Todd M. Brusko
@Bruskolab
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Professor - Director at the UFDI- Father, immunologist, proponent of evidence-based policy. All opinions are my own.
Gainesville, FL
Joined November 2016
Emerging technologies to acquire high-parameter tissue images are expanding rapidly but they still require robust analytical pipelines. Here, @BruskoMaigan and @ufdiabetes investigators publish detailed instructions to enable analysis.
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Pleased to contribute to this exciting work on how HLA shapes the T cell receptor repertoire - TCR2HLA: calibrated inference of HLA genotypes from TCR repertoires enables identification of immunologically relevant metaclonotypes
biorxiv.org
T cell receptors (TCRs) recognize peptides presented by polymorphic human leukocyte antigen (HLA) molecules, but HLA genotype data are often missing from TCR repertoire sequencing studies. To address...
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Super cool thread on how tech interfaces with biology to provide novel insights.
1/ Better late than never, here’s a long thread of threads summarizing our MOSAIC preprint. If you’re curious about the process by which a new microscope is conceived and brought into the world, this is the thread for you. If you’ve come for eye candy, there’s plenty of that too.
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RT @DKThomp: Yes. Writing is not a second thing that happens after thinking. The act of writing is an act of thinking. Writing *is* think….
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Excited to present this today at #ENDO2025 with Drs. Dirk Homann and Al Powers who organized. Swing by and join the discussion.
Michels et al integrate and summarize information about the pathogenesis of T1D, highlight gaps in current knowledge, and propose future activities that may lead to additional approaches to treat the underlying autoimmunity and β-cell defects in #diabetes.
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RT @ufdiabetes: A new grant from the American Diabetes Association's Innovative Translational Clinical Science program was awarded to Dr. A….
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Happening today! Come out to hear about spatial transcriptomics in T1D as Miguel defends his dissertation.
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Epic day on the water yesterday. Hogfish, flounder, Black Sea bass and white grunts…topped off with fresh homemade smoked mullet dip. Hope everyone enjoyed the 4th!
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RT @T1D_TrialNet: TrialNet screens families of people with T1D & offers clinical studies testing ways to slow down & prevent disease progre….
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RT @ufdiabetes: Take a look at our UFDI spotlights today at the @AmDiabetesAssn 85th Scientific Sessions! #ADASciSessions .
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RT @AnuSharma1025: Strong work by @UFEndocrinology at #ADASciSessions #ADA2025 .1 consensus report review on MASLD.3 oral presentations.8 p….
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RT @ufdiabetes: .Today’s speaker lineup at the @AmDiabetesAssn 85th Scientific Sessions features Alexandra E. Cuaycal, PhD, Srilaxmi Kalav….
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RT @BLLPHD: 🚨NEW - In vivo CAR T cell generation to treat cancer and autoimmune disease @capstantx direct delivery of mRNA-encoded CARs to….
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RT @SciImmunology: T follicular helper cells can play unconventional immunoregulatory roles, such as supporting cytotoxic #Tcell responses….
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RT @FOCISimmunology: 🎉 We're heading to Boston to celebrate 25 years of FOCIS!. Don't miss out — registration for the FOCIS 2025 Annual Mee….
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Excited to share a preprint reporting on the cellular and molecular immune profile of human T1D from @DiabetesnPOD. Aberrant immune regulation and enrichment of stem-like CD8+ T cells in the pancreatic lymph node during type 1 diabetes development
biorxiv.org
Effector CD8+ T cells are key cellular drivers of type 1 diabetes (T1D) pathogenesis, yet questions remain regarding the molecular defects leading to altered cytotoxicity, their signature in periph...
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