Great opportunity to join a fantastic lab at @IHB_Research !

Polyisocyanide (PIC) hydrogel with the essential properties of #Matrigel. Functionalised with the integrin activating Yersinia protein #Invasin for #organoid growth. Joost Wijnakker et al. Great collaboration with Paul Kouwer's lab. PMID: 41091766 https://t.co/Ts9R30EQ5T

Grayscale's history is one of pioneering crypto and making our products more accessible overtime. Today we've done that yet again with Grayscale Solana Trust ETF (Ticker: $GSOL). Rest assured, we have become exceedingly efficient at it.

Honored to receive the #AbarcaPrize2025. Not surprisingly, I'm very passionate about #organoids and their immense potential to transform how we approach drug discovery and development.  @AbarcaPrize

For the #organoid research group that I founded at the Princess Máxima Center, we are looking for a motivated postdoc with experience in gene editing and bioinformatics. Contact Karin Sanders (k.sanders@prinsesmaximacentrum.nl) to learn more. @prinsesmaximac

https://t.co/lvifbk2TEY

flying

11/11 Take-home: Gut homeostasis is not passive crowd control. It’s an active, force-regulated process. Cells constantly test each other’s strength; those that fail the tug-of-war extrude. A collaboration between the @_Hubrecht, @_amolf & @IHB_Research lead by @DanielKruegerDK

10/11 Disease link: In EpCAM loss (tufting enteropathy), hyperactive myosin caused excessive extrusion, growth defects, and tissue disruption. Too much force destabilizes the barrier. Mixing mutant & WT cells made healthy cells extrude. Myosin inhibition rescued this effect.

9/11 With point ablations at the base, we intentionally weakened individual cells. Within minutes, these cells extruded - loss of tension likely triggers extrusion.

8/11 Local photoactivation on villus substrates, creating boundaries between highly- & less-contractile cells caused preferential extrusion on the weaker side. In mosaic organoids, less contractile "weaker" cells were consistently eliminated. Are weak cells primed for extrusion?

Your kids spend 7 hours a day in a building designed like a prison, following bells, asking permission to speak, and learning to fear authority figures who aren't their parents. And you call homeschoolers "weird" for opting out of this system.

7/11 Optogenetics let us induce contractility with blue light and spatial precision. Extrusion rates jumped up upon activation, showing that globally increased tension directly drives extrusion.

6/11 A basal actomyosin network generates epithelial tension. On hydrogel substrates that mimic the in vivo villus topology (generated by @IHB_Research) we saw pulsatile contractions—one cell contracts, neighbors expand. A tissue-wide tug-of-war.

5/11 Using CRISPR-generated myosin reporters, we first observed myosin increasing in extruding cells, together with a synchronized response in their neighbors - explaining extrusion dynamics as a coordinated process.

4/11 Are villus tips - where extrusion peaks -compressed by crowding? @_Hubrecht , laser ablation revealed they are under tension, not compression. That tension sets the stage for extrusion.

3/11 Using long-term live imaging & tracking (by @_amolf), we followed hundreds of extrusion events. Most villus cells extruded alive, not apoptotic. Extrusion did not correlate with density.

2/11 The intestinal lining renews every few days. Old cells are shed by extrusion—a process essential for barrier integrity and linked to diseases like IBD. But what actually triggers extrusion in mammals was unclear.

1/11 In @ScienceMagazine: A new perspective on how our intestines renew. Cells are not “pushed out” by crowding or die from apoptosis. Instead, cells play a mechanical tug-of-war, where weaker cells extrude, reframing gut renewal as force-regulated.

Brain diseases are tough to treat because of the blood-brain barrier. For decades, it stumped drug delivery. At Roche pRED, we solved this! Our Brainshuttle™ technology safely transports drugs across, opening new doors for CNS therapies. Learn more:

🚨Open position alert! Seeking a Junior Group Lead in #Computational Biology to join #TeamIHB and establish an independent research programme in computational morphometry of human model systems. More at https://t.co/CcgvrOiKKI #computationbiology #ScienceJobs

Join us this fall for a Cold Spring Harbor Lab meeting (Sept 28 - Oct 1, 2025) on "Bioengineered Tissue Systems & Models" on Long Island, New York. Co-organized by myself, my advisor Gordana Vunjak-Novakovic @GVNlab & collaborator Mirjana Maletic-Savatic: https://t.co/6UXAMCAuan

The @TreutleinLab established long-term, live light-sheet microscopy on unguided brain #organoids generated from fluorescently labelled hiPSCs, which enables tracking of tissue morphology, cell behaviors, and subcellular features. 🧫 @Nature | https://t.co/AKepEzaxvC