genoxphos_lab
@GenoxphosLab
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Understanding mitochondrial physiology and biochemistry at @CNIC_CARDIO #OxPhosSystem #mtDNA #metabolism
Comunidad de Madrid, España
Joined December 2018
🧬🔬 El linaje mitocondrial europeo podría ofrecer protección contra la gravedad del #COVID19. 🦠 Una investigación liderada por el grupo @GenoxphosLab del @CNIC_CARDIO y el @CIBERFES y dirigida por José Antonio Enríquez, proporcionaría nuevas claves sobre la diferente respuesta
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💡¿Nueva diana terapéutica para reducir la inflamación cardiaca?🫀 Un equipo del @CNIC_CARDIO @GenoxphosLab, liderado por José Antonio Enríquez, se propone controlar la inflamación excesiva que acompaña a las #EnfermedadesCardiovasculares y su efecto dañino a través de una vía
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And yet another SCOURGE consortium study just came out today. Association of mtDNA haplogroups and COVID-19 risk:
nature.com
Communications Biology - Genetic and Structural analysis of COVID patients cohort reveals a correlation between mitochondrial haplogroup and SARS-CoV-2 severity.
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Heavy blow to the out of Africa theory! The mtDNA tree of OOA assumes that different haplogroups or lineages of mtDNA are separated by neutral variants and functionally no different.
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🔬 🧬 Investigación #EnfermedadesRaras La neuropatía óptica hereditaria de Leber (#LHON) es una enfermedad rara neurodegenerativa que provoca la pérdida de visión. Investigadores @CNIC_CARDIO descubren parte del mecanismo de su patogenicidad. https://t.co/BtDgOpOxbN
isanidad.com
El hallazgo ofrece una nueva perspectiva sobre el papel del sodio en la fisiología mitocondrial de las células
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Textbook oxidative phosphorylation needs to be rewritten with Fernando Abdulkader https://t.co/j3LDawxKEW Free for 50 days here: https://t.co/uEt0tOJ0Bz
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#CNICconference @CNIC_CARDIO Marta Pérez-Hernández @GenoxphosLab presented her data on how Fgr inhibition can be cardioprotective by dampening the inflammatory response.
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Now online! A transmitochondrial sodium gradient controls membrane potential in mammalian mitochondria
cell.com
The mitochondrial complex I functions as a Na+/H+ exchanger (mNHE), utilizing the H+ gradient to build a Na+ gradient and contribute significantly to the regulation of the mitochondrial membrane...
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El #CNIC descubre una función esencial del sodio en las células que explica la causa de la #neuropatía óptica de Leber @isanidad ➡️
isanidad.com
El hallazgo ofrece una nueva perspectiva sobre el papel del sodio en la fisiología mitocondrial de las células
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Scientists at the @CNIC_CARDIO discover an unexpected involvement of sodium transport in mitochondrial energy generation https://t.co/ENpBIIZdNr
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A transmitochondrial sodium gradient controls membrane potential in mammalian mitochondria: Cell
cell.com
The mitochondrial complex I functions as a Na+/H+ exchanger (mNHE), utilizing the H+ gradient to build a Na+ gradient and contribute significantly to the regulation of the mitochondrial membrane...
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A transmitochondrial sodium gradient controls membrane potential in mammalian mitochondria: Cell https://t.co/o9F4N96ROa congrats Tonio&co!
cell.com
The mitochondrial complex I functions as a Na+/H+ exchanger (mNHE), utilizing the H+ gradient to build a Na+ gradient and contribute significantly to the regulation of the mitochondrial membrane...
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🚨🔬 El grupo de investigación @GenoxphosLabdel @CNIC_CARDIO y del @CIBERFES, dirigido por José Antonio Enríquez, ha revelado un hallazgo crucial sobre el sodio y la generación de energía celular. Publicado en @CellPressNews estos resultados podrían transformar el tratamiento de
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Thrilled to share that I've been selected as a finalist for THE BIG PITCH 2024! 🎉 I'm so grateful for the opportunity to share my current and future research on the @UMDF #MitoMed 2024 ✨ @UMDFScience @avlecvie @IRBBarcelona @MitoTherapx_Lab Together towards a cure!
We're excited to announce our 2024 accelerators finalists! These three postdoctoral researchers will each give a 5-minute "pitch" for their research project at THE BIG PITCH 2024. Want your say in who receives the $50,000 award? Become an accelerator: https://t.co/qFSngbCVoR
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Un estudio del @CNIC_CARDIO revela el papel clave de las proteínas de la mitocondria en la regeneración cardíaca https://t.co/GYpLpG9oBe
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“Este resultado demuestra el papel crucial de estas proteínas en la activación de la capacidad de recuperación del corazón tras un daño”, explica Carolina García-Poyatos @C_GarciaPoyatos, primera autora del estudio.
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We found that -cox7a1 is required for CIV homodimerization, -CIV dimerization affects mitochondrial respiration, -lack of cox7a1 reduces skeletal muscle performance but promotes heart regeneration, -cox7a1 and cox7a2l/scaf1 mediated superassemblies have specific organismal impact
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Here we explored the effect of mitochondrial super complex assembly on cardiac regeneration:
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Thrilled to anounce our latest publication. Together with @GenoxphosLab we had previously studied the role of mitochondrial respiratory complex superassembly during organism homeostasis.
embopress.org
image image This study reveals a physiological function of mitochondrial respiratory supercomplex assembly in metabolism by analyzing scaf1 mutant zebrafish that are unable to form supercomplexes....
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A mammalian-specific Alex3/Gαq protein complex regulates mitochondrial trafficking, dendritic complexity, and neuronal survival | Science Signaling
science.org
Mitochondrial trafficking in neurons requires binding of the G protein Gαq to the mitochondrial protein Alex3.
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