Carolyn Bertozzi
@CarolynBertozzi
Followers
79K
Following
11K
Media
621
Statuses
16K
Joined March 2012
People are asking me about the origins of and key milestones in the timeline of #bioorthogonal chemistry, so here is a quick summary. 1/n.
BREAKING NEWS: .The Royal Swedish Academy of Sciences has decided to award the 2022 #NobelPrize in Chemistry to Carolyn R. Bertozzi, Morten Meldal and K. Barry Sharpless “for the development of click chemistry and bioorthogonal chemistry.”
140
3K
12K
Thanks Tom! Maybe we can get the band back together someday 😉 “Ve-Ri-Loud” @Harvard.
Congrats to my former @Harvard bandmate @CarolynBertozzi on her @NobelPrize in chemistry! We won the Ivy League Battle of the Bands in 1986 with our rockin’ group ‘Bored Of Education’, with her on keyboards & me in spandex.
75
439
6K
By tradition, @Stanford @NobelPrize Laureates are invited to join a football game as celebratory guest 🏈. That was a fantastic experience two weeks ago, but what about women’s athletics, I asked? 1/4.
35
491
5K
Turns out, no one had ever considered the idea, perhaps because I am the first woman Nobel Laureate @Stanford. They responded by making me honorary coach of our championship women’s volleyball team @StanfordWVB for the day 🏐! 2/4.
15
102
3K
@BerkeleyLab @tmorello @Harvard @NobelPrize Here are a few I found of the incomparable @tmorello circa 1986 @Harvard
27
182
2K
Next month I will have the equally incredible honor of joining our amazing women’s basketball team for a game @StanfordWBB 🏀. So honored to support Stanford Athletics in this way. 4/4.
25
41
2K
Proud to support this important project, thank you @_pamelabgreen for brining Ben Barres’ life story to the big screen 🙏, followers please RT!.
2
19
86
Garbage alert: this “big authorship data” analysis stumbles on what we already know about gender bias in academia, then stupidly advises that the key to women’s success is to avoid female mentors and instead align with privileged males. Who reviewed this?
67
376
2K
Iranian women are showing the world what courage looks like, standing up for their very basic human rights in an historic movement 💪, freedom of thought, freedom of speech, and autonomy as human beings are cornerstones of a just society and essential for advancement of science.
45
314
2K
Incredibly disrespectful to legions of biopharma (and academic) scientists and physicians who dropped everything to deploy their skills for #COVID19, on no sleep, progressing toward diagnostics, therapeutics and vaccines at unprecedented pace. Finest people in their finest hour.
Sanders: “In the midst of this epidemic, you’ve got people in the pharmaceutical industry saying, ‘Wow,’ <rubs hands together> ‘what an opportunity to make a fortune.’” #COVID19 #DemDebate.
47
280
2K
It would be great if @ChemicalScience could help me share this message 😃.
Impactful words by @CarolynBertozzi today on how diversity in her trainees enabled creativity, not playing by the rules, and ultimately the work that built the field of bioorthogonal chemistry. Diverse science leads to better science!
11
319
2K
Legendary chemist and educator @drdre4000 profiled @Nature. TikTok’s dancing chemist catalyses joy in students
16
177
1K
Important article about the extra burden minoritized academics often bear in the form committees and service, important work that is rarely valued in promotions, problem that needs to change while greater care is taken to avoid overburdening.
17
398
1K
Deeply honored and grateful to join this list of spectacular scientists.
The Wolf Prize in Chemistry 2022 is awarded to Professors Bonnie L. Bassler, Carolyn R. Bertozzi, and Benjamin F. Cravatt III 3/6
98
72
1K
One thing we all agree on is that science is of great benefit to humanity @amyklobuchar @RandPaul
43
28
1K
People are asking me to share an old photo of me and my younger sister Diana with Larry Bird (~1986). Our mother insisted we stand in line for hrs to get his signature on that poster, which hung in our house like a shrine. She was an avid @celtics fan, d. Oct 16, 2021 ❤️🩹
16
28
1K
Thank you @POTUS for taking the time to meet with us, and for your enduring support of science and education 🙏.
Yesterday I met the 2022 U.S. Nobel Prize Winners in Chemistry, Physics, and Economic Sciences. They've created some of the most exciting breakthroughs in human understanding and have expanded our sense of possibility. Congratulations, Dr. Clauser, Dr. Bertozzi, and Dr. Diamond.
5
54
1K
My sister Diana is a health care worker in NJ, she had and recovered from COVID-19, now back at work in the COVID ward working double shifts. There is no break for these warriors.
11
56
1K
Small RNAs are modified with N-glycans and displayed on the surface of living cells - ScienceDirect
17
228
1K
Mind racing with emotions after the shock of this news, Sabatini fired from MIT/HHMI for sexual harassment/toxic behavior. Reactions suggest his behavior was an open secret for >decade. My line is open for survivors and trainee refugees whose careers are (temporarily) derailed.
15
142
968
🤦♀️ . A Nobel laureate claimed antimale discrimination. An early-career researcher called it out | Science | AAAS
24
186
859
Twitter at its best: I retweeted a posting about an open postdoc position, an academic follower saw it and pointed it out to his student who was looking for postdoc, she applied and it turned out to be a great match, the deal is done! Love it.
6
48
831
And so many applications of bioorthogonal chemistry beyond glycan labeling, too many to recount. It has been an amazing ride of mechanistic and synthetic chemistry, cell biology and most recently clinical translation. 27/fin.
38
31
870
Thank you @AmerChemSociety for this tremendous honor, and for all you do for the "central science" 🙏.
37
63
868
When we recruited @doudna_lab to @berkeleyMCB and @UCB_Chemistry in 2002 we already saw her as high potential for @NobelPrize for her groundbreaking work in RNA structural biology and enzymology. I still contend she is worthy of a second! Nice to see Wikipedia keeping pace:
2
50
831
Wonderful recognition of what it took to develop a revolutionary new class of vaccines and medicines based on mRNA, congratulations!.
BREAKING NEWS.The 2023 #NobelPrize in Physiology or Medicine has been awarded to Katalin Karikó and Drew Weissman for their discoveries concerning nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19.
7
36
801
What I most valued about Twitter was following journal, news, biopharma, and sports feeds, and the diverse community of scientists I meet and sometimes collaborate with. I love amplifying cool discoveries and celebrating scientists’ accomplishments where the world rarely does/1.
12
64
844
“In my training and career across seven institutions…I have only been taught by three Black professors. It would have made such a difference to have seen more faculty who looked like me. I hope I can make that difference for future students.”
5
162
772
Thank you @UCB_Chemistry for this incredible honor, made even deeper by decades of memories working in Latimer Hall and gazing at the legends on that wall. Extra special that I share the space with the other two American women who have won the prize, all in the great state of CA.
🎉🎉🎉We were delighted to host a reception to unveil the @CarolynBertozzi plaque in Latimer Hall last week celebrating her Nobel Prize. Prof. Bertozzi is an alumna & former professor at the College. She is the 3rd woman associated with our College to win the prize. @NobelPrize
11
34
791
PERFECTION!.
BREAKING NEWS: .The 2020 #NobelPrize in Chemistry has been awarded to Emmanuelle Charpentier and Jennifer A. Doudna “for the development of a method for genome editing.”
2
52
751
A special day in Washington DC with physics @NobelPrize Laureate John Clauser and 2-time chemistry Nobel winner Barry Sharpless, all from the great state of CA!
9
47
761
Whoa, just noticed that @verified came through! Thank you all the supporters who joined my little chorus!.
15
6
725
Fun fact: The grad student who did this work, Eliana Saxon, was the third person I pitched the project to. The first two thought it wouldn't work and took a pass. Eliana got her first big results during the summer before grad school even started! 16/n.
4
38
699
Glycans are the most diverse and structurally complex of all biopolymers. They are found attached to proteins, lipids and, yes, RNA on cell surfaces and are sometime free on their own, and they are “read” by glycan binding proteins that orchestrate cell-cell interactions and more
6
78
661
Look who showed up in Stockholm!! Great celebrating with the @UCB_Chemistry grad student team that built the house of #bioorthogonal chemistry 🙏 . Can you name the now-famous scientists in this photo?
7
19
632
Exciting announcement - JHU to name new building after Henrietta Lacks who gave us the HeLa cell line
3
143
627
Let me acknowledge the brilliant work of Prof. Dr. Rolf Huisgen, who passed in 2020 just a few months shy of his 100th birthday (. I had the great privilege of meeting him at Univ. Munich in 2012, where he sat in the front row for my lecture😅. 1/n
1
41
647
One might consider this as a prize for use of the C-glycoside pseudouridine to reduce RNA immunogenicity, another win for #glycotime!.
BREAKING NEWS.The 2023 #NobelPrize in Physiology or Medicine has been awarded to Katalin Karikó and Drew Weissman for their discoveries concerning nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19.
2
40
632
My superstar lab manager made this cool graphic of our group members, Halloween style 🎃
10
15
620
Thanks for the birthday note @UCBerkeley @UCB_Chemistry and @BerkeleyLab, best wishes from that “other school” 😂.
Happy Birthday to Carolyn Bertozzi, @Cal Ph.D. 1993 & Professor of Chemistry 1996-2015. She won the 2022 Nobel Prize in Chemistry "for the development of click chemistry and bioorthogonal chemistry," for work done primarily at @BerkeleyLab, though she is now at some other school.
16
13
613
My scientific hero @francesarnold @Caltech just won the @NobelPrize. What a fabulous day this has turned out to be. 🌈🍾🎉.
6
40
574
What an incredible honor to share a selfie with the talented #GilliamFellows @HHMINEWS! Looking forward to seeing them many more times as their careers skyrocket 🎉
6
21
565
The @WolfPrize_ ceremony is extra special when shared with good friends like Ben Cravatt!
22
29
565
As a postdoc @UCSF in Steve Rosen's lab, I was struck by how powerful live cell and in vivo imaging tools for proteins and nucleic acids had become, while cell-surface glycans remained in accessible. 2/n.
2
27
553
To all X followers, come join me and many other science lovers where the clouds have parted 😉.
14
64
537
Overheard a conversation about trainees preferring career paths that differed by gender. So I analyzed permanent jobs of my own former trainees to see how it breaks down, data as follows. Some observations.
13
100
522
I am excited to announce that Nathanael Gray and Priscilla Yang are moving to @Stanford !!Nathanael will join us @Stanford_ChEMH and Dept of Chem & Sys Biol and Priscilla will join Dept of Micro & Immunol, supercharging chem bio on The Farm🔥.
14
40
528
This is kindest, most meaningful and humbling thing a person could ever say about a coworker. I am so touched by this blog @Koopgirl, we miss you too!!. A good win – View From an Irish Back Yard
8
57
511
What I love most about the mRNA vaccines is their reliance on 1-methyl-pseudouridine, a synthetic C-glycoside, to avoid innate immunity while enhancing translation. #glycotime to the rescue once again!.
6
83
512
How can we teach high school students in any geography about the power and magic of CRISPR gene editing? @Stanford_ChEMH Institute Scholar @stanleyqilab and affiliate @MichaelCJewett @StanfordEng developed this affordable kit! .
4
105
494
Poignant 🧵 by @glycocode, my first grad student @UCB_Chemistry who took a chance on a new prof and launched us on the path we walk today. We shared experiences of prejudice and obstacles, and, ultimately, triumphs. And of course a love of #glycotime !.
4
32
477
Congratulations David Macmillan @MacMillan_Lab and Ben List! A cause to celebrate pure organic chemistry and two extraordinary chemists 🎉🥂.
BREAKING NEWS: .The 2021 #NobelPrize in Chemistry has been awarded to Benjamin List and David W.C. MacMillan “for the development of asymmetric organocatalysis.”
2
29
469
Honored to be among the incredible people associated with this award, and deeply grateful to my coworkers/trainees @UCB_Chemistry, @Stanford_ChEMH and @StanfordUChem, whose work is being recognized by the @hein_prizes.
#breaking Biochemist Carolyn Bertozzi is receiving the Dr H.P. Heineken Prize for Biochemistry and Biophysics 2022 for her ground-breaking research into communication between cells and methods of influencing this communication. Read the press release:
31
28
457
Amazingly, the Staudinger ligation could be performed in live animals, a feat accomplished by @jenn_prescher @UCIrvine and Danielle Dube @BowdoinCollege. A first-in-class achievement by these intrepid young chemists, published @Nature in 2004: 17/n.
3
32
454
@grubreport This 👆entire thing happened to us today as well! But it was my kid who changed his name to “this video sucks” and got an unpleasant email from teacher. All while I zoom lecture and meet with Deans etc.
4
11
412
We figured out how to do just that with the "Staudinger Ligation" as we called it (and others added my name later on, "Bertozzi-Staudinger Ligation", 🥳). This was the next big story from our lab, published @ScienceMagazine in 2000: 15/n.
2
23
422
Another brilliant @LEGO_Group avatar by the great @20tauri! 🙏 Can I get one for my office collection?.
Happiest birthday, @CarolynBertozzi! In light of last week's Nobel news, I gave your minifig an update ;-)
6
20
431
Questions like, what kinds of sugars are expressed on different cell types and how do they change upon perturbation, could not be answered without destroying cells and much labor. The first project I worked on illustrates the point. 3/n.
1
28
431
I was teaching first semester organic chem as I often do, and in the course of writing my annual lecture on ring strain a thought came to mind. Perhaps a strained alkyne in a ring system would react faster. 21/n.
5
22
413
Please consider @ACSCentSci for more chemical/biochemical work, we are open access with no fees for authors or readers! $0.
6
72
428
Wow, I am so happy to see this work, single molecule imaging of glycoproteins and glycolipids showing attachment sites of glycans. Breathtaking to see these #glycotime images! .
2
48
423
@michelleoyen Actually I have always appreciated how I can just be myself as an academic scientist, dress as I want, look as I want, with a lot less pressure to conform to feminine appearance pressures that women in other sectors are subjected to. Frees up tons of time as well!.
6
13
408
Lara Mahal @glycocode @UAlberta and Kevin Yarema @JohnsHopkins pulled it off with this amazing study, the first big paper from my fledgling lab. 9/n.
1
26
403
Grateful for this recognition of the hard work of my many trainees over >25 years 🙏.
20
21
426
Excited to speak at the Chinese Bioscience Association today, what a thoughtful gift from CBA sponsorship director Charlie Ao!
9
17
412
A tremendous honor to join the list of Carty Award recipients, looking forward to celebrating with all the scientists at the NAS meeting.
We’re honoring #NASmember @CarolynBertozzi of @Stanford @HHMINEWS with the 2020 John J. Carty Award for the Advancement of Science for her invention of bioorthogonal #chemistry! #NASaward #PhysicalSciences
16
21
408
Applications welcome for the Stanford Science Fellows postdoctoral scholars program:. Science Fellows
1
164
430
This is devastating news, we lost a superstar. Sammy's work @BlackInChem will have a lasting positive effects in our field, we must be diligent in honoring her legacy by carrying on the work.
It is with utmost sorrow and heavy hearts to announce the passing of our President and Co-Founder of BlackinChem, Samantha “Sammy” Mensah. She was a phenomenal activist, leader, inventor, science communicator. and a doctoral candidate in chemistry at UCLA. (1/3)
4
52
371
Congratulations David Baker, Demis Hassabis and John Jumper! Protein design and folding prediction for the win, big year for AI in the Nobel suite!.
BREAKING NEWS.The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”
1
28
389
Congratulations to @StevenMBanik and the team on their publication of #LYTACs @nature. Steve joins our faculty @Stanford_ChEMH and @StanfordUChem in Jan 2021, great opportunity for new students and postdocs.
9
116
399
Kudos to @nature for calling attention to this issue of STEM conferences held in hostile locations: “A decision to host in an LGBT+ hostile country should never be taken lightly”. Nature is proud to support Pride in STEM
5
68
362
As a postdoc I had a serendipitous encounter with the great Prof. Dr. Werner Reutter at a boutique conference in Southampton, England, where he talked about sialic acid biosynthetic enzymes tolerating unnatural substrates: 5/n.
2
22
372
Thank you again @NagoyaUniv and host @Itamilab for this beautiful medal and the honor of sharing the work of my students and postdocs with such a distinguished audience.
9
10
374
This is an incredible honor and I look forward to the chance to celebrating with the amazing faculty, students and postdoc @TAMUChemistry once we are all back in action!.
.@Stanford chemist, @theNASciences member & bioorthogonal chemistry founder @CarolynBertozzi has been selected to receive the 2020 F.A. Cotton Medal for Excellence in Chemical Research, presented by @TAMUChemistry & the @TAMU Section of @AmerChemSociety:
12
23
370
I wonder if they stopped for a moment to think it through one more step: once those male-enabled women finish their training and become a mentor themselves, who will be advised to work for them? This paper is a joke, not a funny one unfortunately.
10
11
348
Look who I (finally) got to meet in person! It’s about time I got a selfie with the great @jenheemstra
1
7
365
Woo hoo!.
Based on our exhaustive research, scientists will be more successful by choosing mentors and/or mentees whose last name starts with 'B'. Wondering where I could submit this.
18
12
338
Methods for imaging and profiling sugars on live cells/animals were lacking, a clear unmet need that I thought might be tackled with chemical approaches. But how to do it? 4/n.
1
18
351
Congratulations to this trio, quantum dots for the win!.
BREAKING NEWS.The Royal Swedish Academy of Sciences has decided to award the 2023 #NobelPrize in Chemistry to Moungi G. Bawendi, Louis E. Brus and Alexei I. Ekimov “for the discovery and synthesis of quantum dots.”
1
13
355
This one was a long time coming and wonderfully deserved, a discovery that has impacted the world in such a tangible way. I say this as someone who sleeps with her phone under the pillow!.
The 2019 #NobelPrize in Chemistry has been awarded to John B. Goodenough, M. Stanley Whittingham and Akira Yoshino “for the development of lithium-ion batteries.”
1
27
342
The tolerance of that pathway for nonnative acyl groups got me thinking about whether metabolism could allow delivery of chemical handles to cell surface sialic acids for covalent labeling with imaging probes. But what type of chemistry would allow this in living systems? 6/n.
1
15
337
Postdoc @raflynn5 and I are keen for feedback on preprint posted @biorxivpreprint. He made the shocking discovery that Y RNAs + other small RNAs are modified in the secretory pathway with N-glycans. Thus begins the new world of “glycoRNA”.
17
128
333
This form of "copper-free click chemistry" had all the right stuff for in vivo imaging. Scott Laughlin @stonybrooku and @basktasktic performed an elegant study of dynamic changes in cell-surface glycans during zebrafish development @ScienceMagazine: 25/n.
2
24
339
But my feed is now overrun by misinformation trolls, hate posters and porn-bots. The gross noise has overwhelmed the signal. Lots of open space for competitors like 🦋 and 🧵s/2.
14
16
348
In celebration of today’s chemistry @NobelPrize here is a look back to a wonderful contribution @ACSCentSci 🎉 . Quantum Dots with Highly Efficient, Stable, and Multicolor Electrochemiluminescence | ACS Central Science
3
52
348
It’s official, I am an honorary member of the @francesarnold lab! Thanks for the T-shirt, what a great way to celebrate chemistry @NobelPrize.
4
11
332
😮 🤯.
Replace an aromatic carbon with nitrogen, leave the rest of the skeleton the same. A huge first step towards the problem I started my lab to tackle, thanks to @tyler_j_pearson, @ryoma_ous, @DriscollJuliaL, @balu_dherange, and Dong-Il.
4
21
344
More imaging studies and reaction improvements ensued, and the field took on a life of its own outside our lab: development of the amazing tetrazine ligation by Neal Devaraj and Joe Fox, more practical cyclooctyne syntheses by the van Hest, van Delft and Rutjes groups, etc. 26/n.
2
17
330
Thalidomide is a molecular glue degrader that acts via cereblon binding. @drcmwoo and collaborator @MattRPratt discovered that cereblon mediates degradation of endogenous protein cyclic imides, a form of protein damage. Art imitates life!
2
43
341
Interesting study by @DirkTrauner and coworkers @J_A_C_S, attachment of medium chain lipids to small molecule drugs enhances their cell permeability.
4
37
341
Look I am sitting next to at #ACSSpring2023!! @LewisLabMSKCC, pioneer of in vivo human (!) bioorthogonal chemistry @MSKCancerCenter
4
16
334
Prof. Huisgen's foundational 1950's work set the stage for the most important reaction in chemical biology, a development he could not have foreseen in the moment. As well, we don't know today what the impact of our work will ultimately be. Support curiosity-driven basic science.
We are sad to hear that Rolf Huisgen, best known for research on 1,3-dipolar cycloadditions, has passed away. Sharpless included and extended this work in his Click Chemistry. #chemheroes.Huisgen's #Classicsinchem: Click Chemistry:
1
80
335