine @GrayCampLab @TheSpenceLab
https://t.co/uot3FLrgLK
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We are very excited to officially launch our single cell proteomics service!! Please, check out our website if you want to work with us! https://t.co/3beLRHphKU
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So honored to receive a BWF CAMS and thankful to all of my mentors and supporters along the way! BWF Announces 2025 Career Awards for Medical Scientists
bwfund.org
The Burroughs Wellcome Fund is pleased to announce the recipients of the 2025 Career Awards for Medical Scientists (CAMS). This award supports early-career physician-scientists as they transition...
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Integrated Organoid Atlas benchmarks new protocols, even more impressive as a Highly Variable Cohort for comparison against perturbation and disease models: https://t.co/HntzSYo9zF Lead by @_xuquan @HalleLennard Collaboration with @fabian_theis @TreutleinLab @IHB_Research
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Interested in single cell genomics but need help getting started? Check out the full agenda for our Single Cell Genomics Day on Friday 4/25. All talks will be live-streamed (no registration required) at https://t.co/JqaO6urVPF
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Lab’s latest: (mouse) mums grow their guts during pregnancy and lactation: https://t.co/bk54zNof0k
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Organoids of human intestine made more functionally life-like with epiregulin – promoting neurons, vessel & smooth muscle cells 📷: @c_j_childs et al @TheSpenceLab @UMichMedSchool in @CellStemCell ➡️: https://t.co/aXyzbGU1RD
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Thank you to everyone who attended the 2025 RIKEN BDR-@CuSTOMOrganoids Joint Organoid Symposium, in Kobe! The last two and a half days were filled with exciting talks on the latest advancements in #organoid research. We wish everyone a safe journey home! https://t.co/WY7lCfYHaX
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I truly appreciate all speakers and participants who attended the BDR-CuSTOM Organoid Symposium! See you again!　@Takashima_Lab,@fu_jianping,@GrayCampLab,@AnsethGroup,@nmontlab,@TheSpenceLab,@YokokawaLab,@MasayaHagiwara,@CuSTOMOrganoids,@Takebelab_JP,@TakebeLab,@ZornLab
Thank you to everyone who attended the 2025 RIKEN BDR-@CuSTOMOrganoids Joint Organoid Symposium, in Kobe! The last two and a half days were filled with exciting talks on the latest advancements in #organoid research. We wish everyone a safe journey home! https://t.co/WY7lCfYHaX
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Online Now! Coordinated differentiation of human intestinal organoids with functional enteric neurons and vasculature https://t.co/3yDOmq2ckI
#stemcells
cell.com
Childs et al. leverage the human intestinal stem cell niche factor EPIREGULIN (EREG) to enhance PSC-derived human intestinal organoid (HIO) differentiations. EREG-grown HIOs pattern epithelium,...
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