Matthew Merrins
@merrinslab
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We study metabolic signaling in the pancreatic islet and its deficiency in diabetes.
Madison, WI
Joined June 2019
We are arranging an international islet and transcale imaging meeting in Aug, with a good combination of imaging technology, fluorescent probes, mathematical modeling, and of course, the islet researcher from the world! Here is the preliminary notice. We welcome all of you😀
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Fixed it: --> last year, the U.S. sold more educational services to the rest of the world than it sold in natural gas and coal **combined** --> every $1 of research funded by NIH generates $2.56 in economic activity --> more than 1.1M foreign students come to the U.S. each year
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Standing shoulder-to-shoulder with my #WashU colleagues #StandUpForScience fighting for our work and our future #standupforscience2025
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This 3 minute video by @RepAuchincloss is exactly right and worth your time. Of course it’s easy to find some silly study or even the occasional bad science in nih grants But the solution to that is better peer review, not gutting the scientific enterprise
Basic science is inspired by curiosity, accountable to evidence, and subject to peer review. Politics should have no role.
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About a month after Donald Trump took office as the 47th US president, almost all grant-review meetings remain suspended at the US National Institutes of Health (NIH), preventing the world’s largest public funder of biomedical research from spending much of its US$47 billion
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Last year, $9B of the $35B that the National Institutes of Health (NIH) granted for research was used for administrative overhead, what is known as “indirect costs.” Today, NIH lowered the maximum indirect cost rate research institutions can charge the government to 15%, above
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Thrilled to share one of our biggest discoveries: “Inceptor binds to and directs insulin towards lysosomal degradation in beta cells”. https://t.co/GKx6eslJz0 A tremendous collaborative effort led by @JohannaSiehler, @BilekovaSara and other members of the @LickertHeiko lab.
nature.com
Nature Metabolism - The insulin inhibitory receptor (inceptor) is found to bind to insulin and to regulate insulin stores by directing proinsulin and insulin towards lysosomal degradation.
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Looking for a fluorescent biosensor and don’t know where to start? Want a comprehensive overview of the field? Check out our new review in @ACSChemRev online now as an ASAP article! From co-first authors @AMMGest @AyseZSahan @yanghao_zhong
https://t.co/YId0ttkqkf
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🚨📖New #DiabetesResearch led by @Andi_Microscopy from the @msolimena lab uses advanced 3D #microscopy 🔬 to investigate the structure and function of primary cilia in #BetaCells. The study has now been published in @NatureComms. 👉 https://t.co/cl0teSvBtq
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Wow! Mathematical modelling of insulin secretion, integrating many upstream and downstream processes - including dual effects of H2O2 and NADPH (and SENP1) at distinct points in secretion. From some colleagues in Maribor. https://t.co/dFE9Qtl8LC
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This Thursday 10/3 Danielle Dean @deanlab8 on alpha cells as amino acid and not glucose sensors.
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Wednesday! - 9 am PT//12 pm ET 📢: https://t.co/O2KGagKhGr
@DiabetesnPOD @ULBCDiabRes @AMP_CMDKP
@ufdiabetes @IUSweetTweets @T1D_researcher
@PennIDOM @DiabResearch @Diabetes_DRI
@StanfordDRC @BCDiabResNet @T1D_TrialNet
@JoslinDiabetes @Bruskolab @merrinslab @BennyScience
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Super-excited to reveal our latest fluorescent voltage indicator, ASAP5, now online @NeuroCellPress! ASAP5 features higher responsivity and kinetics, allowing detection of single synaptic transmission events. The link gives free access until 2024.11.09: https://t.co/9GSeEyq0Fi
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A transmitochondrial sodium gradient controls membrane potential in mammalian mitochondria: Cell
cell.com
The mitochondrial complex I functions as a Na+/H+ exchanger (mNHE), utilizing the H+ gradient to build a Na+ gradient and contribute significantly to the regulation of the mitochondrial membrane...
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A transmitochondrial sodium gradient controls membrane potential in mammalian mitochondria: Cell
cell.com
The mitochondrial complex I functions as a Na+/H+ exchanger (mNHE), utilizing the H+ gradient to build a Na+ gradient and contribute significantly to the regulation of the mitochondrial membrane...
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You don’t wanna know how much antibody this project took - totally worth it, every last drop. https://t.co/K6ALWophzr Expansion microscopy of axonemal dyneins in islet primary cilia
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Our new preprint presents 3D light-sheet imaging of the intact islet, focusing on β-cell subpopulations that lead and coordinate islet Ca2+ oscillations. Great collaboration between Erli Jin, @JenniferKBriggs, and @BennyScience .
biorxiv.org
Ca2+-driven oscillations in insulin secretion are crucial for glycemic control. Prior studies, performed with single-plane imaging, suggest that subpopulations of electrically coupled β-cells have...
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Excited to share our publication in Science Translational Medicine. Harmine and exendin-4 combination therapy safely expands human β cell mass in vivo in a mouse xenograft system.
science.org
Combination DYRK1A inhibitor–GLP1RA treatment shows potential as a safe and effective approach to diabetes treatment.
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The June #DiabetesBio #Podcast is now online! Topics include: Int. w/ Drs. Matthew Merrins & Richard Kibbey on Pont-Counterpoint feature in this months Diabetes Issue and more! 🎙️ https://t.co/kBwbgMDsMa
@thewilliamslab @KirkMHabegger @DarleenSandoval
@merrinslab @guy_rutter
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