Gord Fishell
@GordFishell
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labs at HMS Neurobiology and the Stanley center at the Broad, doing our best to understand cortical interneurons through developmental genetics and physiology.
Boston, MA
Joined February 2017
Here is a chat with Bosilijka Tasic and myself about the enhancer-mediated AAVs that we were both centrally involved in publishing. I truly believe these approaches are fundamentally important for both basic and clinical approaches!
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Thrilled to see our PNAS paper featured in @GiacomoI commentary. A fantastic recognition of how biologically grounded cortical microcircuits can accelerate the next generation of NeuroAI—and a meaningful step connecting it to neuroscience
pnas.org
Biological fidelity: The engine driving the neuromorphic renaissance
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Excited to share our new preprint! LARIS enables accurate and efficient ligand and receptor interaction analysis in spatial transcriptomics https://t.co/nYk1nbZAHy Joint work from Fishell lab @GordFishell and Fei Chen lab @insitubiology @sundakao at the Broad @broadinstitute 1/n
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Excited to report the publication of LARIS, a program that can predict spatiotranscriptic LIgand-Receptor interactions. This work was led by @artofbiology (Min Dai in my lab) with Fei Chen's lab at the Broad.
biorxiv.org
Advances in spatially resolved transcriptomics provide unprecedented opportunities to characterise intercellular communication pathways. However, robust and computationally efficient incorporation of...
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And now the Neuromorphic piece has been picked up a one of the 10 most notable AI papers this week! Exciting! Well done Suraj!! https://t.co/4tsMGYvHCC
aiworld.eu
This week’s AI research highlights how technological innovation and societal responsibility are increasingly intertwined. Studies range from AI-driven advances ...
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Well to complement my son's efforts here is some background into my own first foray into neuromorphic computing. The original article can be seen in PNAS! A big shout out to Suraj Honnuraiah, who made it all happen!.
growkudos.com
Our brains are remarkably good at recognizing patterns, generalizing to new situations, and filtering important signals from background noise while using very little energy. This study identifies...
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Well when it rains it pours. My son Will @fishell_will , just published a paper on biorxiv, much closer to my heart with my lab member Suraj Honnuraiah on spiking neural networks and understanding why they struggle as LLMs.
biorxiv.org
Spiking neural networks (SNNs) have attracted growing interest for their ability to operate efficiently on low-power neuromorphic hardware, offering a biologically grounded route toward energy-effi...
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In a whimsical review of his https://t.co/ZQS4gCGRdI paper, my son Will discusses the use of TempoBench in evaluating LLMs. I particularly enjoyed the faux ad for the TempoBench "product". You go Will!
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Really excited to see my son Will @fishell_will publish his first work Tempobench that measures temporal causality and reasoning in LLMs.
arxiv.org
Large Language Models (LLMs) are increasingly excelling and outpacing human performance on many tasks. However, to improve LLM reasoning, researchers either rely on ad-hoc generated datasets or...
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Updated how pyramidal neurons impact specific interneuron subtypes. Turns out spontaneous activity, Wnt signaling in Parvalbumin Interneurons and integrin-signaling in Somatostatin neurons are the culprits! Also see how optimal transport tracks identity. https://t.co/6WpvRBZnkV
biorxiv.org
The mammalian cerebral cortex comprises a complex neuronal network that maintains a precise balance between excitatory pyramidal neurons and inhibitory interneurons. Accumulating evidence indicates...
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Outside my usual comfort zone. This is the amazing work of Dionnet Bhatti a graduate student who examined the defensive behavior mediated lateral septum through careful SC analysis of the CRHR2 populations. Dionnet is someone you should keep your eyes on!
researchsquare.com
The ability to rapidly detect and evaluate potential threats is essential for survival and requires the integration of sensory information, with internal state and prior experience. The lateral...
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At my last year of attending the McKnight conference. Such an amazing group of scientists. A big shout out to Lauren Orefice @lauren_orefice who gave an amazing talk this morning!
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New Neuron issue! Discover methods for accessing neuronal and non-neuronal cell types in the CNS from the BRAIN Armamentarium Consortium 🧠🔧 Read insights from Bosiljka Tasic & @GordFishell: https://t.co/I4au6iPKX7 Explore the full issue here: https://t.co/ImgPc6z4Dp
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Just moved to bluesky social. I hope to see you guys there!
I agree, #neuroscience has officially moved. This will be my last tweet Please like and RT this to make sure everyone knows where to join us!
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Not enough science and too much noise. You can now find me @gordfishell.bsky.social
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Here is a general public AI-generated podcast reviewing work I did with Suraj Honnoraiah, Asim Aqbal and Greg Stuart on using the logic of inhibition in V1 cortex to program neuromorphic chips to perform working memory and improve AI. Check it out! https://t.co/VeuFMuS1Bi. .
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Non-autonomous signaling in cell specification. An area very close to my heart!
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1/7 🚀Excited to share our primary effort in building neocortex-inspired algorithm-hardware co-design for artificial intelligence in collab with an amazing team (Hassan, @GregStuartLab, @GordFishell) co-lead by Suraj 🙌 #NeuroAI #Neuromorphic #Biology 📢👏 https://t.co/MSrgRoA2Xu
biorxiv.org
Understanding the computational principles of the brain and replicating them on neuromorphic hardware and modern deep learning architectures is crucial for advancing neuro-inspired AI (NeuroAI)....
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Excited to work with my amazing postdoc Suraj Honnuraiah and Asim Iqbal to get this out on biorxiv! Biophysical use of V1 computations used on neuromorphic chips! Here’s the link:
biorxiv.org
Understanding the computational principles of the brain and replicating them on neuromorphic hardware and modern deep learning architectures is crucial for advancing neuro-inspired AI (NeuroAI)....
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Ever considered applying for a Mcknight scholarship but need to know more? It is amazing society and open to the broadest neuroscientists out there !
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