Shane Liddelow 🍊
@LiddelowSA
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Neuroscientist and glia aficionado @nyulangone , @nyugrossman , @NYULH_Neuro Tweets in my individual/personal capacity. he/him
New York, NY
Joined June 2017
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With COVID-19 quarantines, now everyone can feel like a PI - locked in a room, looking at your computer screen, eating lunch alone.
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IF. YOU. DON'T. ACKNOWLEDGE. YOUR. TRAINEES. WHILE. YOU'RE. PRESENTING. THEIR. WORK. YOU. DON'T. DESERVE. TO. PRESENT. THEIR. DATA.
(skipping over your acknowledgements slide at the end because you forgot to plan accordingly is not appropriate)
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Full disclosure for the grad students struggling out there.
I was in lab for 15h yesterday. And my experiments didn't work. I've done this assay over 1000 times. And it didn't work. It happens sometimes.
Looking at my lab notes today to work out what went wrong.
Hang in there.
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@KarenMSmith_bio
@effatma
he did, and he was wonderful in every way
here is an example of this
(if the time stamp didnt copy - skip ahead to 11:30)
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Out Today in
@NatureNeuro
– work from
@HaselPhilip
- 𝗡𝗲𝘂𝗿𝗼𝗶𝗻𝗳𝗹𝗮𝗺𝗺𝗮𝘁𝗼𝗿𝘆 𝗮𝘀𝘁𝗿𝗼𝗰𝘆𝘁𝗲 𝘀𝘂𝗯𝘁𝘆𝗽𝗲𝘀 𝗶𝗻 𝘁𝗵𝗲 𝗺𝗼𝘂𝘀𝗲 𝗯𝗿𝗮𝗶𝗻 (, data at , )
READ MORE below: (1/9, a thread)
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Out today in
@Nature
– we report on the identity of the astrocyte-derived toxic factor. An important discovery for the neurodegenerative disease and trauma fields.
Lead author
@kevinguttenplan
wrote a great thread – check it out below.
(mini thread 1/4)
People have long thought that astrocytes release something that kills neurons, which could partly explain why neurons die in injury/neurodegenerative disease. In a paper that just came out, we think we found one of these long-sought toxic factors! (1/8)
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Very humbled to both receive this award from
@AlzResearchUK
, and to be called 'super cool'!
Lots of exciting stuff coming out soon in the neurodegeneration space from the lab. Shout out to
@JessSadick
,
@IVLRose
,
@HaselPhilip
,
@_rdkim
, Alice Kwon, and
@kevinguttenplan
.
#BestLab
We’re pleased to announce that the super cool Dr Shane Liddelow has won the prestigious David Hague Early Career Investigator of the Year Award for his outstanding work in the field of biomedical dementia research. Well done,
@LiddelowSA
!
Researchers
#MakeBreakthroughsPossible
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Happy birthday
#BenBarres
.
Not a day goes by where you aren't missed, or I don't call on your wisdom.
A thoughtful scientist, and an excellent mentor. Your contributions to science, and scientists is immense.
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COVID-19: I'm going to get everyone, but older people first.
Young PIs: OK, I best shutdown the lab and isolate, even though we're at less risk.
Old PIs: GET TO WORK - I NEED DATA
(institutions should look closely at WHO won't shut down their labs... then ask why... then fix it)
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Happy birthday to
#BenBarres
. You taught us a lot about science in general, glia more specifically, and how to be better mentors and humans.
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accepted!
it's a big one, so keep your eyes peeled
lots of data and resources for the community
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When applying for positions (grad school, postdoc, faculty) please use "I" in your presentations. We need to know what YOU did. Always acknowledgement those who helped you... but don't be afraid to say "I did this" "I planned this". We're hiring you, not your colleagues.
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11 years ago today I arrive at
@Stanford
for my postdoc with
#BenBarres
. Nowhere to live, only two suitcases, and no local support network.
Remember to touch base with your immigrant trainees - its tough to get going, and have continued support.
What helped everyone else?
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Today in lab meeting I presented a topic chosen by the lab - lab finances/accounting.
This was something I wish we covered when I was a postdoc. There are so many things you don't realize about 'grownup' science life.
What other topics should we cover in future lab meetings?
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Full disclosure: it's been a long string of grant rejections. But this week was met with a great impact score followed by paper acceptances three days in a row.
_*you just gotta hang in there*_
Big things coming out soon - watch this space and stay tuned for the Tweeprints!
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(Tweeprint: 1/6)
Why would astrocytes, which normally support neuron health, start killing them during disease? This was the question
@kevinguttenplan
set out to answer in our latest paper in
@CellReports
.
We used the visual system... (partly)for the googly eye gifs.
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PAPER ALERT - "Molecular and metabolic heterogeneity of astrocytes and microglia"
Great fun working on this review in
@Cell_Metabolism
with
@HaselPhilip
,
@willaise
, and
@FChrisBennett
.
we didnt make the cover - but I love this image of micros and astros
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Wanna see something cool? How about a primary immunopanned astrocyte, grown in serum-free conditions... with 9 primary processes!
All credit to Rachel Kim (2.0) - amazing graduate student in the lab
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So incredibly honored to receive this award. Particularly poignant given that Inge Grundke-Iqbal stood for so many of the same fairness and equality measures as we do.
Congratulations to Shane Liddelow
@LiddelowSA
on receiving the Grundke-Iqbal Award for Alzheimer’s Research for research on the role of reactive astrocytes in driving cell death in neurodegenerative disorders.
#AAIC19
.
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"Good mentorship is not only pivotal for career success, but it is pivotal for driving innovation"
Happy birthday Ben
I miss your advice and advocacy daily.
Today is a perfect time to remind incoming graduate students - choose your advisor carefully
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Today I got to prove that I can still do experiments as a PI.
It's true... you do miss the bench. But the thought of all that other stuff I didn't get to do today because I was playing with astrocytes is a bit scary.
Also... largest prep in the lab since opening!
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Interested in reactive astrocyte sub-states and brain location?
TONNES of data from
@HaselPhilip
's latest paper in
@NatureNeuro
.
Paper here -
Data here - ,
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Exciting work out of the lab in
@NeuroCellPress
today. Big congratulations to
@michaelrodea
,
@JessSadick
, and other members of the lab who contributed.
Lots of data for mining on our updated sequencing portal:
As always - more to come!
Happy to share that our paper on transcriptional changes in glia in Alzheimer’s disease is out today in
@NeuroCellPress
! You can explore the data interactively at .
@JessSadick
@LiddelowSA
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updated look... same data
new QoL improvements:
1. datset downloads
2. orthologs - hello swimmers & squirmers!
3. modern design, still mobile friendly
new APP coming soon - FREE for all - share your RNAseq data with only a spreadsheet and 20 minutes
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NOA
that's the tweet
(everyone else was doing it, I just wanted to be popular)
underlying honesty - this one took a while, lots of near misses and failures along the way
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10 years to the day that I moved full time to the US. Flew from MEL->SFO with only two suitcases, lots of debt, and no apartment ... it was a stressful first week finding something in Palo Alto that I could afford!
A supportive lab and friends helped a lot.
Thanks everyone!
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Happy birthday Ben.
Every day you're missed, and every day I'd still like to ask for some advice (or show you another gene list!)
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Do you like glia?
What about Berlin, or amazing coffee, or street art, dance parties, or any number of amazing things you'll be able to do at
#EuroGlia23
?
Abstract submission now open (through 02/06/23) -
Travel awards available -
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For those who would like the CliffsNotes version the
@nyugrossman
press office wrote a nice accessible piece available here -
full paper available
@Nature
here -
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When you just gotta tell people glia are important you need to have a partner in crime.
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On a page with some of my science heros and favorite people.
#brainsexplained
is a great book - bravo
@alie_astrocyte
@neuroyoutube
@micah_psych
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A stressful start to the week for a junior PI - first student defense 😥
But... congratulations to Dr Alice Kwon 🥳 great job and exciting defense talk
@nyugrossman
,
@NYULH_Neuro
You thought we just worked on astrocytes and the brain? Nope!
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It's been a rough few weeks, so I followed
@drosophilosophy
and got a custom lab mask.
Hope our motto is ok...
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“When I grow up, I want to be a __”. Most of us had to answer this question at some point; however, we don’t understand how the nervous system answers it.
We investigated how CNS cells decide what identity (‘job’) they should acquire when they mature (‘grow up’).
(thread: 1/12)
A large longitudinal (298,000 cells and nuclei) transcriptomic investigation of glial differentiation in mouse embryos and hiPSCs used to optimize a mouse astrocyte differentiation protocol
New from
@LiddelowSA
and colleagues
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that feeling when you submit revisions... relax... and then get a kind note from the editor letting you know you forgot to include the actual manuscript
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"...it can be worth aiming for prestigious universities, even if their professors are research-first, students-second."
WORST ADVICE EVER. DON'T DO THIS GRAD APPLICANTS. Support is important during grad school. Don't join programs if you're treated poorly.
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Since everyone else has been doing it...
Input: Write a Broadway hit about an astrocyte becoming reactive and killing neurons.
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Today I was a bit teary when searching our Reactive Astrocyte datasets generated by
@HaselPhilip
and
@JessSadick
.
Ben would have loved this - he got so excited about seq data, and when went live he was ecstatic.
DATA and PAPERS coming SOON!
SO MUCH DATA!
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WE'RE HIRING (please RT)
do you live in NYC and want to work with an amazing group of scientists on glia/neurodegenerative disease?
we're looking for a Research Associate to join us in our ongoing research efforts. Details below, and more about the lab at
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Congratulations to Joon-Hyuk Lee, Li-Young Kim, WOn-Suck Chung and lab. Paper out in
@nature
today!
Astrocytes modulate synapse remodel hippocampal circuits in adult mice.
TLDR?: microglia aren't the only cells that get hungry!
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Color scheme correct, but didn't get the cover.
Thanks
@mistgrafik
for an amazing illustration of
@kevinguttenplan
's work 𝗡𝗲𝘂𝗿𝗼𝘁𝗼𝘅𝗶𝗰 𝗿𝗲𝗮𝗰𝘁𝗶𝘃𝗲 𝗮𝘀𝘁𝗿𝗼𝗰𝘆𝘁𝗲𝘀 𝗶𝗻𝗱𝘂𝗰𝗲 𝗰𝗲𝗹𝗹 𝗱𝗲𝗮𝘁𝗵 𝘃𝗶𝗮 𝘀𝗮𝘁𝘂𝗿𝗮𝘁𝗲𝗱 𝗹𝗶𝗽𝗶𝗱𝘀
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Reminder to people running faculty searches. Let people know the outcome of their applications. Even if they are triaged at the first round, it is polite and helps a lot of people to stop stressing unnecessarily.
An acknowledged 'no' is a lot better than silence.
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Plot twist: it was the astrocyes and micros all along.
Complement C3aR Inactivation Attenuates Tau Pathology and Reverses an Immune Network Deregulated in Tauopathy Models and Alzheimer’s Disease
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Sometimes it doesn't matter how many times you read a manuscript file - you still find 'goast serum' in the proofs :-|
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I love datablitz in lab: 1 piece of prelim data per person. Discuss in 5 minutes. Fantastic quick-fire new ideas and discussion of experiments not working. Use the hivemind to work out solutions.
An idea from
@SciPaulie
, and one we will keep for a long time.
HIGHLY RECOMMEND
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Great lab news today from
@MindPrize
We're in excellent company with the '24 cohort:
@hchung03
,
@FaranakFattahi
,
@antferrui
,
@brainevodevo
,
@tanlongzhi
,
@wu_xuebing
.
Bringing together some of the best minds from
@NYULH_Neuro
/
@nyugrossman
,
@Columbia
,
@UCSF
,
@Cornell
,
@Stanford
We are thrilled to announce the recipients of the 2024 MIND Prize! Seven researchers across the USA who are paving the way to a deeper and transformative understanding of the brain:
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LOOK HOW FANTASTIC THIS SPEAKER LIST IS!
Thanks for organizing
@LJohnsonLab
@rikvanderkant
For those who missed the initial thread about this:
* Alzheimer's Afternoons Seminar Series *
Link to join:
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I was getting very tired and restless toward the end of 2019. A two week break to see family and friends and recharge the batteries has helped - since yesterday I have submitted two grants and two papers!
Rest and relaxation is important people - don't ignore your tired mind.
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Chair: (interjecting during question time) 'I think you're being very aggressive'
Person: 'I AM NOT BEING AGGRESSIVE'
Chair: 'then why are you yelling?'
Person: '...' sits down
@overheardsfn
#DontYellAtTrainees
#UseYourWords
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My lab asked me to give lab meeting today. Requests for:
1. How much money do we spend a month?
2. What do you think we do?
The finance overview and chalktalk was a lot of fun... for me at least!
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Today was the day I wore my very adult 'sloths in astronaut suits' tshirt to lab.
Today was also the day I recorded a lecture on astrocyte responses in AD for a medical conference.
... good idea/bad idea?
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Now it's out in print, it's time for a wee Tweeprint about this powerful resource generated by
@michaelrodea
and
@JessSadick
.
Link below, and mini-thread to follow (1/7).
Check this
#Neuroresource
on transcriptional changes in
#glia
occurring in
#Alzheimer
's disease.
@JessSadick
,
@michaelrodea
& coll. from
@LiddelowSA
's lab also identify putative biologically important astrocyte subpopulations
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Honored to be named among such excellent pillars of the field at the Promotion of Women in Neuroscience Awards: Jill Becker,
@DulacLab
, Laura O'Connell, and Leslie Ungerleider.
Many many thanks to
@SfNtweets
and the Trubatch family.
Congrats
@LiddelowSA
for your Janett Rosenberg Trubatch Career Development Award
#SfN21
Very well deserved!
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Quick question to authors: do you find this reassuring?
Quick question to reviewers: does this make you change your tone/approach?
Quick question to journals: why doesn't every journal have such a statement?
Bravo
@SciReports
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will 2024 be the year that we have a representative from each cell in the brain?
would be GREAT to have a speaker for astrocytes, microglia, oligodendrocytes, endothelial cells, pericytes, choroid plexus, neurons, etc
APPLY NOW -
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(please RT)
Are you a postdoc?
Do you want to give a presentation about your awesome science?
APPLY for our SPiNES (Seminars from Postdocs in Neuroscience: Extramural Series):
(more info - )
WE LOVE GLIA/DISEASE APPLICATIONS!
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Together as a lab, we prepared & uploaded an Inclusivity Statement, Action Plan, and Resources section to our lab website. Taking guidance from other great examples by
@cssmity
,
@stevens1lab
,
@MartinUCSF
, and more.
We welcome your thoughts and comments.
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Happy birthday Ben!
You're sorely missed. So much I would have liked to ask you about this transition to PI.
For those who want to learn more about my science hero, his autobiography is here (PDF version)-
and here (hardcover)
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People have been asking about HOW they can investigate the interaction between astrocytes and microglia - look no further.
An amazing piece of work spearheaded by
@kevinguttenplan
Astrocytes and microglia: Models and tools
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Ben Barres: neuroscience pioneer, gender champion
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Realized at
#CSHLGlia
meet the speaker event today that most of us were first generation college students.
Special shout out to all glialbiologists who are the first in their family to get a BS, MS, or PhD - you rock!
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I'll just leave this here...
Our Society
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Feeling like you need to scratch that glia itch? Sad that the GRS will not be happening next year? Look no further - the GTS is here and it's organized by trainees, run by trainees, for trainees.
More info at , or reach out to
@Dr_Oligo
and
@neuro_runnerd
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taking a note from
@WashUGlia
- today our Molecular Neuroscience class discussed two papers on the same topic, 20 years apart, with similar but improved techniques in the latter.
For those who love astrocytes and synaptogenesis - these two are must reads!
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full disclosure: we had a grant rejected today. Luckily I'm working on a new one right now - and this one has me really (like REALLY) excited!
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The lab is 6 years old today... I forgot... the lab made me buy beers.
Lots of successes over the 2190 days... some exciting new news to come soon.
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Reviewers: don't say this, it's racist and not helpful
Editors: do not pass on such racist comments, and do not re-invite these reviewers
Got a reviewer commenting that my writing should be proofread by a native English speaker. I hope this reply I’m drafting isn’t too much! 😬
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Congratulations to
@RafaelTaeho
&
@_rdkim
for working with
@AnnaMolofskyLab
and I on this review in
@ImmunityCP
. Important roles of astrocytes in health and disease.
FREE access here:
(mini thread 1/4)
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I wanted to post about this exciting collaboration with
@liliannebarbar
and
@fossati_v
from
@nyscf
when it was published, but there were more important voices to be heard at that time.
Here is a quick Tweeprint rundown of this amazing piece of work.
Have a happy Friday everyone!
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It's early and still dark outside in NYC, but the conversation and science is bright during Margherita Zamboni's thesis defense at the
@karolinskainst
.
First time as Swedish opponent - great fun.
(also the FIKA helps at this time of the day!)
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So this created some interest.
Any other PIs out there want to share stories of their failed experiments to help those struggling in the lab?
Full disclosure for the grad students struggling out there.
I was in lab for 15h yesterday. And my experiments didn't work. I've done this assay over 1000 times. And it didn't work. It happens sometimes.
Looking at my lab notes today to work out what went wrong.
Hang in there.
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Exciting news:
@doudna_lab
and Emmanuelle Charpentier winning Nobel for CRISPR - CONGRATULATIONS!
Sad news: there are not more amazing women who are awarded this prize.
Hopefully this is the beginning of empowerment for young women everywhere to pursue science and kick ass!
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#SfN22
- if you see a presenter being yelled at, step in and calm the situation down if you can.
If you don't feel comfortable, look for faculty to help you out.
There are some aggressive happenings on the poster floor.
Also DON'T TAKE PHOTOS IF YOU DON'T ASK THE SPEAKER
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If astrocytes and neurons can hug and be BFFs, surely we can work together to achieve anything!
@LiddelowSA
@SebastianSeung
@RedGiantNews
@PrincetonNeuro
@AllenInstitute
@IARPAnews
Top left ended up being part of a huge merger. I have however procured a beautiful alternative. Storyboard flight path something like this as I experiment with particles and sss and shaders. Pyramidal + Glia BFF
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#cshlglia
No lobster yet, but stealing
@nachoriko
's husband
@FChrisBennett
.
Photo credit:
@c_eroglu
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@SfNtweets
#Glia
**PLEASE RT**
Don't forget the
#SfN2023
Neuron-Glia Interactions Social
WHEN: Monday NOV 13, 645-854pm
WHERE: Westin (formerly Renaissance – 999 9th St.) - River Birch
come see friends new & old, & maybe learn about the secret after party from
@Dr_Oligo
:-P
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!!we're hiring - please RT!!
the is hiring a Research Technician and/or Lab Manager
we study astrocyte function in a range of neurodegenerative disease - and we're fun(ish)
animal colony management & cell culture experience a bonus
reach out via email
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Had to take a night off grant and paper writing tonight... to install lights on my Dr Who lego!
I wonder if Timelords have astrocytes?
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Congratulations to
@kevinguttenplan
!
Kevin has been the leader on some of the most insightful astrocyte discoveries in recent years.
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MEETING ALERT
The 7th Venusberg Meeting on Neuroinflammation
Neuroimmune interactions in acute and chronic CNS disorders
Campus Belval, Luxembourg
May 11-13, 2023
for more information reach out to
@HenekaMichael
, or see the conference website here -
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Silencing neuroinflammatory reactive astrocyte activating factors ameliorates disease outcomes in perinatal white matter injury
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I got listed as a 'senior faculty' in a consortium website today... I'll just be in the corner quietly crying while wondering where my youth went.
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Achievement unlocked: fell asleep in seminar, then woke up to ask a question.
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I'd also love to point out that our impressive article "title" has been cited "number" of times now.
This is one of the best Monday morning emails... still useless spam, but a giggle that is needed in 2020.
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Things only a scientist can giggle at.
#1
will blow your mind.
(can I have a job at
@buzzfeed
now?)
@nachoriko
- this one's for you :-)
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Everyone else was sharing how awesome their lab and holiday parties were... so I wanted to show you how amazing the glia team that I get to work with are.
Thanks for a fantastic 2019 Liddelow Lab... there are a LOT of you now.
Let's get even bigger and better in 2020!
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Monday, going slow
Thinking: when will things improve.
Paper accepted
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The Parekh Center for Interdisciplinary Neurology is open for business! It will bring together researchers across
@nyugrossman
@nyulangone
to find common causes of neurological diseases.
Many thanks to
@djparekh
and Monika Parekh for their support
(1/3)
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🧠🌟 Join us at the
#SfN2023
@SfNtweets
for an exciting Glial Social!
🎉 Connect with fellow glia and neuroimmunology enthusiasts, and explore the fascinating world of non-neurons ;-P
Don't miss this opportunity to network and learn! See you there!
#GlialSocial
#SfN2023
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