Guy Rutter1
@guy_rutter
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Professor of Medicine Université de Montréal, Imperial College London, Nanyang Technological University Singapore. Wellcome Investigator.
Joined November 2014
Impaired cAMP–PKA–CREB1 signalling drives mitochondrial dysfunction in skeletal muscle during cancer cachexia | Nature Metabolism
nature.com
Nature Metabolism - Tumour-induced dysregulation of cAMP–PKA–CREB1 signalling in skeletal muscle is shown to be a driver of mitochondrial dysfunction, contributing to cancer cachexia in...
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Out today in Diabetes! Additive Effects of Dorzagliatin and Glucagon-Like Peptide-1 Receptor Agonism in a Novel Mouse Model of GCK-MODY and in Obese db/db Mice | Diabetes | American Diabetes Association @CRCHUM @ImperialMDR
diabetesjournals.org
Glucokinase (GK) catalyzes the key regulatory step in glucose-stimulated insulin secretion (GSIS). Correspondingly, hetero- and homozygous mutations in hum
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#Throwback REVIEW | @guy_rutter , @BennyScience et al Exploring pancreatic beta-cell subgroups and their connectivity https://t.co/AaT8evxbXa
nature.com
Nature Metabolism - Rutter and Benninger discuss the role of putative controlling beta-cell populations in the context of intra-islet connectivity, how such a cellular hierarchy might be achieved...
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Relaunching our @CRCHUM Cardiometabolic Axis data sessions data sessions today with amazing talks from #mathiasguayasamin and #luisdelgadillosilva. #ciaranmurphyroyal @CRCHUM_CELLS
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Not one, but TWO endocrinologists to join the Canadian Medical Hall of Fame in 2026. Both Drs Hegele and Zinman have changed the way we treat metabolic disorders forever. In addition though … they are just kind humans. Congratulations!!🎉🎊🎈
Join us in congratulating the #2026CMHFInductees! https://t.co/KZkZwtzqjy PAVEL HAMET, MD PhD ROBERT ALEXANDER HEGELE, MD MICHAEL D. HILL, MD MARY R. L'ABBÉ, PhD MORAG PARK, PhD BERNARD ZINMAN, MDCM @kellygrant1 @Megan_Ogilvie @LaurenPelley @DubinskiKa4985 @JenLeeCBC @Avis_Favaro
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Important new review from my @CRCHUM colleague #MarcDonath
Inflammation is a key driver of the pathophysiology of cardiometabolic disorders #obesity #T2D and new metabolic medicines based on GLP-1 action exert their magic in part by reducing inflammation. A new review from Professor Donath summarizes the field https://t.co/7mDWLvqvyw
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I‑BET151 modulates glucokinase gene expression and beta cellfunction in part through changes in FOXO1 expression https://t.co/psZGz6vLqH Assoc. Prof Yusuf Ali's team @NTU_LKCMedicine in collaboration with @guy_rutter and @astar_research discovered that BET protein inhibition
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All true. But the same rigour should be applied to ALL the antibodies we use. Those against glucokinase are a case in point.
In some of these papers, glp1r detection is a small element. In others it's a large element. Don't trust antibody vendors, and do the legwork. As a field we are always happy to provide reagents/models to help with validation.
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Our new report with #YaChiHuang #MarjanRupnik using high-speed imaging in pancreatic slices. Pancreatic α-cells are functionally heterogeneous and sex-dependently regulated by neighboring endocrine cells | bioRxiv
biorxiv.org
Glucose and paracrine regulation on α-cells, particularly with respect to sex differences, remains unclear. Hence, we imaged islets of GluCre:GCaMP6ffl/fl mice in pancreatic slices, additionally...
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#Throwback REVIEW | @guy_rutter , @BennyScience et al Exploring #pancreatic #BetaCell subgroups and their connectivity https://t.co/AaT8evxJMI
nature.com
Nature Metabolism - Rutter and Benninger discuss the role of putative controlling beta-cell populations in the context of intra-islet connectivity, how such a cellular hierarchy might be achieved...
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Our new kid on the block to rival or beat existing dual agonists? Binding kinetics, bias, receptor internalization and effects on insulin secretion in vitro and in vivo of a novel GLP-1R/GIPR dual agonist, HISHS-2001 - PubMed.
pubmed.ncbi.nlm.nih.gov
HISHS-2001 represents a novel dual receptor agonist with a promising pharmacological profile and actions. Future clinical studies will be needed to assess the safety and efficacy of this molecule in...
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The influence of metformin treatment on the circulating proteome - PubMed. Important new study led by @LeentHart and the EU-funded IMI -Rhapsody and IMI-DIRECT consortia
pubmed.ncbi.nlm.nih.gov
Innovative Medicines Initiative Joint Undertaking 2, under grant agreement no. 115881 (RHAPSODY) and the Innovative Medicines Initiative Joint Undertaking under grant agreement no. 115317 (DIRECT),...
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Thanks again @SoleimanpourLab for the opportunity to be involved and to #MarieGasser for her vital input! Also grateful to the ever-resourceful @carapetop for her help!
@nesvilab @epgnomike @guy_rutter @NIDDKgov @ADA_DiabetesPro @BreakthroughT1D @DeptVetAffairs P.S. we would be remiss if we did not also thank the amazing reviewers and editor who made our work better and more complete. As well as @cevansmo for the lovely commentary on our work!
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Hard to disagree! Looking forward to it!
The best small islet biology symposium in China and Asia, maybe in the world as well:)
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Nice one @daveyboyhod !
Dr. David Hodson (@daveyboyhod) and team show that GLP1R is enriched as nanodomains on beta cell membranes that contact alpha cells, in keeping with increased single-molecule transcript expression. 💡 Learn more: https://t.co/4DCPJoI97d
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Pleased to share that I start a new role today as Head of the Cardiometabolic Axis at the CRCHUM in Montreal. Looking forward to the challenge!
chumontreal.qc.ca
À compter du 1er juillet 2025, Guy Rutter devient le nouveau responsable de l’axe Cardiométabolique du Centre de recherche du CHUM (CRCHUM) pour un mandat initial de quatre ans. Il intégrera ainsi le...
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A huge step forward for cell replacement therapy for #T1D @NEJM Vertex clinical trials for zimislecel https://t.co/r0COO2dMEQ
nejm.org
Zimislecel is an allogeneic stem cell–derived islet-cell therapy. Data on the safety and efficacy of zimislecel in persons with type 1 diabetes are needed. We conducted a phase 1–2 study of zimisle...
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Delighted to be elected a Fellow of the Academy of Medical Sciences today. Looking forward to playing an active role in the Academy’s activities in the U.K and abroad. @ImperialMDR @CRCHUM @RIMUHC1 @NTUsg
Congratulations to the 54 exceptional scientists who have been elected to the Academy Fellowship today in recognition of their remarkable contributions to biomedical and health sciences 🎉 Discover more: https://t.co/NIVSM2BNIN
#AcademyFellows
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"If you're working non-stop all the time you will burn out." How do you keep a healthy work-life balance as a scientist? Hear 2009 chemistry laureate Venki Ramakrishnan share his best advice on how to achieve a good work-life balance. #NobelPrize
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