Chris Bennett
@FChrisBennett
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Microglia enthusiast and psychiatrist
Philadelphia, PA
Joined May 2018
We wanted a safe and specific way to replace microglia, so we created one.
Ending 2022 on a high note with the Bennett Lab’s first paper! Excited to finally share this work! TLDR: We (@FChrisBennett and @BlurtonJonesLab) engineered an inhibitor-resistant human CSF1R variant that can be used for microglial replacement. 🧵 below.
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We are excited that our work describing microglia cannibalism is now officially in press! https://t.co/9mrfB0gC2Z Stay tuned because we are on to the genetic mechanisms! 😀
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Thrilled to share new work from our lab led by @mitchkim_mw! The results provide new insight to immune privilege and hopefully diagnostic/therapeutic tools || Endogenous self-peptides guard immune privilege of the central nervous system | Nature
nature.com
Nature - Central nervous system (CNS)-derived regulatory self-peptides are essential for maintaining a continuous dialogue between the CNS and the immune system while balancing overt autoreactivity.
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Interested in studying type I interferonopathy? Here is a primer on existing tools from the self proclaimed "AGS supergroup".
onlinelibrary.wiley.com
Aicardi-Goutières syndrome (AGS) is a progressive genetic encephalopathy caused by pathogenic mutations in genes controlling cellular anti-viral responses and nucleic acid metabolism. The mutations...
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New paper ALERT!! @MaraCowen discovered and defined how conserved autism-associated genes modify a 'social' behavior in C. elegans!! So proud of her work in the lab!
nature.com
Nature Communications - C. elegans aggregate in large clumps during feeding. Here, the authors find conserved autism-associated genes mediate distinct molecular and circuit signaling components...
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looking forward to tomorrow!!
The Vollum Seminar Series continues Thursday (10/24) with Dr. Jennifer Orthmann-Murphy presenting “Targeting glia for remyelination” at noon in M1441 of the Vollum. Hosted by Dr. Kelly Monk. #OHSUResearch can login & stream from link on our site: https://t.co/M9JrnE6SCJ
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Excited to share our new paper where we explore why dCas9-KRAB protein levels drop so drastically after neuronal differentiation in WTC11 and KOL2.1J iPSC lines. https://t.co/SBRXfWau75
biorxiv.org
The use of CRISPR-associated enzymes in iPSC-derived neurons for precise gene targeting and high-throughput gene perturbation screens offers great potential but presents unique challenges compared to...
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🚨Postdoc positions available🚨 If you have expertise in T cell biology (primarily TCR specificity/function) and/or in artificial intelligence, and if you would like to apply your knowledge to cool questions in #neuroimmunology, please email me for inquiry.
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One of the best ways to spend a sunny day in Philly is with these brilliant, creative, and fun people! So honored to work with this awesome team! Happy #newpi Morris-Blanco Lab #strokeresearch
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Congrats to @ChildrensPhila's Dr. Evan Weber, recipient of the @NIHDirector's New Innovator Award! Dr. Weber will pursue a novel approach to reprogram T cells with enhanced tumor killing function, paving the way for more efficacious #cancer therapeutics. @CHOPCancerCntr
Early-stage investigators proposed #innovative high-impact research ideas for the @NIHDirector’s New Innovator Award. See the projects the awardees will pursue: https://t.co/ujuDoPOLUu
#NIHHighRisk
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So delighted that one of my very favorite scientists and people Dr Allen is a Pioneer Awardee (you heard it here first!) woooohooo! @salkinstitute
The @NIHDirector's Pioneer Award funds researchers from all career stages pursuing groundbreaking new ideas to tackle significant challenges in #behavioral, #SocialScience, & #BiomedicalResearch. Meet this year’s awardees: https://t.co/HiKSu82d5M
#NIHHighRisk
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📢Great speaker line-up: Belinda Pletzer @PLUS_1622, @roxana_zeraati & @MatthiasPhilip6, Read Montague @FralinBiomed, @romy_lorenz @MPICybernetics, @L_Genzel @Radboud_Uni, @icouzin @MPI_animalbehav, @EmilieMaceLab @yourUMG & @FChrisBennett @Penn 📅Program https://t.co/prVGzakrbw
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New protocols from Jessica Kahng and Andre Xavier for quantifying synapse engulfment by OPCs, based on foundational work from @SchaferLabUMass @stevens1lab @wonsukchung and others (1/4)
nature.com
Nature Protocols - An approach that combines a pH-sensitive synaptic biomarker expressed in vivo with the ex vivo staining of oligodendrocyte precursor cells enables quantification of synapse...
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https://t.co/cgdK16JdGJ Itching can be annoying but could it also be beneficial? Maybe it’s your body 🚨 you of a secret invasion… Our freshly baked manuscript is trying to answer these and other neuron, 🪱 and macrophage-related questions. (1/n)🧵 👇🏼
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Tremendously proud to share my fellowship work, online today in @NatureMedicine. We tried to understand why CAR T therapy for AML doesn't work as well as we hoped it would, and how we can solve that. 👇🧵1/10 @PennMedicine @CHOP_Research @GillSaar
nature.com
Nature Medicine - In a phase 1 trial followed by translational analyses, patients with acute myeloid leukemia (AML) treated with chimeric antigen receptor (CAR) T cell therapy targeting CD123...
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Thanks to all the support from @UMassChan @NeurobioUMass. It is a honor to be part of this community.
#ICYMI: @UMassChan has 12 new endowed chairs, including five @umassmemorial Health chairs: https://t.co/a3oZ09Z4b5
@ambarrett @UMassChanNeuro @UMassRadiology @UMassMedicine @PRCUMassChan @ollie_rando @UMassChan_BMB @SchaferLabUMass @NeurobioUMass @Pthompsn1018 #fbf
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Pooled endogenous protein tagging & recruitment for systematic profiling of protein function ft. @YSereb, Deepak Mani, @ophirshalem (@PennGenetics/ @CHOP_Research), @MaujeanT & @GMBurslem (@BB_UPenn/ @Penn_CBIO/ @PennEpiInst) @CellGenomics
https://t.co/figonl7gag
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In honor of Hispanic Heritage Month, we present The Atlas of Inspiring Hispanic/Latinx Scientists. This resource showcases the scientific excellence of nearly 400 outstanding scientists. #LatinxAtlas #HispanicHeritageMonth
https://t.co/f9VAR8mJoK
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#NGG is proud to present our next Thesis Defense given by Kelsey Nemec @Kel_Nem of the Bennett (@FChrisBennett) lab! Please join us in person or virtually (DM us for the link) on 9/4. Best of luck, Kelsey! #PhAlmostDone 🥳
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