ecDNA biology is one of those weird, fascinating corners of bio that hook me every time there's a new result. So I loved reading about this one from @HowardYChang & Paul Mischel's labs in @Nature. Very interesting implications for design of non-diluting, non-integrating gene

one of my strongest held beliefs is that the vast majority of media covering biotech is awful, not because it could not be produced better, but because the producer is often attempting to speak to a population that, one, couldn't care less, or two, wouldn't understand the

SDR-seq on the cover of @naturemethods !🤩

Ask not why would you work in biology, but rather: why wouldn't you? https://t.co/7zkdjniFQ9 openai/gemini gave this essay an A- for evocative imagery. claude gave it a C- for being emotionally manipulative. both are probably right. i feel a little sick re-reading it

@E11BIO is excited to unveil PRISM technology for mapping brain wiring with simple light microscopes. Today, brain mapping in humans and other mammals is bottlenecked by accurate neuron tracing. PRISM uses molecular ID codes and AI to help neurons trace themselves. We discovered

Huntington's disease was successfully treated for the first time with gene therapy. 75% reduction in symptoms & 113% protection of cognition. This is what a real medical breakthrough looks like.

Rooting for @EliahOverbey to get to go to space (for science)! & check out her convo with @yashevde who’s pioneering “spacecare” with @UrsaBio - a super interesting approach to accelerate discovery of therapies for diseases that affect humans on earth & in space alike

In two weeks, the 2025 Nobel Prizes will be announced. Based on looking at other pre-Nobel “predictor” prizes, I think that these 36 scientists are the most likely candidates:

!!!

@NikoMcCarty @ParallelSqTech @AsimovPress Staggering sample loading to fit more samples per mass spec run:

@NikoMcCarty @ParallelSqTech @AsimovPress Screening for more peptide barcodes:

@NikoMcCarty @ParallelSqTech The @AsimovPress essay:

I was super excited to learn from @NikoMcCarty's essay, "How to Scale Proteomics", that there's an FRO working on high-throughput single-cell proteomics (@ParallelSqTech), and even more excited to see the progress they've made in just 2 years via their preprints. So here's a

@ScienceMagazine CORRECTION‼️: Syn61 can incorporate 3 ncAAs, Syn57 can incorporate 7. My mistake comes from the assuption that you'd need to reengineer the native E Coli tRNAs for charging with different amino acids, in which case there would not be enough codon-anticodon specificity to use

Potential biosignature on Mars: confirmed. ✔️ After a year of scientific review, we are more sure than ever that our Mars Perseverance's 'Sapphire Canyon' sample could contain signs of ancient microbial life. Learn more about the discovery: https://t.co/RMO2UFfnjv

Can you rejuvenate an old brain by giving it young immune cells? 🧠 My lab @calico put it to the test. In our new study, we replaced the brain's immune cells in old mice with young ones. The result? The old brain environment forced the young cells to age RAPIDLY. A 🧵👇

We are excited to share that our paper (D. Lindenhofer et al.) on SDR-seq, a combined single-cell DNA-RNA sequencing method, has been published in @naturemethods! 🎉  Watch co-author Julia Bauman’s video on how SDR-seq links coding & non-coding variants to gene expression.

Is the longevity field making progress? @NornGroup formed in 2021 to address that question. We’ve now built a website to make it clear who we are and how we work to make longevity medicine real. Read on for a summary, and some of our outputs.

https://t.co/kfpLa00cH3

What good is a science communication channel if you don't get to talk about your own papers on it occasionally, right?😊 We developed a method to simultaneously sequence single-cell DNA and RNA targets, enabling association of genomic variants (including non-coding!) with gene