Jin Zhang Lab
@jinzhanglab
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We are a lab of diverse scientists developing genetically encoded biosensors for studying cell signaling at UC San Diego
UC San Diego
Joined July 2018
Congratulations to graduate student Evan Wen on receiving and NIH F31 Fellowship Award for his project “Spatial diversity of GPCR-mediated ERK signaling and its role in cardiovascular disease”!
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Check out this recent paper from the lab, which sheds light on the physiological role of RIa phase separation, including its impact on insulin secretion! https://t.co/jsrDPzZxNF This was led by project scientist Skott and former grad student Julia, our phase separation team!
journals.plos.org
The type I regulatory subunit of cAMP-dependent protein kinase (PKA) undergoes liquid-liquid phase separation to facilitate spatial compartmentalization of cAMP. This study shows that such cAMP...
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Last week we celebrated Wei, @weilin1113 , who has left the Zhang lab to start his independent career at Jiangnan University, focused on glycobiology. Wei has led numerous projects including the kinase integrator, KINACT. We’re proud of his work here and excited for what’s next!
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Congratulations to Dr Ayse Sahan! Ayse defended her thesis this summer, and just finished up in the lab to move to her next adventure: a postdoc at UChicago! We’re very proud of what she’s accomplished here and excited to see her future work! #DragonKnife #PhDone
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Congratulations to Dr Emily Pool, who defended her thesis last week! She’s been an incredible asset to the lab, from her precision, to her mentorship, to her work on phase separation of PKA regulatory subunits. We’re so excited to see what she does next! Congrats, Dr. Pool!
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Congratulations to graduate student Rosie Zhou, who won the Shu and KC Chien Best Poster in Bioengineering award at the annual Jacobs School of Engineering Research Expo for her poster “Visualizing Protein Communication in Human Cells to Improve Cancer Treatment” @UCSDJacobs
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Yingqi will be receiving support from the Tobacco Related Disease Research Program (TRDRP) for her project on spatiotemporal cGAMP signaling in tobacco-induced non-small cell lung cancer metastasis. Congrats to them both!
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Nick’s fellowship is from the Dutch Research Council @NWOFunding and will support his project on “Spatial Organization of AT1R-Gaq-mediated ERK signaling in the diseased heart”
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Congratulations to two lab members on their recent awards and fellowships! Postdoc Dr. Nick Bergkamp received the Rubicon Postdoctoral Fellowship *and* the Van Zwieten PhD Thesis award! And Grad student Yingqi Zhu received the TRDRP Predoctoral Award!
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Everyone’s efforts enabled us to develop a new class of chemigenetic kinase activity reporters with a large dynamic range, far-red spectral range, live cell super resolution capacity, and a design that is generalizable to several kinase targets.
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This project was a massive collaborative effort, including our graduate students @Sam_A_Sanchez and @XinchangHe_ , @wang_yingxiao ‘s lab at USC, especially Longwei, Falk Schneider in Scott Fraser’s lab, and more.
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Check out our new paper in @NatureBiotech sharing our latest kinase activity reporters! Led by former postdoc Michelle Frei, these reporters are based on HaloTag rather than an FP, for far-red imaging and superresolution!
nature.com
Nature Biotechnology - Far-red kinase biosensors are applied to image kinase signaling networks at super resolution.
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Save the date for the next @VUBasicSciences Apex Lecture with @jinzhanglab @UCSanDiego: “Illuminating the Biochemical Activity Architecture of the Cell” Tuesday, April 17, 3:00 pm, 1220 MRB III A reception will follow!
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With these sensors, we’re able to track PI(3,4)P2 and PIP3 signaling in the cell, and show the lysosome is a PIP3 signaling site!
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Congratulations to graduate student Ayse Sahan and former student Shawn Mingyuan Chen on the publication of their lipid biosensors in PNAS!
pnas.org
3-Phosphoinositides (3-PIs), phosphatidylinositol (3,4) bisphosphate [PI(3,4)P2] and phosphatidylinositol (3,4,5) trisphosphate (PIP3), are importa...
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Last week we celebrated 3 lab birthdays! Happy birthday to grad students Qian and Pal, and Project Scientist Skott! #DragonKnife
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On Friday we had our lab farewell party for postdoc @chrisqs5 , with lunch, cake, and lab sweater and mug! #DragonKnife Qi is moving on to a position in Dr. Diane Simeone’s lab at Moores Cancer Center. We’ve loved working with Qi, and are excited to see what he does next!
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Get to know MCC's Dr. Jin Zhang (@jinzhanglab) in this #ResearcherSpotlight! Discover her journey into cancer research, leading-edge projects & the crucial connection between fundamental cellular mechanisms and disease-related applications: https://t.co/g9fcI23ryL.
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Congratulations and thank you to @doctorsohum for 15 wonderful years in the Zhang lab! You’ve contributed so much to the work we do, the culture of our lab, and each of our lives! Thanks for 15 amazing years, and here’s to many more!
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