Cold Spring Harbor Laboratory
@CSHL
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Non-profit research and educational institution at the forefront of molecular biology, cancer, neuroscience, plant biology, and genetics.
Long Island, NY
Joined August 2009
As we age, food hits different—sometimes triggering inflammation or even leaky gut from #RadiationTherapy or natural #Aging. CSHL scientists Corina Amor Vegas @amore_Labs & Semir Beyaz have identified a way to stimulate intestinal cell repair, opening the door to new treatments
cshl.edu
Ever notice that as you get older, some foods no longer sit with you the same? This could be due to a breakdown of the intestinal epithelium, a single layer of cells that forms the organ’s lining....
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Remarkable energy at the inaugural @CSHL conference on Assembloids and complex cell–cell interactions across tissues and systems. A wonderful series of talks so far highlighting advances and discoveries being made with these self-organizing multi-cellular systems and a few
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Plants get around. Think about millions of generations of flowers and seeds. A new study from CSHL’s Lippman lab provides a comprehensive view of one crucial plant gene family’s evolution over 140 million years.
cshl.edu
As global temperatures rise, Cold Spring Harbor Laboratory (CSHL) scientists work to grow stronger, more resilient crops. Yet, this process is challenging. Plants often have several related genes...
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In this episode of At the Lab, Dr. Kiran Musunuru from the University of Pennsylvania Perelman School of Medicine, and Dr. Rebecca Ahrens-Nicklas from the Children’s Hospital of Philadelphia, discuss CRISPR, medicine, and the future of both fields.
cshl.edu
How does science make life better? Here’s one example spanning eons. There’s an adaptive immune system called CRISPR that has existed in bacteria for billions of years. Thanks to fundamental biology...
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The CSHL School of Biological Sciences (@CSHLsbs) has launched a new Ph.D. program in BioAI. Machine learning has transformed science. This new program will equip today’s students with the tools they’ll need to make the groundbreaking biomedical discoveries of the future.
cshl.edu
AI and machine learning have transformed science, enabling new discoveries and laying the groundwork for lifesaving treatments. Yet, as valuable as these tools may be for science and medicine, few if...
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When Medicare payments to physicians fall behind the rate of inflation, everyone feels the strain. Learn how these cuts affect you.
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Ever see a mouse stand on its hind legs and belt out a song? @ArkarupBanerjee, @xmikezheng20, and Cliff Harpole track this behavior in Alston’s singing mice. See what that looks like and what it might say about the origins of communication.
cshl.edu
All mice squeak, but only some sing. Scotinomys teguina, aka Alston’s singing mice, hail from the cloud forests of Costa Rica. More than 2,000 miles north, Cold Spring Harbor Laboratory (CSHL)...
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Recognized for their commitment to inclusivity, CSHL’s Lab Animal Resources team recently received the National Disability Employment Awareness Month (NDEAM) award for 2025 by the New York State Education Department. Working with the Abilities program, CSHL provided a team
cshl.edu
In 2023, the Viscardi Center (VC), a statewide nonprofit helping persons with disabilities find jobs and succeed in the workplace, assisted James Schaefer in securing a position at Cold Spring Harbor...
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We’re excited to share that @jeremynigri, a postdoctoral fellow in the Tuveson Lab at CSHL, has been awarded the @PanCAN Catalyst Monahan Fellowship Award. This fellowship supports bold, innovative work that pushes pancreatic cancer research forward. #PanCAN
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POU2F3 defines the identity of tuft cells and underlies a distinct molecular subtype of SCLC. .@CSHL scientists show that acute suppression of either POU2F3 or OCA-T1 induces regression of tuft cell-like SCLC xenografts in vivo. 👉 https://t.co/byTgLajwdo
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Nature research paper: Mechanism of conductance control and neurosteroid binding in NMDA receptors https://t.co/CKelhXFZgw
nature.com
Nature - Ion-channel conductance levels are controlled by the bending patterns of pore-forming transmembrane helices in the heterotetrameric neuronal channel GluN1a-2B N-methyl-D-aspartate receptor.
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Two breakthroughs in one! Two new studies from CSHL molecular biologist Chris Vakoc, published in @NatureComms and @CellReports, help explain the bizarre behaviors of pancreatic cancers and lung cancers that can change identities. https://t.co/QOh7mxayRH
cshl.edu
Some tumors are almost impossible to treat. That’s especially true for carcinomas, which don’t behave like other malignancies. Some of these tumors act as shapeshifters and start to resemble cells...
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CSHL NeuroAI Scholars Kyle Daruwalla and Christian Pehle joined our most recent episode of At the Lab to discuss how unlikely artificial superintelligence is to develop, despite an influx of research in the field. Listen now wherever you get your podcasts.
cshl.edu
How close is artificial intelligence to matching biological intelligence? When will computers be able to think and act as humans do? If you ask one of the big tech companies currently developing AI,...
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What is a carcinogen, exactly? How do carcinogens impact our daily lives? Watch Assistant Professor Peter Westcott in action, teaching our audience about cancer on an environmental level. https://t.co/SSJhne8Pz0
cshl.edu
Peter Westcott begins the latest installment in our Cocktails & Chromosomes series with an inspirational quote from Oscar the Grouch.
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🧬✨ Historic meeting to decode human immunome convened at Cold Spring Harbor Banbury Center! "If reading the human genome was going to the Moon, decoding the immunome is like going to Mars"—per HIP Exec Chair @janemetcalfe 🚀 Learn more: https://t.co/edlsCplZq2...
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Make Pure Water from Air with WaterCube — Smart, Safe, and Sustainable for Your Family.
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“I’m blessed to have been able to carry out my research & ideas in the US, particularly at CSHL, a magical place to do science. The freedom, insistence on excellence, opportunity, collaborations & support—all enable you to be brave in the questions you set out to answer.” Leemor
cshl.edu
Cold Spring Harbor Laboratory (CSHL) Director of Research Leemor Joshua-Tor has been inducted to the American Academy of Sciences and Letters. The W.M. Keck Professor of Structural Biology and HHMI...
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At CSHL's Uplands Farm, researchers are are cultivating corn, sorghum, and more to test the roles of different genes. Read more to discover CSHL's long history and exciting future in plant biology.
cshl.edu
At first glance, Uplands Farm—12 carefully tended acres about a mile east of the Cold Spring Harbor Laboratory (CSHL) campus—resembles farms you might have seen before. Orderly rows of corn dominate...
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CSHL Professor David Spector and grad student Disha Aggarwal examined tissue samples from a 59-year-old woman diagnosed with stage 1 triple-negative breast cancer. Their findings could help inform clinical trials of a drug targeting the long non-coding RNA MALAT1.
cshl.edu
When researchers look for potential cancer therapy targets, they typically go after protein-coding genes that participate in disease progression. Disrupt them and negate whatever role they play in...
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It is with sadness that we acknowledge the passing of Dr. James Watson, Nobel prize-winning scientist and former Director and President of CSHL. We extend our sincere condolences to his wife Liz and family during this difficult time. We recognize Dr. Watson’s incredible
cshl.edu
Jim Watson made many contributions to science, education, public service, and especially Cold Spring Harbor Laboratory (CSHL). As a scientist, his and Francis Crick’s determination of the structure...
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In this episode of "At the Lab", Phil Renna and Chris Vakoc, CSHL Deputy Director of the Cancer Center, sit down to discuss the tireless work researchers are doing to help patients and families alike. Listen now, wherever you get your podcasts:
cshl.edu
Pediatric cancer—two words that carry immense weight. For many, it’s a distant fear; for some, it’s a daily reality. And for my family, it became a devastating truth. After losing our teenage...
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Congratulations to CSHL’s Kate Alexander for winning the @KidneyCancer Association’s 2025 Trailblazer Award! Could a tumor cell’s nuclear speckles one day help doctors figure out the best course of treatment? Alexander aims to find out. Read more at the link:
cshl.edu
Over 600,000 people in the United States are living with kidney or renal pelvis cancer. This year, over 80,000 new patients will be diagnosed. Could the speckles inside a tumor cell nucleus one day...
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