Orly Reiner's Lab
@reiner_lab
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🧠 BrainBuild: Unravelling Corticogenesis 🧠 Prof. Orly Reiner's Lab @WeizmannScience
Rehovot, Israel
Joined April 2022
Check out the press release of our latest Nature paper by the talented alumnus of our lab @MaayanKarlin
wis-wander.weizmann.ac.il
Researchers from the University of Michigan and the Weizmann Institute develop the first-ever complete central nervous system on a chip; it faithfully emulates that of a human embryo, from the...
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Reconstructing Waddington's Landscape from Data https://t.co/xXaJ34hgAw conceptually cool- I will have to take your word for it when it comes to the maths
biorxiv.org
The development of a zygote into a functional organism requires that this single progenitor cell gives rise to numerous distinct cell types. Attempts to exhaustively tabulate the interactions within...
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From today, all new submissions to Nature that are published will be accompanied by referees’ reports and author responses — to illuminate the process of producing rigorous science https://t.co/Fua3YQ8XPt
nature.com
Nature - From today, all new submissions to Nature that are published will be accompanied by referees’ reports and author responses — to illuminate the process of producing rigorous science.
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This is the first map of human brain mitochondria. 🧵1/11
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🚨New Preprint 🚨: What are the key epigenetic mechanisms that drive species-specific gene regulation during primate neurogenesis — and how do they contribute to the evolution of the human neocortex? Curious? 👇 https://t.co/z7OAyJSOWP Led by Silvia Vangelisti @sinsy_ and Boyan
biorxiv.org
The expansion of the neocortex is a hallmark of human evolution and is closely linked to neural stem cell biology. Yet, the epigenetic mechanisms driving divergent gene regulation during primate...
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Hiring alert! @SRsrivatsan @fredhutch and I @HHMIJanelia are looking for a joint postdoc to combine single-cell omics and ex utero embryogenesis. Please retweet! If you are interested, DM us or send an email to sanjay@fredhutch.org ; alejandroac@janelia.hhmi.org
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Adding to this unraveling is spatial omics at subcelluar resolution https://t.co/eUyM4Gmjld
@ScienceMagazine @HHMINEWS @GandinValentina
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Conducted by @RuedaEneritz, we have seen that pallial neurons are generated in different regions and stages of the embryonic brain🐣🦎🐀: pallial neurons and circuits have evolved separately. Evolutionary CONVERGENCE of neurons and circuits! https://t.co/2ctu2n8tkk
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In vivo hyperphosphorylation of #tau is associated with synaptic loss and behavioral abnormalities even in the absence of tau seeds https://t.co/jc6we5ZM36
nature.com
Nature Neuroscience - Mice expressing humanized mutant tau exhibit synaptic loss and behavioral abnormalities in the absence of abnormal tau conformers, suggesting that hyperphosphorylated tau can...
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Mice lacking microglia (Csf1r∆FIRE/∆FIRE) have normal -synapse number and maturation -seizure susceptibility and hippocampal-prefrontal cortex coherence -segregation of inputs into the lateral geniculate nucleus -neuronal and astrocytic gene expression https://t.co/C6FBRqwwMA
nature.com
Nature Neuroscience - Microglia are proposed to have a role in brain development through synaptic engulfment and paracrine signaling. O’Keeffe et al. show that certain neurodevelopmental...
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I'm shocked to see racism happening in academia again, at the best AI conference @NeurIPSConf. Targeting specific ethnic groups to describe misconduct is inappropriate and unacceptable. @NeurIPSConf must take a stand. We call on Rosalind Picard @MIT @medialab to retract and
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Always going the extra mile in order to make a difference, #creativity #strength #inspiration @shubhatole @NCBS_Bangalore @TIFRScience
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Latest paper out in @Nature this week: an atlas integrating 36 single-cell transcriptomic datasets spanning 26 protocols for making neural hashtag#organoids Effort led by @TreutleinLab @fabian_theis and @GrayCampLab In Figure 4 you can also find the pojection of the neural
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A picture of the fabulous group of scientists who will be speakers at this meeting! If you work on Cortex, you should come!
Please hold the date for the next CORTICAL DEVELOPMENT MEETING in Giardini Naxos, Sicily, Italy - May 25-28, 2025 @corticaldev2022
@Kriegsteinlab
@GordFishell
@FloraVaccarino
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Gene regulatory landscape of cerebral cortex folding | Science Advances
science.org
Epigenetic regulation of Cux2 expression triggers downstream signaling to implement the protomap of cortex folding pattern.
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We recently uncovered new types of Radial Glia Cells in the developing cerebral cortex, and their involvement in multiple lineages that run parallel to generate neurons. All explained in this video 🤓. Enjoy! @NeuroAlc @CsicLifehub @CSIC @UniversidadMH
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Happy to start 2024 by sharing our latest paper in @CellCellPress. FeBOs are tissue-derived human regional brain organoids to study brain tumor initiation, morphogen responses, and brain development!🧠🔬 @HendriksDelilah @HansClevers
https://t.co/Aqx9rtPett
cell.com
Tissue-derived human fetal brain organoids (FeBOs) are established from different anatomical regions that can be expanded in culture. FeBOs may help understand developmental and disease-related...
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In a pair of studies published in Cell today, we used interspecies blastocyst complementation to study brain function and evolution. https://t.co/v7oFHBp6oz.
https://t.co/5Eb4h7ktnw.
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Plenary speakers @AlainChedotal @reiner_lab @orly_reiner Linda Richards @RichardsNeuro and Laure Bally-Cuif @zenlabpasteur and an exciting lineup of symposia! Short talks to be selected from poster submissions, travel awards for trainees, all in beautiful Montpellier.
Deadline extended! If you missed the recent deadline for abstract submission, please note abstracts will be accepted for talks and posters at #ISDN2024 until 24 May 2024 while we commence the review process. Speakers and symposia listed at: https://t.co/ikHXfWnxQR
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