Martin Kampmann
@MartinUCSF
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Professor @UCSF. Molecular/cellular mechanisms of neurodegeneration. Functional Genomics. Diversity & Inclusion. 🏳️🌈 he/him. kampmann on https://t.co/M6DBnaVo4j
San Francisco, CA
Joined January 2019
I'm no longer actively using Twitter/X. Follow me on blue sky:
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Thank you @alzforum for featuring our new preprint identifying regulators of disease states of microglia. Project led by @AmandaKMcQuade, computational analysis by @reetm09. Collaboration with the labs of @jamesknunez & Phil De Jager https://t.co/7EJJXOfgpU
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Excited to share our new preprint uncovering regulators of disease-relevant states of #microglia. Led by @AmandaKMcQuade, computational analysis by @reetm09, collaboration with the labs of @jamesknunez & Phil De Jager. Read Amanda's tweetorial below. https://t.co/WTfZfY98rE
biorxiv.org
Microglia, the brain’s innate immune cells, can adopt a wide variety of activation states relevant to health and disease. Dysregulation of microglial activation occurs in numerous brain disorders,...
I’m super excited to announce our preprint on Transcriptional regulation of disease-relevant microglial activation programs. To determine regulators of microglia activation states, we performed six transcription factor-wide CRISPRi screens. https://t.co/UHoWo5LyZy
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Apply by Oct 15 - please spread the word!
Tenure-track faculty search of the @Ucsf_Biochem Department is open for applications! We are looking for creative, innovative scientists asking fundamental questions in any area of biology. Join our vibrant, collaborative, and supportive community! https://t.co/o8SJlLNNlg
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CRISPR screening by AAV episome-sequencing (CrAAVe-seq): a scalable cell-type-specific in vivo platform uncovers neuronal essential genes @MartinUCSF
https://t.co/9Da8KJDKCJ
nature.com
Nature Neuroscience - The authors developed an adeno-associated virus-based high-throughput in vivo CRISPR screening platform for endogenous mouse brain cell types. Using this platform, they define...
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For Martin Kampmann (@MartinUCSF), combatting neurodegenerative diseases is personal. "I had experienced how devastating these diseases are through my grandmother, who suffered from dementia,” he says. "My goal is to find new therapies that can intervene."
ucsf.edu
The Byers Award recognizes outstanding research by faculty members in the middle of their careers. Martin Kampman’s honorary 2025 lecture is titled “A CRISPR approach to neurodegenerative diseases.”
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Tenure-track faculty search of the @Ucsf_Biochem Department is open for applications! We are looking for creative, innovative scientists asking fundamental questions in any area of biology. Join our vibrant, collaborative, and supportive community! https://t.co/o8SJlLNNlg
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🧠Have you ever cried when your #iPSC transgene vanished after differentiation? Yeah, we’ve cried too, and built a solution. Our PiggyBac vector keeps expression stable even after differentiation! Check out our #preprint👇 🔗 https://t.co/Tq8mNiHtg5 Supported by @cziscience
biorxiv.org
While high and stable transgene expression can be achieved in undifferentiated pluripotent stem cells, conventional transgene expression systems are often silenced upon differentiation. Silencing...
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Check out our new preprint: Network-aware self-supervised learning enables high-content phenotypic screening for genetic modifiers of neuronal activity dynamics Project led by @parkergrosjean - see his "tutorial" below!
I am excited to announce the release of our BioRxiv preprint: “Network-aware self-supervised learning enables high-content phenotypic screening for genetic modifiers of neuronal activity dynamics”. 1/ https://t.co/eeo4SoMMI4
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We are excited to continue the GRC on Functional Genomics of Human Brain Development and Disease in April 2025. Please check out the great line-up of speakers. Oral presentation slots and poster presentations are still open! Deadline March 9th https://t.co/3218PfBZIB
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Our latest paper with @Molofsky_lab is out! tweetorial to follow. Group 2 innate lymphoid cells promote inhibitory synapse development and social behavior | Science https://t.co/u2fQ2j2OeN
@jerika_barron @ Nick Mroz
science.org
The innate immune system shapes brain development and is implicated in neurodevelopmental diseases. It is critical to define the relevant immune cells and signals and their impact on brain circuits....
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$ADUR signed an LOI for the site of its first commercial plastic recycling plant, in the Netherlands. We wrote about the many advantages the location offers, expected to be operational in early 2027. Low cap-ex, convenient for supply and sales, Euro regulations…
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excited to share COMET! A scalable CRISPR approach we (@carwils) developed to identify multidomain proteins that modulate transcription at specific endogenous genomic loci. @arcinstitute @ucsf
https://t.co/Qhe38N1zzj
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Congratulations Dr. @noamteyssier, on your PhD and your many achievements. Thank you for your contributions to the lab - and science at large. We’ll will miss you lots! But excited for your next adventures - @arcinstitute is lucky to have you! #kampmannlabproud
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The Integrated Stress Response Suppresses PINK1-dependent Mitophagy by Preserving Mitochondrial Import Efficiency - exciting new work from @XiaoyanGuo99! https://t.co/S4FaXvbKEo
biorxiv.org
Mitophagy is crucial for maintaining mitochondrial health, but how its levels adjust to different stress conditions remains unclear. In this study, we investigated the role of the DELE1-HRI axis of...
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💥 Democrats cave… and the base explodes From the ladies of the View to Edna Mode, calls for Chuck Schumer to step down are coming from all directions. Can he survive with a party surging behind anti-establishment figures like Zohran Mamdani?
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Proud to share a new preprint from Farzané Mirfakhar using super resolution microscopy to understand how FTD-causing tau mutations disrupt lysosomal transport and tau degradation https://t.co/nJUFkgpzBx
@WUADRC @FTDcwow
biorxiv.org
Tau degradation is disrupted in neurodegenerative tauopathies, such as frontotemporal dementia (FTD), which may contribute to Tau aggregation. The prevailing hypothesis has been that Tau degradation...
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CRISPR–Cas9 screens reveal regulators of ageing in neural stem cells - exciting work from @BrunetLab
nature.com
Nature - CRISPR–Cas9 screens in cultures of young and old neural stem cells (NSCs) and in vivo in old mice identify gene knockouts that can boost old NSC activation and neurogenesis, with...
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Honored to be part of the first cohort of investigators funded by the Kissick Family Foundation & @MilkenInstitute Frontotemporal Dementia research program. #endFTD
milkeninstitute.org
September 25, 2024 (Washington, DC)—The Kissick Family Foundation Frontotemporal Dementia (FTD) Grant Program, in partnership with the Milken Institute Scienc
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Are you interested in "skipping the postdoc" and starting your independent lab in biomedical research as a fellow? Check out the @UCSF Sandler Fellows Program! Nominations are due 1/10/2025 - more info below. https://t.co/O7w3Ac0Cvp
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How does the Carrier Delivery Catheter get the aspiration catheter to the face of the clot in 100% of cases? It's tapered distal segment is optimized for seeking primary vessel with atraumatic navigation. Check out the article here
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🚨Excited to share another paper in @MolecularCell!🚨 In collab w/ @Columbia’s Marko Jonvanoic, Lena Street, & @HoustonMethodist’s Kris Brannan, we mapped RNA-aware, RBP-centric protein-protein interactions (PPIs) across the mRNA life cycle in human cells! https://t.co/F1W4js2Ad7
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